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USD 100 /hr
Hire Dr. Francesc Xavier R.
United States
USD 100 /hr

Structural biologist & enzymologist — 15+ years experience

Profile Summary
Subject Matter Expertise
Services
Writing Medical Writing
Research Scientific and Technical Research, Systematic Literature Review
Consulting Scientific and Technical Consulting
Data & AI Data Visualization, Data Processing
Work Experience

Assistant Research Professor

Rutgers University

March 2019 - Present

Education

Doctor in Biochemistry and Molecular Biology

Universitat Autónoma de Barcelona - Spain

March 2003 - December 2010

Certifications
Publications
PREPRINT
The Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> .
Ruchi Yadav, Valentine V. Courouble, Sanjay K. Dey, Jerry Joe E.K. Harrison, Jennifer Timm, Jesse B. Hopkins, Ryan L. Slack, Stefan G. Sarafianos, Francesc X. Ruiz, Patrick R. Griffin, et al. (2022). Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro .
JOURNAL ARTICLE
Jerry Joe E. K. Harrison, Dario Oliveira Passos, Jessica F. Bruhn, Joseph D. Bauman, Lynda Tuberty, Jeffrey J. DeStefano, Francesc Xavier Ruiz, Dmitry Lyumkis, Eddy Arnold (2022). Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation . Science Advances.
Francesc Xavier Ruiz, Xavier Par&#233;s, Jaume Farr&#233;s (2021). Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition . Metabolites.
Francesc Xavier Ruiz, Xavier Pares, Jaume Farr&#233;s (2021). Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition . Metabolites.
(2020). Integrative Structural Biology Studies of HIV-1 Reverse Transcriptase Binding to a High-Affinity DNA Aptamer . Current Research in Structural Biology.
Steve Tuske, Jie Zheng, Erik D. Olson, Francesc X. Ruiz, Bruce D. Pascal, Anthony Hoang, Joseph D. Bauman, Kalyan Das, Jeffrey J. DeStefano, Karin Musier-Forsyth, et al.(2020). Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer . Current Research in Structural Biology. 2. p. 116--129. Elsevier {BV}
(2020). Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance . Current Opinion in Structural Biology.
(2020). Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel . Journal of Medicinal Chemistry.
(2019). Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1 . Journal of Medicinal Chemistry.
(2018). Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase . European Journal of Medicinal Chemistry.
(2017). Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008 . Chemico-Biological Interactions.
(2016). IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors . ACS Chemical Biology.
(2016). Introducing Our Authors . ACS Chemical Biology.
(2016). X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain . PLOS ONE.
(2016). Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53 . Nature.
(2015). Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10 . ChemMedChem.
(2015). Cover Picture: Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10 (ChemMedChem 12/2015) . ChemMedChem.
(2015). Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase . PLOS ONE.
(2015). The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition . ACS Chemical Biology.
(2015). New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM . Acta Crystallographica Section D Biological Crystallography.
(2015). Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10 . Chemico-Biological Interactions.
(2014). Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design . Acta Crystallographica Section D Biological Crystallography.
(2014). A missense mutation in ALDH1A3 causes isolated microphthalmia/anophthalmia in nine individuals from an inbred Muslim kindred . European Journal of Human Genetics.
(2013). Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning . ACS Chemical Biology.
(2013). Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction . Bioorganic & Medicinal Chemistry Letters.
(2013). 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors . Bioorganic & Medicinal Chemistry Letters.
(2013). Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury . Journal of Medicinal Chemistry.
(2013). Aldo–keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivity . Chemico-Biological Interactions.
(2013). X-ray structure of the V301L aldo–keto reductase 1B10 complexed with NADP+ and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity . Chemico-Biological Interactions.
(2012). Crystal packing modifies ligand binding affinity: The case of aldose reductase . Proteins: Structure, Function, and Bioinformatics.
(2012). Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling . Frontiers in Pharmacology.
(2011). Retinaldehyde is a substrate for human aldo–keto reductases of the 1C subfamily . Biochemical Journal.
(2011). Human and rodent aldo–keto reductases from the AKR1B subfamily and their specificity with retinaldehyde . Chemico-Biological Interactions.
(2009). Aldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels . Chemico-Biological Interactions.
(2007). Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10 . Proceedings of the National Academy of Sciences.
(2006). Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids . Biochemical Journal.
(2003). Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: effects on CK2α activity . Biochemical Journal.
OTHER
Jerry Joe E. K. Harrison, Dario Oliveira Passos, Jessica F. Bruhn, Joseph D. Bauman, Lynda Tuberty, Jeffrey J. DeStefano, Francesc Xavier Ruiz, Dmitry Lyumkis, Eddy Arnold(2021). Cryo-EM Structure of the Pol Polyprotein Provides Insights into HIV Maturation . Cold Spring Harbor Laboratory
Jerry Joe E. K. Harrison, Steve Tuske, Kalyan Das, Francesc X. Ruiz, Joseph D. Bauman, Paul Boyer, Jeffrey J. DeStefano, Stephen H. Hughes, Eddy Arnold(2020). Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT) . Cold Spring Harbor Laboratory