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USD 100 /hr
Hire Dr. Floriano S.
Brazil
USD 100 /hr

Researcher in Computational Biochemistry and Drug Discovery with 15+ years of experience on international collaboration

Profile Summary
Subject Matter Expertise
Services
Writing Technical Writing
Research Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection
Product Development Formulation, Stability/Shelf Life Testing
Work Experience

Researcher

FIOCRUZ

November 2006 - Present

Education

PhD

Universidade Federal do Rio de Janeiro

2002 - December 2005

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Marcos V. S. Santana, Floriano P. Silva-Jr(2021). De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning . BMC Chemistry. 15. (1). Springer Science and Business Media {LLC}
(2021). De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning . BMC chemistry.
Bruno Junior Neves, Jonathan Paulo Agnes, Marcelo do Nascimento Gomes, Marcio Roberto Henriques Donza, Rosângela Mayer Gonçalves, Marina Delgobo, Lauro Ribeiro de Souza Neto, Mario Roberto Senger, Floriano Paes Silva-Junior, Sabrina Baptista Ferreira, et al.(2020). Efficient identification of novel anti-glioma lead compounds by machine learning models . European Journal of Medicinal Chemistry. 189. p. 111981. Elsevier {BV}
(2020). Efficient identification of novel anti-glioma lead compounds by machine learning models . European journal of medicinal chemistry.
(2020). Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells . Protein expression and purification.
(2020). COVID-19: molecular targets, drug repurposing and new avenues for drug discovery . Memorias do Instituto Oswaldo Cruz.
(2020). Strategies to Support Fragment-to-Lead Optimization in Drug Discovery . Frontiers in chemistry.
Mario Roberto Senger, Tereza Cristina Santos Evangelista, Rafael Ferreira Dantas, Marcos Vinicius da Silva Santana, Luiz Carlos Saramago Gonçalves, Lauro Ribeiro de Souza Neto, Sabrina Baptista Ferreira, Floriano Paes Silva-Junior(2020). COVID-19: molecular targets, drug repurposing and new avenues for drug discovery . Memórias do Instituto Oswaldo Cruz. 115. {FapUNIFESP} ({SciELO})
Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes, Floriano Paes Silva-Jr(2019). The diverse mechanisms and anticancer potential of naphthoquinones . Cancer Cell International. 19. (1). Springer Science and Business Media {LLC}
Rafael F. Dantas, Mario R. Senger, Mariana F. C. Cardoso, Vitor F. Ferreira, Maria Cecília B. V. de Souza, Fernando de C. da Silva, Floriano P. Silva, Jr.(2019). Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity . Medicinal Chemistry Research. 28. (9). p. 1579--1588. Springer Science and Business Media {LLC}
Pedro H. M. Torres, Ana C. R. Sodero, Paula Jofily, Floriano P. Silva-Jr(2019). Key Topics in Molecular Docking for Drug Design . International Journal of Molecular Sciences. 20. (18). p. 4574. {MDPI} {AG}
Pedro Torres, Ana C. R. Sodero, Paula Jofily, Floriano Silva-Jr (2019). Key Topics in Molecular Docking for Drug Design . International Journal of Molecular Sciences.
(2019). Key Topics in Molecular Docking for Drug Design . International journal of molecular sciences.
(2019). Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation . Pharmaceutical biology.
(2019). Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling . MedChemComm.
(2019). Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity . Medicinal Chemistry Research.
(2019). Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings . Expert opinion on drug discovery.
(2019). FindTargetsWEB: A User-Friendly Tool for Identification of Potential Therapeutic Targets in Metabolic Networks of Bacteria . Frontiers in genetics.
(2019). The diverse mechanisms and anticancer potential of naphthoquinones . Cancer cell international.
