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Hire Hoai T.

Vietnam

USD 15 /hr

Researcher

Profile Summary

- Investigated the effect of common dandelion (Taraxacum officinale) on the binding of Sars-CoV-2 S1 Spike to hACE2 receptor using a specific inhibitor assay, flow cytometry, and pseudotyped lentivirus entry into human ACE2 – TMPRSS2 overexpressing A549 cells. - Examined immune activating potential of some herbal medicinal extracts in human primary cells and cell lines, in terms of Sars- CoV-2 stimulation using ELISA, RT-PCR, and flow cytometry. - Analysed the relevance of bitter taste receptor (T2R38) expression in the regulation of immune response to T2R38 agonist (allyl isothiocyanate from Brassica plants). Determined the impact of endocrine disruptors at the levels of current human exposure on primary T lymphocyte functions and ageing isolated from healthy subjects through the non-classical pathway by using the TeloTAGGG Telomerase PCR ELISA, single cell gel electrophoresis assay (Comet), RT-PCR array, immunoblotting, and flow cytometry. - Studied the anti-inflammatory efficacy of Nasturtium in human immune cells and provided its underlying mechanism of action which is different from non-steroidal anti-inflammatory drugs

Subject Matter Expertise

• ☆ Complementary & Alternative Medicine
• ☆ Herbal Medicine
• ☆ Photomedicine/Phototherapy
• ☆ Inflammation
• ☆ Nutraceuticals

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing, General Proofreading & Editing, Translation

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Processing

Work Experience

Postdoc Researcher

Universitätsklinikum Freiburg

November 2020 - Present

Researcher assistant

Universitätsklinikum Freiburg

March 2013 - October 2020

Education

Dr. rer. nat (Faculty of Chemistry and Pharmacy)

Albert-Ludwigs-Universität Freiburg

2016 - 2020

MSc

University of the West of England

September 2011 - August 2012

BSc (Hons)

University of the West of England

September 2007 - July 2012

Certifications

• Certification details not provided.

Publications

PREPRINT

Hoai Thi Thu Tran, Michael Gigl, Corinna Dawid, Evelyn Lamy (2022). Common dandelion (Taraxacum officinale) leaf extract efficiently inhibits SARS-CoV-2 Omicron infectionin vitro .

JOURNAL ARTICLE

Hoai Thi Thu Tran, Philipp Peterburs, Jan Seibel, D. Abramov-Sommariva, Evelyn Lamy, Niranjan Parajuli (2022). In vitro Screening of Herbal Medicinal Products for Their Supportive Curing Potential in the Context of SARS-CoV-2 . Evidence-Based Complementary and Alternative Medicine.

Hoai Thi Thu Tran, Michael Gigl, Nguyen Phan Khoi Le, Corinna Dawid, Evelyn Lamy(2021). In Vitro Effect of Taraxacum officinale Leaf Aqueous Extract on the Interaction between ACE2 Cell Surface Receptor and SARS-CoV-2 Spike Protein D614 and Four Mutants . Pharmaceuticals. 14. (10). p. 1055. {MDPI} {AG}

Hoai Tran, Michael Gigl, Nguyen Le, Corinna Dawid, Evelyn Lamy (2021). In Vitro Effect of <i>Taraxacum officinale</i> Leaf Aqueous Extract on the Interaction between ACE2 Cell Surface Receptor and SARS-CoV-2 Spike Protein D614 and Four Mutants . Pharmaceuticals.

Tran, H.T.T., Stetter, R., Herz, C., Sp&#246;ttel, J., Krell, M., Hanschen, F.S., Schreiner, M., Rohn, S., Behrens, M., Lamy, E.(2021). Allyl Isothiocyanate: A TAS2R38 Receptor-Dependent Immune Modulator at the Interface Between Personalized Medicine and Nutrition . Frontiers in Immunology. 12.

Wiesner-Reinhold, M., Dutra Gomes, J.V., Herz, C., Tran, H.T.T., Baldermann, S., Neugart, S., Filler, T., Glaab, J., Einfeldt, S., Schreiner, M., et al.(2021). Subsequent treatment of leafy vegetables with low doses of UVB-radiation does not provoke cytotoxicity, genotoxicity, or oxidative stress in a human liver cell model . Food Bioscience. 43.

