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Hire Jose Francis O.

Brazil

USD 100 /hr

Pharmacist and Neuroscientist for scientific and medical writing

Profile Summary

I have a wide background in neurosciences, with expertise in the serotonergic system and how it can affect behavior. In my PhD thesis, I investigated depressive-like behavior and the serotonergic system using the maternal separation model, looking at the role of potassium channel TREK-1 and 5HT1A receptors on synaptic plasticity at the prelimbic cortex and the neural stress response. Currently, the cingulate cortex is my focus, with emphasis on the projection from cingulate to prelimbic cortex and its role in modulating social and depressive-like behavior. My skills include molecular biology techniques such as immunohistochemistry, immunofluorescence and western blot, drug administration in rodents, behavioral testing, brain slice electrophysiology and stereotaxic surgery in rodents. At the moment I'm working to further develop techniques in the neurosciences, such as in vivo calcium imaging and optogenetics. Have some experience writing grants, as I got funding for my PhD project and participated in writing two grants for the laboratory which was awarded. Alongside my Master’s and PhD, I cooperated with my peers and guided other undergraduate and Master students, giving me teamwork experience. Additionally, I acquired teaching skills when I worked as faculty for undergraduate and graduate courses for some years in Brazilian universities, where I taught physiology, biophysics, pharmacology and neurosciences.

Subject Matter Expertise

• ★ Neuroscience
• ☆ Neurophysiology
• ☆ Drug Development
• ☆ Preclinical Pharmacology
• ☆ Human Physiology
• ☆ Psychopharmacology
• ☆ Medical Sciences

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Technical Writing, Creative Writing, Translation

Research Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization

Work Experience

Postdoctoral Fellow

The University of Alabama at Birmingham

May 2021 - Present

Professor Assistente (Temporário) - Farmacologia

Universidade Estadual do Oeste do Paraná

January 2021 - April 2021

Professor Assistente (Temporário) - Farmacologia

Universidade Estadual de Londrina

August 2020 - April 2021

Professor de Neurociências

Unicampo

November 2014 - December 2015

Professor Fisiologia e Biofísica

Faculdade Dom Bosco

March 2014 - December 2015

Professor Análises Clínicas

Centro Universitário Filadélfia

March 2011 - February 2014

Education

PhD in Human Physiology (Fisiologia e Biofísica)

Universidade de São Paulo

May 2016 - May 2020

MSc in Physiological Sciences (Ciências Fisiológicas)

Universidade Estadual de Londrina

March 2011 - February 2013

Pharmacy (Farmácia)

Universidade Estadual de Londrina

March 2006 - December 2010

Certifications

• C2 English

  Cambridge English

  January 2026 - Present

Publications

JOURNAL ARTICLE

Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, José Francis-Oliveira, Emily Cruvinel, Thainá Soares Franchin, Tania Marcourakis, Henning Ulrich, Roberto De Pasquale (2024). Serotonergic Neuromodulation of Synaptic Plasticity . Neuropharmacology.

Owen Leitzel, Jose Francis-Oliveira, Shaimaa M. Khedr, Lila Ariste, Stefanie Robel, Shin-ichi Kano, Andrew Arrant, Minae Niwa (2024). Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice . Frontiers in Neuroscience.

Niwa M, Lockhart S, Wood DJ, Yang K, Francis-Oliveira J, Kin K, Ahmed A, Wand GS, Kano SI, Payne JL, et al. (2024). Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: A cross-species translational study . Nature. Mental health.

José Francis-Oliveira, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Emily Cruvinel, Estevão Carlos-Lima, Fernando da Silva Borges, Thais Tessari Zampieri, Fernanda Pereira Rebello, Henning Ulrich, Roberto De Pasquale (2024). TREK-1 inhibition promotes synaptic plasticity in the prelimbic cortex . Experimental Neurology.

Estevão Carlos-Lima, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Alicia Moraes Tamais, Emily Cruvinel, Fernando da Silva Borges, José Francis-Oliveira, Henning Ulrich, Roberto De Pasquale (2023). Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex . International Journal of Molecular Sciences.

Estevão Carlos-Lima, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Alicia Moraes Tamais, Emily Cruvinel, Fernando da Silva Borges, José Francis-Oliveira, Henning Ulrich, Roberto De Pasquale (2023). Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex . International Journal of Molecular Sciences.

