Profile Details

Create Project

★★★★★

☆☆☆☆☆

USD 100 /hr

★★★★★

☆☆☆☆☆

Hire Dr. Fabiana L.

Switzerland

USD 100 /hr

Senior Scientist and writer in Immunology with 10+years

Profile Summary

Scientific expert in immunology studying infectious diseases as malaria and Chagas disease and vaccines development. Experience leading multidisciplinary teams in international contexts. Management experience in strategic and operational needs of laboratories researching immunology. Dynamic and versatile personality to work in international and multi-disciplinary teams. Technical competences: • Development vaccine platforms, such as recombinant modified vaccinia ankara (MVA), adenoviruses and Virus like particle (VLP) for malaria, Chagas and HIV. • Performing monocytes, neutrophils, mastocytes, T and B cells immunophenotyping assays involving multicolor flow cytometry (LRS Fortessa and FACSCanto), ELISA and ELISPOT assays • Developing various techniques to separate innate immune cells (dendritic cells, monocytes and neutrophils) using magnetic beads. • Developing in vitro cultivation methods of Plasmodium vivax using purified reticulocytes from whole blood and cord blood from donors. • Performing experiments using OT-II transgenic mice, C57BL/6J, C3H/HeJ and Balb/c mice.

Subject Matter Expertise

• ★ Cell Biology
• ★ Basic Immunology
• ★ Cell Surface Receptors
• ☆ Molecular Biology
• ☆ PCR
• ☆ Cell-Based Assays
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Blotting
• ☆ Cytometry
• ☆ Vaccine Development
• ☆ Human Biology
• ☆ Infectious Disease
• ☆ Tropical Medicine
• ☆ Malaria

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Clinical Trial Documentation, Technical Writing, Translation

Research User Research, Fact Checking, Gray Literature Search, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis

Work Experience

Laboratory Manager/ Research fellow

University of Bern

February 2016 - November 2018

Post-doctoral Fellow

Jenner Institute, University of Oxford

September 2013 - August 2015

Post-doctoral Fellow

University Notre Dame Centre for Rare and Neglected Diseases South Bend -USA

July 2012 - July 2013

Post-doctoral Fellow

Centre of Research René Rachou, FIOCRUZ Laboratory Immnunopathology Brazil

February 2009 - July 2012

Education

Sciences

University of São Paulo (Faculty of Medicine)

July 2005 - September 2009

Sciences

University of São Paulo (Faculty of Medicine)

July 2001 - August 2004

Biochemistry Pharmacist

University Camilo Castelo Branco

February 1995 - December 1998

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Young Chan Kim, Barbara Dema, Roberto Rodriguez-Garcia, CESAR LOPEZ-CAMACHO, Fabiana M. S. Leoratti, Amar Lall, Edmond J. Remarque, Clemens H. M. Kocken, Arturo Reyes-Sandoval (2020). Evaluation of Chimpanzee Adenovirus and MVA Expressing TRAP and CSP from Plasmodium cynomolgi to Prevent Malaria Relapse in Nonhuman Primates . Vaccines.

Gurdip Mann, Amanda F. Francisco, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, Francisco Olmo, Elisangela Oliveira de Freitas, Fabiana M. S. Leoratti, CESAR LOPEZ-CAMACHO, Arturo Reyes-Sandoval, et al. (2020). Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection . PLOS Neglected Tropical Diseases.

Ariane C. Gomes, Mona O. Mohsen, Julius E. Mueller, Fabiana M. S. Leoratti, Gustavo Cabral-Miranda, Martin F. Bachmann (2019). Early Transcriptional Signature in Dendritic Cells and the Induction of Protective T Cell Responses Upon Immunization With VLPs Containing TLR Ligands—A Role for CCL2 . Frontiers in Immunology.

Caroline C. Krueger, Franziska Thoms, Elsbeth Keller, Fabiana M. S. Leoratti, Monique Vogel, Martin F. Bachmann (2019). RNA and Toll-Like Receptor 7 License the Generation of Superior Secondary Plasma Cells at Multiple Levels in a B Cell Intrinsic Fashion . Frontiers in Immunology.

Lisha Zha, Fabiana M.S. Leoratti, Lichun He, Mona O. Mohsen, Mark Cragg, Federico Storni, Monique Vogel, Martin F. Bachmann (2018). An unexpected protective role of low-affinity allergen-specific IgG through the inhibitory receptor FcγRIIb . Journal of Allergy and Clinical Immunology.

Fabiana Leoratti, Gustavo Cabral-Miranda, Matthew Heath, Mona Mohsen, Ariane Gomes, Paul Engeroff, Amy Flaxman, Aadil El-Turabi, Arturo Reyes-Sandoval, Murray Skinner, et al. (2017). Virus-Like Particle (VLP) Plus Microcrystalline Tyrosine (MCT) Adjuvants Enhance Vaccine Efficacy Improving T and B Cell Immunogenicity and Protection against Plasmodium berghei/vivax . Vaccines.

