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Greece

USD 90 /hr

Associate Professor of Analytical Chemistry | Ph.D. Chem. Eng. & Pharmacy | Expert in Chemometrics & Biochromatography

Profile Summary

I am an Associate Professor of Analytical Chemistry with a dual background in Chemical Engineering and Pharmacy, specializing in the intersection of advanced instrumentation and predictive data modeling.

With over 15 years of academic leadership, I have authored 48 peer-reviewed publications and served as Associate Editor for Microchimica Acta (Springer). My expertise lies in extracting high-value insights from complex chemical systems using Multivariate Data Analysis (PCA, PLS-DA, Class-Modelling) and advanced analytical techniques.

Core High-Level Expertise:

Chemometrics & QSPR/QSAR: Expert in SIMCA and SPSS for drug design, ADME property estimation, ecotoxicity of xenobiotics, and food adulteration studies.

Biomimetic Chromatography: Specialist in Quantitative Retention-Property Relationships (QRPR) for estimation of pharmacokinetic properties of candidate drugs and evaluation of ecotoxicity of xenobiotics.

Electroanalytical Chemistry: Advanced Voltammetric methods and their applications.

Project Leadership: Coordinator of 3 international research projects and supervisor of over 60 thesis projects.

I provide high-level consultancy for pharmaceutical industries, food quality labs, and environmental agencies. My services range from sophisticated data treatment and method validation to strategic R&D advisory and scientific writing/reviewing for top-tier journals.

Subject Matter Expertise

Services

Writing
Research
Consulting
Data & AI
Product Development

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis, Algorithm Design-Non ML, Algorithm Design-ML, Data Visualization, Big Data Analytics, Text Mining & Analytics, Data Processing, Data Insights

Product Development Quality Assurance & Control (QA/QC)

Work Experience

Associate Professor of Analytical Chemistry

Ethniko Metsobio Polytechneio Schole Chemikon Mechanikon

October 2025 - Present

Education

Ph.D. (Chemical Engineering)

National Technical University of Athens

June 2000 - September 2007

B.Sc. (Pharmacy)

National and Kapodistrian University of Athens Faculty of Pharmacy

January 2000 - October 2004

Diploma (Chemical Engineering)

National Technical University of Athens

September 1994 - October 1999

Certifications

Certification details not provided.

Publications

JOURNAL ARTICLE

Theodosia Vallianatou, Fotios Tsopelas, Anna Tsantili-Kakoulidou (2025). Predicting retention on immobilized artificial membrane chromatography: Lipophilicity-based versus lipophilicity-independent models . Journal of Chromatography A.

Fotios Tsopelas (2025). Electroanalytical Approaches to Combatting Food Adulteration: Advances in Non-Enzymatic Techniques for Ensuring Quality and Authenticity . Molecules.

Chrysanthos Stergiopoulos, Fotios Tsopelas, Maria Ochsenkühn-Petropoulou, Klara Valko (2024). Predicting the acute aquatic toxicity of organic UV filters used in cosmetic formulations . ADMET and DMPK.

Chrysanthos Stergiopoulos, Lamprini‐ Areti Tsakanika, Maria Ochsenkühn-Petropoulou, Anna Tsantili‐ Kakoulidou, Fotios Tsopelas (2023). Application of micellar liquid chromatography to model ecotoxicity of pesticides. Comparison with immobilized artificial membrane chromatography and n-octanol-water partitioning . Journal of Chromatography A.

Theodosia Vallianatou, Fotios Tsopelas, Anna Tsantili-Kakoulidou (2022). Prediction Models for Brain Distribution of Drugs Based on Biomimetic Chromatographic Data . Molecules.

Annita Katopodi, Evangelia Tsotsou, Triantafylia Iliou, Georgia-Eirini Deligiannidou, Eleni Pontiki, Christos Kontogiorgis, Fotios Tsopelas, Anastasia Detsi(2021). Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives . Molecules. 26. (19). p. 5999. {MDPI} {AG}

Annita Katopodi, Evangelia Tsotsou, Triantafylia Iliou, Georgia-Eirini Deligiannidou, Eleni Pontiki, Christos Kontogiorgis, Fotios Tsopelas, Anastasia Detsi (2021). Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives . Molecules.

Chrysanthos Stergiopoulos, Fotios Tsopelas, Klara Valko (2021). Prediction of hERG inhibition of drug discovery compounds using biomimetic HPLC measurements . ADMET and DMPK.

