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Hire Dr. Jamie J.

United States

Profile Summary

I have a broad neuroscience background, with focused training in behavior genetics relevant to the study of schizophrenia spectrum disorders. My current research involves analyzing the relationships of biomarkers associated with an attenuated lifespan in a chronic schizophrenia sample including: C-reactive protein, body mass index, and Framingham cardiovascular disease risk. I have also been assessing the roles of cytokines, chemokines, F2-isoprostanes, and neurotrophins in relation to age related changes in cognitive and functional outcomes in schizophrenia. I have assisted with analyzing age and illness influences that are associated with acquiring wisdom in a hospice patient sample. In addition to the contributions described above, I am working on a study to investigate the relationship of leaky gut markers in association with incidence of systemic inflammation and metabolic syndrome in schizophrenia. My graduate and early postdoctoral work was primarily focused on human behavior genetics relevant to schizophrenia spectrum disorders. I assisted with recruitment and administration of cognitive tasks (JOVI, RISE, AX-CPT, DPX, CCE, MSCEIT, HVLT), psychiatric assessments (SCID, BPRS), premorbid and functional outcome scales (WTAR, UPSA, SLOF), and data compiling for a multi-site schizophrenia cognition study. My dissertation work was a behavioral genetics study to identify SNP correlates of a schizophrenia subtype characterized by perceptual organization and premorbid functioning deficits. I completed this study with psychiatric assessments (DIGS, PANSS, MINI, SAPS, SANS), premorbid and smoking scales (PAS, SHIPLEY, FTND-PRISM), visual perceptual tasks (Jittered Orientation Visual Integration (JOVI), Ebbinghaus Illusion, Illusory Contours – FatThin Paradigm, Numerosity) genetic databases (dbSNP, HapMap, UCSC Genome Browser, SYSNPs) and analysis software (SYSTAT, SPSS, PLINK). I compiled and analyzed data for a novel scale of lifespan functional outcomes relevant to schizophrenia spectrum disorders. My research experiences as an undergraduate research assistant and senior laboratory technician were primarily focused on behavior genetics of neuropsychiatric disorders with the use of mouse models. My undergraduate research primarily involved the use of PCR and UCSC Genome Browser to identify quantitative trait loci associated with phenotypic variation in a mouse model of neural tube defects. I was involved with the genotyping (PCR and Southern Blotting) of transgenic and knock out mouse models of autism and anxiety disorders and assisting with various methods of behavioral phenotype characterization (Open Field Test, Contextual and Cued Fear Conditioning, Elevated Plus Maze, Maternal Behavior and the Morris Water Maze). I was also responsible for the subsequent histological preparation (Perfusion, Cyrosectioning) of mouse brains and analyses of amygdala enriched gene, immediate early gene, and protein expression (In Situ Hybridization and Immunohistochemistry).

Subject Matter Expertise

• ★ Visual Neuroscience
• ★ Geriatric Psychiatry
• ☆ Biology/Life Sciences
• ☆ Biomarkers
• ☆ PCR
• ☆ Neuropsychology
• ☆ Data Analysis
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Behavioral Genetics
• ☆ Science Education
• ☆ Cardiovascular Disease
• ☆ Anxiety Disorders
• ☆ Schizophrenia
• ☆ Inflammation

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

Postdoctoral Fellow

University of California San Diego

August 2013 - Present

Adjunct Lecturer

University of San Diego

January 2014 - May 2014

Graduate Research Assistant

Rutgers University Behavioral Health Care

May 2009 - February 2010

Senior Laboratory Technician

Rutgers University - Busch Campus

May 2004 - August 2007

Education

PhD (GSBS Neuroscience)

Rutgers University New Brunswick

September 2007 - October 2013

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Jamie M. Joseph, Catrin Law(2019). Cross-species examination of single- and multi-strain probiotic treatment effects on neuropsychiatric outcomes . Neuroscience {\&} Biobehavioral Reviews. 99. p. 160--197. Elsevier {BV}

Joseph, J., Depp, C., Martin, A. S., Daly, R. E., Glorioso, D. K., Palmer, B. W., & Jeste, D. V. (2015). Associations of high sensitivity C-reactive protein levels in schizophrenia and comparison groups. Schizophrenia research, 168(1), 456-460.

Jamie Joseph, Colin Depp, Averria Sirkin Martin, Rebecca E. Daly, Danielle K. Glorioso, Barton W. Palmer, Dilip V. Jeste(2015). Associations of high sensitivity C-reactive protein levels in schizophrenia and comparison groups . Schizophrenia Research. 168. (1-2). p. 456--460. Elsevier {BV}

Joseph, J., Kremen, W. S., Glatt, S. J., Franz, C. E., Chandler, S. D., Liu, X., ... & Twamley, E. W. (2015). Assessment of Lifespan Functioning Attainment (ALFA) scale: A quantitative interview for self-reported current and functional decline in schizophrenia. Journal of psychiatric research, 65, 102-107.

Joseph, J., Gara, M. A., & Silverstein, S. M. (2015). Hierarchical Classes Analysis (HICLAS): A novel data reduction method to examine associations between biallelic SNPs and perceptual organization phenotypes in schizophrenia. Schizophrenia Research: Cognition.

Jamie Joseph, Michael A. Gara, Steven M. Silverstein(2015). Hierarchical Classes Analysis ({HICLAS}): A novel data reduction method to examine associations between biallelic {SNPs} and perceptual organization phenotypes in schizophrenia . Schizophrenia Research: Cognition. 2. (2). p. 56--63. Elsevier {BV}

stathmin, a gene enriched in the amygdala, controls both learned and innate fear.

Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects.

Sex, symptom, and premorbid social functioning associated with perceptual organization dysfunction in schizophrenia.

Late, not early, stages of Kanizsa shape perception are compromised in schizophrenia.

The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development.

Synaptically released zinc gates long-term potentiation in fear conditioning pathways.