Lucila Emiko Tsugiyama, Ruan Carlos Macedo Moraes, Yaslle Andrade Cavalcante Moraes, Jose Francis-Oliveira (2023). Promising new pharmacological targets for depression: The search for efficacy . Drug Discovery Today.

Kyohei Kin, Jose Francis-Oliveira, Shin-ichi Kano, Minae Niwa (2023). Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice . Nature Communications.

Carolina Parga Martins Pereira, José Francis-Oliveira, Monique Patricio Singulani, Ana Flávia Fernandes Ferreira, Luiz Roberto G. Britto (2023). Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's disease . Journal of Neuroimmunology.

Guilherme Shigueto Vilar Higa, José Francis-Oliveira, Estevão Carlos-Lima, Alicia Moraes Tamais, Fernando da Silva Borges, Alexandre Hiroaki Kihara, Ianê Carvalho Shieh, Henning Ulrich, Silvana Chiavegatto, Roberto De Pasquale (2022). 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development . Scientific Reports.

Sara Joushi, Vahid Sheibani, Khadijeh Esmaeilpour, José Francis‐Oliveira, Zahra Taherizadeh, Fatemeh Mohtashami Borzadaran(2021). Maternal separation impairs mother's cognition 1 month beyond the separation . International Journal of Developmental Neuroscience. 81. (7). p. 605--615. Wiley

Sara Joushi and Vahid Sheibani and Khadijeh Esmaeilpour and Jos{\'{e}} Francis-Oliveira and Zahra Taherizadeh and Fatemeh Mohtashami Borzadaran(2021). Maternal separation impairs mother's cognition 1 month beyond the separation . International Journal of Developmental Neuroscience. Wiley

J. Francis-Oliveira and I.C Shieh and G.S. Vilar Higa and M.A. Barbosa and R. De Pasquale(2021). Maternal separation induces changes in TREK-1 and 5HT1A expression in brain areas involved in the stress response in a sex-dependent way . Behavioural Brain Research. 396. p. 112909. Elsevier {BV}

(2018). Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring’s brain and affects the social interaction of rat . Brain Research Bulletin.

A.S. Silva, L.V. Toffoli, V.B. Estrada, L.F. Veríssimo, J. Francis-Oliveira, E.G. Moreira, M.V. Gomes, G.G. Pelosi(2018). Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring’s brain and affects the social interaction of rat . Brain Research Bulletin. 142. p. 409--413. Elsevier {BV}

José Francis-Oliveira, Guilherme S. Vilar Higa, Lívia Mendonça Munhoz Dati, Ianê Carvalho Shieh, Roberto De Pasquale(2018). Metaplasticity in the Visual Cortex: Crosstalk Between Visual Experience and Reactive Oxygen Species . The Journal of Neuroscience. 38. (25). p. 5649--5665. Society for Neuroscience

Francis-Oliveira J, Vilar Higa GS, Mendonça Munhoz Dati L, Carvalho Shieh I, De Pasquale R(2018). Metaplasticity in the Visual Cortex: Crosstalk Between Visual Experience and Reactive Oxygen Species . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Beckhauser, T. F., Francis-Oliveira, J., De Pasquale, R.(2016). Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity . J Exp Neurosci. 10. p. 23-48.

Rodrigues, G.M., Toffoli, L.V., Manfredo, M.H., Francis-Oliveira, J., Silva, A.S., Raquel, H.A., Martins-Pinge, M.C., Moreira, E.G., Fernandes, K.B., Pelosi, G.G., et al.(2015). Acute stress affects the global DNA methylation profile in rat brain: Modulation by physical exercise . Behavioural Brain Research. 279. p. 123-128.

Toffoli, L.V., Rodrigues, G.M., Oliveira, J.F., Silva, A.S., Moreira, E.G., Pelosi, G.G., Gomes, M.V.(2014). Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: Modulation by folic acid supplementation . Behavioural Brain Research. 265. p. 142-147.

Francis-Oliveira, J., Ponte, B., Barbosa, A.P.M., Veríssimo, L.F., Gomes, M.V., Pelosi, G.G., de Britto, L.R.G., Moreira, E.G.(2013). Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats . Behavioural Brain Research. 252. p. 195-203.