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Ph. D Neuroscientist Offering Molecular Dynamics Expertise for Research & Biotech Projects

Profile Summary

. Identification of potential binding sites on biomolecules . Analysis of molecular dynamics simulation for complex systems . Building complex systems for molecular dynamics simulation (for soluble or membrane proteins) . Review of molecular models / Paper that use molecular modeling and/or molecular dynamics simulation . Scientific illustration and visualization using real 3D molecular models . Ab-initio or de-novo modelization of biomolecules (protein, peptide, lipids or DNA) . AI-driven modeling and AI-driven analysis for biomolecular interfaces

Subject Matter Expertise

• ★ Computational Biology
• ☆ Materials Science & Engineering
• ☆ Molecular Modeling
• ☆ Molecular Docking
• ☆ Structural Chemistry
• ☆ Biochemistry
• ☆ Structural Biology
• ☆ Data Analysis
• ☆ Computer Simulation/Computational Modeling
• ☆ Predictive Modeling & Analytics
• ☆ Bioinformatics
• ☆ Structural Bioinformatics
• ☆ Drug Discovery
• ☆ Drug Design

Services

• Research
• Consulting
• Data & AI

Research Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Data Visualization, Data Insights

Work Experience

Postdoctoral Researcher

INSERM UA16, UNIS

September 2024 - August 2025

Doctoral Researcher

Aix-Marseille Université

September 2020 - November 2023

Education

PhD in Structural Molecular and Computational Biology

Aix-Marseille University

October 2020 - November 2023

Structural Biology

Aix-Marseille University

September 2019 - July 2020

Certifications

• Certification details not provided.

Publications

PREPRINT

Fodil Azzaz, Kévin Debreux, Christian Lévêque, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far (2026). Leucine-rich glioma inactivated 1 is a ganglioside-binding protein .

Fodil Azzaz, Jacques Fantini (2025). An AI-Driven Platform for Deconstructing and Engineering Biomolecular Recognition .

Fodil Azzaz, Oussama El Far, Jacques Fantini (2025). Membrane constraints reshape synaptotagmin recognition by botulinum neurotoxin B1 .

Fodil Azzaz, Didier Hilaire, Jacques Fantini (2022). Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors .

JOURNAL ARTICLE

Fantini, J., Azzaz, F., Di Scala, C., Aulas, A., Chahinian, H., Yahi, N.(2025). Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow . Pharmacology and Therapeutics. 267.

Fantini, J., Azzaz, F., Aulas, A., Chahinian, H., Yahi, N.(2025). Correction: Preclinical assessment of a ganglioside-targeted therapy for Parkinson’s disease with the first-in-class adaptive peptide AmyP53 (Scientific Reports, (2025), 15, 1, (9144), 10.1038/s41598-025-94148-1) . Scientific Reports. 15. (1).

Fantini, J., Azzaz, F., Aulas, A., Chahinian, H., Yahi, N.(2025). Preclinical assessment of a ganglioside-targeted therapy for Parkinson’s disease with the first-in-class adaptive peptide AmyP53 . Scientific Reports. 15. (1).

Fantini J, Azzaz F, Bennaï R, Yahi N, Chahinian H (2024). Cholesterol-Dependent Serotonin Insertion Controlled by Gangliosides in Model Lipid Membranes . International journal of molecular sciences.

Fantini, J., Azzaz, F., Bennaï, R., Yahi, N., Chahinian, H.(2024). Cholesterol-Dependent Serotonin Insertion Controlled by Gangliosides in Model Lipid Membranes . International Journal of Molecular Sciences. 25. (18).

Fodil Azzaz, Morgane Mazzarino, Henri Chahinian, Nouara Yahi, Coralie Di Scala, Jacques Fantini (2023). Structure of the Myelin Sheath Proteolipid Plasmolipin (PLLP) in a Ganglioside-Containing Lipid Raft . Frontiers in Bioscience-Landmark.

Azzaz F, Mazzarino M, Chahinian H, Yahi N, Scala CD, Fantini J (2023). Structure of the Myelin Sheath Proteolipid Plasmolipin (PLLP) in a Ganglioside-Containing Lipid Raft . Frontiers in bioscience (Landmark edition).

Fodil Azzaz, Didier Hilaire, Jacques Fantini (2023). Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors . Chemico-Biological Interactions.

Azzaz F, Hilaire D, Fantini J (2023). Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors . Chemico-biological interactions.

Fantini J, Azzaz F, Chahinian H, Yahi N (2023). Electrostatic Surface Potential as a Key Parameter in Virus Transmission and Evolution: How to Manage Future Virus Pandemics in the Post-COVID-19 Era . Viruses.

Azzaz F, Chahinian H, Yahi N, Fantini J, Di Scala C (2023). AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer's Disease Therapy . International journal of molecular sciences.

