Want to hire this expert for a project? Request a quote for free.
Profile Details
Create Project
USD 300 /hr
Hire Dr. Ismael S.
Canada
USD 300 /hr
Tumor immunologist with deep expertise in metabolic biochemistry, immunoassays, animal models, and flow cytometry.
Profile Summary
Subject Matter Expertise
Services
Writing
Technical Writing,
Newswriting
Research
Feasibility Study,
Fact Checking,
Systematic Literature Review,
Secondary Data Collection
Consulting
Scientific and Technical Consulting
Product Development
Formulation
Work Experience
Sr. Director R&D
Virogin Biotech Ltd.
February 2019 - Present 
Director
Centre for Drug Research and Development
October 2018 - February 2019
Head
Centre for Drug Research and Development
March 2016 - October 2018
Immunotherapy Scientist
Centre for Drug Research and Development
March 2015 - March 2016
Education
Ph.D. (Genetics)
Texas A&M University
September 1997 - August 2002
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Li, Y., Shen, Y., Zhao, R., Samudio, I., Jia, W., Bai, X., Liang, T.(2020). Oncolytic virotherapy in hepato-bilio-pancreatic cancer: The key to breaking the log jam? . Cancer Medicine. 9. (9). p. 2943-2959.
Samudio, I., Hofs, E., Cho, B., Li, M., Bolduc, K., Bu, L., Liu, G., Lam, V., Rennie, P., Jia, W., et al.(2019). UV Light-inactivated HSV-1 Stimulates Natural Killer Cell-induced Killing of Prostate Cancer Cells . Journal of Immunotherapy. 42. (5). p. 162-174.
Holtzman, S.H., Cohen, R., Levin, J.M., Maraganore, J., Albers, J., Aoun, J.E., Audia, J.E., Bailey, M.P., Barrett, P., Bartel, D., et al.(2019). Chinese scientists and US leadership in the life sciences . Nature Biotechnology. 37. (11). p. 1261-1263.
Kuhlmann, L., Cummins, E., Samudio, I., Kislinger, T.(2018). Cell-surface proteomics for the identification of novel therapeutic targets in cancer . Expert Review of Proteomics. 15. (3). p. 259-275.
Tcheng, M., Samudio, I., Lee, E.A., Minden, M.D., Spagnuolo, P.A.(2017). The mitochondria target drug avocatin B synergizes with induction chemotherapeutics to induce leukemia cell death . Leukemia and Lymphoma. 58. (4). p. 986-988.
González, M., Samudio, I., Sequeda-Castañeda, L.G., Celis, C., Iglesias, J., Morales, L.(2017). Cytotoxic and antioxidant capacity of extracts from Vaccinium meridionale Swartz (Ericaceae) in transformed leukemic cell lines . Journal of Applied Pharmaceutical Science. 7. (3). p. 24-30.
Zeng, Z., Liu, W., Tsao, T., Qiu, Y.H., Zhao, Y., Samudio, I., Sarbassov, D.D., Kornblau, S.M., Baggerly, K.A., Kantarjian, H.M., et al.(2017). High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia . Haematologica. 102. (9). p. 1537-1548.
Ismael Samudio, Katayoun Rezvani, Hila Shaim, Elyse Hofs, Mor Ngom, Luke Bu, Guoyu Liu, Jason T. C. Lee, Suzan Imren, Vivian Lam, et al.(2016). {UV}-inactivated {HSV}-1 potently activates {NK} cell killing of leukemic cells . Blood. 127. (21). p. 2575--2586. American Society of Hematology
Velez, J., Pan, R., Lee, J.T.C., Enciso, L., Suarez, M., Duque, J.E., Jaramillo, D., Lopez, C., Morales, L., Bornmann, W., et al.(2016). Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport . Oncotarget. 7. (32). p. 51435-51449.
Samudio, I., Rezvani, K., Shaim, H., Hofs, E., Ngom, M., Bu, L., Liu, G., Lee, J.T.C., Imren, S., Lam, V., et al.(2016). UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells . Blood. 127. (21). p. 2575-2586.
Elisia, I., Nakamura, H., Lam, V., Hofs, E., Cederberg, R., Cait, J., Hughes, M.R., Lee, L., Jia, W., Adomat, H.H., et al.(2016). DMSO represses inflammatory cytokine production from human blood cells and reduces autoimmune arthritis . PLoS ONE. 11. (3).
