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Hire Dr. Ghizlane B.

Morocco

USD 25 /hr

Ph.D Immunology and Molecular Biology | Research Assistant | Biostatistics: R | scientific writer

Profile Summary

I am Ph.D. in Immunology and Molecular Biology. In my thesis, I focus on H. pylori infection, inflammation, and gastric cancer. Firstly, I conducted an epidemiological study to assess H. pylori infection and the severity of the gastric lesions. Secondly, I investigated the genetic variations and the serum levels of potent factors implicated in inflammation, tumorigenesis, and tumor regression (TNF-α, TNFR1, and USF1/USF2), in patients with chronic gastritis, gastric precancerous lesions, and gastric cancer. The findings of my thesis report that genes variations and serum levels can be associated with variations in disease susceptibility and can be used as predictive biomarkers for gastric cancer. I have also taken part in other projects within the lab which enabled me to be a co-author of various publications. We conducted a study to assess the virulence of H. pylori strains that circulate in our area, based on the genotyping of two oncogenes cagA and VacA, and their association with gastric carcinogenesis risk. We remarked that virulent strains were associated with a high risk of gastric cancer and precancerous lesions compared to the non-virulent ones. Furthermore, we led a study to compare the sensitivity and the specificity of PCR technique, histological examination, and ELISA test for the detection of H. pylori infection. We remarked that histological examination should be completed by PCR test to give a reliable diagnosis of H. pylori infection. Moreover, we conducted in silico study to evaluate the interaction of a set of flavonoid compounds with H. pylori-CagA and H. pylori-VacA proteins to identify novel therapeutic molecules. This study showed that some compounds may be a potential alternative treatment to suppress the pathogenicity of H. pylori at a time when the antibiotic resistance of H. pylori increases. Currently, we investigated H. pylori antibiotic resistance to monitor the antibiotic resistance curve of H. pylori in our region and guide clinicians to the right antibiotic to decrease eradication failure. Skills: Designing and Executing scientific projects, Collecting Data and Conducting experiments, Statistical Data Analysis, ‎Writing and Reviewing Scientific papers.

Subject Matter Expertise

• ★ Biology/Life Sciences
• ★ Molecular Biology

Services

• Writing
• Research
• Data & AI

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing

Research Market Research, User Research, Gap Analysis, Systematic Literature Review

Data & AI Statistical Analysis

Work Experience

Product manager

Bioscience company

October 2022 - Present

Ph.D research assistant

Institut Pasteur du Maroc

January 2021 - Present

Reviewer

Plos One

January 2020 - Present

Reviewer

Biomarkers Journal

January 2020 - Present

Regulatory Affairs Officer: Pharmaceutical, Medical device, Professional Cleaning Product,

Health Care Solution

April 2022 - October 2022

Research Assistant

Institut Pasteur du Maroc

2015 - 2022

Ph.D. Student

Institut Pasteur du Maroc/Faculté des sciences Ben M'Sik

2015 - 2021

Education

Ph.D. in Immunology and Molecular Biology

Hassan II University, Faculty of sciences Ben M’sik, Biology and Health Laboratory / Institut Pasteur du Maroc, Helicobacter pylori and Gastric Patho

October 2015 - January 2021

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Mohamed Reda Jouimyi and Ghizlane Bounder and Imane Essaidi and Hasna Boura and Wafaa Badre and Hakima Benomar and Khalid Zerouali and Halima Lebrazi and Anass Kettani and Fatima Maachi(2021). Association of Helicobacter pylori vacA polymorphisms with the risk of gastric precancerous lesions in a Moroccan population . The Journal of Infection in Developing Countries. 15. (08). p. 1124--1132. Journal of Infection in Developing Countries

(2021). Epidemiological study of Helicobacter pylori infection and its association with gastric carcinogenesis. The Gulf journal of oncology.

Ghizlane Bounder, Mohamed R. Jouimyi, Hasna Boura, Hassan Jouhadi, Wafaa Badre, Hakima Benomar, Anass Kettani, Halima Lebrazi, Fatima Maachi(2020). Association of Tumor Necrosis Factor Receptor 1 Promoter Gene Polymorphisms (-580 A/G and -609 G/T) and TNFR1 Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to H. pylori Infection in a Moroccan Population . BioMed Research International. 2020. p. 1--7. Hindawi Limited

Ghizlane Bounder, Mohamed Reda Jouimyi, Imane Essaidi, Hasna Boura, Khalid Zerouali, Halima Lebrazi, Anass Kettani, Fatima Maachi(2020). Molecular docking of a set of flavonoid compounds with Helicobacter pylori virulence factors CagA and VacA . Journal of Herbmed Pharmacology. 9. (4). p. 412--419. Maad Rayan Publishing Company

Associations of the -238(G/A) and -308(G/A) TNF-α Promoter Polymorphisms and TNF-α Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to Helicobacter pylori Infection in a Moroccan Population . Asian Pacific Journal of Cancer Prevention.

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population . Journal of life sciences.

TNF-α Receptor 1 Promoter Gene Polymorphisms and Susceptibility to Gastric Cancer Related to H. Pylori Infection in Moroccan Population . International Journal of Science and Research (IJSR).

PCR for Diagnosing Helicobacter pylori Infection in Moroccan Patients: Comparison with ELISA and Histopathological Tests . International Journal of Science and Research.

CONFERENCE ABSTRACT

I Essaidi and H Boura and G Bounder and R Jouimy and A Majd and H Jouhadi and H Benomar and K Zerouali and F Maachi(2020). EPIDEMIOLOGY OF HELICOBACTER PYLORI FOR PATIENTS WITH GASTRIC DISEASES AND ASYMPTOMATIC POPULATION IN MOROCCO . ESGE Days. {\textcopyright} Georg Thieme Verlag {KG}

M Reda Jouimyi and G Bounder and H Boura and I Essaidi and W Badre and M Eljihad and M Kadi and A Bendahmane and H Benomar and K Zerouali and H Lebrazi and A Kettani and F Maachi(2020). GENOTYPING OF HELICOBACTER PYLORI CAGA EPIYA MOTIF AS A RISK FACTOR OF GASTRIC LESIONS SEVERITY IN A MOROCCAN POPULATION . ESGE Days. {\textcopyright} Georg Thieme Verlag {KG}