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Hire Dr. Johannes G.

United States

USD 150 /hr

Expert in Photoredox Catalysis, Radical Chemistry & Medicinal Chemistry Synthesis | Princeton Postdoctoral Researcher

Profile Summary

I am a synthetic organic chemist specializing in the design and optimization of catalytic reactions for the efficient synthesis of complex, medicinally relevant molecules. I currently conduct research at Princeton University in the MacMillan Research Group, where I develop new catalytic strategies based on photoredox and transition-metal catalysis. My work focuses on translating fundamental reaction design into practical synthetic solutions that can accelerate discovery and enable the construction of challenging molecular architectures. I have extensive experience in reaction development, catalytic method optimization, and mechanistic problem solving, particularly for radical and transition-metal mediated transformations relevant to medicinal chemistry. Through my research, I have worked closely with major pharmaceutical companies on collaborative projects, contributing to the development of new synthetic methodologies and addressing real-world challenges in complex molecule synthesis. This experience has given me strong insight into industry priorities such as robustness, scalability, and efficiency in reaction development. I am available to support pharmaceutical, biotech, and chemical companies with: reaction troubleshooting and optimization synthetic route design for complex molecules catalytic reaction development mechanistic analysis and literature evaluation consulting on modern catalytic methods including photoredox and radical chemistry My goal is to help teams identify practical synthetic solutions, overcome challenging transformations, and accelerate research timelines through mechanism-informed reaction design.

Subject Matter Expertise

• ☆ Chemical Reagent Development
• ☆ Catalysis
• ☆ Natural Product Chemistry
• ☆ Electrochemistry
• ☆ Petrochemistry
• ☆ Organometallic Chemistry
• ☆ Photochemistry
• ☆ Peptide Synthesis
• ☆ Physical Organic Chemistry
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Combinatorial Chemistry
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical ADME/PK/PD
• ☆ Investigational New Drug (IND) Application Consulting

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Clinical Trial Documentation, Business & Legal Writing, General Proofreading & Editing

Research Market Research, Fact Checking, Gap Analysis, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Business Strategy Consulting, Scientific and Technical Consulting

Data & AI Data Visualization, Data Cleaning, Data Processing, Data Insights

Work Experience

Postdoctoral Fellow

Princeton University

September 2023 - Present

PhD Student

Technische Universität München

December 2019 - June 2023

Education

PhD

Technische Universität München - Germany

December 2019 - June 2023

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Johannes J. Großkopf, Danielle C. Morgan, Aimee K. Clarke, David W. C. MacMillan (2025). A General Metallaphotoredox Platform for N-Alkylated Sulfoximines as Bioisosteric Building Blocks . Journal of the American Chemical Society.

Johannes Großkopf, Chawanansaya Gopatta, Robert T. Martin, Alexander Haseloer, David W. C. MacMillan (2025). Generalizing arene C–H alkylations by radical–radical cross-coupling . Nature.

Johannes Großkopf, Thorsten Bach (2023). Catalytic Photochemical Deracemization via Short‐Lived Intermediates . Angewandte Chemie International Edition.

Johannes Großkopf, Thorsten Bach (2023). Katalytische photochemische Deracemisierung über kurzlebige Intermediate . Angewandte Chemie.

Johannes Großkopf, Manuel Plaza, Roger Jan Kutta, Patrick Nuernberger, Thorsten Bach (2023). Creating a Defined Chirality in Amino Acids and Cyclic Dipeptides by Photochemical Deracemization . Angewandte Chemie International Edition.

Johannes Großkopf, Manuel Plaza, Roger Jan Kutta, Patrick Nuernberger, Thorsten Bach (2023). Creating a Defined Chirality in Amino Acids and Cyclic Dipeptides by Photochemical Deracemization . Angewandte Chemie.

Johannes Großkopf, Alexandra A. Heidecker, Thorsten Bach (2023). Photochemical Deracemization of 3‐Substituted Oxindoles . Angewandte Chemie.

Johannes Großkopf, Alexandra A. Heidecker, Thorsten Bach (2023). Photochemical Deracemization of 3‐Substituted Oxindoles . Angewandte Chemie International Edition.

Roger Jan Kutta, Johannes Großkopf, Nils van Staalduinen, Antonia Seitz, Philipp Pracht, Stefan Breitenlechner, Christoph Bannwarth, Patrick Nuernberger, Thorsten Bach (2023). Multifaceted View on the Mechanism of a Photochemical Deracemization Reaction . Journal of the American Chemical Society.

Johannes Gro{\ss}kopf and Manuel Plaza and Antonia Seitz and Stefan Breitenlechner and Golo Storch and Thorsten Bach(2021). Photochemical Deracemization at sp3-Hybridized Carbon Centers via a Reversible Hydrogen Atom Transfer . Journal of the American Chemical Society. American Chemical Society ({ACS})

Manuel Plaza and Johannes Gro{\ss}kopf and Stefan Breitenlechner and Christoph Bannwarth and Thorsten Bach(2021). Photochemical Deracemization of Primary Allene Amides by Triplet Energy Transfer: A Combined Synthetic and Theoretical Study . Journal of the American Chemical Society. 143. (29). p. 11209--11217. American Chemical Society ({ACS})

Johannes Gro{\ss}kopf and Thilo Kratz and Thomas Rigotti and Thorsten Bach(2021). Enantioselective Photochemical Reactions Enabled by Triplet Energy Transfer . Chemical Reviews. American Chemical Society ({ACS})

Xinyao Li and Johannes Gro{\ss}kopf and Christian Jandl and Thorsten Bach(2021). Enantioselective, Visible Light Mediated Aza Paternò–Büchi Reactions of Quinoxalinones . Angewandte Chemie. 133. (5). p. 2716--2720. Wiley

PREPRINT

Steve D. Knutson, Jacob A. Boyer, Danielle C. Morgan, Johannes Großkopf, Joshua D. Rabinowitz, David W. C. MacMillan (2025). Micromapping (µMap) of HER2 Across Human Breast Cancers: Photocatalytic Proximity Labeling Identifies Primary Resistance Mechanisms and Functional Interactors .