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Hire Greg P.

United States

USD 20 /hr

Uses and designs MRI and PET quality control and medical finding software in order to improve data analysis outcomes.

Profile Summary

* Coordinated all communications with affiliated research clinics and universities regarding neural MRI data collection for ARIC, DHA, DIANL, DIANTU, NiAD, TRC-DS, ABC-DS studies. Responsible for MR image quality control and image analysis. * Designed an update to medical finding tracking and display to assist Data Safety Monitoring Boards for various Alzheimer’s studies. * Advanced the quality control criteria for arterial spin labeling scans. * Developed quality control criteria and process for Freesurfer results. * Assisted programming team in the development of medical imaging protocol checking software. * Requirement gathering, analysis and system design for internal software used for radiologic medical finding tracking and image QC. * Expert hippocampal tracer on EADC-ADNI harmonized segmentation project. * Evaluated and quantified hippocampal and whole brain atrophy, as well as measured total intracranial and white matter disease volumes in the human brain using MRI scans and computer software. * Conducted an independent study on the effects of various brain image editing techniques on brain and ventricle volume calculations. * Authored a study on how several common MR image non-idealities affect measures of brain atrophy. * Operated a 9.4 Tesla MR scanner and processed the MR images in a collaborative study with the University of Minnesota involving Alzheimer’s diseased mice.

Subject Matter Expertise

• ☆ Medical Imaging/Radiology
• ☆ Neurology
• ☆ Alzheimer's Disease
• ☆ Magnetic Resonance Imaging (MRI)
• ☆ Positron Emission Tomography (PET)
• ☆ Quality Assurance & Quality Control (QA/QC)
• ☆ Software Development
• ☆ Software QA & Testing

Services

• Research

Research User Research, Feasibility Study, Fact Checking, Scientific and Technical Research

Work Experience

Data Science Analyst

Mayo Clinic in Rochester, Minnesota

January 2003 - Present

Education

MS Biomedical Engineering

University of Cincinnati

June 2000 - December 2002

Civil Engineering

University of Wisconsin - Madison

August 1994 - May 2000

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Pradeep A, Raghavan S, Przybelski SA, Preboske GM, Schwarz CG, Lowe VJ, Knopman DS, Petersen RC, Jack CR Jr, Graff-Radford J, et al. (2024). Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population? . Alzheimer's research & therapy.

(2024). Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population? . Alzheimers Res Ther .

Joseph-Mathurin N, Feldman RL, Lu R, Shirzadi Z, Toomer C, Saint Clair JR, Ma Y, McKay NS, Strain JF, Kilgore C, et al. (2024). Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage . Alzheimer's & dementia : the journal of the Alzheimer's Association.

Shirzadi Z, Schultz SA, Yau WW, Joseph-Mathurin N, Fitzpatrick CD, Levin R, Kantarci K, Preboske GM, Jack CR Jr, Farlow MR, et al. (2023). Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease . JAMA neurology.

Hartley SL, Handen B, Tudorascu D, Lee L, Cohen A, Schworer EK, Peven JC, Zammit M, Klunk W, Laymon C, et al. (2023). AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome . Alzheimer's & dementia : the journal of the Alzheimer's Association.

Reynolds EL, Votruba K, Jack CR, Beare R, Reid RI, Preboske GM, Waseta C, Pop-Busui R, Nelson RG, Callaghan BC, et al. (2023). Association between brain health outcomes and metabolic risk factors in persons with diabetes . Annals of clinical and translational neurology.

Joseph-Mathurin N, Llibre-Guerra JJ, Li Y, McCullough AA, Hofmann C, Wojtowicz J, Park E, Wang G, Preboske GM, Wang Q, et al. (2022). Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease . Annals of neurology.

Shirzadi Z, Yau WW, Schultz SA, Schultz AP, Scott MR, Goubran M, Mojiri-Forooshani P, Joseph-Mathurin N, Kantarci K, Preboske G, et al. (2022). Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy . Annals of neurology.

Graff-Radford J, Lesnick T, Rabinstein AA, Gunter JL, Przybelski SA, Noseworthy PA, Preboske GM, Mielke MM, Lowe VJ, Knopman DS, et al. (2021). Cerebral Microbleeds: Relationship to Antithrombotic Medications . Stroke.

Joseph-Mathurin N, Wang G, Kantarci K, Jack CR Jr, McDade E, Hassenstab J, Blazey TM, Gordon BA, Su Y, Chen G, et al. (2021). Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease . Neurology.

Graff-Radford J, Aakre JA, Knopman DS, Schwarz CG, Flemming KD, Rabinstein AA, Gunter JL, Ward CP, Zuk SM, Spychalla AJ, et al. (2020). Prevalence and Heterogeneity of Cerebrovascular Disease Imaging Lesions . Mayo Clinic proceedings.

Scharf EL, Graff-Radford J, Przybelski SA, Lesnick TG, Mielke MM, Knopman DS, Preboske GM, Schwarz CG, Senjem ML, Gunter JL, et al. (2019). Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging . Stroke.

Graff-Radford J, Botha H, Rabinstein AA, Gunter JL, Przybelski SA, Lesnick T, Huston J 3rd, Flemming KD, Preboske GM, Senjem ML, et al. (2018). Cerebral microbleeds: Prevalence and relationship to amyloid burden . Neurology.

