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Hire Josh M.

United States

USD 100 /hr

Analytical chemist and bioinformatician in untargeted metabolomics

Profile Summary

Analytical chemist and bioinformatician specializing in chromatography, mass spectrometry, and data analysis for pharmaceutical, metabolomic, and medical device applications. Experienced in method development, instrument stewardship, software development, and teaching.

Subject Matter Expertise

• ☆ Analytical Chemistry
• ☆ Separation & Purification
• ☆ Spectroscopy
• ☆ UV Spectroscopy
• ☆ Fluorescence Spectroscopy
• ☆ Spectrophotometry
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Gas Chromatography
• ☆ Data Analysis
• ☆ Data Processing
• ☆ Statistics
• ☆ Regression Analysis
• ☆ Multivariate Analysis
• ☆ Food Sensory Analysis
• ☆ Flavor & Fragrance Chemistry
• ☆ Python
• ☆ LaTex
• ☆ R
• ☆ Markup Languages
• ☆ Drug Development
• ☆ Bioanalytical Testing
• ☆ Preclinical ADME/PK/PD

Services

• Research
• Consulting
• Data & AI

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Cleaning, Data Processing, Data Insights

Work Experience

Senior Scientist

Overpotential

April 2026 - Present

Research Associate

Massachusetts Institute of Technology

February 2020 - Present

Lecturer

Tufts University

September 2021 - December 2021

Graduate Student

Tufts University

September 2015 - August 2021

Research Assistant

Tufts University Sensory and Science Center

January 2017 - September 2019

Education

PhD (Chemistry)

Tufts University

September 2015 - August 2021

MS (Chemistry)

Tufts University

September 2015 - August 2018

BSc (Chemistry)

University of Rhode Island

September 2011 - May 2015

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Federico Stilo, Giulia Tredici, Carlo Bicchi, Albert Robbat, Joshua Morimoto, Chiara Cordero (2020). Climate and Processing Effects on Tea (<i>Camellia sinensis</i> L. Kuntze) Metabolome: Accurate Profiling and Fingerprinting by Comprehensive Two-Dimensional Gas Chromatography/Time-of-Flight Mass Spectrometry . Molecules.

Changes in Tea Plant Secondary Metabolite Profiles as a Function of Leafhopper Density and Damage @ARTICLE{10.3389/fpls.2020.00636,AUTHOR={Scott, Eric R. and Li, Xin and Wei, Ji-Peng and Kfoury, Nicole and Morimoto, Joshua and Guo, Ming-Ming and Agyei, Amma and Robbat, Albert and Ahmed, Selena and Cash, Sean B. and Griffin, Timothy S. and Stepp, John R. and Han, Wen-Yan and Orians, Colin M.},TITLE={Changes in Tea Plant Secondary Metabolite Profiles as a Function of Leafhopper Density and Damage},JOURNAL={Frontiers in Plant Science},VOLUME={11},YEAR={2020},URL={https://www.frontiersin.org/articles/10.3389/fpls.2020.00636},DOI={10.3389/fpls.2020.00636},ISSN={1664-462X},ABSTRACT={Insect herbivores have dramatic effects on the chemical composition of plants. Many of these induced metabolites contribute to the quality (e.g., flavor, human health benefits) of specialty crops such as the tea plant (Camellia sinensis). Induced chemical changes are often studied by comparing plants damaged and undamaged by herbivores. However, when herbivory is quantitative, the relationship between herbivore pressure and induction can be linearly or non-linearly density dependent or density independent, and induction may only occur after some threshold of herbivory. The shape of this relationship can vary among metabolites within plants. The tea green leafhopper (Empoasca onukii) can be a widespread pest on tea, but some tea farmers take advantage of leafhopper-induced metabolites in order to produce high-quality “bug-bitten” teas such as Eastern Beauty oolong. To understand the effects of increasing leafhopper density on tea metabolites important for quality, we conducted a manipulative experiment exposing tea plants to feeding by a range of E. onukii densities. After E. onukii feeding, we measured volatile and non-volatile metabolites, and quantified percent damaged leaf area from scanned leaf images. E. onukii density had a highly significant effect on volatile production, while the effect of leaf damage was only marginally significant. The volatiles most responsive to leafhopper density were mainly terpenes that increased in concentration monotonically with density, while the volatiles most responsive to leaf damage were primarily fatty acid derivatives and volatile phenylpropanoids/benzenoids. In contrast, damage (percent leaf area damaged), but not leafhopper density, significantly reduced total polyphenols, epigallocatechin gallate (EGCG), and theobromine concentrations in a dose-dependent manner. The shape of induced responses varied among metabolites with some changing linearly with herbivore pressure and some responding only after a threshold in herbivore pressure with a threshold around 0.6 insects/leaf being common. This study illustrates the importance of measuring a diversity of metabolites over a range of herbivory to fully understand the effects of herbivores on induced metabolites. Our study also shows that any increases in leafhopper density associated with climate warming, could have dramatic effects on secondary metabolites and tea quality.}} . Frontiers in Plant Science.

Joshua Morimoto, Marta Ciali&#232; Rosso, Nicole Kfoury, Carlo Bicchi, Chiara Cordero, Albert Robbat (2019). Untargeted/Targeted 2D Gas Chromatography/Mass Spectrometry Detection of the Total Volatile Tea Metabolome . Molecules.

Eric R. Scott, Xin Li, Nicole Kfoury, Joshua Morimoto, Wen-Yan Han, Selena Ahmed, Sean B. Cash, Timothy S. Griffin, John R. Stepp, Albert Robbat, et al.(2019). Interactive effects of drought severity and simulated herbivory on tea (Camellia sinensis) volatile and non-volatile metabolites . Environmental and Experimental Botany. 157. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 283--292. Elsevier {BV}

Noelani Kamelamela, Michael Zalesne, Joshua Morimoto, Albert Robbat, Benjamin E. Wolfe(2018). Indigo- and indirubin-producing strains of Proteus and Psychrobacter are associated with purple rind defect in a surface-ripened cheese . Food Microbiology. 76. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 543--552. Elsevier {BV}

Nicole Kfoury, Joshua Morimoto, Amanda Kern, Eric R. Scott, Colin M. Orians, Selena Ahmed, Timothy Griffin, Sean B. Cash, John Richard Stepp, Dayuan Xue, et al.(2018). Striking changes in tea metabolites due to elevational effects . Food Chemistry. 264. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 334--341. Elsevier {BV}