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USD 100 /hr
Hire Dr. Fanny L.
United States
USD 100 /hr

PhD Immunology | Pharmacy | Scientific communicator 10+ yrs of experience in biomedical research | Analyst | Manager

Profile Summary
Subject Matter Expertise
Services
Writing Clinical Trial Documentation, Technical Writing
Research Feasibility Study, Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection
Consulting Scientific and Technical Consulting
Data & AI Statistical Analysis, Data Processing, Data Insights
Work Experience

Consultant

Planet Pharma LLC

June 2022 - Present

Research Fellow

National Institutes of Health

October 2016 - October 2019

Post-doctoral Fellow

National Institutes of Health

October 2011 - October 2016

Research and Teaching Assistant

Université du Droit et la Santé de Lille 2 - Faculté de Médecine Henri-Warembourg

November 2009 - November 2011

Intern in Pharmacy and Biology

Centre Hospitalier Regional et Universitaire de Lille

2008 - 2009

Research and Teaching Assistant

Université de Lille II Faculté des Sciences Pharmaceutiques et Biologiques

2006 - 2008

Education

Pharm D (Immunology)

Université de Lille II Faculté des Sciences Pharmaceutiques et Biologiques

September 1998 - October 2009

Ph.D. Immunology (EDBSL)

Université Lille 2 Droit et Santé

November 2005 - November 2008

Research Master (Pharmacy)

Université de Lille II Faculté des Sciences Pharmaceutiques et Biologiques

October 2003 - October 2004

Certifications

  • Intellectual Property for Entrepreneurs

    Coursera online non-credit course - University of Maryland, College Park, US
    https://coursera.org/share/9b03b2a42660e6a1bdbccc80b928fb46

    January 2022 - Present

  • Qualification in teaching Cellular Biology and Biological, Fundamental and Clinical Sciences