Alberto Oliveira, Lucas Bleicher, Carlos G. Schrago, Floriano Paes Silva Junior(2018). Conservation analysis and decomposition of residue correlation networks in the phospholipase A2 superfamily (PLA2s): Insights into the structure-function relationships of snake venom toxins . Toxicon. 146. p. 50--60. Elsevier {BV}
Teixeira MAC, Belloze KT, Cavalcanti MC, Silva-Junior FP(2018). Data mart construction based on semantic annotation of scientific articles: A case study for the prioritization of drug targets . Computer methods and programs in biomedicine.
(2018). Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives . Bioorganic & medicinal chemistry.
Sodero AC, Abrahim-Vieira B, Torres PH, Pascutti PG, Garcia CR, Ferreira VF, Rocha DR, Ferreira SB, Silva FP, Memorias do Instituto Oswaldo Cruz, 2017, vol. 112, no. 4, pp. 299-308, 2017 .
Gasparotto J, Kunzler A, Senger MR, Souza CD, Simone SG, Bortolin RC, Somensi N, Dal-Pizzol F, Moreira JC, Abreu-Silva AL, Calabrese KD, Silva FP, Gelain DP, Memorias do Instituto Oswaldo Cruz, 2017, vol. 112, no. 2, pp. 146-154, 2017 .
Bruno J. Neves, Rafael F. Dantas, Mario R. Senger, Cleber C. Melo-Filho, Walter C. G. Valente, Ana C. M. de Almeida, João M. Rezende-Neto, Elid F. C. Lima, Ross Paveley, Nicholas Furnham, et al.(2016). Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening . J. Med. Chem. 59. (15). p. 7075--7088. American Chemical Society ({ACS})
Cleber C. Melo-Filho, Rafael F. Dantas, Rodolpho C. Braga, Bruno J. Neves, Mario R. Senger, Walter C. G. Valente, João M. Rezende-Neto, Willian T. Chaves, Eugene N. Muratov, Ross A. Paveley, et al.(2016). QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni . J. Chem. Inf. Model. 56. (7). p. 1357--1372. American Chemical Society ({ACS})
Mario R. Senger, Carlos A.M. Fraga, Rafael F. Dantas, Floriano P. Silva(2016). Filtering promiscuous compounds in early drug discovery: is it a good idea? . Drug Discovery Today. 21. (6). p. 868--872. Elsevier {BV}
Bruno Junior Neves, Rafael Ferreira Dantas, Mario Roberto Senger, Walter César Góes Valente, João de Mello Rezende-Neto, Willian Távora Chaves, Lee Kamentsky, Anne Carpenter, Floriano Paes Silva-Junior, Carolina Horta Andrade(2016). The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery . Med. Chem. Commun. 7. (6). p. 1176--1182. Royal Society of Chemistry ({RSC})
Costa, Livia Bandeira, de Oliveira Cardoso, Marcos Verssimo, de Oliveira Filho, Gevanio Bezerra, Teixeira de Moraes Gomes, Paulo Andre, Pontes Espindola, Jose Wanderlan, de Jesus Silva, Thays Gabrielle, Monteiro Torres, Pedro Henrique, Silva Junior, Floriano Paes, Martin, Julio, Bressan Queiroz de Figueiredo, Regina Celia, et al.(2016). Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi . Bioorganic & Medicinal Chemistry. 24. (8). p. 1608-1618.
Gelain, D., Gasparotto, J., Bortolin, R., Girardi, C., Moreira, J. C., Senger, M. R., Schirato, G., Rezende-Neto, J., Dantas, R., Silva-, F., Jr.(2015). Mice experimentally infected with schistosoma mansoni exhibit molecular markers of idiopathic neurodegenerative diseases . Journal of Neurochemistry. 134. p. 121.
Gasparotto, J., Senger, M.R., Kunzler, A., Degrossoli, A., de Simone, S.G., Bortolin, R.C., Somensi, N., Girardi, C.S., de Souza, C.D.S.F., Calabrese, K.D.S., et al.(2015). Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis . Brain, Behavior, and Immunity. 43. p. 37-45.
