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Profile Details
Subject Matter Expertise
Services
Writing
Technical Writing
Research
Scientific and Technical Research
Consulting
Scientific and Technical Consulting
Data & AI
Data Processing
Work Experience
Scientific and technical writing, consulting
Freelancer
April 2022 - Present
Postdoctoral Researcher
University of California, San Francisco
April 2020 - April 2022
Marie Curie postdoctoral fellow
Trinity College Dublin
January 2019 - March 2020
Education
PhD (Chemistry and Chemical Biology)
University of California San Francisco
August 2011 - September 2018 
(Chemistry)
University of Pennsylvania
July 2010 - June 2011
BA (Chemistry)
Swarthmore College
August 2006 - June 2010
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Jessica L. Thomaston, Marley L. Samways, Athina Konstantinidi, Chunlong Ma, Yanmei Hu, Hannah E. Bruce Macdonald, Jun Wang, Jonathan W. Essex, William F. DeGrado, Antonios Kolocouris (2021). Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity . Biochemistry.
Jessica L. Thomaston, Athina Konstantinidi, Lijun Liu, George Lambrinidis, Jingquan Tan, Martin Caffrey, Jun Wang, William F. Degrado, Antonios Kolocouris (2020). X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance . Biochemistry.
Jessica L. Thomaston, Yibing Wu, Nicholas Polizzi, Lijun Liu, Jun Wang, William F. DeGrado (2019). X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case . Journal of the American Chemical Society.
Marco Mravic, Jessica L. Thomaston, Maxwell Tucker, Paige E. Solomon, Lijun Liu, William F. DeGrado (2019). Packing of apolar side chains enables accurate design of highly stable membrane proteins . Science.
Jessica L. Thomaston, Nicholas F. Polizzi, Athina Konstantinidi, Jun Wang, Antonios Kolocouris, William F. DeGrado (2018). Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters . Journal of the American Chemical Society.
Huong T. Kratochvil, Jessica L. Thomaston, Feng Gai, William F. DeGrado(2018). Proton Stabilization and Conduction Pathway in the Matrix Protein M2 . Biophysical Journal. 114. (3). p. 240a--241a. Elsevier {BV}
Jessica L. Thomaston, William F. DeGrado(2018). X-Ray Crystal Structures of the Influenza a M2 Proton Channel Bound to Amantadine, Rimantadine, and Inhibiting Compounds . Biophysical Journal. 114. (3). p. 204a. Elsevier {BV}
Thomaston, J.L., Woldeyes, R.A., Nakane, T., Yamashita, A., Tanaka, T., Koiwai, K., Brewster, A.S., Barad, B.A., Chen, Y., Lemmin, T., et al.(2017). XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction . Proceedings of the National Academy of Sciences of the United States of America. 114. (51). p. 13357-13362.
Jessica L. Thomaston, William F. DeGrado(2016). Crystal structure of the drug-resistant S31N influenza M2 proton channel . Protein Science. 25. (8). p. 1551--1554. Wiley-Blackwell
Jessica Thomaston, Elizabeth L. Baxter, Laura Aguila, Roberto Alonso-Mori, Christopher O. Barnes, Christopher A. Bonagura, Winnie Brehmer, Axel T. Brunger, Guillermo Calero, Tom T. Caradoc-Davies, et al.(2016). High-density grids for efficient data collection from multiple crystals . Acta Crystallographica Section D Structural Biology. 72. (1). p. 2--11. International Union of Crystallography ({IUCr})
Baxter, E.L., Aguila, L., Alonso-Mori, R., Barnes, C.O., Bonagura, C.A., Brehmer, W., Brunger, A.T., Calero, G., Caradoc-Davies, T.T., Chatterjee, R., et al.(2016). High-density grids for efficient data collection from multiple crystals . Acta Crystallographica Section D: Structural Biology. 72. (1). p. 2-11.
Jessica L. Thomaston, Mercedes Alfonso-Prieto, Rahel A. Woldeyes, James S. Fraser, Michael L. Klein, Giacomo Fiorin, William F. DeGrado(2015). High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction . Proceedings of the National Academy of Sciences. 112. (46). p. 14260--14265. Proceedings of the National Academy of Sciences
Jessica Thomaston, Shenstone Huang, Bryan Green, Megan Thompson, Richard Chen, William F. DeGrado, Kathleen P. Howard(2015). C-terminal juxtamembrane region of full-length M2 protein forms a membrane surface associated amphipathic helix . Protein Science. 24. (3). p. 426--429. Wiley-Blackwell
Jessica L. Thomaston, Phuong A. Nguyen, Emily C. Brown, Mary Alice Upshur, Jun Wang, William F. DeGrado, Kathleen P. Howard(2012). Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling . Protein Science. 22. (1). p. 65--73. Wiley-Blackwell
Jessica Thomaston, Kathleen Howard(2010). Site-Directed Spin-Label EPR Studies Report on Drug-Induced Conformational Change of Influenza a M2 Protein . Biophysical Journal. 98. (3). p. 48a. Elsevier {BV}
OTHER
J.L. Thomaston, R.A. Woldeyes, J.S. Fraser, W.F. DeGrado(2017). XFEL structure of influenza A M2 wild type TM domain at low pH in the lipidic cubic phase at room temperature . Protein Data Bank, Rutgers University
J.L. Thomaston, R.A. Woldeyes, J.S. Fraser, W.F. DeGrado(2017). XFEL structure of influenza A M2 wild type TM domain at high pH in the lipidic cubic phase at room temperature . Protein Data Bank, Rutgers University
J.L. Thomaston, R.A. Woldeyes, J.S. Fraser, W.F. DeGrado(2017). XFEL structure of influenza A M2 wild type TM domain at intermediate pH in the lipidic cubic phase at room temperature . Protein Data Bank, Rutgers University
J.L. Thomaston, W.F. DeGrado(2016). Influenza A M2 transmembrane domain drug-resistant S31N mutant at pH 8.0 . Protein Data Bank, Rutgers University
J.L. Thomaston(2015). Influenza A M2 wild type TM domain at high pH in the lipidic cubic phase under cryo diffraction conditions . Protein Data Bank, Rutgers University
J.L. Thomaston, W.F. DeGrado(2015). Influenza A M2 wild type TM domain at high pH in the lipidic cubic phase under room temperature diffraction conditions . Protein Data Bank, Rutgers University
J.L. Thomaston, W.F. DeGrado(2015). Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under cryo diffraction conditions . Protein Data Bank, Rutgers University
J.L. Thomaston, W.F. DeGrado(2015). Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under room temperature diffraction conditions . Protein Data Bank, Rutgers University
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