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Hire Dr. Dr. Himakshi S.

India

Computational Biologist & Bioinformatician | PhD with 5+ years of Post Doc Experience

Profile Summary

I am a Computational Biologist, my research interests are centered on NGS data analysis, Variant calling, computer-aided drug design, drug repurposing and unravelling the biological mechanisms of protein-protein interaction using classical molecular dynamics simulations and state-of-the-art molecular modelling approaches. I am also interested in the transcriptomic data analysis of various cancers with a special focus on Breast cancer to identify novel biomarkers and hub genes employing network pharmacology and machine-learning approaches.

Subject Matter Expertise

• ☆ Computational Biology
• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ Next Generation Sequencing (NGS)
• ☆ Cell Biology
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Statistics
• ☆ Health Data Analysis
• ☆ Python
• ☆ Excel
• ☆ R

Services

• Writing
• Research
• Data & AI

Writing Technical Writing

Research Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Data & AI Statistical Analysis, Image Processing, Data Visualization, Data Cleaning, Data Processing, Data Insights

Work Experience

Project Scientist-I

CSIR-North East Institute of Science and Technology, Jorhat, Assam, India

February 2021 - Present

Project Scientist-I

CSIR-NEIST, Jorhat

February 2021 - Present

Senior Project Associate

CSIR-North East Institute of Science and Technology

May 2019 - January 2021

Senior Project Associate

CSIR-North East Institute of Science and Technology

May 2019 - January 2021

Research Assistant

Bodoland University, Kokrajhar, Assam, India

September 2018 - May 2019

Education

Research arear was Computer Aided Drug Design (CADD)

Tezpur University

January 2015 - July 2019

Ph D (Molecular Biology and Biotechnology)

Tezpur University

January 2015 - June 2019

Masters in Biotechnology

North Eastern Hill University - India

June 2012 - September 2014

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Priyadarsinee, L., Jamir, E., Nagamani, S., Mahanta, H.J., Kumar, N., John, L., Sarma, H., Kumar, A., Gaur, A.S., Sahoo, R., et al.(2024). Molecular Property Diagnostic Suite for COVID-19 (MPDS^COVID-19): an open-source disease-specific drug discovery portal . GigaByte. 2024. p. 1-17.

Sarma, H., Kiewhuo, K., Jamir, E., Sastry, G.N.(2023). In silico investigation on the mutational analysis of BRCA1-BARD1 RING domains and its effect on nucleosome recognition and ubiquitination . Biophysical Chemistry. 300.

Jamir, E., Sarma, H., Priyadarsinee, L., Kiewhuo, K., Nagamani, S., Sastry, G.N.(2023). Polypharmacology guided drug repositioning approach for SARS-CoV2 . PLoS ONE. 18. (8 August).

Kiewhuo, K., Priyadarsinee, L., Sarma, H., Sastry, G.N.(2023). Molecular dynamics simulations reveal the effect of mutations in the RING domains of BRCA1-BARD1 complex and its relevance to the prognosis of breast cancer . Journal of Biomolecular Structure and Dynamics. 41. (22). p. 12734-12752.

Wahengbam, R., Bharali, P., Manna, P., Phukan, T., Singh, M.G., Gogoi, G., Tapadar, Y.B., Singh, A.K., Konwar, R., Chikkaputtaiah, C., et al.(2023). Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India . Indian Journal of Medical Microbiology. 43. p. 58-65.

Sarma, H., Sastry, G.N.(2022). A Computational Study on the Interaction of NSP10 and NSP14: Unraveling the RNA Synthesis Proofreading Mechanism in SARS-CoV-2, SARS-CoV, and MERS-CoV . ACS Omega. 7. (34). p. 29995-30014.

Jamir, E., Sarma, H., Priyadarsinee, L., Nagamani, S., Kiewhuo, K., Gaur, A.S., Rawal, R.K., Murugan, N.A., Subramanian, V., Sastry, G.N.(2022). Applying polypharmacology approach for drug repurposing for SARS-CoV2 . Journal of Chemical Sciences. 134. (2).

Priyadarsinee, L., Sarma, H., Sastry, G.N.(2022). Glycoprotein attachment with host cell surface receptor ephrin B2 and B3 in mediating entry of nipah and hendra virus: a computational investigation . Journal of Chemical Sciences. 134. (4).

Sarma, H., Jamir, E., Sastry, G.N.(2022). Protein-protein interaction of RdRp with its co-factor NSP8 and NSP7 to decipher the interface hotspot residues for drug targeting: A comparison between SARS-CoV-2 and SARS-CoV . Journal of Molecular Structure. 1257.

Jamir, E., Kiewhuo, K., Priyadarsinee, L., Sarma, H., Nagamani, S., Sastry, G.N.(2022). Structure-function relationships among selected human coronaviruses . Indian Journal of Biochemistry and Biophysics. 59. (5). p. 536-551.

Kumar, N., Sarma, H., Sastry, G.N.(2022). Repurposing of approved drug molecules for viral infectious diseases: a molecular modelling approach . Journal of Biomolecular Structure and Dynamics. 40. (17). p. 8056-8072.

Phukan, S., Sarmah, N., Sarma, H., Dutta, A., Mattaparthi, V.S.K., Baruah, M.N., Ahmed, G.N., Saharia, D., Baruah, S.(2022). Higher affinity binding alleles and copy number variation of inhibitory KIR2DL1 gene influence the immune surveillance in head and neck squamous cell carcinoma in the population of Assam, North-East India . Human Gene. 34.

Kumar, N., Kumar, Y.B., Sarma, H., Sastry, G.N.(2021). Fate of Sc-Ion Interaction With Water: A Computational Study to Address Splitting Water Versus Solvating Sc Ion . Frontiers in Chemistry. 9.

Pradhan, S., Sarma, H., Mattaparthi, V.S.K.(2019). Investigation of the probable homo-dimer model of the Xeroderma pigmentosum complementation group A (XPA) protein to represent the DNA-binding core . Journal of Biomolecular Structure and Dynamics. 37. (13). p. 3322-3336.

Sarma, H., Mattaparthi, V.S.K.(2019). Structure-Based Virtual Screening of High-Affinity ATP-Competitive Inhibitors Against Human Lemur Tyrosine Kinase-3 (LMTK3) Domain: A Novel Therapeutic Target for Breast Cancer . Interdisciplinary Sciences – Computational Life Sciences. 11. (3). p. 527-541.

Sarma, H., Mattaparthi, V.S.K.(2018). Unveiling the transient protein-protein interactions that regulate the activity of human lemur tyrosine kinase-3 (LMTK3) domain by cyclin dependent kinase 5 (CDK5) in breast cancer: An in silico study . Current Proteomics. 15. (1). p. 62-70.

Sarma, H., Mattaparthi, V.S.K.(2017). Unveiling the transient protein-protein interactions that modulate the activity of estrogen receptor(ER)-α by human lemur tyrosine kinase-3 (LMTK3) domain: an in silico study . Current Proteomics. 14. (2). p. 157-164.

OTHER

Priyadarsinee, L., Jamir, E., Nagamani, S., Mahanta, H.J., Kumar, N., John, L., Sarma, H., Kumar, A., Gaur, A.S., Sahoo, R., et al.(2023). Molecular Property Diagnostic Suite for COVID-19 (MPDS^COVID-19): An open access disease specific drug discovery portal . bioRxiv.

Jamir, E., Sarma, H., Priyadarsinee, L., Kiewhuo, K., Nagamani, S., Sastry, G.N.(2022). A structure-based drug repurposing approach by considering the twenty four SARS-CoV2 Targets: A consensus scoring approach . Research Square.

Wahengbam, R., Bharali, P., Manna, P., Phukan, T., Singh, M.G., Gogoi, G., Tapadar, Y.B., Singh, A.K., Konwar, R., Chikkaputtaiah, C., et al.(2022). Seroepidemiological and genomic investigation of COVID-19 spread in North East region of India . medRxiv.

BOOK CHAPTER

Sarma, H., Pradhan, S., Mattaparthi, V.S.K., Kaushik, S.(2018). Phylogenetic analysis: Early evolution of life . Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics. 1-3. p. 938-952.