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USD 450 /hr
Hire Dr. JAMES B.
United Kingdom
USD 450 /hr
Group leader in the biotech sector. Expert in antibody engineering and structural and molecular biology
Profile Summary
Subject Matter Expertise
Services
Work Experience
Principal Scientist
Epsilogen Ltd
August 2022 - Present
Principal Scientist
Celltech Group Limited
May 2017 - July 2022 
PostdoctoralResearcher
UMass Medical School
July 2012 - May 2017
PostdoctoralResearcher
Demokritos, Athens, Greece
May 2009 - May 2012
Postdoctoral Researcher
University of Manchester
February 2008 - March 2010
Education
Structural biology
Imperial College London
October 2000 - September 2004
MRES
University of Edinburgh
October 1999 - September 2000
BSc (Hons) Molecular Genetics and Molecular Biology
University of Edinburgh
October 1994 - June 1999
Certifications
Publications
JOURNAL ARTICLE
Marano F, McKenzie C, Birtley JR, Hussain SA, Macleod O, Goodacre A, Wu S, Amin OE, Faulkner N, Devlin J, et al.(2026). Publisher Correction: Elucidating the relationship between affinity and potency in the performance of therapeutic IgE . Scientific reports.
Marano F, McKenzie C, Birtley JR, Hussain SA, Macleod O, Goodacre A, Wu S, Amin OE, Faulkner N, Devlin J, et al.(2026). Elucidating the relationship between affinity and potency in the performance of therapeutic IgE . Scientific reports.
James Birtley, Melanie Grandits, Lais C. G. F. Palhares, Olivia Macleod, John Devlin, Oliver E. Amin, Leanne Partington, Tim Wilson, Elizabeth Hardaker, Sophia N. Karagiannis, et al. (2025). Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality . mAbs.
James Birtley, Melanie Grandits, Lais C G F Palhares, Gabriel Osborn, Jitesh Chauhan, Katie Stoker, Heng Sheng Sow, Rebecca Adams, Alex J McCraw, Alicia Chenoweth, et al. (2025). Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors . Journal for ImmunoTherapy of Cancer.
Palhares LCGF, Grandits M, Stoker K, Chauhan J, Sow HS, Fruhwirth GO, Tsoka S, Birtley J, Partington L, Wilson T, et al.(2025). An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities . Journal of experimental & clinical cancer research : CR.
Ikelle L, Makia M, Lewis T, Crane R, Kakakhel M, Conley SM, Birtley JR, Arshavsky VY, Al-Ubaidi MR, Naash MI(2023). Correction: Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones . Cellular and molecular life sciences : CMLS.
Ikelle L, Makia M, Lewis T, Crane R, Kakakhel M, Conley SM, Birtley JR, Arshavsky VY, Al-Ubaidi MR, Naash MI(2023). Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones . Cellular and molecular life sciences : CMLS.
Meza-Segura M, Birtley JR, Maldonado-Contreras A, Mueller C, Simin KJ, Stern LJ, McCormick BA(2021). SepA Enhances <i>Shigella</i> Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant . mBio.
Macpherson A, Birtley JR, Broadbridge RJ, Brady K, Schulze MED, Tang Y, Joyce C, Saunders K, Bogle G, Horton J, et al.(2021). The Chemical Synthesis of Knob Domain Antibody Fragments . ACS chemical biology.
Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, et al.(2021). The allosteric modulation of complement C5 by knob domain peptides . eLife.
Antony J, Zanini E, Birtley JR, Gabra H, Recchi C(2020). Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers . Cancer gene therapy.
Author Correction: In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls <head>
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Wei Jiang, James R. Birtley, Shu-Chen Hung, Weiqi Wang, Shin-Heng Chiou, Claudia Macaubas, Birgitte Kornum, Lu Tian, Huang Huang, Lital Adler, et al. (2019). In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls . Nature Communications.
Birtley JR, Alomary M, Zanini E, Antony J, Maben Z, Weaver GC, Von Arx C, Mura M, Marinho AT, Lu H, et al.(2019). Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions . Nature communications.
Maldonado-Contreras A, Birtley JR, Boll E, Zhao Y, Mumy KL, Toscano J, Ayehunie S, Reinecker HC, Stern LJ, McCormick BA(2017). Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation . Gut microbes.
Keighren MA, Flockhart J, Hodson BA, Shen GY, Birtley JR, Notarnicola-Harwood A, West JD(2015). Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers . Transgenic research.
Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, et al.(2013). Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses . Proceedings of the National Academy of Sciences of the United States of America.
Bozoky Z, Krzeminski M, Muhandiram R, Birtley JR, Al-Zahrani A, Thomas PJ, Frizzell RA, Ford RC, Forman-Kay JD(2013). Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions . Proceedings of the National Academy of Sciences of the United States of America.
Leen EN, Kwok KY, Birtley JR, Simpson PJ, Subba-Reddy CV, Chaudhry Y, Sosnovtsev SV, Green KY, Prater SN, Tong M, et al.(2013). Structures of the compact helical core domains of feline calicivirus and murine norovirus VPg proteins . Journal of virology.
Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, et al.(2012). A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing . Journal of immunology (Baltimore, Md. : 1950).
Birtley JR, Saridakis E, Stratikos E, Mavridis IM(2011). The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing . Biochemistry.
Ford RC, Birtley J, Rosenberg MF, Zhang L(2011). CFTR three-dimensional structure . Methods in molecular biology (Clifton, N.J.).
Zhang L, Aleksandrov LA, Zhao Z, Birtley JR, Riordan JR, Ford RC(2009). Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding . Journal of structural biology.
Monie TP, Perrin AJ, Birtley JR, Sweeney TR, Karakasiliotis I, Chaudhry Y, Roberts LO, Matthews S, Goodfellow IG, Curry S(2007). Structural insights into the transcriptional and translational roles of Ebp1 . The EMBO journal.
Jaulent AM, Fahy AS, Knox SR, Birtley JR, Roqué-Rosell N, Curry S, Leatherbarrow RJ(2007). A continuous assay for foot-and-mouth disease virus 3C protease activity . Analytical biochemistry.
Nayak A, Goodfellow IG, Woolaway KE, Birtley J, Curry S, Belsham GJ(2006). Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication . Journal of virology.
Sweeney TR, Roqué-Rosell N, Birtley JR, Leatherbarrow RJ, Curry S(2006). Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis . Journal of Virology.
Birtley JR, Curry S(2005). Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy . Acta crystallographica. Section D, Biological crystallography.
Birtley JR, Knox SR, Jaulent AM, Brick P, Leatherbarrow RJ, Curry S(2005). Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity . The Journal of biological chemistry.
PREPRINT
Macpherson A, Birtley JR, Broadbridge RJ, Brady K, Tang Y, Joyce C, Saunders K, Bogle G, Horton J, Kelm S, et al.(2021). The chemical synthesis of knob domain antibody fragments .
Macpherson A, Laabei M, Ahdash Z, Graewert M, Birtley JR, Schulze S, Crennell S, Robinson SA, Holmes B, Oleinikovas V, et al.(2020). The allosteric modulation of Complement C5 by knob domain peptides .
DISSERTATION THESIS
Birtley JR(2003). Crystal structure of the 3C protease from foot-and-mouth disease virus .
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