    National University Council, Paris, France

    January 2011 - January 2021

Publications
PREPRINT
Andrea C. Bohrer and Ehydel Castro and Claire E. Tocheny and Maike Assmann and Benjamin Schwarz and Eric Bohrnsen and Michelle A. Makiya and Fanny Legrand and Kerry L. Hilligan and Paul J. Baker and Flor Torres-Juarez and Zhidong Hu and Hui Ma and Lin Wang and Liangfei Niu and Wen Zilu and Sang H. Lee and Olena Kamenyeva and Keith D. Kauffman and Michele Donato and Alan Sher and Daniel L. Barber and Laura E. Via and Thomas J. Scriba and Purvesh Khatri and Yanzheng Song and Ka-Wing Wong and Catharine M. Bosio and Amy D. Klion and Katrin D. Mayer-Barber and(2022). Rapid GPR183-mediated recruitment of eosinophils to the lung after <i>Mycobacterium tuberculosis</i> infection . []. Cold Spring Harbor Laboratory
JOURNAL ARTICLE
Fanny Legrand(2021). Legends of allergy and immunology: Monique Capron . Allergy. 76. (3). p. 937--939. Wiley
(2021). Eosinophil Purification from Peripheral Blood of Rhesus Monkeys . Methods in molecular biology (Clifton, N.J.).
Fanny Legrand, So Gun Hong, Noriko Sato, Manasi Gadkari, Michelle Makiya, Kindra Stokes, Katherine N. Howe, Shiqin Judy Yu, Nathaniel Seth Linde, Randall R. Clevenger, et al. (2020). Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration . Blood.
(2020). A randomized, placebo-controlled, double-blind pilot study of single-dose humanized anti-IL5 antibody (reslizumab) for the reduction of eosinophilia following diethylcarbamazine treatment of Loa loa infection . Clinical Infectious Diseases.
(2020). Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration . Blood.
(2019). Clinical Spectrum, Long-Term Outcomes and Predictors of Relapse after Imatinib Discontinuation in FIP1L1-Pdgfra-Associated Chronic Eosinophilic Leukemia: Data from 150 Patients . Blood.
Fanny Legrand, Nadine Landolina, Ilan Zaffran, Robert O. Emeh, Elizabeth Chen, Amy D. Klion, Francesca Levi-Schaffer(2019). Siglec-7 on peripheral blood eosinophils: Surface expression and function . Allergy. Wiley
(2019). Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome . The New England journal of medicine.
(2019). In vivo tracking of rhesus macaque eosinophils to assess migration in response to glucocorticoids . Journal of Allergy and Clinical Immunology.
Legrand, F., Cao, Y., Wechsler, J.B., Zhu, X., Zimmermann, N., Rampertaap, S., Monsale, J., Romito, K., Youngblood, B.A., Brock, E.C., et al.(2019). Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies . Journal of Allergy and Clinical Immunology. 143. (6). p. 2227-2237.e10.
Kuang, F.L., Legrand, F., Makiya, M., Ware, J.A., Wetzler, L., Brown, T., Magee, T., Piligian, B., Yoon, P., Ellis, J.H., et al.(2019). Benralizumab for PDGFRA-negative hypereosinophilic syndrome . New England Journal of Medicine. 380. (14). p. 1336-1346.
Legrand, F., Landolina, N., Zaffran, I., Emeh, R.O., Chen, E., Klion, A.D., Levi-Schaffer, F.(2019). Siglec-7 on peripheral blood eosinophils: Surface expression and function . Allergy: European Journal of Allergy and Clinical Immunology. 74. (7). p. 1257-1265.
(2018). Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies . The Journal of allergy and clinical immunology.
(2018). Transcript- and protein-level analyses of the response of human eosinophils to glucocorticoids . Scientific data.
P. Khoury, K. Stokes, M. Gadkari, M. A. Makiya, F. Legrand, Z. Hu, A. Klion, L. M. Franco(2018). Glucocorticoid‐induced eosinopenia in humans can be linked to early transcriptional events . Allergy. 73. (10). p. 2076--2079. Wiley
(2018). Characterization and isolation of rhesus macaque eosinophils . Journal of Immunology.
(2018). Soluble Siglec-8 Levels Are Detectable In Subjects With Myeloid Variant Hypereosinophilic Syndromes, But Not In Those With D816V KIT + Systemic Mastocytosis . Journal of Allergy and Clinical Immunology.