Sadok Menna-Barreto, Rubem Figueiredo, Belloze, Kele Teixeira, Perales, Jonas, Silva-, Floriano Paes, Jr.(2014). Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old Puzzle . Current Drug Targets. 15. (3). p. 255-271.
Gonzaga, Daniel, Senger, Mario Roberto, da Silva, Fernando de Carvalho, Ferreira, Vitor Francisco, Silva, Floriano Paes, Jr.(2014). 1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases . European Journal of Medicinal Chemistry. 74. p. 461-476.
Forezi, L.D.S.M., Tolentino, N.M.C., De Souza, A.M.T., Castro, H.C., Montenegro, R.C., Dantas, R.F., Oliveira, M.E.I.M., Silva Jr., F.P., Barreto, L.H., Burbano, R.M.R., et al.(2014). Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3- carboxamide derivatives: Finding new potential anticancer drugs . Molecules. 19. (5). p. 6651-6670.
Cardoso, M.F.C., Rodrigues, P.C., Oliveira, M.E.I.M., Gama, I.L., Da Silva, I.M.C.B., Santos, I.O., Rocha, D.R., Pinho, R.T., Ferreira, V.F., De Souza, M.C.B.V., et al.(2014). Synthesis and evaluation of the cytotoxic activity of 1,2- furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines . European Journal of Medicinal Chemistry. 84. p. 708-717.
Tschoeke, D.A., Nunes, G.L., Jardim, R., Lima, J., Dumaresq, A.S.R., Gomes, M.R., Pereira, L.M., Loureiro, D.R., Stoco, P.H., de Matos Guedes, H.L., et al.(2014). The comparative genomics and phylogenomics of Leishmania amazonensis parasite . Evolutionary Bioinformatics. 10. p. 131-153.
Gonzaga, D., Senger, M.R., Da Silva, F.D.C., Ferreira, V.F., Silva Jr., F.P.(2014). 1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases . European Journal of Medicinal Chemistry. 74. p. 461-476.
Forezi, Luana da S. M., Tolentino, Nathalia M. C., de Souza, Alessandra M. T., Castro, Helena C., Montenegro, Raquel C., Dantas, Rafael F., Oliveira, Maria E. I. M., Silva, Floriano P., Jr., Barreto, Leilane H., Burbano, Rommel M. R., et al.(2014). Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs . Molecules. 19. (5). p. 6651-6670.
De Oliveira, R.B., Senger, M.R., Vasques, L.M., Gasparotto, J., Dos Santos, J.P.A., De Bittencourt Pasquali, M.A., Moreira, J.C.F., Silva, F.P., Gelain, D.P.(2013). Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice . International Journal for Parasitology. 43. (5). p. 371-379.
Farias, Leonardo P., Krautz-Peterson, Greice, Tararam, Cibele A., Araujo-Montoya, Bogar O., Fraga, Tatiana R., Rofatto, Henrique K., Silva-, Floriano P., Jr., Isaac, Lourdes, Da'dara, Akram A., Wilson, R. Alan, et al.(2013). On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni . Plos Neglected Tropical Diseases. 7. (10).
Silveira, L.B., Marchi-Salvador, D.P., Santos-Filho, N.A., Silva, F.P., Marcussi, S., Fuly, A.L., Nomizo, A., da Silva, S.L., Stábeli, R.G., Arantes, E.C., et al.(2013). Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom . Journal of Pharmaceutical and Biomedical Analysis. 73. p. 35-43.
Silveira, Lucas B., Marchi-Salvador, Daniela P., Santos-Filho, Norival A., Silva, Floriano P., Jr., Marcussi, Silvana, Fuly, Andre L., Nomizo, Auro, da Silva, Saulo L., Stabeli, Rodrigo G., Arantes, Eliane C., et al.(2013). Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A(2) from Bothrops moojeni snake venom . Journal of Pharmaceutical and Biomedical Analysis. 73. p. 35-43.
de Oliveira, Ramatis Birnfeld, Senger, Mario Roberto, Vasques, Laura Milan, Gasparotto, Juciano, Almeida dos Santos, Joao Paulo, de Bittencourt Pasquali, Matheus Augusto, Fonseca Moreira, Jose Claudio, Silva, Floriano Paes, Jr., Gelain, Daniel Pens(2013). Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice . International Journal For Parasitology. 43. (5). p. 371-379.