Ho, V.W., Hofs, E., Elisia, I., Lam, V., Hsu, B.E., Lai, J., Luk, B., Samudio, I., Krystal, G.(2016). All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages . PLoS ONE. 11. (12).
Matre, P., Velez, J., Jacamo, R., Qi, Y., Su, X., Cai, T., Chan, S.M., Lodi, A., Sweeney, S.R., Ma, H., et al.(2016). Inhibiting glutaminase in acute myeloid leukemia: Metabolic dependency of selected AML subtypes . Oncotarget. 7. (48). p. 79722-79735.
Ismael Samudio, Marina Konopleva(2015). Targeting leukemia's {\textquotedblleft}fatty tooth{\textquotedblright} . Blood. 126. (16). p. 1874--1875. American Society of Hematology
Phan, L., Chou, P.-C., Velazquez-Torres, G., Samudio, I., Parreno, K., Huang, Y., Tseng, C., Vu, T., Gully, C., Su, C.-H., et al.(2015). The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming . Nature Communications. 6.
Ríos, D.L., López, C., Álvarez, M.E., Samudio, I.J., Carmona, J.U.(2015). Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide Pathophysiology of musculoskeletal disorders . BMC Musculoskeletal Disorders. 16. (1).
Samudio, I., Konopleva, M.(2015). Targeting leukemia's fatty tooth . Blood. 126. (16). p. 1874-1875.
Ho, V.W., J.Hamilton, M., Dang, N.-H.T., E.Hsu, B., H.Adomat, H., S.Guns, E., Weljie, A., Samudio, I., L.Bennewith, K., Krystal, G.(2014). A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis . Carcinogenesis. 35. (10). p. 2291-2299.
Velez, J., Enciso, L.J., Suarez, M., Fiegl, M., Grismaldo, A., López, C., Barreto, A., Cardozo, C., Palacios, P., Morales, L., et al.(2014). Platelets promote mitochondrial uncoupling and resistance to apoptosis in leukemia cells: A novel paradigm for the bone marrow microenvironment . Cancer Microenvironment. 7. (1-2). p. 79-90.
Torrente, D., Avila, M.F., Cabezas, R., Morales, L., Gonzalez, J., Samudio, I., Barreto, G.E.(2014). Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model . Human and Experimental Toxicology. 33. (7). p. 673-684.
Asem Mansour, Yousef Ismael, Hikmat Abdel-Razeq(2013). Limited Benefit Gained From Inferior Vena Cava Filter Insertion In Patients With Advanced-Stage Cancer . Blood. 122. (21). p. 1147--1147. American Society of Hematology
Ismael Samudio, Marina Konopleva(2013). Asparaginase unveils glutamine-addicted {AML} . Blood. 122. (20). p. 3398--3400. American Society of Hematology
Ismael Samudio, Polina Matre, Rodrigo Jacamo, Ying Wang, Jing Wang, R Eric Davis, Xiaohua Su, Sonja Schindela, Rachel Newman, Jianhua Hu, et al.(2013). Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias . Blood. 122. (21). p. 606--606. American Society of Hematology
Samudio, I., Konopleva, M.(2013). Asparaginase unveils glutamine-addicted AML . Blood. 122. (20). p. 3398-3400.
Nair, V., Pathi, S., Jutooru, I., Sreevalsan, S., Basha, R., Abdelrahim, M., Samudio, I., Safe, S.(2013). Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors . Carcinogenesis. 34. (12). p. 2870-2879.
Giraldo, C.E., López, C., Álvarez, M.E., Samudio, I.J., Prades, M., Carmona, J.U.(2013). Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel . BMC Veterinary Research. 9.
Dembinski, J.L., Wilson, S.M., Spaeth, E.L., Studeny, M., Zompetta, C., Samudio, I., Roby, K., Andreeff, M., Marini, F.C.(2013). Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer . Cytotherapy. 15. (1).
Vélez, J., Hail, N., Konopleva, M., Zeng, Z., Kojima, K., Samudio, I., Andreeff, M.(2013). Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells . Frontiers in Oncology. 3 APR.
Zhou, L., Ruvolo, V.R., McQueen, T., Chen, W., Samudio, I.J., Conneely, O., Konopleva, M., Andreeff, M.(2013). HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML . Leukemia. 27. (6). p. 1358-1368.