Tryfon Kekes, Maria-Christina Nika, Fotios Tsopelas, Nikolaos S. Thomaidis, Constantina Tzia(2020). Use of δ-manganese dioxide for the removal of acetaminophen from aquatic environment: Kinetic – thermodynamic analysis and transformation products identification . Journal of Environmental Chemical Engineering. 8. (6). p. 104565. Elsevier {BV}

Fotios Tsopelas, Panagiotis Danias, Athina Pappa, Anna Tsantili-Kakoulidou(2020). Biopartitioning micellar chromatography under different conditions: Insight into the retention mechanism and the potential to model biological processes . Journal of Chromatography A. 1621. p. 461027. Elsevier {BV}

Tsopelas, F., Danias, P., Pappa, A., Tsantili-Kakoulidou, A.(2020). Biopartitioning micellar chromatography under different conditions: Insight into the retention mechanism and the potential to model biological processes . Journal of Chromatography A. 1621.

Nikolaou, P., Deskoulidis, E., Topoglidis, E., Kakoulidou, A.T., Tsopelas, F.(2020). Application of chemometrics for detection and modeling of adulteration of fresh cow milk with reconstituted skim milk powder using voltammetric fingerpriting on a graphite/ SiO<inf>2</inf> hybrid electrode . Talanta. 206.

Chrysanthos Stergiopoulos, Dimitra Makarouni, Anna Tsantili-Kakoulidou, Maria Ochsenkühn-Petropoulou, Fotios Tsopelas(2019). Immobilized artificial membrane chromatography as a tool for the prediction of ecotoxicity of pesticides . Chemosphere. 224. p. 128--139. Elsevier {BV}

Stergiopoulos, C., Makarouni, D., Tsantili-Kakoulidou, A., Ochsenkühn-Petropoulou, M., Tsopelas, F.(2019). Immobilized artificial membrane chromatography as a tool for the prediction of ecotoxicity of pesticides . Chemosphere. 224. p. 128-139.

Tsopelas, F., Tsantili-Kakoulidou, A.(2019). Advances with weak affinity chromatography for fragment screening . Expert Opinion on Drug Discovery. 14. (11). p. 1125-1135.

Fotis Tsopelas, Maria Ochsenkuehn-Petropoulou, Lamprini-Areti Tsakanika, Theopisti Lymperopoulou, Klaus-Michael Ochsenkuehn, Konstantinos Hatzilyberis, Paraskevas Georgiou, Chrysanthos Stergiopoulos, Olga Serifi (2018). Efficiency of Sulfuric Acid on Selective Scandium Leachability from Bauxite Residue . Metals.

Fotios Tsopelas, Maria Tsagkrasouli, Pavlos Poursanidis, Maria Pitsaki, George Vasios, Panagiotis Danias, Irene Panderi, Anna Tsantili‐Kakoulidou, Constantinos Giaginis (2018). Retention behavior of flavonoids on immobilized artificial membrane chromatography and correlation with cell‐based permeability . Biomedical Chromatography.

Konstantinos Hatzilyberis, Theopisti Lymperopoulou, Lamprini-Areti Tsakanika, Klaus-Michael Ochsenkühn, Paraskevas Georgiou, Nikolaos Defteraios, Fotios Tsopelas, Maria Ochsenkühn-Petropoulou(2018). Process Design Aspects for Scandium-Selective Leaching of Bauxite Residue with Sulfuric Acid . Minerals. 8. (3). p. 79. {MDPI} {AG}

Tsopelas, F., Stergiopoulos, C., Tsantili-Kakoulidou, A.(2018). Immobilized artificial membrane chromatography: From medicinal chemistry to environmental sciences . ADMET and DMPK. 6. (3). p. 225-241.

Tsopelas, F., Konstantopoulos, D., Kakoulidou, A.T.(2018). Voltammetric fingerprinting of oils and its combination with chemometrics for the detection of extra virgin olive oil adulteration . Analytica Chimica Acta. 1015. p. 8-19.

Tsopelas, F., Tsagkrasouli, M., Poursanidis, P., Pitsaki, M., Vasios, G., Danias, P., Panderi, I., Tsantili-Kakoulidou, A., Giaginis, C.(2018). Retention behavior of flavonoids on immobilized artificial membrane chromatography and correlation with cell-based permeability . Biomedical Chromatography. 32. (3).

Ochsenkuehn-Petropoulou, M., Tsakanika, L.-A., Lymperopoulou, T., Ochsenkuehn, K.-M., Hatzilyberis, K., Georgiou, P., Stergiopoulos, C., Serifi, O., Tsopelas, F.(2018). Efficiency of sulfuric acid on selective scandium leachability from bauxite residue . Metals. 8. (11).

Hatzilyberis, K., Lymperopoulou, T., Tsakanika, L.-A., Ochsenkühn, K.-M., Georgiou, P., Defteraios, N., Tsopelas, F., Ochsenkühn-Petropoulou, M.(2018). Process design aspects for scandium-selective leaching of bauxite residue with sulfuric acid . Minerals. 8. (3).