Farias, L.P., Krautz-Peterson, G., Tararam, C.A., Araujo-Montoya, B.O., Fraga, T.R., Rofatto, H.K., Silva-Jr, F.P., Isaac, L., Da'dara, A.A., Wilson, R.A., et al.(2013). On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni . PLoS Neglected Tropical Diseases. 7. (10).
Neves, A.P., Pereira, M.X.G., Peterson, E.J., Kipping, R., Vargas, M.D., Silva-Jr, F.P., Carneiro, J.W.M., Farrell, N.P.(2013). Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes . Journal of Inorganic Biochemistry. 119. p. 54-64.
Neves, Amanda P., Pereira, Michelle X. G., Peterson, Erica J., Kipping, Ralph, Vargas, Maria D., Silva-, Floriano P., Jr., Carneiro, J. Walkimar M., Farrell, Nicholas P.(2013). Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes . Journal of Inorganic Biochemistry. 119. p. 54-64.
Trevizano, Larissa Mattos, Ventorim, Rafaela Zandonade, de Rezende, Sebastiao Tavares, Silva Junior, Floriano Paes, Guimaraes, Valeria Monteze(2012). Thermostability improvement of Orpinomyces sp xylanase by directed evolution . Journal of Molecular Catalysis B-Enzymatic. 81. p. 12-18.
Trevizano, L.M., Ventorim, R.Z., De Rezende, S.T., Silva Jr., F.P., Guimarães, V.M.(2012). Thermostability improvement of Orpinomyces sp. xylanase by directed evolution . Journal of Molecular Catalysis B: Enzymatic. 81. p. 12-18.
Senger, Mario Roberto, Andrade Gomes, Lucas Da Costa, Ferreira, Sabrina Baptista, Kaiser, Carlos Roland, Ferreira, Vitor Francisco, Silva, Floriano Paes, Jr.(2012). Kinetics Studies on the Inhibition Mechanism of Pancreatic alpha-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity . Chembiochem. 13. (11). p. 1584-1593.
Rubem Figueiredo Sadok Menna-Barreto, Daniela Gois Beghini, André Teixeira da Silva Ferreira, Vivian Corrêa de Almeida, Marcelle Almeida Caminha, Floriano Paes Silva-Jr, Jonas Perales(2012). New insights in Trypanosoma cruzi proteomic map: further post-translational modifications and potential drug targets in Y strain epimastigotes . JIOMICS. 2. (2). Proteomass
Senger, M.R., Gomes, L.D.C.A., Ferreira, S.B., Kaiser, C.R., Ferreira, V.F., Silva, F.P.(2012). Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity . ChemBioChem. 13. (11). p. 1584-1593.
Teixeira, Sabrina S., Silveira, Lucas B., da Silva, Franco M. N., Marchi-Salvador, Daniela P., Silva, Floriano P., Jr., Izidoro, Luiz Fernando M., Fuly, Andre L., Juliano, Maria A., dos Santos, Camila R., Murakami, Mario T., et al.(2011). Molecular characterization of an acidic phospholipase A(2) from Bothrops pirajai snake venom: synthetic C-terminal peptide identifies its antiplatelet region . Archives of Toxicology. 85. (10). p. 1219-1233.
Teixeira, S.S., Silveira, L.B., Da Silva, F.M.N., Marchi-Salvador, D.P., Silva Jr., F.P., Izidoro, L.F.M., Fuly, A.L., Juliano, M.A., Dos Santos, C.R., Murakami, M.T., et al.(2011). Molecular characterization of an acidic phospholipase A 2 from Bothrops pirajai snake venom: Synthetic C-terminal peptide identifies its antiplatelet region . Archives of Toxicology. 85. (10). p. 1219-1233.