Carmona, J.U., López, C., Samudio, I.J.(2013). Autologous Platelet Concentrates as an Adjunctive Treatment for Chronic Laminitis in a Mare with Pituitary Pars Intermedia Dysfunction . Journal of Equine Veterinary Science. 33. (3). p. 191-195.
Frolova, O., Samudio, I., Benito, J., Jacamo, R., Kornblau, S.M., Markovic, A., Schober, W., Lu, H., Qiu, Y.H., Buglio, D., et al.(2012). Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment . Cancer Biology and Therapy. 13. (10). p. 858-870.
Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J., Gonzalo, L., Capani, F., Morales, L., Barreto, G.E.(2012). Effects of natural antioxidants in neurodegenerative disease . Nutritional Neuroscience. 15. (1). p. 1-9.
Duque, J.E., Velez, J., Samudio, I., Lai, E.(2012). Metformin as a Novel Component of Metronomic Chemotherapeutic Use: A Hypothesis . Journal of Experimental and Clinical Medicine. 4. (3). p. 140-144.
Sutachan, J.J., Casas, Z., Albarracin, S.L., Stab II, B.R., Samudio, I., Gonzalez, J., Morales, L., Barreto, G.E.(2012). Cellular and molecular mechanisms of antioxidants in Parkinson's disease . Nutritional Neuroscience. 15. (3). p. 120-126.
Álvarez, M.E., López, C., Giraldo, C.E., Samudio, I., Carmona, J.U.(2011). In vitro bactericidal activity of equine platelet concentrates, platelet poor plasma, and plasma against methicillin-resistant Staphylococcus aureus . Archivos de Medicina Veterinaria. 43. (2). p. 155-161.
Jutooru, I., Chadalapaka, G., Abdelrahim, M., Basha, M.R., Samudio, I., Konopleva, M., Andreeff, M., Safe, S.(2011). Methyl 2-cyano-3,12-dioxooleana-1, 9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: Role of microRNA-27a (Molecular Pharmacology (2010) 78, (226-236)) . Molecular Pharmacology. 79. (2). p. 336.
Kidd, S., Caldwell, L., Dietrich, M., Samudio, I., Spaeth, E.L., Watson, K., Shi, Y., Abbruzzese, J., Konopleva, M., Andreeff, M., et al.(2010). Mesenchymal stromal cells alone or expressing interferon-β suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment . Cytotherapy. 12. (5). p. 615-625.
Duque, J.E., López, C., Cruz, N., Samudio, I.(2010). Antitumor mechanisms of metformin: Signaling, metabolism, immunity and beyond,Mecanismos antitumorales de la metformina: Señalización, metabolismo, inmunidad y más allá . Universitas Scientiarum. 15. (2). p. 122-129.
Jutooru, I., Chadalapaka, G., Abdelrahim, M., Basha, M.R., Samudio, I., Konopleva, M., Andreeff, M., Safe, S.(2010). Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: Role of microRNA-27a . Molecular Pharmacology. 78. (2). p. 226-236.
Samudio, I., Harmancey, R., Fiegl, M., Kantarjian, H., Konopleva, M., Korchin, B., Kaluarachchi, K., Bornmann, W., Duvvuri, S., Taegtmeyer, H., et al.(2010). Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction . Journal of Clinical Investigation. 120. (1). p. 142-156.
Samudio, I.J., Duvvuri, S., Clise-Dwyer, K., Watt, J.C., Mak, D., Kantarjian, H., Yang, D., Ruvolo, V., Borthakur, G.(2010). Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells . Leukemia and Lymphoma. 51. (5). p. 911-919.
López, C., Carmona, J.U., Samudio, I.(2010). Use of autologous platelet concentrates as treatment for a scapular fracture and brachial plexus nerve injury produced by a gunshot in a horse,Uso de concentrados autólogos de plaquetas como tratamiento de una fractura escapular y una lesión del plexo braquial producidas por un disparo en un caballo . Archivos de Medicina Veterinaria. 42. (3). p. 209-214.
Fiegl, M., Samudio, I., Mnjoyan, Z., Korchin, B., Fritsche, H., Andreeff, M.(2010). Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells . Leukemia. 24. (7). p. 1364-1367.