Mona O. Mohsen, Ariane C. Gomes, Gustavo Cabral-Miranda, Caroline C. Krueger, Fabiana MS Leoratti, Jens V. Stein, Martin F. Bachmann (2017). Delivering adjuvants and antigens in separate nanoparticles eliminates the need of physical linkage for effective vaccination . Journal of Controlled Release.

Fabiana Leoratti, Eduardo Alves, Ahmed M. Salman, Cesar Lopez-Camacho, Martha Eva Viveros-Sandoval, Amar Lall, Aadil El-Turabi, Martin F. Bachmann, Adrian V. S. Hill, Chris J. Janse, et al. (2017). Evaluation of Plasmodium vivax Cell-Traversal Protein for Ookinetes and Sporozoites as a Preerythrocytic P. vivax Vaccine . Clinical and Vaccine Immunology.

Elisangela Oliveira de Freitas, Fabiana Maria de Souza Leoratti, Célio Geraldo Freire-de-Lima, Alexandre Morrot, Daniel Ferreira Feijó (2016). The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis . Frontiers in Immunology.

Pedro A. C. Costa, Fabiana M. S. Leoratti, Maria M. Figueiredo, Mauro S. Tada, Dhelio B. Pereira, Caroline Junqueira, Irene S. Soares, Daniel L. Barber, Ricardo T. Gazzinelli, Lis R. V. Antonelli (2015). Induction of Inhibitory Receptors on T Cells During<i>Plasmodium vivax</i>Malaria Impairs Cytokine Production . Journal of Infectious Diseases.

Bruno&#160;Coelho Rocha, Pedro&#160;Elias Marques, Fabiana&#160;Maria&#160;de&#160;Souza Leoratti, Caroline Junqueira, Dhelio&#160;Batista Pereira, Lis&#160;Ribeiro&#160;do&#160;Valle Antonelli, Gustavo&#160;Batista Menezes, Douglas&#160;Taylor Golenbock, Ricardo&#160;Tostes Gazzinelli (2015). Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria . Cell Reports.

Lis R. V. Antonelli, Fabiana M. S. Leoratti, Pedro A. C. Costa, Bruno C. Rocha, Suelen Q. Diniz, Mauro S. Tada, Dhelio B. Pereira, Andrea Teixeira-Carvalho, Douglas T. Golenbock, Ricardo Gon&#231;alves, et al. (2014). The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria . PLoS Pathogens.

Fabiana Maria de Souza Leoratti, Silvia Cellone Trevelin, Fernando Queiroz Cunha, Bruno Coelho Rocha, Pedro Augusto Carvalho Costa, Humberto Dorigu&#234;tto Gravina, Mauro Shugiro Tada, Dhelio Batista Pereira, Douglas Taylor Golenbock, Lis Ribeiro do Valle Antonelli, et al. (2012). Neutrophil Paralysis in Plasmodium vivax Malaria . PLoS Neglected Tropical Diseases.

Fabiana MS Leoratti, Rui R Durlacher, Marcus VG Lacerda, Maria G Alecrim, Antonio W Ferreira, Maria CA Sanchez, Sandra L Moraes (2008). Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria . Malaria Journal.

Fabiana&#160;M.&#160;S. Leoratti, Lilian Farias, Fabiana&#160;P. Alves, Martha&#160;C. Suarez‐M&#250;tis, Jos&#233;&#160;R. Coura, Jorge Kalil, Erney&#160;P. Camargo, Sandra&#160;L Moraes, Rajendranath Ramasawmy (2008). Variants in the Toll‐Like Receptor Signaling Pathway and Clinical Outcomes of Malaria . The Journal of Infectious Diseases.

Martha C. Su&#225;rez-Mutis, Patricia Cuervo, Fabiana M.S. Leoratti, Sandra L. Moraes-Avila, Antonio Walter Ferreira, Octavio Fernandes, Jos&#233; Rodrigues Coura (2007). Cross sectional study reveals a high percentage of asymptomatic Plasmodium vivax infection in the Amazon Rio Negro area, Brazil . Revista do Instituto de Medicina Tropical de São Paulo.

Kelly A. Kanunfre, Fabiana M. S. Leoratti, Erika H. E. Hoffmann, Rui R. Durlacher, Antônio W. Ferreira, Sandra L. Moraes-Ávila, Marcelo U. Ferreira (2003). Differential Recognition of <i>Plasmodium falciparum</i> Merozoite Surface Protein 2 Variants by Antibodies from Malaria Patients in Brazil . Clinical and Vaccine Immunology.