Romero, L., Marcussi, S., Marchi-Salvador, D.P., Silva, F.P., Fuly, A.L., Stábeli, R.G., da Silva, S.L., González, J., Monte, A.D., Soares, A.M.(2010). Enzymatic and structural characterization of a basic phospholipase A 2 from the sea anemone Condylactis gigantea . Biochimie. 92. (8). p. 1063-1071.
Romero, Lazara, Marcussi, Silvana, Marchi-Salvador, Daniela P., Silva, Floriano P., Jr., Fuly, Andre L., Stabeli, Rodrigo G., da Silva, Saulo L., Gonzalez, Jorge, del Monte, Alberto, Soares, Andreimar M.(2010). Enzymatic and structural characterization of a basic phospholipase A(2) from the sea anemone Condylactis gigantea . Biochimie. 92. (8). p. 1063-1071.
Ferreira, Sabrina B., Sodero, Ana C. R., Cardoso, Mariana F. C., Lima, Emerson S., Kaiser, Carlos R., Silva, Floriano P., Jr., Ferreira, Vitor F.(2010). Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as alpha-Glucosidases Inhibitors . Journal of Medicinal Chemistry. 53. (6). p. 2364-2375.
Ferreira, S., Sodero, A.C.R., Cardoso, M.F.C., Lima, E.S., Kaiser, C.R., Silva Jr., F.P., Ferreira, V.F.(2010). Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as a-Glucosidases Inhibitors . Journal of Medicinal Chemistry. 53. (6). p. 2364-2375.
Teixeira, Raquel L. F., Silva Junior, Floriano P., Silveira, Aline R., Cabello, Pedro H., Mendonca-Lima, Leila, Rabahi, Marcelo F., Kritski, Afranio L., Mell, Fernanda C. Q., Suffys, Philip N., de Miranda, Antonio B., et al.(2010). Sequence analysis of NAT2 gene in Brazilians: Identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure . Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 683. (1-2). p. 43-49.
Teixeira, R.L.F., Silva Jr., F.P., Silveira, A.R., Cabello, P.H., Mendonça-Lima, L., Rabahi, M.F., Kritski, A.L., Mello, F.C.Q., Suffys, P.N., de Miranda, A.B., et al.(2010). Sequence analysis of NAT2 gene in Brazilians: Identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure . Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 683. (1-2). p. 43-49.
Ana C. R. Sodero, Salvatore G. De Simone, Floriano P. Silva-Jr(2009). Catalytic mechanism and protonation state of pepsin-like aspartyl protease active site . Revista Virtual de Química. 1. (2). Sociedade Brasileira de Quimica ({SBQ})
Davila, Alberto M. R., Mendes, Pablo N., Wagner, Glauber, Tschoeke, Diogo A., Cuadrat, Rafael R. C., Liberman, Felipe, Matos, Luciana, Satake, Thiago, Ocana, Kary A. C. S., Triana, Omar, et al.(2008). ProtozoaDB: dynamic visualization and exploration of protozoan genomes . Nucleic Acids Research. 36. p. D547-D552.
Guedes, H.L.M., Silva Jr., F.P., Netto, C.C., de Salles, C.M.C., Alexandre, G., Oliveira, C.L.P., Torriani, Í., De Simone, S.G.(2008). Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom . Biophysical Chemistry. 132. (2-3). p. 159-164.
Silva, F. P., Jr., Alexandre, G. M. C., Ramos, C. H. I., De-Simone, S. G.(2008). On the quaternary structure of a C-type lectin from Bothrops jararacussu venom - BJ-32 (BjcuL) . Toxicon. 52. (8). p. 944-953.
Dávila, A.M.R., Mendes, P.N., Wagner, G., Tschoeke, D.A., Cuadrat, R.R.C., Liberman, F., Matos, L., Satake, T., Ocaña, K.A.C.S., Triana, O., et al.(2008). ProtozoaDB: Dynamic visualization and exploration of protozoan genomes . Nucleic Acids Research. 36. (SUPPL. 1).
