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Hire Dr. Isobel O.

Canada

USD 50 /hr

Immunology Expert | Bridging Research and Teaching | Translational Science Advocate

Profile Summary

I have a PhD in Immunology, with 15+ years of research experience in the role of T cell responses in cancers and infectious diseases. I am passionate about translational research- bench to bedside studies, the implementation of research outcomes in solving of real-world problems.

Subject Matter Expertise

• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Microarrays
• ☆ PCR
• ☆ Gene Expression Analysis
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Stem Cell Research
• ☆ Adjuvant & Antigen Research
• ☆ Primary Cells
• ☆ Cell Surface Receptors
• ☆ Cytometry
• ☆ Cell Aging
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Gap Analysis
• ☆ Instructional Webinars
• ☆ Continuing Medical Education (CME) Training
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Creative Writing
• ☆ Course Content Writing
• ☆ Grant Writing

Services

• Writing

Writing Medical Writing, Technical Writing, Creative Writing, General Proofreading & Editing

Work Experience

Sessional lecturer

McMaster University

September 2022 - Present

Research Associate

University of Alberta

March 2016 - April 2022

PostdoctoralResearcher

National Institute of Biological Standards and Control, UK

April 2014 - October 2015

PostdoctoralResearcher

NIMR UK

November 2010 - February 2014

PostdoctoralResearcher

Imperial College London

November 2007 - November 2010

Education

PhD

Imperial College - United Kingdom

October 2003 - March 2008

MSc

London School of Hygiene & Tropical Medicine, University of London - United Kingdom

September 1998 - November 1999

Certifications

• Teaching and Learning Practice and Application

  Paul R MacPherson Institute, McMaster University

  December 2023 - Present

• Professional Scrum Master level I

  scrum.org

  https://scrum.org/certificates/975284

  June 2023 - Present

• Foundations of Project Management

  coursera

  June 2023 - Present

• Writing with Flair: How to Become an Exceptional Writer

  LinkedIn Learning

  January 2023 - Present

Publications

PREPRINT

Marriott H, Duchesne M, Moitra S, Okoye I, Gerla L, Mayers I, Moolji J, Adatia A, Lacy P(2024). Upper Airway Alarmin Cytokine Expression in Asthma of Different Severities .

JOURNAL ARTICLE

Bozorgmehr N, Okoye I, Mashhouri S, Lu J, Koleva P, Walker J, Elahi S(2023). CD71⁺ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors . Journal for immunotherapy of cancer.

Duchesne M, Okoye I, Lacy P(2022). Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response . Frontiers in immunology.

Shahbaz S, Okoye I, Blevins G, Elahi S(2022). Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8+ T cells of HIV-infected individuals . PLoS pathogens.

Mashhouri S, Koleva P, Huynh M, Okoye I, Shahbaz S, Elahi S(2021). Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females . Frontiers in immunology.

Okoye I, Xu L, Oyegbami O, Shahbaz S, Pink D, Gao P, Sun X, Elahi S(2021). Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4⁺ T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells <i>via</i> miR-139-5p Transfer . Frontiers in immunology.

Tabana Y, Okoye IS, Siraki A, Elahi S, Barakat KH(2021). Tackling Immune Targets for Breast Cancer: Beyond PD-1/PD-L1 Axis . Frontiers in oncology.

Okoye I, Xu L, Motamedi M, Parashar P, Walker JW, Elahi S(2020). Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors . Journal for immunotherapy of cancer.

Hajizadeh F, Okoye I, Esmaily M, Ghasemi Chaleshtari M, Masjedi A, Azizi G, Irandoust M, Ghalamfarsa G, Jadidi-Niaragh F(2019). Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells . Life sciences.

Chen R, Ganesan A, Okoye I, Arutyunova E, Elahi S, Lemieux MJ, Barakat K(2019). Targeting B7-1 in immunotherapy . Medicinal research reviews.

Hosseini SM, Okoye I, Chaleshtari MG, Hazhirkarzar B, Mohamadnejad J, Azizi G, Hojjat-Farsangi M, Mohammadi H, Shotorbani SS, Jadidi-Niaragh F(2019). E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions . Clinica chimica acta; international journal of clinical chemistry.

Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, et al.(2019). Comprehensive in vitro characterization of PD-L1 small molecule inhibitors . Scientific reports.

Okoye I, Namdar A, Xu L, Crux N, Elahi S(2017). Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling . Oncotarget.

Okoye IS, Houghton M, Tyrrell L, Barakat K, Elahi S(2017). Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8⁺ T Cell Responses to Chronic Viral Infections and Cancer . Frontiers in immunology.

Pelly VS, Coomes SM, Kannan Y, Gialitakis M, Entwistle LJ, Perez-Lloret J, Czieso S, Okoye IS, R&#252;ckerl D, Allen JE, et al.(2017). Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths . The Journal of experimental medicine.

Kannan Y, Li Y, Coomes SM, Okoye IS, Pelly VS, Sriskantharajah S, G&#252;ckel E, Webb L, Czieso S, Nikolov N, et al.(2016). Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells . The Journal of allergy and clinical immunology.

Perez-Lloret J, Okoye IS, Guidi R, Kannan Y, Coomes SM, Czieso S, Mengus G, Davidson I, Wilson MS(2016). T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy . Proceedings of the National Academy of Sciences of the United States of America.

Coomes SM, Pelly VS, Kannan Y, Okoye IS, Czieso S, Entwistle LJ, Perez-Lloret J, Nikolov N, Potocnik AJ, Bir&#243; J, et al.(2015). IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells . PLoS pathogens.

RETRACTED: T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration. @article{PMID:25883318, title = {RETRACTED: T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.}, author = {Okoye I and Wang L and Pallmer K and Richter K and Ichimura T and Haas R and Crouse J and Choi O and Heathcote D and Lovo E and Mauro C and Abdi R and Oxenius A and Rutschmann S and Ashton-Rickardt PG}, doi = {10.1126/science.aaa7516}, journal = {Science (New York, N.Y.)}, month = {05}, year = {2015} } . Science (New York, N.Y.).

Okoye IS, Coomes SM, Pelly VS, Czieso S, Papayannopoulos V, Tolmachova T, Seabra MC, Wilson MS(2014). MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells . Immunity.

Okoye IS, Czieso S, Ktistaki E, Roderick K, Coomes SM, Pelly VS, Kannan Y, Perez-Lloret J, Zhao JL, Baltimore D, et al.(2014). Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity . Proceedings of the National Academy of Sciences of the United States of America.

Okoye IS, Coomes SM, Pelly VS, Czieso S, Papayannopoulos V, Tolmachova T, Seabra MC, Wilson MS(2014). MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells . Immunity.

Kelada S, Sethupathy P, Okoye IS, Kistasis E, Czieso S, White SD, Chou D, Martens C, Ricklefs SM, Virtaneva K, et al.(2013). miR-182 and miR-10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation . PLoS pathogens.

Okoye IS, Wilson MS(2011). CD4+ T helper 2 cells--microbial triggers, differentiation requirements and effector functions . Immunology.