Michael Andreeff, Michael Fiegl, Marina Konopleva, Borys Korchin, Kumar Kaluarachchi, William G. Bornmann, Patrick H. Guthrie, Romain Harmancey, Heinrich Taegtmeyer, Ismael J. Samudio(2009). Pharmacological Inhibition of Fatty Acid Oxidation as a Novel Therapeutic Concept for Acute Myeloid Leukemia . Blood. 114. (22). p. 3779--3779. American Society of Hematology
Zhihong Zeng, Yue Xi Shi, Ismael J. Samudio, Rui-Yu Wang, Xiaoyang Ling, Olga Frolova, Mark Levis, Joshua B. Rubin, Robert R. Negrin, Elihu H. Estey, et al.(2009). Targeting the leukemia microenvironment by {CXCR}4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in {AML} . Blood. 113. (24). p. 6215--6224. American Society of Hematology
Ismael Samudio, Michael Fiegl, Karen Clise-Dwyer, Jared K. Burks, Zakar Mnjoyan, Michael Andreeff(2009). {CXCR}4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure . Blood. 113. (7). p. 1504--1512. American Society of Hematology
Zeng, Z., Shi, Y.X., Samudio, I.J., Wang, R.-Y., Ling, X., Frolova, O., Levis, M., Rubin, J.B., Negrin, R.R., Estey, E.H., et al.(2009). Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML . Blood. 113. (24). p. 6215-6224.
Samudio, I., Fiegl, M., Andreeff, M.(2009). Mitochondrial uncoupling and the warburg effect: Molecular basis for the reprogramming of cancer cell metabolism . Cancer Research. 69. (6). p. 2163-2166.
Fiegl, M., Samudio, I., Clise-Dwyer, K., Burks, J.K., Mnjoyan, Z., Andreeff, M.(2009). CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure . Blood. 113. (7). p. 1504-1512.
Ismael J. Samudio, Michael Fiegl, Marina Konopleva, Kumar Kaluarachchi, John S. McMurray, Borys Korchin, Karen Clise Dwyer, Romain Harmancey, Patrick Guthrie, Heinrich Taegtmeyer, et al.(2008). Targeting Anaplerotic Pathways That Support Fatty Acid Metabolism as a Therapeutic Strategy for Hematological Malignancies: The Achilles' Heel of the Warburg Effect . Blood. 112. (11). p. 1631--1631. American Society of Hematology
Konopleva, M., Watt, J., Contractor, R., Tsao, T., Harris, D., Estrov, Z., Bornmann, W., Kantarjian, H., Viallet, J., Samudio, I., et al.(2008). Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (Obatoclax) . Cancer Research. 68. (9). p. 3413-3420.
Samudio, I., Kurinna, S., Ruvolo, P., Korchin, B., Kantarjian, H., Beran, M., Dunner Jr., K., Kondo, S., Andreeff, M., Konopleva, M.(2008). Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana- 1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells . Molecular Cancer Therapeutics. 7. (5). p. 1130-1139.
Samudio, I., Fiegl, M., McQueen, T., Clise-Dwyer, K., Andreeff, M.(2008). The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation . Cancer Research. 68. (13). p. 5198-5205.
Kojima, K., Shimanuki, M., Shikami, M., Samudio, I.J., Ruvolo, V., Corn, P., Hanaoka, N., Konopleva, M., Andreeff, M., Nakakuma, H.(2008). The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML . Leukemia. 22. (9). p. 1728-1736.
Hong, J., Samudio, I., Chintharlapalli, S., Safe, S.(2008). 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines . Molecular Carcinogenesis. 47. (7). p. 492-507.
Ismael Samudio, Zhihong Zeng, Michael Andreeff, Marina Konopleva(2007). Synergistic Induction of Apoptosis by Simultaneous Disruption of the Bcl-2 and {mTOR}/Akt Pathways in Acute Myeloid Leukemia . Blood. 110. (11). p. 1588--1588. American Society of Hematology
Ismael Samudio, Michael Andreeff, Martin Dietrich, Paul Corn, Sergej Konoplev, Marina Konopleva(2007). The Hypoxic Microenvironment in Acute Myelogenous Leukemia: Critical Role of {CXCR}4 in the Induction of {HIF}-1$\upalpha$ . Blood. 110. (11). p. 1819--1819. American Society of Hematology
Zeng, Z., Sarbassov, D.D., Samudio, I.J., Yee, K.W.L., Munsell, M.F., Jackson, C.E., Giles, F.J., Sabatini, D.M., Andreeff, M., Konopleva, M.(2007). Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML . Blood. 109. (8). p. 3509-3512.