Gadkari, M., Makiya, M.A., Legrand, F., Stokes, K., Brown, T., Howe, K., Khoury, P., Hu, Z., Klion, A., Franco, L.M.(2018). Data descriptor: Transcript-and protein-level analyses of the response of human eosinophils to glucocorticoids . Scientific Data. 5.
Khoury, P., Stokes, K., Gadkari, M., Makiya, M.A., Legrand, F., Hu, Z., Klion, A., Franco, L.M.(2018). Glucocorticoid-induced eosinopenia in humans can be linked to early transcriptional events . Allergy: European Journal of Allergy and Clinical Immunology. 73. (10). p. 2076-2079.
(2017). Serum soluble Siglec-8 in hypereosinophilic syndromes . Journal of Immunology.
Legrand, Fanny, Herrick, Jesica A., Gounoue, Raceline, Nchinda, Godwin, Montavon, Celine, Bopda, Jean, Tchana, Steve Mbickmen, Ondigui, Bienvenu Etogo, Nguluwe, Konrad, Fay, Michael P., et al.(2017). Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection . Clinical Infectious Diseases. 64. (8). p. 1017-1025.
Legrand, Fanny, Landolina, Nadine A., Levi-Schaffer, Francesca, Klion, Amy D.(2016). Siglec-7 on Peripheral Blood Eosinophils: Surface Expression and Functional Analysis . Journal of Allergy and Clinical Immunology. 137. (2). p. AB167.
Legrand, Fanny and Landolina, Nadine A. and Levi-Schaffer, Francesca and Klion, Amy D.(2016). Siglec-7 on Peripheral Blood Eosinophils: Surface Expression and Functional Analysis . Journal of Allergy and Clinical Immunology. 137. (2). p. AB167.
Legrand, Fanny, Klion, Amy D.(2015). Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects . Journal of Allergy and Clinical Immunology-in Practice. 3. (2). p. 167-174.
Legrand, Fanny, Alpaugh, Alexandra, Falahati, Rustom, Makiya, Michelle, Klion, Amy D.(2015). A Novel Therapeutic Target for the Treatment of Eosinophilic Disorders . Journal of Allergy and Clinical Immunology. 135. (2). p. AB221.
Legrand, F., Klion, A.D.(2015). Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects . Journal of Allergy and Clinical Immunology: In Practice. 3. (2). p. 167-174.
Lef&#232;vre, G., Copin, M.-C., Staumont-Sall&#233;, D., Avenel-Audran, M., Aubert, H., Taieb, A., Salles, G., Maisonneuve, H., Ghomari, K., Ackerman, F., et al.(2014). The lymphoid variant of hypereosinophilic syndrome study of 21 patients with CD3-CD4+ aberrant T-cell phenotype . Medicine (United States). 93. (17). p. 255-266.
Legrand, Fanny, Tomasevic, Nenad, Simakova, Olga, Lee, Chyi-Chia Richard, Wang, Zengfang, Raffeld, Mark, Makiya, Michelle A., Palath, Varghese, Leung, John, Baer, Mark, et al.(2014). The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders . Journal of Allergy and Clinical Immunology. 133. (5). p. 1439-U350.
Legrand, Fanny, Lefevre, Guillaume, Copin, Marie-Christine, Staumont-Salle, Delphine, Avenel-Audran, Martine, Aubert, Helene, Taieb, Alain, Salles, Gilles, Maisonneuve, Herve, Ghomari, Kamel, et al.(2014). The Lymphoid Variant of Hypereosinophilic Syndrome Study of 21 Patients With CD3-CD4+ Aberrant T-Cell Phenotype . Medicine. 93. (17). p. 255-266.
Legrand, Fanny, Tomasevic, Nenad, Makiya, Michelle, Bebbington, Christopher, Klion, Amy D.(2014). Human EMR1, An Eosinophil-Specific Surface Receptor Of Unknown Function, Is Modulated In Vivo and In Vitro . Journal of Allergy and Clinical Immunology. 133. (2). p. AB61.
Legrand, F., Tomasevic, N., Simakova, O., Lee, C.-C.R., Wang, Z., Raffeld, M., Makiya, M.A., Palath, V., Leung, J., Baer, M., et al.(2014). The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders . Journal of Allergy and Clinical Immunology. 133. (5).
Legrand, Fanny, Driss, Virginie, Capron, Monique(2013). Eosinophil Receptor Profile . Eosinophils in Health and Disease. p. 30-38.
Legrand, Fanny, Grainger, John R., Wohlfert, Elizabeth A., Fuss, Ivan J., Bouladoux, Nicolas, Askenase, Michael H., Koo, Lily Y., Brenchley, Jason M., Fraser, Iain D. C., Belkaid, Yasmine(2013). Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection . Nature Medicine. 19. (6). p. 713-+.