Pavel Mucaji, Atanas G. Atanasov, Andrzej Bak, Violetta Kozik, Karolina Sieron, Mark Olsen, Weidong Pan, Yazhou Liu, Shengchao Hu, Junjie Lan, et al.(2017). The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot † . Molecules. 22. (11). p. 1848. {MDPI} {AG}

(2017). The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot <sup>†</sup> . Molecules.

Mucaji, P., Atanasov, A.G., Bak, A., Kozik, V., Sieron, K., Olsen, M., Pan, W., Liu, Y., Hu, S., Lan, J., et al.(2017). The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot <sup>†</sup> . Molecules. 22. (11).

Tsopelas, F., Giaginis, C., Tsantili-Kakoulidou, A.(2017). Lipophilicity and biomimetic properties to support drug discovery . Expert Opinion on Drug Discovery. 12. (9). p. 885-896.

Tsopelas, F., Stergiopoulos, C., Tsakanika, L.-A., Ochsenkühn-Petropoulou, M., Tsantili-Kakoulidou, A.(2017). The use of immobilized artificial membrane chromatography to predict bioconcentration of pharmaceutical compounds . Ecotoxicology and Environmental Safety. 139. p. 150-157.

Tsopelas, F., Vallianatou, T., Tsantili-Kakoulidou, A.(2016). Advances in immobilized artificial membrane (IAM) chromatography for novel drug discovery . Expert Opinion on Drug Discovery. 11. (5). p. 473-488.

Tsopelas, F., Vallianatou, T., Tsantili-Kakoulidou, A.(2016). The potential of immobilized artificial membrane chromatography to predict human oral absorption . European Journal of Pharmaceutical Sciences. 81. p. 82-93.

Tsopelas, F., Malaki, N., Vallianatou, T., Chrysanthakopoulos, M., Vrakas, D., Ochsenkühn-Petropoulou, M., Tsantili-Kakoulidou, A.(2015). Insight into the retention mechanism on immobilized artificial membrane chromatography using two stationary phases . Journal of Chromatography A. 1396. p. 25-33.

Serifi, O., Tsopelas, F., Kypreou, A.-M., Ochsenkühn-Petropoulou, M., Kefalas, P., Detsi, A.(2013). Antioxidant behaviour of 2′-hydroxy-chalcones: A study of their electrochemical properties . Journal of Physical Organic Chemistry. 26. (3). p. 226-231.

Chrysanthakopoulos, M., Tsopelas, F., Tsantili-Kakoulidou, A.(2013). Biomimetic chromatography a useful tool in the drug discovery process . Advances in Chromatography. 51. p. 91-125.

Tsopelas, F., Kakoulidou, A.T., Ochsenkühn-Petropoulou, M.(2013). Lipophilicity, biomimetic retention profile and antioxidant activity of selenium species . Microchemical Journal. 110. p. 711-718.

Paraskevas, M., Tsopelas, F., Ochsenkühn-Petropoulou, M.(2012). Determination of Pt and Pd in particles emitted from automobile exhaust catalysts using ion-exchange matrix separation and voltammetric detection . Microchimica Acta. 176. (1-2). p. 235-242.

Tsopelas, F., Tsantili-Kakoulidou, A., Ochsenkühn-Petropoulou, M.(2011). Exploring the elution mechanism of selenium species on liquid chromatography . Journal of Separation Science. 34. (4). p. 376-384.

Tsopelas, F., Ochsenkühn-Petropoulou, M., Zikos, N., Spyropoulou, E., Andreadou, I., Tsantili-Kakoulidou, A.(2011). Electrochemical study of some non-steroidal anti-inflammatory drugs: Solvent effect and antioxidant activity . Journal of Solid State Electrochemistry. 15. (6). p. 1099-1108.

Tsopelas, F., Tsantili-Kakoulidou, A., Ochsenkuhn-Petropoulou, M.(2010). Environmental distribution, biological role and toxicity of selenium species . Pharmakeftiki. 23. (1). p. 16-32.

Tsopelas, F., Ochsenkühn-Petropoulou, M., Tsantili-Kakoulidou, A.(2010). Void volume markers in reversed-phase and biomimetic liquid chromatography . Journal of Chromatography A. 1217. (17). p. 2847-2854.

Tsopelas, F., Tsantili-Kakoulidou, A., Ochsenkühn-Petropoulou, M.(2010). Biomimetic chromatographic analysis of selenium species: Application for the estimation of their pharmacokinetic properties . Analytical and Bioanalytical Chemistry. 397. (6). p. 2171-2180.

Ochsenkühn-Petropoulou, M., Lyberopoulou, T., Argyropoulou, R., Tsopelas, F., Ochsenkühn, K.-M.(2009). Chemical and structural characterization of airborne particulate matter in an industrial and an Urban area in Greece . Fresenius Environmental Bulletin. 18. (11 A). p. 2210-2218.