Guedes, Herbert L. M., Silva, Floriano P., Jr., Netto, Carlos Correa, de Salles, Cristiane M. C., Alexandre, Giani, Oliveria, Cristiano L. P., Torriani, Iris, De Simone, Salvatore Giovanni(2008). Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom . Biophysical Chemistry. 132. (2-3). p. 159-164.
Silva Jr., F.P., Alexandre, G.M.C., Ramos, C.H.I., De-Simone, S.G.(2008). On the quaternary structure of a C-type lectin from Bothrops jararacussu venom - BJ-32 (BjcuL) . Toxicon. 52. (8). p. 944-953.
Silva-Junior, F.P., Guedes, H.L.M., Garvey, L.C., Aguiar, A.S., Bourguignon, S.C., Di Cera, E., Giovanni-De-Simone, S.(2007). BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: Role of N-glycosylation in thermostability and active site accessibility . Toxicon. 50. (1). p. 18-31.
Silva-Junior, Floriano P., Guedes, Herbert L. M., Garvey, Laura C., Aguiar, Aniesse S., Bourguignon, Saulo C., Di Cera, Enrico, Giovanni-De-Simone, Salvatore(2007). BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: Role of N-glycosylation in thermostability and active site accessibility . Toxicon. 50. (1). p. 18-31.
Vermelho, A.B., De Simone, S.G., d'Avila-Levy, C.M., do Santos, A.L.S., de Melo, A.C.N., Silva Jr., F.P., da Silva Bon, E.P., Branquinha, M.H.(2007). Trypanosomatidae peptidases: A target for drugs development . Current Enzyme Inhibition. 3. (1). p. 19-48.
Silva, Floriano P., Jr., Ellena, Javier, de Lima Ferreira, Marcelle, Mascarenhas, Yvonne P., de Souza, Marcus V. N., Vasconcelos, Thatyana R. A., Wardell, James L., Wardell, Solange M. S. V.(2006). Experimental and theoretical structure characterization of two isoniazid derivatives: 2,4-difluoro-N '-isonicotinoylbenzohydrazide and 2,4-dichloro-N '-isonicotinoylbenzohydrazide hydrochloride . Journal of Molecular Structure. 788. (1-3). p. 63-71.
De-Simone, S. G., Netto, C. C., Silva, F. P., Jr.(2006). Simple affinity chromatographic procedure to purify beta-galactoside binding lectins . Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 838. (2). p. 135-138.
Silva Jr., F.P., Antunes, O.A.C., De Alencastro, R.B., De Simone, S.G.(2006). The Na+ binding channel of human coagulation proteases: Novel insights on the structure and allosteric modulation revealed by molecular surface analysis . Biophysical Chemistry. 119. (3). p. 282-294.
de Salles, Cristiane M. C., Guedes, Herbert L. M., Salles, Joao B., Silva, Floriano P., Jr., De Simone, Salvatore G.(2006). Optimization of sample preparation from skin mucus of a neotropical fish for two-dimensional substrate gel electrophoresis . Analytical Biochemistry. 357. (1). p. 153-155.
Silva, FP, Antunes, OAC, de Alencastro, RB, De Simone, SG(2006). The Na+ binding channel of human coagulation proteases: Novel insights on the structure and allosteric modulation revealed by molecular surface analysis . Biophysical Chemistry. 119. (3). p. 282-294.
de Salles, C.M.C., Guedes, H.L.M., Salles, J.B., Silva Jr., F.P., De Simone, S.G.(2006). Optimization of sample preparation from skin mucus of a neotropical fish for two-dimensional substrate gel electrophoresis . Analytical Biochemistry. 357. (1). p. 153-155.
De-Simone, S.G., Netto, C.C., Silva Jr., F.P.(2006). Simple affinity chromatographic procedure to purify β-galactoside binding lectins . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 838. (2). p. 135-138.