Kojima, K., Konopleva, M., Samudio, I.J., Ruvolo, V., Andreeff, M.(2007). Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells . Cancer Research. 67. (7). p. 3210-3219.
Ismael Samudio, Olga Frolova, Daniela Buglio, Teresa McQueen, Hagop Kantarjian, Mary A. Weiser, Michael Andreeff, Marina Konopleva(2006). Relationship between {mTOR}-Mediated Upregulation of Glycolysis and Chemosensitivity of {ALL} Blasts . Blood. 108. (11). p. 1833--1833. American Society of Hematology
Ismael Samudio, Martin Dietrich, Paul Corn, Dajun Yang, Gautam Borthakur(2006). Novel Small Molecule {MDM}2 Inhibitor {MI}-63 Induces p53-Dependent Apoptosis in {AML} Cell Lines . Blood. 108. (11). p. 2596--2596. American Society of Hematology
Vanderlaag, K., Samudio, I., Burghardt, R., Barhoumi, R., Safe, S.(2006). Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3′-indolyl)methane (DIM) and 5,5′-dibromoDIM . Cancer Letters. 236. (2). p. 198-212.
Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., Safe, S.(2006). 3,3′-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5 . Carcinogenesis. 27. (4). p. 717-728.
Zeng, Z., Samudio, I.J., Munsell, M., An, J., Huang, Z., Estey, E., Andreeff, M., Konopleva, M.(2006). Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias . Molecular Cancer Therapeutics. 5. (12). p. 3113-3121.
Samudio, I., Konopleva, M., Pelicano, H., Huang, P., Frolova, O., Bornmann, W., Ying, Y., Evans, R., Contractor, R., Andreeff, M.(2006). A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: Direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis . Molecular Pharmacology. 69. (4). p. 1182-1193.
Konopleva, M., Contractor, R., Tsao, T., Samudio, I., Ruvolo, P.P., Kitada, S., Deng, X., Zhai, D., Shi, Y.-X., Sneed, T., et al.(2006). Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia . Cancer Cell. 10. (5). p. 375-388.
Zeng, Z., Samudio, I.J., Zhang, W., Estrov, Z., Pelicano, H., Harris, D., Frolova, O., Hail Jr., N., Chen, W., Kornblau, S.M., et al.(2006). Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia . Cancer Research. 66. (7). p. 3737-3746.
Kojima, K., Konopleva, M., Samudio, I.J., Schober, W.D., Bornmann, W.G., Andreeff, M.(2006). Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML . Cell Cycle. 5. (23). p. 2778-2786.
Ismael Samudio, Rooha Contractor, Marina Konopleva, Hagop Kantarjian, Michael Andreeff(2005). Inhibition of Bcl-2 Signaling by Small Molecule {BH}3 Inhibitor {GX}15-070 as a Novel Therapeutic Strategy in {AML} . Blood. 106. (11). p. 3372--3372. American Society of Hematology
Ismael Samudio, Michael Andreeff, Rooha Contractor, Peter P. Ruvolo, Xingming Deng, Yue-Xi Shi, Teresa McQueen, Rui-Yu Wang, Wendy Schober, Xiaoyang Ling, et al.(2005). Mechanisms of Apoptosis Induction by {BH}3 Inhibitor {ABT}-737 in {AML} . Blood. 106. (11). p. 244--244. American Society of Hematology
Ismael Samudio, Marina Konopleva, Stephen Safe, Michael Andreeff(2005). Guggulsterones Induce Apoptosis and Differentiation in {AML}: Identification of Isomer-Specific Antileukemic Activities of the Pregnanedienedione Structure . Blood. 106. (11). p. 4466--4466. American Society of Hematology
Ismael Samudio, Marina Konopleva, Helene Pelicano, Peng Huang, Olga Frolova, William Bornmann, Yun-ming Ying, Randall Evans, Michael Andreeff(2005). A Novel Mechanism of Action of Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate ({CDDO}-Me): Direct Permeabilization of the Inner Mitochondrial Membrane To Inhibit Electron Transport and Induce Apoptosis . Blood. 106. (11). p. 4462--4462. American Society of Hematology
Ismael Samudio, Daniela Buglio, Marina Konopleva, Teresa McQueen, Kristine R. Broglio, Vivian Ruvolo, Rooha Contractor, Wenjing Chen, Hagop Kantarjian, Michael Andreeff, et al.(2005). Relationship between m-{TOR}-Mediated Upregulation of Glycolysis, Chemoresistance, and Prognosis in Patients with {ALL} . Blood. 106. (11). p. 12--12. American Society of Hematology
Contractor, R., Samudio, I.J., Estrov, Z., Harris, D., McCubrey, J.A., Safe, S.H., Andreeff, M., Konopleva, M., Contractor, R., Samudio, I.J., et al.(2005). A novel ring-substituted diindolylmethane, 1,1-bis[3′-(5- methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia . Cancer Research. 65. (7). p. 2890-2898.