Tsopelas, F., Tsakanika, L.-A., Ochsenkühn-Petropoulou, M.(2008). Extraction of arsenic species from airborne particulate filters-Application to an industrial area of Greece . Microchemical Journal. 89. (2). p. 165-170.

Gikas, S., Tsopelas, F., Giaginis, C., Dimitrakopoulos, J., Livadara, T., Archontaki, H., Tsantili-Kakoulidou, A.(2008). Chromatographic behavior of zwitterionic enalapril-Exploring the conditions for lipophilicity assessment . Journal of Pharmaceutical and Biomedical Analysis. 48. (3). p. 739-743.

Tsopelas, F., Tsantili-Kakoulidou, A., Ochsenkühn-Petropoulou, M.(2007). Investigation of the chromatographic behaviour of some selenium species-Comparison with their octanol-water partitioning . Talanta. 73. (1). p. 127-133.

Tsopelas, F.N., Ochsenkühn-Petropoulou, M.Th., Mergias, I.G., Tsakanika, L.V.(2005). Comparison of ultra-violet and inductively coupled plasma-atomic emission spectrometry for the on-line quantification of selenium species after their separation by reversed-phase liquid chromatography . Analytica Chimica Acta. 539. (1-2). p. 327-333.

Tsopelas, F.N., Ochsenkühn-Petropoulou, M.Th., Tsantili-Kakoulidou, A., Ochsenkühn, K.-M.(2005). Study of the lipophilicity of selenium species . Analytical and Bioanalytical Chemistry. 381. (2). p. 420-426.

Ochsenkühn-Petropoulou, M.Th., Tsopelas, F.N.(2004). Separation of organoselenium compounds and their electrochemical detection . Analytical and Bioanalytical Chemistry. 379. (5-6). p. 770-776.

Ochsenkühn-Petropoulou, M., Tsopelas, F.(2002). Speciation analysis of selenium using voltammetric techniques . Analytica Chimica Acta. 467. (1-2). p. 167-178.

Ochsenkühn, K.-M., Ochsenkühn-Petropoulou, M., Tsopelas, F., Mendrinos, L.(2001). Different behavior of organotin compounds by anodic stripping voltammetry and their quantification after partial ion exchange separation . Mikrochimica Acta. 136. (3-4). p. 129-135.

Ochsenkühn, K.M., Ochsenkühn -Petropoulou, M., Tsopelas, F., Mendrinos, L.(2001). Separation of organotin compounds by ion-exchange chromatography and their determination by inverse voltammetry . Analytical and Bioanalytical Chemistry. 369. (7-8). p. 633-637.

PREPRINT

Fotios Tsopelas (2025). Electroanalytical Approaches to Combat Food Adulteration: Advances in Non-Enzymatic Techniques for Ensuring Quality and Authenticity .

OTHER

Fotis Tsopelas, Maria Ochsenkuehn-Petropoulou, Lamprini-Areti Tsakanika, Theopisti Lymperopoulou, Klaus-Michael Ochsenkuehn, Konstantinos Hatzilyberis, Paraskevas Georgiou, Chrysanthos Stergiopoulos, Olga Serifi(2018). Efficiency of Sulfuric Acid on Selective Scandium Leachability from Bauxite Residue . {MDPI} {AG}

BOOK CHAPTER

Giaginis, C., Tsopelas, F., Tsantili-Kakoulidou, A.(2018). The impact of lipophilicity in drug discovery: Rapid measurements by means of reversed-phase HPLC . Methods in Molecular Biology. 1824. p. 217-228.

Lambrinidis, G., Tsopelas, F., Giaginis, C., Tsantili-Kakoulidou, A.(2017). QSAR/QSPR modeling in the design of drug candidates with balanced pharmacodynamic and pharmacokinetic properties . Challenges and Advances in Computational Chemistry and Physics. 24. p. 339-384.

Ochsenkühn-Petropoulou, M., Tsopelas, F.(2016). Selenium and Selenium Species . Metallomics Analytical Techniques and Speciation Methods. p. 131-172.

WORKING PAPER

Electroanalytical Approaches to Combat Food Adulteration: Advances in Non-Enzymatic Techniques for Ensuring Quality and Authenticity .

level-one heading

Associate Professor of Analytical Chemistry | Ph.D. Chem. Eng. & Pharmacy | Expert in Chemometrics & Biochromatography

Associate Professor of Analytical Chemistry

Ethniko Metsobio Polytechneio Schole Chemikon Mechanikon

Ph.D. (Chemical Engineering)

National Technical University of Athens

B.Sc. (Pharmacy)

National and Kapodistrian University of Athens Faculty of Pharmacy

Diploma (Chemical Engineering)

National Technical University of Athens