Fatemi F, Kantarci K, Graff-Radford J, Preboske GM, Weigand SD, Przybelski SA, Knopman DS, Machulda MM, Roberts RO, Mielke MM, et al. (2018). Sex differences in cerebrovascular pathologies on FLAIR in cognitively unimpaired elderly . Neurology.

Wolf D, Bocchetta M, Preboske GM, Boccardi M, Grothe MJ, Alzheimer's Disease Neuroimaging Initiative (2017). Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative harmonized protocol: Utility in automated volumetry . Alzheimer's & dementia : the journal of the Alzheimer's Association.

Duchesne S, Valdivia F, Robitaille N, Mouiha A, Valdivia FA, Bocchetta M, Apostolova LG, Ganzola R, Preboske G, Wolf D, et al. (2015). Manual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project . Alzheimer's & dementia : the journal of the Alzheimer's Association.

Vemuri P, Lesnick TG, Przybelski SA, Knopman DS, Preboske GM, Kantarci K, Raman MR, Machulda MM, Mielke MM, Lowe VJ, et al. (2015). Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly . Brain : a journal of neurology.

Frisoni GB, Jack CR Jr, Bocchetta M, Bauer C, Frederiksen KS, Liu Y, Preboske G, Swihart T, Blair M, Cavedo E, et al. (2014). The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity . Alzheimer's & dementia : the journal of the Alzheimer's Association.

Bocchetta M, Boccardi M, Ganzola R, Apostolova LG, Preboske G, Wolf D, Ferrari C, Pasqualetti P, Robitaille N, Duchesne S, et al. (2014). Harmonized benchmark labels of the hippocampus on magnetic resonance: the EADC-ADNI project . Alzheimer's & dementia : the journal of the Alzheimer's Association.

Jack CR Jr, Wiste HJ, Weigand SD, Rocca WA, Knopman DS, Mielke MM, Lowe VJ, Senjem ML, Gunter JL, Preboske GM, et al. (2014). Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study . The Lancet. Neurology.

Raman MR, Preboske GM, Przybelski SA, Gunter JL, Senjem ML, Vemuri P, Murphy MC, Murray ME, Boeve BF, Knopman DS, et al. (2014). Antemortem MRI findings associated with microinfarcts at autopsy . Neurology.

Roberts RO, Knopman DS, Przybelski SA, Mielke MM, Kantarci K, Preboske GM, Senjem ML, Pankratz VS, Geda YE, Boeve BF, et al. (2014). Association of type 2 diabetes with brain atrophy and cognitive impairment . Neurology.

Marjańska M, Weigand SD, Preboske G, Wengenack TM, Chamberlain R, Curran GL, Poduslo JF, Garwood M, Kobayashi D, Lin JC, et al. (2013). Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization . Neuroscience.

Boccardi M, Bocchetta M, Apostolova LG, Preboske G, Robitaille N, Pasqualetti P, Collins LD, Duchesne S, Jack CR Jr, Frisoni GB, et al. (2013). Establishing magnetic resonance images orientation for the EADC-ADNI manual hippocampal segmentation protocol . Journal of neuroimaging : official journal of the American Society of Neuroimaging.

Murray ME, Ferman TJ, Boeve BF, Przybelski SA, Lesnick TG, Liesinger AM, Senjem ML, Gunter JL, Preboske GM, Lowe VJ, et al. (2013). MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies . Neurology.

Kantarci K, Weigand SD, Przybelski SA, Preboske GM, Pankratz VS, Vemuri P, Senjem ML, Murphy MC, Gunter JL, Machulda MM, et al. (2013). MRI and MRS predictors of mild cognitive impairment in a population-based sample . Neurology.

Murray ME, Vemuri P, Preboske GM, Murphy MC, Schweitzer KJ, Parisi JE, Jack CR Jr, Dickson DW (2012). A quantitative postmortem MRI design sensitive to white matter hyperintensity differences and their relationship with underlying pathology . Journal of neuropathology and experimental neurology.

Kantarci K, Lowe V, Przybelski SA, Weigand SD, Senjem ML, Ivnik RJ, Preboske GM, Roberts R, Geda YE, Boeve BF, et al. (2011). APOE modifies the association between Aβ load and cognition in cognitively normal older adults . Neurology.

Poduslo JF, Hultman KL, Curran GL, Preboske GM, Chamberlain R, Marjańska M, Garwood M, Jack CR Jr, Wengenack TM (2011). Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles . Journal of neuropathology and experimental neurology.

Murray ME, Senjem ML, Petersen RC, Hollman JH, Preboske GM, Weigand SD, Knopman DS, Ferman TJ, Dickson DW, Jack CR Jr (2010). Functional impact of white matter hyperintensities in cognitively normal elderly subjects . Archives of neurology.

Jack CR Jr, Marjanska M, Wengenack TM, Reyes DA, Curran GL, Lin J, Preboske GM, Poduslo JF, Garwood M (2007). Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research . The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

Preboske GM, Gunter JL, Ward CP, Jack CR Jr (2005). Common MRI acquisition non-idealities significantly impact the output of the boundary shift integral method of measuring brain atrophy on serial MRI . NeuroImage.

Jack CR Jr, Wengenack TM, Reyes DA, Garwood M, Curran GL, Borowski BJ, Lin J, Preboske GM, Holasek SS, Adriany G, et al. (2005). In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice . The Journal of neuroscience : the official journal of the Society for Neuroscience.