Kojima, K., Konopleva, M., Samudio, I.J., Shikami, M., Cabreira-Hansen, M., McQueen, T., Ruvolo, V., Tsao, T., Zeng, Z., Vassilev, L.T., et al.(2005). MDM2 antagonists induce p53-dependent apoptosis in AML: Implications for leukemia therapy . Blood. 106. (9). p. 3150-3159.
Chintharlapalli, S., Papineni, S., Konopleva, M., Andreef, M., Samudio, I., Safe, S.(2005). 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor γ-dependent and -independent pathways . Molecular Pharmacology. 68. (1). p. 119-128.
Calabrò, P., Samudio, I., Safe, S.H., Willerson, J.T., Yeh, E.T.H.(2005). Inhibition of tumor-necrosis-factor-α induced endothelial cell activation by a new class of PPAR-γ agonists: An in vitro study showing receptor-independent effects . Journal of Vascular Research. 42. (6). p. 509-516.
Samudio, I., Konopleva, M., Safe, S., McQueen, T., Andreeff, M.(2005). Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: Identification of isomer-specific antileukemic activities of the pregnadienedione structure . Molecular Cancer Therapeutics. 4. (12). p. 1982-1992.
Samudio, I., Konopleva, M., Hail Jr., N., Shi, Y.-X., McQueen, T., Hsu, T., Evans, R., Honda, T., Gribble, G.W., Sporn, M., et al.(2005). 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer . Journal of Biological Chemistry. 280. (43). p. 36273-36282.
Rooha Contractor, Ismael J. Samudio, Zeev Estrov, David Harris, James A. McCubrey, Stephen H. Safe, Michael Andreeff, Marina Konopleva(2004). A Novel Ring-Substituted Diindolylmethane 1,1-bis [3$\prime$-(5-methoxyindolyl)]-1-(p-t-butylphenyl) Methane Abrogates {ERK} Activation and Induces Apoptosis in Acute Myeloid Leukemia ({AML}) . Blood. 104. (11). p. 3399--3399. American Society of Hematology
Ismael Samudio, Masato Shikami, Marina Konopleva, Koyu Hoshino, Guillermo Garcia-Manero, Kensuke Kojima, Twee Tsao, Teresa McQueen, Michael Andreeff(2004). {ARTS}, a Pro-Apoptotic Mitochondrial Septin-Like Protein That Binds to {XIAP}, Is Silenced in Acute Lymphoblastic and Primitive Acute Myeloblastic Leukemia Cells . Blood. 104. (11). p. 3378--3378. American Society of Hematology
Calabro, P., Samudio, I., Willerson, J.T., Yeh, E.T.H.(2004). Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways . Circulation. 110. (21). p. 3335-3340.
Hong, J., Samudio, I., Liu, S., Abdelrahim, M., Safe, S.(2004). Peroxisome proliferator-activated receptor γ-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins . Endocrinology. 145. (12). p. 5774-5785.
Chintharlapalli, S., Smith III, R., Samudio, I., Zhang, W., Safe, S.(2004). 1,1-Bis(3′-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor γ-mediated growth inhibition, transactivation, and differeatiation markers in colon cancer cells . Cancer Research. 64. (17). p. 5994-6001.
Stoner, M., Wormke, M., Saville, B., Samudio, I., Qin, C., Abdelrahim, M., Safe, S.(2004). Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor α and SP proteins . Oncogene. 23. (5). p. 1052-1063.
Qin, C., Samudio, I., Ngwenya, S., Safe, S.(2004). Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways . Molecular Carcinogenesis. 40. (3). p. 160-170.