Legrand, Fanny, Renneville, Aline, MacIntyre, Elizabeth, Mastrilli, Samuel, Ackermann, Felix, Cayuela, Jean Michel, Rousselot, Philippe, Schmidt-Tanguy, Aline, Fain, Olivier, Michel, Marc, et al.(2013). The Spectrum of FIP1L1-PDGFRA-Associated Chronic Eosinophilic Leukemia New Insights Based on a Survey of 44 Cases . Medicine. 92. (5). p. E1-E9.
Grainger, J.R., Wohlfert, E.A., Fuss, I.J., Bouladoux, N., Askenase, M.H., Legrand, F., Koo, L.Y., Brenchley, J.M., Fraser, I.D.C., Belkaid, Y.(2013). Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection . Nature Medicine. 19. (6). p. 713-721.
Legrand, F., Renneville, A., MacIntyre, E., Mastrilli, S., Ackermann, F., Cayuela, J.M., Rousselot, P., Schmidt-Tanguy, A., Fain, O., Michel, M., et al.(2013). The spectrum of FIP1L1-PDGFRA-associated chronic eosinophilic leukemia: New insights based on a survey of 44 cases . Medicine (United States). 92. (5).
Driss, V., Hermann, E., Legrand, F., Loiseau, S., Delbeke, M., Kremer, L., Guerardel, Y., Dombrowicz, D., Capron, M.(2012). CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan . Immunology Letters. 143. (2). p. 202-207.
Legrand, Fanny, Driss, Virginie, Hermann, Emmanuel, Loiseau, Sylvie, Delbeke, Marie, Kremer, Laurent, Guerardel, Yann, Dombrowicz, David, Capron, Monique(2012). CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan . Immunology Letters. 143. (2). p. 202-207.
Kahn, J.-E., Lef&#232;vre, G., Legrand, F.(2012). Hypereosinophilia,Hyperéosinophilies . Feuillets de Biologie. 53. (305). p. 5-12.
Gatault, S., Legrand, F., Delbeke, M., Loiseau, S., Capron, M.(2012). Involvement of eosinophils in the anti-tumor response . Cancer Immunology, Immunotherapy. 61. (9). p. 1527-1534.
Gatault, Solene, Delbeke, Marie, Loiseau, Sylvie, Capron, Monique, Legrand, Fanny(2012). Involvement of eosinophils in the anti-tumor response . Cancer Immunology Immunotherapy. 61. (9). p. 1527-1534.
(2011). Hyperéosinophilies et syndromes hyperéosinophiliques . EMC - Hématologie.
Kahn, J.-E., Schoindre, Y., Legrand, F., Bletry, O., Ackermann, F.(2011). Unexplained chronic hypereosinophilia and hypereosinophilic syndrome,Hyperéosinophilies chroniques inexpliquées et syndromes hyperéosinophiliques . Revue des Maladies Respiratoires Actualites. 3. (2). p. 108-113.
Freymond, N., Kahn, J.-E., Legrand, F., Renneville, A., Cordier, J.-F., Cottin, V.(2011). Clonal expansion of T cells in patients with eosinophilic lung disease . Allergy: European Journal of Allergy and Clinical Immunology. 66. (11). p. 1506-1508.
Kahn, J.-E., Ackermann, F., Prin, L., Capron, M., Legrand, F., Bletry, O.(2011). The eosinophil: From physiology to diagnostic procedure,L'éosinophile: de la physiologieà la démarche diagnostique . Revue des Maladies Respiratoires Actualites. 3. (2). p. 102-107.
Legrand, F., Driss, V., Delbeke, M., Loiseau, S., Hermann, E., Dombrowicz, D., Capron, M.(2010). Human Eosinophils Exert TNF-alpha and Granzyme A-Mediated Tumoricidal Activity toward Colon Carcinoma Cells . Journal of Immunology. 185. (12). p. 7443-7451.
Kahn, J. E., Grandpeix-Guyodo, C., Ackermann, F., Charles, P., Legrand, F., Bletry, O.(2010). Hypereosinophilic syndromes: Pathogenic and therapeutic up-to-date . Revue De Medecine Interne. 31. (4). p. 268-276.
Legrand, F., Driss, V., Delbeke, M., Loiseau, S., Hermann, E., Dombrowicz, D., Capron, M.(2010). Human eosinophils exert TNF-α and granzyme a-mediated tumoricidal activity toward colon carcinoma cells . Journal of Immunology. 185. (12). p. 7443-7451.
Kahn, J.-E., Grandpeix-Guyodo, C., Ackermann, F., Charles, P., Legrand, F., Bl&#233;try, O.(2010). Hypereosinophilic syndromes: Pathogenic and therapeutic up-to-date,Syndromes hyperéosinophiliques: Actualités physiopathologiques et thérapeutiques . Revue de Medecine Interne. 31. (4). p. 268-276.
Bletry, O., Kahn, J. E., Ackermann, F., Charles, P., Legrand, F.(2010). New insights into hypereosinophilic syndromes . Bulletin De L Academie Nationale De Medecine. 194. (3). p. 547-559.
