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Profile Details
Contact
★★★★★
☆☆☆☆☆
USD 100 /hr
Hire Dr. Fanny L.
United States
USD 100 /hr

PhD Immunology | Pharmacy | Scientific communicator 10+ yrs of experience in biomedical research | Analyst | Manager

Profile Summary
Subject Matter Expertise
Services
Writing Clinical Trial Documentation, Technical Writing
Research Feasibility Study, Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection
Consulting Scientific and Technical Consulting
Data & AI Statistical Analysis, Data Processing, Data Insights
Work Experience

Research Fellow

National Institutes of Health

October 2016 - October 2019

Post-doctoral Fellow

National Institutes of Health

October 2011 - October 2016

Research and Teaching Assistant

Université du Droit et la Santé de Lille 2 - Faculté de Médecine Henri-Warembourg

November 2009 - November 2011

Intern in Pharmacy and Biology

Centre Hospitalier Regional et Universitaire de Lille

2008 - 2009

Research and Teaching Assistant

Université de Lille II Faculté des Sciences Pharmaceutiques et Biologiques

2006 - 2008

Education

Pharm D (Immunology)

Université de Lille II Faculté des Sciences Pharmaceutiques et Biologiques

September 1998 - October 2009

Ph.D. Immunology (EDBSL)

Université Lille 2 Droit et Santé

November 2005 - November 2008

Research Master (Pharmacy)