Fantini, J., Azzaz, F., Chahinian, H., Yahi, N.(2023). Electrostatic Surface Potential as a Key Parameter in Virus Transmission and Evolution: How to Manage Future Virus Pandemics in the Post-COVID-19 Era . Viruses. 15. (2).

Azzaz, F., Chahinian, H., Yahi, N., Fantini, J., Di Scala, C.(2023). AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer’s Disease Therapy . International Journal of Molecular Sciences. 24. (2).

Azzaz, F., Hilaire, D., Fantini, J.(2023). Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors . Chemico Biological Interactions. 373.

Azzaz, F., Mazzarino, M., Chahinian, H., Yahi, N., Scala, C.D., Fantini, J.(2023). Structure of the Myelin Sheath Proteolipid Plasmolipin (PLLP) in a Ganglioside-Containing Lipid Raft . Frontiers in Bioscience Landmark. 28. (8).

Azzaz F, Hilaire D, Fantini J (2022). Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: <i>In Silico</i> Studies at the Periphery of a Lipid Raft . Biomolecules.

Azzaz F, Yahi N, Chahinian H, Fantini J (2022). The Epigenetic Dimension of Protein Structure Is an Intrinsic Weakness of the AlphaFold Program . Biomolecules.

Ramirez-Franco J, Azzaz F, Sangiardi M, Ferracci G, Youssouf F, Popoff MR, Seagar M, L&#233;v&#234;que C, Fantini J, El Far O (2022). Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex . Cellular and molecular life sciences : CMLS.

Gu&#233;rin P, Yahi N, Azzaz F, Chahinian H, Sabatier JM, Fantini J (2022). Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable Epitopes . Molecules (Basel, Switzerland).

Azzaz F, Fantini J (2022). The epigenetic dimension of protein structure . Biomolecular concepts.

Azzaz, F., Fantini, J.(2022). The epigenetic dimension of protein structure . Biomolecular Concepts. 13. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 55-60.

Azzaz, F., Hilaire, D., Fantini, J.(2022). Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: In Silico Studies at the Periphery of a Lipid Raft . Biomolecules. 12. (12).

Gu&#233;rin, P., Yahi, N., Azzaz, F., Chahinian, H., Sabatier, J.-M., Fantini, J.(2022). Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable Epitopes . Molecules. 27. (12).

Azzaz, F., Yahi, N., Chahinian, H., Fantini, J.(2022). The Epigenetic Dimension of Protein Structure Is an Intrinsic Weakness of the AlphaFold Program . Biomolecules. 12. (10).

Ramirez-Franco, J., Azzaz, F., Sangiardi, M., Ferracci, G., Youssouf, F., Popoff, M.R., Seagar, M., L&#233;v&#234;que, C., Fantini, J., El Far, O.(2022). Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex . Cellular and Molecular Life Sciences. 79. (9).

Azzaz F, Yahi N, Di Scala C, Chahinian H, Fantini J (2021). Ganglioside binding domains in proteins: Physiological and pathological mechanisms . Advances in protein chemistry and structural biology.

Incontro S, Sammari M, Azzaz F, Inglebert Y, Ankri N, Russier M, Fantini J, Debanne D (2021). Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Fantini J, Yahi N, Azzaz F, Chahinian H (2021). Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks . The Journal of infection.

Fantini, J., Yahi, N., Azzaz, F., Chahinian, H.(2021). Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks . Journal of Infection. 83. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 197-206.

Incontro, S., Sammari, M., Azzaz, F., Inglebert, Y., Ankri, N., Russier, M., Fantini, J., Debanne, D.(2021). Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of postsynaptic Kv7 channels . Journal of Neuroscience. 34. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9521-9538.

OTHER

Azzaz, F., Hilaire, D., Fantini, J.(2022). Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors . Biorxiv.

Ramirez-Franco, J., Azzaz, F., Sangiardi, M., Ferracci, G., Youssouf, F., Popoff, M.R., Seagar, M., L&#233;v&#234;que, C., Fantini, J., Far, O.E.(2021). Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex . Biorxiv.

Gu&#233;rin, P., Yahi, N., Azzaz, F., Chahinian, H., Sabatier, J.-M., Fantini, J.(2021). Distinct evolution of infection-enhancing and neutralizing epitopes in the spike protein of SARSCoV-2 variants (from alpha to omicron): a structural and molecular epidemiology study . Research Square.

BOOK CHAPTER

Azzaz, F., Chahinian, H., Yahi, N., Di Scala, C., Baier, C.J., Barrantes, F.J., Fantini, J.(2022). Cholesterol-recognizing amino acid consensus motifs in transmembrane proteins: Comparative analysis of in silico studies and structural data . Cholesterol from Chemistry and Biophysics to the Clinic. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 127-145.

Azzaz, F., Yahi, N., Di Scala, C., Chahinian, H., Fantini, J.(2022). Ganglioside binding domains in proteins: Physiological and pathological mechanisms . Advances in Protein Chemistry and Structural Biology. 128. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 289-324.