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USD 250 /hr

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☆☆☆☆☆

Hire Dr. Jeff L.

United States

USD 250 /hr

Biomedical research scientist with 20+ years of experience in the areas of neuroscience and pharmacology.

Profile Summary

I have performed biomedical research and published papers in peer-reviewed biomedical journals in the areas of Alzheimer's disease, stroke, the blood-brain barrier, and drug delivery.

Subject Matter Expertise

• ☆ Neuroscience
• ☆ Neurochemistry
• ☆ Neuropharmacology
• ☆ Molecular Neuroscience

Services

• Writing
• Research
• Consulting

Writing Medical Writing, Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Work Experience

Research Assistant Professor

University of Arizona

November 2016 - Present

Postdoctoral Associate

University of Wisconsin Madison

January 2011 - November 2016

Research Technician

Banner Sun Health

November 2000 - August 2004

Education

Neuroscience

University of Arizona

August 2004 - December 2010

B.Sc. Microbiology

Northern Arizona University

August 2000 - May 2004

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Junzhi Yang, Robert D. Betterton, Erica I. Williams, Joshua A. Stanton, Elizabeth S. Reddell, Chidinma E. Ogbonnaya, Emma Dorn, Thomas P. Davis, Jeffrey Lochhead, Patrick Ronaldson (2022). High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats . Pharmaceutics.

Jeffrey Lochhead, Thomas P. Davis (2019). Perivascular and Perineural Pathways Involved in Brain Delivery and Distribution of Drugs after Intranasal Administration . Pharmaceutics.

(2019). Distribution of insulin in trigeminal nerve and brain after intranasal administration . Scientific reports.

Kumar, Niyanta N, Lochhead, Jeffrey J, Pizzo, Michelle E, Nehra, Geetika, Boroumand, Sam, Greene, Gretchen, Thorne, Robert G(2018). Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery . Journal of controlled release : official journal of the Controlled Release Society. 286. p. 467-484.

Boroumand, Sam, Kumar, Niyanta, Lochhead, Jeffrey, Pizzo, Michelle, Nehra, Geetika, Thorne, Robert G.(2018). Intranasal delivery of antibodies bypasses the blood-brain barrier and results in significantly higher central nervous system levels than systemic administration . Faseb Journal. 32. (1).

Lochhead, Jeffrey J., Ronaldson, Patrick T., Davis, Thomas P.(2017). Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System . Aaps Journal. 19. (4). p. 910-920.

Kumar, Niyanta N., Gautam, Mohan, Lochhead, Jeffrey J., Wolak, Daniel J., Ithapu, Vamsi, Singh, Vikas, Thorne, Robert G.(2016). Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery . Scientific Reports. 6.

Lochhead, Jeffrey J., Wolak, Daniel J., Pizzo, Michelle E., Thorne, Robert G.(2015). Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration . Journal of Cerebral Blood Flow and Metabolism. 35. (3). p. 371-381.

Lochhead, Jeffrey J., Thorne, Robert G.(2012). Intranasal delivery of biologics to the central nervous system . Advanced Drug Delivery Reviews. 64. (7). p. 614-628.

Lochhead, Jeffrey J., McCaffrey, Gwen, Sanchez-Covarrubias, Lucy, Finch, Jessica D., DeMarco, Kristin M., Quigley, Colleen E., Davis, Thomas P., Ronaldson, Patrick T.(2012). Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain . American Journal of Physiology-Heart and Circulatory Physiology. 302. (3). p. H582-H593.

Lochhead, Jeffrey J., McCaffrey, Gwen, Quigley, Colleen E., Finch, Jessica, DeMarco, Kristin M., Nametz, Nicole, Davis, Thomas P.(2011). Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation (vol 30, pg 1625, 2010) . Journal of Cerebral Blood Flow and Metabolism. 31. (2). p. 790-791.

Lochhead, Jeffrey J., McCaffrey, Gwen, Quigley, Colleen E., Finch, Jessica, DeMarco, Kristin M., Nametz, Nicole, Davis, Thomas P.(2010). Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation . Journal of Cerebral Blood Flow and Metabolism. 30. (9). p. 1625-1636.

McCaffrey, Gwen, Willis, Colin L., Staatz, William D., Nametz, Nicole, Quigley, Carolyn A., Hom, Sharon, Lochhead, Jeffrey J., Davis, Thomas P.(2009). Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress . Journal of Neurochemistry. 110. (1). p. 58-71.

Sparks, DL, Sabbagh, MN, Connor, DJ, Lopez, J, Launer, LJ, Browne, P, Wasser, D, Johnson-Traver, S, Lochhead, J, Ziolwolski, C(2005). Atorvastatin for the treatment of mild to moderate Alzheimer disease - Preliminary results . Archives of Neurology. 62. (5). p. 753-757.

Lochhead, Jeff, Sparks, D Larry, Sabbagh, Marwan N, Connor, Donald J, Lopez, Jean, Launer, Lenore J, Petanceska, Suzana, Browne, Patrick, Wassar, Dawn, Johnson-Traver, Sherry, et al.(2005). Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD . Current Alzheimer research. 2. (3). p. 343-53.

Lochhead, Jeff, Sparks, D Larry, Petanceska, Suzana, Sabbagh, Marwan, Connor, Donald, Soares, Holly, Adler, Charles, Lopez, Jean, Ziolkowski, Chuck, Browne, Patrick(2005). Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT) . Current Alzheimer research. 2. (5). p. 527-39.

Sparks, DL, Sabbagh, MN, Connor, DJ, Launer, LJ, Petanceska, S, Baxter, L, Browne, P, Lopez, J, Wassar, D, Lochhead, J, et al.(2004). Benefits of atorvastatin in subjects with Alzheimer's disease . Circulation. 110. (17). p. 813.

Sparks, DL, Connor, D, Lopez, J, Launer, L, Petanceska, S, Baxter, L, Wasser, D, Lochhead, J, Ziolowski, C, Idouraine, A, et al.(2004). Benefit of atorvastatin in the treatment of Alzheimer disease . Neurobiology of Aging. 25. p. S24.

Schreurs, BG, Smith-Bell, CA, Lochhead, J, Sparks, DL(2003). Cholesterol modifies classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response . Behavioral Neuroscience. 117. (6). p. 1220-1232.

Lochhead, Jeff, Sparks, D. Larry, Horstman, Donna, Wagoner, Tom, Martin, Tim(2002). Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (A beta) in rabbit brain . Journal of Alzheimers Disease. 4. (6). p. 523-529.