Université de Lille II Faculté des Sciences Pharmaceutiques et Biologiques

October 2003 - October 2004

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Fanny Legrand(2021). Legends of allergy and immunology: Monique Capron . Allergy. 76. (3). p. 937--939. Wiley
(2021). Eosinophil Purification from Peripheral Blood of Rhesus Monkeys . Methods in molecular biology (Clifton, N.J.).
Fanny Legrand, So Gun Hong, Noriko Sato, Manasi Gadkari, Michelle Makiya, Kindra Stokes, Katherine N. Howe, Shiqin Judy Yu, Nathaniel Seth Linde, Randall R. Clevenger, et al. (2020). Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration . Blood.
(2020). A randomized, placebo-controlled, double-blind pilot study of single-dose humanized anti-IL5 antibody (reslizumab) for the reduction of eosinophilia following diethylcarbamazine treatment of Loa loa infection . Clinical Infectious Diseases.
(2020). Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration . Blood.
(2019). Clinical Spectrum, Long-Term Outcomes and Predictors of Relapse after Imatinib Discontinuation in FIP1L1-Pdgfra-Associated Chronic Eosinophilic Leukemia: Data from 150 Patients . Blood.
Fanny Legrand, Nadine Landolina, Ilan Zaffran, Robert O. Emeh, Elizabeth Chen, Amy D. Klion, Francesca Levi-Schaffer(2019). Siglec-7 on peripheral blood eosinophils: Surface expression and function . Allergy. Wiley
(2019). Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome . The New England journal of medicine.
(2019). In vivo tracking of rhesus macaque eosinophils to assess migration in response to glucocorticoids . Journal of Allergy and Clinical Immunology.
Kuang, F.L., Legrand, F., Makiya, M., Ware, J.A., Wetzler, L., Brown, T., Magee, T., Piligian, B., Yoon, P., Ellis, J.H., et al.(2019). Benralizumab for PDGFRA-negative hypereosinophilic syndrome . New England Journal of Medicine. 380. (14). p. 1336-1346.
Legrand, F., Landolina, N., Zaffran, I., Emeh, R.O., Chen, E., Klion, A.D., Levi-Schaffer, F.(2019). Siglec-7 on peripheral blood eosinophils: Surface expression and function . Allergy: European Journal of Allergy and Clinical Immunology. 74. (7). p. 1257-1265.
Legrand, F., Cao, Y., Wechsler, J.B., Zhu, X., Zimmermann, N., Rampertaap, S., Monsale, J., Romito, K., Youngblood, B.A., Brock, E.C., et al.(2019). Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies . Journal of Allergy and Clinical Immunology. 143. (6). p. 2227-2237.e10.
(2018). Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies . The Journal of allergy and clinical immunology.
(2018). Transcript- and protein-level analyses of the response of human eosinophils to glucocorticoids . Scientific data.
P. Khoury, K. Stokes, M. Gadkari, M. A. Makiya, F. Legrand, Z. Hu, A. Klion, L. M. Franco(2018). Glucocorticoid‐induced eosinopenia in humans can be linked to early transcriptional events . Allergy. 73. (10). p. 2076--2079. Wiley
(2018). Characterization and isolation of rhesus macaque eosinophils . Journal of Immunology.
(2018). Soluble Siglec-8 Levels Are Detectable In Subjects With Myeloid Variant Hypereosinophilic Syndromes, But Not In Those With D816V KIT + Systemic Mastocytosis . Journal of Allergy and Clinical Immunology.
Gadkari, M., Makiya, M.A., Legrand, F., Stokes, K., Brown, T., Howe, K., Khoury, P., Hu, Z., Klion, A., Franco, L.M.(2018). Data descriptor: Transcript-and protein-level analyses of the response of human eosinophils to glucocorticoids . Scientific Data. 5.
Khoury, P., Stokes, K., Gadkari, M., Makiya, M.A., Legrand, F., Hu, Z., Klion, A., Franco, L.M.(2018). Glucocorticoid-induced eosinopenia in humans can be linked to early transcriptional events . Allergy: European Journal of Allergy and Clinical Immunology. 73. (10). p. 2076-2079.