Qin, C., Morrow, D., Stewart, J., Spencer, K., Porter, W., Smith, R., Phillips, T., Abdelrahim, M., Samudio, I., Safe, S.(2004). A new class of peroxisome proliferator-activated receptor γ (PPARγ) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl) methanes . Molecular Cancer Therapeutics. 3. (3). p. 247-259.
Khan, S., Abdelrahim, M., Samudio, I., Safe, S.(2003). Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17β-estradiol in breast cancer cells . Endocrinology. 144. (6). p. 2325-2335.
Saville, B., Poukka, H., Wormke, M., Jänne, O.A., Palvimo, J.J., Stoner, M., Samudio, I., Safe, S.(2002). Cooperative coactivation of estrogen receptor α in ZR-75 human breast cancer cells by SNURF and TATA-binding protein . Journal of Biological Chemistry. 277. (4). p. 2485-2497.
Abdelrahim, M., Samudio, I., Smith 3rd., R., Burghardt, R., Safe, S.(2002). Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells . The Journal of biological chemistry. 277. (32). p. 28815-28822.
Qin, C., Nguyen, T., Stewart, J., Samudio, I., Burghardt, R., Safe, S.(2002). Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor κB/CCAAT-binding transcription factor-1 complex . Molecular Endocrinology. 16. (8). p. 1793-1809.
Castro-Rivera, E., Samudio, I., Safe, S.(2001). Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements . Journal of Biological Chemistry. 276. (33). p. 30853-30861.
Samudio, I., Vyhlidal, C., Wang, F., Stoner, M., Chen, I., Kladde, M., Barhoumi, R., Burghardt, R., Safe, S.(2001). Transcriptional activation of deoxyribonucleic acid polymerase α gene expression in MCF-7 cells by 17β-estradiol . Endocrinology. 142. (3). p. 1000-1008.
Wang, F., Samudio, I., Safe, S.(2001). Transcriptional activation of cathepsin D gene expression by 17β-estradiol: Mechanism of aryl hydrocarbon receptor-mediated inhibition . Molecular and Cellular Endocrinology. 172. (1-2). p. 91-103.
Stoner, M., Wang, F., Wormke, M., Nguyen, T., Samudio, I., Vyhlidal, C., Marme, D., Finkenzeller, G., Safe, S.(2000). Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor α and Sp3 proteins . Journal of Biological Chemistry. 275. (30). p. 22769-22779.
Xie, W., Duan, R., Chen, I., Samudio, I., Safe, S.(2000). Transcriptional activation of thymidylate synthase by 17β-estradiol in MCF-7 human breast cancer cells . Endocrinology. 141. (7). p. 2439-2449.
Safe, S., Wormke, M., Samudio, I.(2000). Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells . Journal of Mammary Gland Biology and Neoplasia. 5. (3). p. 295-306.
Vyhlidal, C., Samudio, I., Kladde, M.P., Safe, S.(2000). Transcriptional activation of transforming growth factor α by estradiol: Requirement for both a GC-rich site and an estrogen response element half-site . Journal of Molecular Endocrinology. 24. (3). p. 329-338.
Duan, R., Porter, W., Samudio, I., Vyhlidal, C., Kladde, M., Safe, S.(1999). Transcriptional activation of c-fos protooncogene by 17β-Estradiol: Mechanism of aryl hydrocarbon receptor-mediated inhibition . Molecular Endocrinology. 13. (9). p. 1511-1521.
Dong, L., Wang, W., Wang, F., Stoner, M., Reed, J.C., Harigai, M., Samudio, I., Kladde, M.P., Vyhlidalll, C., Safe, S.(1999). Mechanisms of transcriptional activation of bcl-2 gene expression by 17β-estradiol in breast cancer cells . Journal of Biological Chemistry. 274. (45). p. 32099-32107.
BOOK CHAPTER
Samudio, I., Vélez, J.(2015). Molecular and biochemical basis for the reprogramming of intermediary metabolism in leukemia cells . Targeted Therapy of Acute Myeloid Leukemi. p. 725-733.
BOOK
Samudio, I., Konopleva, M., Carter, B., Andreeff, M.(2010). Apoptosis in leukemias: Regulation and therapeutic targeting . Cancer Treatment and Research. 145. p. 197-217.
Ratings and Comments
Total Projects Awarded:
Comments:
