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Profile Details
Hire Hanumantha Rao M.
United States
Senior Scientist ♦ Principal Scientist ♦ Biochemist ♦ Cell Biologist ♦ Immunotherapeutics ♦ Translational Sciences
Profile Summary
Subject Matter Expertise
Services
Writing
Medical Writing,
Technical Writing,
Copywriting,
Creative Writing,
General Proofreading & Editing,
Translation
Research
Market Research,
Meta-Research,
Feasibility Study,
Technology Scouting,
Fact Checking,
Gap Analysis,
Scientific and Technical Research,
Systematic Literature Review
Consulting
Healthcare Consulting,
Scientific and Technical Consulting
Data & AI
Image Analysis,
Data Visualization,
Big Data Analytics,
Data Mining,
Data Cleaning,
Data Processing
Work Experience
Sr. Scientist
Xilio Therapeutics (United States)
January 2022 - Present 
Sr. Scientist
Resonance Medicine
August 2023 - November 2023
Scientist
Xilio Therapeutics (United States)
December 2019 - December 2021
Research Fellow
Harvard Medical School
July 2018 - November 2020
Research Fellow
Massachusetts General Hospital
July 2018 - November 2020
Education
PhD (Pharmaceutical Sceinces)
Texas Tech University Health Sciences Center
August 2014 - May 2018
Master's (Pharmaceutical Sciences)
Long Island University
September 2011 - July 2014
Bachelor's (Pharmaceutical Sceinces)
Rajiv Gandhi University of Health Sciences
September 2006 - July 2010
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Hanumantha Rao Madala, Ekta Patel, Natalia V. Malkova, David Crowe, Magali Pederzoli-Ribeil, Damiano Fantini, Manoussa Fanny, Kurt A. Jenkins, Oleg Yerov, Justin Greene, et al. (2023). XTX301, a tumor-activated Interleukin-12 has the potential to widen the therapeutic index of IL-12 treatment for solid tumors as evidenced by pre-clinical studies . Molecular Cancer Therapeutics.
Hanumantha Rao Madala, Iiro Taneli Helenius, Jing-Ruey Joanna Yeh (2021). An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate’s Emerging Roles in Cell Proliferation and Survival . Biomolecules.
Hanumantha Rao Madala, Iiro Taneli Helenius, Jing-Ruey Joanna Yeh (2021). An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate’s Emerging Roles in Cell Proliferation and Survival . Biomolecules.
Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, et al.(2020). Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction . Cancer Research. 80. (17). p. 3492--3506. American Association for Cancer Research ({AACR})
Hanumantha Rao Madala, Surendra Reddy Punganuru, Viswanath Arutla, Ruiwen Zhang, Kalkunte S. Srivenugopal (2019). Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging . Scientific Reports.
Hanumantha Rao Madala, Surendra Reddy Punganuru, Viswanath Arutla, Kalkunte S. Srivenugopal (2018). Cancer-Specific Biomarker hNQO1-Activatable Fluorescent Probe for Imaging Cancer Cells In Vitro and In Vivo . Cancers.
(2018). Selective killing of human breast cancer cells by the styryl lactone (R)-goniothalamin is mediated by glutathione conjugation, induction of oxidative stress and marked reactivation of the R175H mutant p53 protein . Carcinogenesis.
Punganuru SR, Madala HR, Mikelis CM, Dixit A, Arutla V, Srivenugopal KS(2018). Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models . Oncotarget.
Mostofa A, Punganuru SR, Madala HR, Srivenugopal KS(2018). S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells . Neoplasia (New York, N.Y.).
(2018). Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies . Cancers.
Madala HR, Punganuru SR, Ali-Osman F, Zhang R, Srivenugopal KS(2017). Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts . Oncotarget.
Madala HR, Punganuru SR, Srivenugopal K, Ali-Osman F(2017). EXTH-36. DEVELOPMENT OF STABLE AND BRAIN-PENETRATING DISULFIRAM NANOPARTICLES, CHARACTERIZATION AND EFFICACY IN GLIOMA CELL CULTURE AND XENOGRAFT MODELS . Neuro-Oncology.
Mostofa AG, Punganuru SR, Madala HR, Al-Obaide M, Srivenugopal KS(2017). The Process and Regulatory Components of Inflammation in Brain Oncogenesis . Biomolecules.
Paranjpe A, Bailey NI, Konduri S, Bobustuc GC, Ali-Osman F, Yusuf MA, Punganuru SR, Madala HR, Basak D, Mostofa A, et al.(2016). New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy . Journal of biomedical research.
Punganuru SR, Mostofa AGM, Madala HR, Basak D, Srivenugopal KS(2016). Potent anti-proliferative actions of a non-diuretic glucosamine derivative of ethacrynic acid . Bioorganic & medicinal chemistry letters.
Srivenugopal KS, Rawat A, Niture SK, Paranjpe A, Velu C, Venugopal SN, Madala HR, Basak D, Punganuru SR(2016). Posttranslational Regulation of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and New Opportunities for Treatment of Brain Cancers . Mini reviews in medicinal chemistry.
Punganuru SR, Madala HR, Venugopal SN, Samala R, Mikelis C, Srivenugopal KS(2015). Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties . European journal of medicinal chemistry.
PREPRINT
Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, et al. (2023). Supplemental Methods from Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction .
Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, et al. (2023). Supplementary Figures from Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction .
Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, et al. (2023). Supplementary Figures from Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction .
Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, et al. (2023). Data from Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction .
Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, et al. (2023). Data from Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction .
Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, et al. (2023). Supplemental Methods from Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction .
Ratings and Comments
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