(2017). Serum soluble Siglec-8 in hypereosinophilic syndromes . Journal of Immunology.
Legrand, Fanny, Herrick, Jesica A., Gounoue, Raceline, Nchinda, Godwin, Montavon, Celine, Bopda, Jean, Tchana, Steve Mbickmen, Ondigui, Bienvenu Etogo, Nguluwe, Konrad, Fay, Michael P., et al.(2017). Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection . Clinical Infectious Diseases. 64. (8). p. 1017-1025.
Legrand, Fanny and Landolina, Nadine A. and Levi-Schaffer, Francesca and Klion, Amy D.(2016). Siglec-7 on Peripheral Blood Eosinophils: Surface Expression and Functional Analysis . Journal of Allergy and Clinical Immunology. 137. (2). p. AB167.
Legrand, Fanny, Landolina, Nadine A., Levi-Schaffer, Francesca, Klion, Amy D.(2016). Siglec-7 on Peripheral Blood Eosinophils: Surface Expression and Functional Analysis . Journal of Allergy and Clinical Immunology. 137. (2). p. AB167.
Legrand, Fanny, Alpaugh, Alexandra, Falahati, Rustom, Makiya, Michelle, Klion, Amy D.(2015). A Novel Therapeutic Target for the Treatment of Eosinophilic Disorders . Journal of Allergy and Clinical Immunology. 135. (2). p. AB221.
Legrand, Fanny, Klion, Amy D.(2015). Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects . Journal of Allergy and Clinical Immunology-in Practice. 3. (2). p. 167-174.
Legrand, F., Klion, A.D.(2015). Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects . Journal of Allergy and Clinical Immunology: In Practice. 3. (2). p. 167-174.
Legrand, Fanny, Tomasevic, Nenad, Makiya, Michelle, Bebbington, Christopher, Klion, Amy D.(2014). Human EMR1, An Eosinophil-Specific Surface Receptor Of Unknown Function, Is Modulated In Vivo and In Vitro . Journal of Allergy and Clinical Immunology. 133. (2). p. AB61.
Lefèvre, G., Copin, M.-C., Staumont-Sallé, D., Avenel-Audran, M., Aubert, H., Taieb, A., Salles, G., Maisonneuve, H., Ghomari, K., Ackerman, F., et al.(2014). The lymphoid variant of hypereosinophilic syndrome study of 21 patients with CD3-CD4+ aberrant T-cell phenotype . Medicine (United States). 93. (17). p. 255-266.
Legrand, Fanny, Tomasevic, Nenad, Simakova, Olga, Lee, Chyi-Chia Richard, Wang, Zengfang, Raffeld, Mark, Makiya, Michelle A., Palath, Varghese, Leung, John, Baer, Mark, et al.(2014). The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders . Journal of Allergy and Clinical Immunology. 133. (5). p. 1439-U350.
Legrand, F., Tomasevic, N., Simakova, O., Lee, C.-C.R., Wang, Z., Raffeld, M., Makiya, M.A., Palath, V., Leung, J., Baer, M., et al.(2014). The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders . Journal of Allergy and Clinical Immunology. 133. (5).
Legrand, Fanny, Lefevre, Guillaume, Copin, Marie-Christine, Staumont-Salle, Delphine, Avenel-Audran, Martine, Aubert, Helene, Taieb, Alain, Salles, Gilles, Maisonneuve, Herve, Ghomari, Kamel, et al.(2014). The Lymphoid Variant of Hypereosinophilic Syndrome Study of 21 Patients With CD3-CD4+ Aberrant T-Cell Phenotype . Medicine. 93. (17). p. 255-266.
Grainger, J.R., Wohlfert, E.A., Fuss, I.J., Bouladoux, N., Askenase, M.H., Legrand, F., Koo, L.Y., Brenchley, J.M., Fraser, I.D.C., Belkaid, Y.(2013). Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection . Nature Medicine. 19. (6). p. 713-721.
Legrand, Fanny, Grainger, John R., Wohlfert, Elizabeth A., Fuss, Ivan J., Bouladoux, Nicolas, Askenase, Michael H., Koo, Lily Y., Brenchley, Jason M., Fraser, Iain D. C., Belkaid, Yasmine(2013). Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection . Nature Medicine. 19. (6). p. 713-+.
Legrand, Fanny, Renneville, Aline, MacIntyre, Elizabeth, Mastrilli, Samuel, Ackermann, Felix, Cayuela, Jean Michel, Rousselot, Philippe, Schmidt-Tanguy, Aline, Fain, Olivier, Michel, Marc, et al.(2013). The Spectrum of FIP1L1-PDGFRA-Associated Chronic Eosinophilic Leukemia New Insights Based on a Survey of 44 Cases . Medicine. 92. (5). p. E1-E9.
Legrand, F., Renneville, A., MacIntyre, E., Mastrilli, S., Ackermann, F., Cayuela, J.M., Rousselot, P., Schmidt-Tanguy, A., Fain, O., Michel, M., et al.(2013). The spectrum of FIP1L1-PDGFRA-associated chronic eosinophilic leukemia: New insights based on a survey of 44 cases . Medicine (United States). 92. (5).
Legrand, Fanny, Driss, Virginie, Capron, Monique(2013). Eosinophil Receptor Profile . Eosinophils in Health and Disease. p. 30-38.
Legrand, Fanny, Driss, Virginie, Hermann, Emmanuel, Loiseau, Sylvie, Delbeke, Marie, Kremer, Laurent, Guerardel, Yann, Dombrowicz, David, Capron, Monique(2012). CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan . Immunology Letters. 143. (2). p. 202-207.
Kahn, J.-E., Lefèvre, G., Legrand, F.(2012). Hypereosinophilia,Hyperéosinophilies . Feuillets de Biologie. 53. (305). p. 5-12.
Legrand, Fanny, Gatault, Solene, Delbeke, Marie, Loiseau, Sylvie, Capron, Monique(2012). Involvement of eosinophils in the anti-tumor response . Cancer Immunology Immunotherapy. 61. (9). p. 1527-1534.
Gatault, S., Legrand, F., Delbeke, M., Loiseau, S., Capron, M.(2012). Involvement of eosinophils in the anti-tumor response . Cancer Immunology, Immunotherapy. 61. (9). p. 1527-1534.
Driss, V., Hermann, E., Legrand, F., Loiseau, S., Delbeke, M., Kremer, L., Guerardel, Y., Dombrowicz, D., Capron, M.(2012). CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan . Immunology Letters. 143. (2). p. 202-207.
(2011). Hyperéosinophilies et syndromes hyperéosinophiliques . EMC - Hématologie.
Freymond, N., Kahn, J.-E., Legrand, F., Renneville, A., Cordier, J.-F., Cottin, V.(2011). Clonal expansion of T cells in patients with eosinophilic lung disease . Allergy: European Journal of Allergy and Clinical Immunology. 66. (11). p. 1506-1508.
Kahn, J.-E., Ackermann, F., Prin, L., Capron, M., Legrand, F., Bletry, O.(2011). The eosinophil: From physiology to diagnostic procedure,L'éosinophile: de la physiologieà la démarche diagnostique . Revue des Maladies Respiratoires Actualites. 3. (2). p. 102-107.
Kahn, J.-E., Schoindre, Y., Legrand, F., Bletry, O., Ackermann, F.(2011). Unexplained chronic hypereosinophilia and hypereosinophilic syndrome,Hyperéosinophilies chroniques inexpliquées et syndromes hyperéosinophiliques . Revue des Maladies Respiratoires Actualites. 3. (2). p. 108-113.
Driss, V., Legrand, F., Loiseau, S., Capron, M.(2010). Eosinophil: A new effector of innate immunity?,L'eosinophile: Nouvel acteur de la réponse immunitaire innée? . Medecine/Sciences. 26. (6-7). p. 621-626.
Driss, V., Legrand, F., Loiseau, S., Capron, M.(2010). Eosinophil: a new effector of innate immunity? . M S-Medecine Sciences. 26. (6-7). p. 621-626.
Legrand, F., Driss, V., Delbeke, M., Loiseau, S., Hermann, E., Dombrowicz, D., Capron, M.(2010). Human Eosinophils Exert TNF-alpha and Granzyme A-Mediated Tumoricidal Activity toward Colon Carcinoma Cells . Journal of Immunology. 185. (12). p. 7443-7451.
Legrand, F., Driss, V., Delbeke, M., Loiseau, S., Hermann, E., Dombrowicz, D., Capron, M.(2010). Human eosinophils exert TNF-α and granzyme a-mediated tumoricidal activity toward colon carcinoma cells . Journal of Immunology. 185. (12). p. 7443-7451.
Kahn, J. E., Grandpeix-Guyodo, C., Ackermann, F., Charles, P., Legrand, F., Bletry, O.(2010). Hypereosinophilic syndromes: Pathogenic and therapeutic up-to-date . Revue De Medecine Interne. 31. (4). p. 268-276.
Kahn, J.-E., Grandpeix-Guyodo, C., Ackermann, F., Charles, P., Legrand, F., Blétry, O.(2010). Hypereosinophilic syndromes: Pathogenic and therapeutic up-to-date,Syndromes hyperéosinophiliques: Actualités physiopathologiques et thérapeutiques . Revue de Medecine Interne. 31. (4). p. 268-276.