Moumbock, A.F.A., Li, J., Tran, H.T.T., Hinkelmann, R., Lamy, E., Jessen, H.J., G&#252;nther, S.(2021). ePharmaLib: A Versatile Library of e-Pharmacophores to Address Small-Molecule (Poly-)Pharmacology . Journal of Chemical Information and Modeling. 61. (7). p. 3659-3666.

Tran, H.T.T., Gigl, M., Le, N.P.K., Dawid, C., Lamy, E.(2021). In vitro effect of taraxacum officinale leaf aqueous extract on the interaction between ace2 cell surface receptor and sars-cov-2 spike protein d614 and four mutants . Pharmaceuticals. 14. (10).

Tran, H.T.T., Herz, C., Lamy, E.(2020). Long-term exposure to “low-dose” bisphenol A decreases mitochondrial DNA copy number, and accelerates telomere shortening in human CD8 + T cells . Scientific Reports. 10. (1).

Hoai Tran, Nina Schlotz, Monika Schreiner, Evelyn Lamy (2019). Short-Term Dietary Intervention with Cooked but Not Raw <em>Brassica</em> Leafy Vegetables Increases Telomerase Activity in CD8+ Lymphocytes in a Randomized Human Trial . Nutrients.

Tran, H.T.T., Schlotz, N., Schreiner, M., Lamy, E.(2019). Short-term dietary intervention with cooked but not raw Brassica leafy vegetables increases telomerase activity in CD8+ lymphocytes in a randomized human trial . Nutrients. 11. (4).

(2018). Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes.

Tran, H.T.T., Herz, C., Ruf, P., Stetter, R., Lamy, E.(2018). Human T2R38 bitter taste receptor expression in resting and activated lymphocytes . Frontiers in Immunology. 9.

Herz, C., Tran, H.T.T., M&#225;rton, M.-R., Maul, R., Baldermann, S., Schreiner, M., Lamy, E.(2017). Evaluation of an Aqueous Extract from Horseradish Root (Armoracia rusticana Radix) against Lipopolysaccharide-Induced Cellular Inflammation Reaction . Evidence-based Complementary and Alternative Medicine. 2017.

Herz, C., Tran, H.T.T., Schlotz, N., Michels, K., Lamy, E.(2017). Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC . Scientific Reports. 7. (1).

Herz, C., Tran, H.T.T., Landerer, S., Gaus, J., Schlotz, N., Lehr, L., Sch&#228;fer, W.R., Treeck, O., Odongo, G.A., Skatchkov, I., et al.(2017). Normal human immune cells are sensitive to telomerase inhibition by Brassica-derived 3,3-diindolylmethane,partly mediated via ERα/β-AP1 signaling . Molecular Nutrition and Food Research. 61. (9).

Herz, C., M&#225;rton, M.-R., Tran, H.T.T., Gr&#252;ndemann, C., Schell, J., Lamy, E.(2016). Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells . Journal of Functional Foods. 23. p. 135-143.

Tran, H.T.T., M&#225;rton, M.-R., Herz, C., Maul, R., Baldermann, S., Schreiner, M., Lamy, E.(2016). Nasturtium (Indian cress, Tropaeolum majus nanum) dually blocks the COX and LOX pathway in primary human immune cells . Phytomedicine. 23. (6). p. 611-620.

OTHER

Hoai Thi Thu Tran, Nguyen Phan Khoi Le, Michael Gigl, Corinna Dawid, Evelyn Lamy(2021). Common dandelion (Taraxacum officinale) efficiently blocks the interaction between ACE2 cell surface receptor and SARS-CoV-2 spike protein D614, mutants D614G, N501Y, K417N and E484K in vitro . Cold Spring Harbor Laboratory

Hoai Thi Thu Tran, Philipp Peterburs, Jan Seibel, D. Abramov-Sommariva, Evelyn Lamy(2021). In vitroscreening of herbal medicinal products for their supportive curing potential in the context of SARS-CoV-2 . Cold Spring Harbor Laboratory

Tran, H.T.T., Peterburs, P., Seibel, J., Abramov‐Sommariva, D., Lamy, E.(2021). In vitro screening of herbal medicinal products for their supportive curing potential in the context of SARS‐CoV‐2 . bioRxiv.

Tran, H.T.T., Le, N.P.K., Gigl, M., Dawid, C., Lamy, E.(2021). Common dandelion (Taraxacum officinale) efficiently blocks the interaction between ACE2 cell surface receptor and SARS-CoV-2 spike protein D614, mutants D614G, N501Y, K417N and E484K in vitro . bioRxiv.