Silva Jr., F.P., Ellena, J., Ferreira, M.d.L., Mascarenhas, Y.P., de Souza, M.V.N., Vasconcelos, T.R.A., Wardell, J.L., Wardell, S.M.S.V.(2006). Experimental and theoretical structure characterization of two isoniazid derivatives: 2,4-Difluoro-N′-isonicotinoylbenzohydrazide and 2,4-dichloro-N′-isonicotinoylbenzohydrazide hydrochloride . Journal of Molecular Structure. 788. (1-3). p. 63-71.
De-Simone, SG, Correa-Netto, C, Antunes, OAC, De-Alencastro, RB, Silva, FP(2005). Biochemical and molecular modeling analysis of the ability of two p-aminobenzamidine-based sorbents to selectively purify serine proteases (fibrinogenases) from snake venoms . Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 822. (1-2). p. 1-9.
De-Simone, S.G., Correa-Netto, C., Antunes, O.A.C., De-Alencastro, R.B., Silva Jr., F.P.(2005). Biochemical and molecular modeling analysis of the ability of two p-aminobenzamidine-based sorbents to selectively purify serine proteases (fibrinogenases) from snake venoms . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 822. (1-2). p. 1-9.
Silva Jr., F.P., De-Simone, S.G.(2004). Erratum: S1 subsite in snake venom thrombin-like enzymes: Can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? (Bioorganic Medicinal Chemistry (2004) 12 (2571) DOI: 10.1016/j.bmc.2004.03.024) . Bioorganic and Medicinal Chemistry. 12. (13).
Silva Jr., F.P., De-Simone, S.G.(2004). S1 subsite in snake venom thrombin-like enzymes: Can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? . Bioorganic and Medicinal Chemistry. 12. (10). p. 2571-2587.
Silva, FP, De-Simone, SG(2004). S1 subsite in snake venom thrombin-like enzymes: can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? (vol 12, pg 2571, 2004) . Bioorganic & Medicinal Chemistry. 12. (13). p. 3755.
Silva, FP, De-Simone, SG(2004). S1 subsite in snake venom thrombin-like enzymes: can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? . Bioorganic & Medicinal Chemistry. 12. (10). p. 2571-2587.
Silva Jr., F.P., Ribeiro, F., Katz, N., Giovanni-De-Simone, S.(2002). Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling . FEBS Letters. 514. (2-3). p. 141-148.
Silva, FP, Ribeiro, F, Katz, N, Giovanni-De-Simone, S(2002). Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling . Febs Letters. 514. (2-3). p. 141-148.
Silva, FP, Veyl, FZ, Clos, J, De Simone, SG(2002). Molecular modeling approaches for determining gene function: Application to a putative poly-A binding protein from Leishmania amazonensis (LaPABP) . Memorias Do Instituto Oswaldo Cruz. 97. (3). p. 335-341.
Bourguignon, S.C., Paes F.S., Jr., Calheiros, E.B., Juliano, M., Aguiar, A.S., Melgarejo, A.R., Giovanni-De-Simone, S.(2001). Bothrops moojeni venom peptides containing bradykinin potentiating peptides sequence . Protein and Peptide Letters. 8. (1). p. 21-26.
Bourguignon, SC, Paes, FS, Calheiros, EB, Juliano, M, Aguiar, AS, Melgarejo, AR, Giovanni-De-Simone, S(2001). Bothrops moojeni venom peptides containing bradykinin potentiating peptides sequence . Protein and Peptide Letters. 8. (1). p. 21-26.
OTHER
Marcos Santana, Floriano Paes Silva(2020). De Novo Design and Bioactivity Prediction of SARS-CoV-2 Main Protease Inhibitors Using ULMFit . Research Square
CONFERENCE PAPER
Belloze, K.T., Monteiro, D.I.S.B., Lima, T.F., Silva Jr., F.P., Cavalcanti, M.C.(2012). An evaluation of annotation tools for biomedical texts . CEUR Workshop Proceedings. 938. p. 108-119.