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Hire Dr. Isaline R.

Italy

USD 10 /hr

Senior Research Scientist (PhD) | Molecular Oncology & Nephrology | Expert in Grant Writing & High-Impact P

Profile Summary

Profile SummarySenior Research Scientist (PhD) | Molecular Oncology & Nephrology | Grant Writing & IP SpecialistI am a Senior Staff Scientist with over 20 years of extensive experience in molecular oncology and nephrology, primarily at the San Raffaele Scientific Institute in Milan. My expertise lies in translating complex preclinical and clinical data into high-impact scientific discoveries and successful therapeutic strategies. Throughout my career, I have managed large-scale research programs from protocol design to milestone reporting. I am a co-inventor of international patents related to metabolic reprogramming in kidney diseases, showcasing my commitment to bridging the gap between basic science and clinical application. _ Key Areas of Expertise:Disease Specialization: Renal Cell Carcinoma (Sporadic & VHL), Autosomal Dominant Polycystic Kidney Disease (ADPKD), and molecular mechanisms of metabolic reprogramming. _ Scientific Writing & Communication: Author of numerous peer-reviewed publications in prestigious journals such as Nature Medicine, Nature Reviews Urology, and Scientific Reports. _ Strategic Funding: drafting and submitting successful grant proposals for national and international bodies. _ Intellectual Property: Expert in identifying and developing patentable therapeutic targets. _ Mentorship: Experienced academic tutor and supervisor for Ph.D. and undergraduate students. I offer high-level scientific consulting for academic institutions, biotech startups, and pharmaceutical companies looking for expertise in preclinical and translational research design, and grant strategy.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Omics
• ☆ Transcriptomics
• ☆ Metabolomics
• ☆ Gene Expression Analysis
• ☆ Cell Biology
• ☆ Cell-Based Assays

Services

• Writing
• Research
• Consulting
• Data & AI

Writing General Proofreading & Editing, Translation

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Data Visualization, Data Mining

Work Experience

Staff Scientist

Ospedale San Raffaele

June 2019 - Present

Ospedale San Raffaele

March 2019 - Present

Senior Post-Doc

Ospedale San Raffaele

January 2013 - February 2019

Post-Doctoral Fellow

Ospedale San Raffaele

July 2009 - December 2012

Post-Doctoral Fellow

Ospedale San Raffaele

July 2004 - June 2008

Education

PhD

UPMC

September 2000 - June 2004

Ph.D in Life Sciences

Université Pierre et Marie Curie

September 2000 - June 2004

2nd year M. Sc in Molecular and Cellular Genetics

Université Pierre et Marie Curie

September 1999 - June 2000

1rst year Msc in Biochemistry

Université Pierre et Marie Curie

September 1998 - June 1999

Bsc in Biology

Université Pierre et Marie Curie

September 1994 - June 1998

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Musso G, Fallara G, Rosiello G, Martini A, Re C, Cei F, Basile G, Cignoli D, Colandrea G, Rowe I, et al.(2023). Differential Prognostic Value of Extrarenal Involvement in Patients With Non-Metastatic Renal Cell Cancer . Clinical genitourinary cancer.

Capitanio U, Freschi M, Rosiello G, Fallara G, Musso G, Cei F, Basile G, Rowe I, Canibus D, Lucianò R, et al.(2022). Case of the Month from San Raffaele Hospital, Milan, Italy: paraneoplastic presentation of small renal masses . BJU international.

Salonia A, Pontillo M, Capogrosso P, Pozzi E, Ferrara AM, Cotelessa A, Belladelli F, Corsini C, Gregori S, Rowe I, et al.(2022). Testosterone in males with COVID-19: a 12-month cohort study . Andrology.

Larcher A, Belladelli F, Fallara G, Rowe I, Capitanio U, Marandino L, Raggi D, Capitanio JF, Bailo M, Lattanzio R, et al.(2022). Multidisciplinary management of patients diagnosed with von Hippel-Lindau disease: A practical review of the literature for clinicians . Asian journal of urology.

Cignoli D, Fallara G, Aleotti F, Larcher A, Rosiello G, Rowe I, Basile G, Colandrea G, Martini A, De Cobelli F, et al.(2022). Pancreatic metastases after surgery for renal cell carcinoma: survival and pathways of progression . World journal of urology.

Capitanio U, Fallara G, Raggi D, Nocera L, Larcher A, Belladelli F, Rowe I, Briganti A, Salonia A, Karakiewicz P, et al.(2022). Pembrolizumab in advanced renal cell carcinoma: a meta-analysis providing level 1a evidence . Current problems in cancer.

Larcher A, Rowe I, Belladelli F, Fallara G, Raggi D, Necchi A, Montorsi F, Capitanio U, Salonia A, OSR VHL Program(2022). Von Hippel-Lindau disease-associated renal cell carcinoma: a call to action . Current opinion in urology.

Salonia A, Pontillo M, Capogrosso P, Gregori S, Carenzi C, Ferrara AM, Rowe I, Boeri L, Larcher A, Ramirez GA, et al.(2021). Testosterone in males with COVID-19: A 7-month cohort study . Andrology.

Salonia A, Pontillo M, Capogrosso P, Gregori S, Tassara M, Boeri L, Carenzi C, Abbate C, Cignoli D, Ferrara AM, et al.(2021). Severely low testosterone in males with COVID-19: A case-control study . Andrology.

Capitanio U, Rosiello G, Erdem S, Rowe I, Kara O, Roussel E, Campi R, Klatte T, Kriegmair MC, Sibona M, et al.(2021). Clinical, surgical, pathological and follow-up features of kidney cancer patients with Von Hippel-Lindau syndrome: novel insights from a large consortium . World journal of urology.

(2018). Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways . Communications biology.

(2015). 2-Deoxy-d-Glucose Ameliorates PKD Progression . Journal of the American Society of Nephrology : JASN.

(2014). Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures . Biochemical and biophysical research communications.

(2014). Defective metabolism in polycystic kidney disease: potential for therapy and open questions . Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

(2013). Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy . Nature medicine.

(2013). Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis . Nature communications.

(2010). Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals . PloS one.

(2009). A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus . PloS one.

(2009). Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1 . Molecular and cellular biology.

(2007). Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus . Proceedings of the National Academy of Sciences of the United States of America.

(2005). Apoptosis of tail muscle during amphibian metamorphosis involves a caspase 9-dependent mechanism . Developmental dynamics : an official publication of the American Association of Anatomists.

(2002). Autonomous regulation of muscle fibre fate during metamorphosis in Xenopus tropicalis . Developmental dynamics : an official publication of the American Association of Anatomists.