Bletry, O., Kahn, J. E., Ackermann, F., Charles, P., Legrand, F.(2010). New insights into hypereosinophilic syndromes . Bulletin De L Academie Nationale De Medecine. 194. (3). p. 547-559.
Bletry, O., Kahn, J.-E., Ackermann, F., Charles, P., Legrand, F.(2010). New insights into hypereosinophilic syndromes,À la redécouverte des syndromes hyperéosinophiliques . Bulletin de l'Academie Nationale de Medecine. 194. (3). p. 547-560.
Legrand, F., Driss, V., Woerly, G., Loiseau, S., Hermann, E., Fournie, J. J., Heliot, L., Mattot, V., Soncin, F., Gougeon, M. L., et al.(2009). A Functional gamma delta TCR/CD3 Complex Distinct from gamma delta T Cells Is Expressed by Human Eosinophils . Plos One. 4. (6).
Legrand, F., Driss, V., Woerly, G., Loiseau, S., Hermann, E., Fournié, J.-J., Héliot, L., Mattot, V., Soncin, F., Gougeon, M.-L., et al.(2009). A functional γδTCR/CD3 complex distinct from γδT cells is expressed by human eosinophils . PLoS ONE. 4. (6).
Kanda, A., Driss, V., Hornez, N., Abdallah, M., Roumier, T., Abboud, G., Legrand, F., Staumont-Sallé, D., Quéant, S., Bertout, J., et al.(2009). Eosinophil-derived IFN-γ induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes . Journal of Allergy and Clinical Immunology. 124. (3).
Capron, M., Legrand, F.(2009). Functions of eosinophil granulocytes: from anti-parasite immunity to anti-tumoral potential . Bulletin De L Academie Nationale De Medecine. 193. (2). p. 339-346.
Driss, V., Legrand, F., Hermann, E., Loiseau, S., Guerardel, Y., Kremer, L., Adam, E., Woerly, G., Dombrowicz, D., Capron, M.(2009). TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins . Blood. 113. (14). p. 3235-3244.
Driss, V., Legrand, F., Hermann, E., Loiseau, S., Guerardel, Y., Kremer, L., Adam, E., Woerly, G., Dombrowicz, D., Capron, M.(2009). TLR2-dependent eosinophil interactions with mycobacteria: Role of α-defensins . Blood. 113. (14). p. 3235-3244.
Kanda, A., Driss, V., Hornez, N., Abdallah, M., Roumier, T., Abboud, G., Legrand, F., Staumont-Salle, D., Queant, S., Bertout, J., et al.(2009). Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes . Journal of Allergy and Clinical Immunology. 124. (3). p. 573-U269.
Capron, M., Legrand, F.(2009). Functions of eosinophil granulocytes: ffrom anti-parasite immunity to anti-tumoral potential,Fonctions des polynucléaires éosinophiles: de I'immunité anti-parasitaire aux potentialités anti tumorales . Bulletin de l'Academie Nationale de Medecine. 193. (2). p. 339-349.
(2008). Innate immune function of eosinophils: from antiparasite to antitumor cells . Methods in molecular biology (Clifton, N.J.).
Jensen-Jarolim, E., Achatz, G., Turner, M. C., Karagiannis, S., Legrand, F., Capron, M., Penichet, M. L., Rodriguez, J. A., Siccardi, A. G., Vangelista, L., et al.(2008). AllergoOncology: the role of IgE-mediated allergy in cancer . Allergy. 63. (10). p. 1255-1266.
Jensen-Jarolim, E., Achatz, G., Turner, M.C., Karagiannis, S., Legrand, F., Capron, M., Penichet, M.L., Rodríguez, J.A., Siccardi, A.G., Vangelista, L., et al.(2008). AllergoOncology: The role of IgE-mediated allergy in cancer . Allergy: European Journal of Allergy and Clinical Immunology. 63. (10). p. 1255-1266.
Legrand, F., Woerly, G., Driss, V., Capron, M.(2008). Innate immune function of eosinophils: from antiparasite to antitumor cells . Methods in molecular biology (Clifton, N.J.). 415. p. 215-240.
(2007). Peau et éosinophilie . EMC - Dermatologie.
BOOK CHAPTER
Weller, P.F., Melo, R.C.N., Dvorak, A.M., Driss, V., Legrand, F., Capron, M.(2013). Eosinophil Structure and Cell Surface Receptors . Eosinophils in Health and Disease. p. 19-38.