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Hire Dr. Guido L.

Italy

USD 45 /hr

Profile Summary

My research interests cover several areas related to the understanding of functional role of genome expression products. I'm trained in microarray rnaseq chipseq exomeseq data analysis and in development of predictors of disease outcome with machine learning methods. I have strong experience in analyzing exomeseq data to discover somatic mutations in cancer patients

Subject Matter Expertise

• ☆ Genetics
• ☆ Microarrays
• ☆ Mutagenesis
• ☆ Bioinformatics

Services

• Data & AI

Work Experience

bioinformatician

Nouscom

September 2015 - Present

Bioinformatician

Nouscom

January 2015 - Present

post doc

Universita degli Studi di Roma La Sapienza

February 2012 - September 2015

Education

Phd in biochemistry

Università degli Studi di Roma La Sapienza Dipartimento di Fisica

January 2010 - June 2012

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Guido Leoni, Anna Morena D'Alise, Gabriella Cotugno, Francesca Langone, Irene Garzia, Maria De Lucia, Imma Fichera, Rosa Vitale, Veronica Bignone, Fabio Giovanni Tucci, et al.(2020). A genetic vaccine encoding shared cancer neoantigens to treat tumors with Microsatellite Instability . Cancer Research. p. canres.1072.2020. American Association for Cancer Research ({AACR})

Guido Leoni, Anna Morena D’Alise, Gabriella Cotugno, Fulvia Troise, Francesca Langone, Imma Fichera, Maria De Lucia, Lidia Avalle, Rosa Vitale, Adriano Leuzzi, et al.(2019). Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade . Nature Communications. 10. (1). Springer Science and Business Media {LLC}

D’Alise, A.M., Leoni, G., Cotugno, G., Troise, F., Langone, F., Fichera, I., De Lucia, M., Avalle, L., Vitale, R., Leuzzi, A., et al.(2019). Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade . Nature Communications. 10. (1).

Giannuzzi, D., Marconato, L., Elgendy, R., Ferraresso, S., Scarselli, E., Fariselli, P., Nicosia, A., Pegolo, S., Leoni, G., Laganga, P., et al.(2019). Longitudinal transcriptomic and genetic landscape of radiotherapy response in canine melanoma . Veterinary and Comparative Oncology. 17. (3). p. 308-316.

Chang K, Taggart MW, Reyes-Uribe L, Borras E, Riquelme E, Barnett RM, Leoni G, San Lucas FA, Catanese MT, Mori F, et al.(2018). Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome . JAMA oncology.

Chang, K., Taggart, M.W., Reyes-Uribe, L., Borras, E., Riquelme, E., Barnett, R.M., Leoni, G., Anthony San Lucas, F., Catanese, M.T., Mori, F., et al.(2018). Immune profiling of premalignant lesions in patients with Lynch syndrome . JAMA Oncology. 4. (8). p. 1085-1092.

Guantario, B., Capolupo, A., Monti, M.C., Leoni, G., Ranaldi, G., Tosco, A., Marzullo, L., Murgia, C., Perozzi, G.(2018). Proteomic analysis of Zn depletion/repletion in the hormone-secreting thyroid follicular cell line FRTL-5 . Nutrients. 10. (12).

Lucchetti, S., Pastore, G., Leoni, G., Arima, S., Merendino, N., Baima, S., Ambra, R.(2018). A simple microsatellite-based method for hazelnut oil DNA analysis . Food Chemistry. 245. p. 812-819.

Farina, B., Di Sorbo, G., Chambery, A., Caporale, A., Leoni, G., Russo, R., Mascanzoni, F., Raimondo, D., Fattorusso, R., Ruvo, M., et al.(2017). Structural and biochemical insights of CypA and AIF interaction . Scientific Reports. 7. (1).

Volpicella, M., Leoni, C., Fanizza, I., Distaso, M., Leoni, G., Farioli, L., Naumann, T., Pastorello, E., Ceci, L.R.(2017). Characterization of maize chitinase-A, a tough allergenic molecule . Allergy: European Journal of Allergy and Clinical Immunology. 72. (9). p. 1423-1429.