Driss, V., Legrand, F., Loiseau, S., Capron, M.(2010). Eosinophil: A new effector of innate immunity?,L'eosinophile: Nouvel acteur de la réponse immunitaire innée? . Medecine/Sciences. 26. (6-7). p. 621-626.
Driss, V., Legrand, F., Loiseau, S., Capron, M.(2010). Eosinophil: a new effector of innate immunity? . M S-Medecine Sciences. 26. (6-7). p. 621-626.
Bletry, O., Kahn, J.-E., Ackermann, F., Charles, P., Legrand, F.(2010). New insights into hypereosinophilic syndromes,À la redécouverte des syndromes hyperéosinophiliques . Bulletin de l'Academie Nationale de Medecine. 194. (3). p. 547-560.
Kanda, A., Driss, V., Hornez, N., Abdallah, M., Roumier, T., Abboud, G., Legrand, F., Staumont-Salle, D., Queant, S., Bertout, J., et al.(2009). Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes . Journal of Allergy and Clinical Immunology. 124. (3). p. 573-U269.
Kanda, A., Driss, V., Hornez, N., Abdallah, M., Roumier, T., Abboud, G., Legrand, F., Staumont-Sall&#233;, D., Qu&#233;ant, S., Bertout, J., et al.(2009). Eosinophil-derived IFN-γ induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes . Journal of Allergy and Clinical Immunology. 124. (3).
Capron, M., Legrand, F.(2009). Functions of eosinophil granulocytes: ffrom anti-parasite immunity to anti-tumoral potential,Fonctions des polynucléaires éosinophiles: de I'immunité anti-parasitaire aux potentialités anti tumorales . Bulletin de l'Academie Nationale de Medecine. 193. (2). p. 339-349.
Driss, V., Legrand, F., Hermann, E., Loiseau, S., Guerardel, Y., Kremer, L., Adam, E., Woerly, G., Dombrowicz, D., Capron, M.(2009). TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins . Blood. 113. (14). p. 3235-3244.
Capron, M., Legrand, F.(2009). Functions of eosinophil granulocytes: from anti-parasite immunity to anti-tumoral potential . Bulletin De L Academie Nationale De Medecine. 193. (2). p. 339-346.
Legrand, F., Driss, V., Woerly, G., Loiseau, S., Hermann, E., Fournie, J. J., Heliot, L., Mattot, V., Soncin, F., Gougeon, M. L., et al.(2009). A Functional gamma delta TCR/CD3 Complex Distinct from gamma delta T Cells Is Expressed by Human Eosinophils . Plos One. 4. (6).
Legrand, F., Driss, V., Woerly, G., Loiseau, S., Hermann, E., Fourni&#233;, J.-J., H&#233;liot, L., Mattot, V., Soncin, F., Gougeon, M.-L., et al.(2009). A functional γδTCR/CD3 complex distinct from γδT cells is expressed by human eosinophils . PLoS ONE. 4. (6).
Driss, V., Legrand, F., Hermann, E., Loiseau, S., Guerardel, Y., Kremer, L., Adam, E., Woerly, G., Dombrowicz, D., Capron, M.(2009). TLR2-dependent eosinophil interactions with mycobacteria: Role of α-defensins . Blood. 113. (14). p. 3235-3244.
(2008). Innate immune function of eosinophils: from antiparasite to antitumor cells . Methods in molecular biology (Clifton, N.J.).
Jensen-Jarolim, E., Achatz, G., Turner, M. C., Karagiannis, S., Legrand, F., Capron, M., Penichet, M. L., Rodriguez, J. A., Siccardi, A. G., Vangelista, L., et al.(2008). AllergoOncology: the role of IgE-mediated allergy in cancer . Allergy. 63. (10). p. 1255-1266.
Jensen-Jarolim, E., Achatz, G., Turner, M.C., Karagiannis, S., Legrand, F., Capron, M., Penichet, M.L., Rodr&#237;guez, J.A., Siccardi, A.G., Vangelista, L., et al.(2008). AllergoOncology: The role of IgE-mediated allergy in cancer . Allergy: European Journal of Allergy and Clinical Immunology. 63. (10). p. 1255-1266.
Legrand, F., Woerly, G., Driss, V., Capron, M.(2008). Innate immune function of eosinophils: from antiparasite to antitumor cells . Methods in molecular biology (Clifton, N.J.). 415. p. 215-240.
(2007). Peau et éosinophilie . EMC - Dermatologie.
BOOK CHAPTER
Weller, P.F., Melo, R.C.N., Dvorak, A.M., Driss, V., Legrand, F., Capron, M.(2013). Eosinophil Structure and Cell Surface Receptors . Eosinophils in Health and Disease. p. 19-38.