Comitato, R., Guantario, B., Leoni, G., Nesaretnam, K., Ronci, M.B., Canali, R., Virgili, F.(2016). Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells . Genes and Nutrition. 11. (1).

Leoni, G., Tramontano, A.(2016). A structural view of microRNA-target recognition . Nucleic Acids Research. 44. (9).

Grassi, L., Leoni, G., Tramontano, A.(2015). RNA editing differently affects protein-coding genes in D. melanogaster and H. sapiens . Scientific Reports. 5.

Natarelli, L., Ranaldi, G., Leoni, G., Roselli, M., Guantario, B., Comitato, R., Ambra, R., Cimino, F., Speciale, A., Virgili, F., et al.(2015). Nanomolar caffeic acid decreases glucose uptake and the effects of high glucose in endothelial cells . PLoS ONE. 10. (11).

(2014). Glucosinolates redox activities: Can they act as antioxidants? . Food Chemistry.

Canali, R., Natarelli, L., Leoni, G., Azzini, E., Comitato, R., Sancak, O., Barella, L., Virgili, F.(2014). Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus: A pilot study in healthy subjects . Genes and Nutrition. 9. (3).

Leoni, G., Rosato, A., Perozzi, G., Murgia, C.(2014). Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies . Genes and Nutrition. 9. (6).

Natella, F., Leoni, G., Maldini, M., Natarelli, L., Comitato, R., Schonlau, F., Virgili, F., Canali, R.(2014). Absorption, metabolism, and effects at transcriptome level of a standardized french oak wood extract, Robuvit, in healthy volunteers: Pilot study . Journal of Agricultural and Food Chemistry. 62. (2). p. 443-453.

Baima, S., Forte, V., Possenti, M., Peñalosa, A., Leoni, G., Salvi, S., Felici, B., Ruberti, I., Morelli, G.(2014). Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module . Molecular Plant. 7. (6). p. 1006-1025.

Ambra, R., Manca, S., Palumbo, M.C., Leoni, G., Natarelli, L., De Marco, A., Consoli, A., Pandolfi, A., Virgili, F.(2014). Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression . Genomics. 103. (5-6). p. 337-348.

Natella, F., Maldini, M., Leoni, G., Scaccini, C.(2014). Glucosinolates redox activities: Can they act as antioxidants? . Food Chemistry. 149. p. 226-232.

Pecorelli, A., Leoni, G., Cervellati, F., Canali, R., Signorini, C., Leoncini, S., Cortelazzo, A., De Felice, C., Ciccoli, L., Hayek, J., et al.(2013). Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of rett syndrome patients . Mediators of Inflammation. 2013.

Ranaldi, G., Ferruzza, S., Canali, R., Leoni, G., Zalewski, P.D., Sambuy, Y., Perozzi, G., Murgia, C.(2013). Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα . Journal of Nutritional Biochemistry. 24. (6). p. 967-976.

Floris, M., Raimondo, D., Leoni, G., Orsini, M., Marcatili, P., Tramontano, A.(2011). MAISTAS: A tool for automatic structural evaluation of alternative splicing products . Bioinformatics. 27. (12). p. 1625-1629.

Leoni, G., Le Pera, L., Ferrè, F., Raimondo, D., Tramontano, A.(2011). Coding potential of the products of alternative splicing in human . Genome Biology. 12. (1).

Comitato, R., Leoni, G., Canali, R., Ambra, R., Nesaretnam, K., Virgili, F.(2010). Tocotrienols activity in MCF-7 breast cancer cells: Involvement of ERβ signal transduction . Molecular Nutrition and Food Research. 54. (5). p. 669-678.

Comitato, R., Nesaretnam, K., Leoni, G., Ambra, R., Canali, R., Bolli, A., Marino, M., Virgili, F.(2009). A novel mechanism of natural vitamin E tocotrienol activity: Involvement of ERβ signal transduction . American Journal of Physiology - Endocrinology and Metabolism. 297. (2).