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Hire Eric R.

Brazil

USD 175 /hr

PhD Immunologist | Clinical Research Expert | Infectious & Tropical Diseases | Fiocruz/INI Brazil

Profile Summary

I am a PhD immunologist and senior clinical researcher at the Evandro Chagas National Institute of Infectology (INI), Oswaldo Cruz Foundation (Fiocruz) — Brazil's leading public health research institution, linked to the Ministry of Health. My research focuses on understanding how the human immune system interacts with major infectious pathogens, with over a decade of hands-on experience in: ▸ Tuberculosis — including the immunology of the RDRio strain, which dominates in Rio de Janeiro and differs significantly from reference strains in macrophage interaction and immune evasion ▸ Visceral and cutaneous leishmaniasis — Th1/Th2 balance, immune exhaustion, and treatment response in Brazilian cohorts ▸ Chagas disease — immunopathogenesis of cardiomyopathy, CD8+ T cell dynamics, and clinical trial design ▸ COVID-19 and post-infection immunity — longitudinal immune profiling of patients and survivors at INI/Fiocruz I can assist clients with: ▸ Scientific protocol review and study design (immunological endpoints, biomarker selection, patient eligibility criteria) ▸ Expert opinion on immunological mechanisms for pharma/biotech pipeline decisions ▸ Critical review of scientific data packages for regulatory submissions or investor materials ▸ Market landscape analysis for infectious disease therapeutics and diagnostics in Latin America I supervise MSc and PhD students, teach immunology at Fiocruz's postgraduate program, and have co-authored peer-reviewed publications with international collaborators. My institutional affiliation provides access to one of the most comprehensive infectious disease patient cohorts in Latin America.

Subject Matter Expertise

• ★ Pathogenesis
• ★ Infectious Disease
• ★ Inflammation
• ☆ Microbiology
• ☆ Parasitology
• ☆ Biochemistry
• ☆ Apoptosis
• ☆ Molecular Biology
• ☆ Omics
• ☆ Transcriptomics
• ☆ Recombinant DNA
• ☆ Biotechnology & Bioengineering
• ☆ Industrial Biotechnology
• ☆ Vaccine Development
• ☆ Viral Diseases
• ☆ COVID-19
• ☆ Pulmonology/Respiratory Disease
• ☆ Tuberculosis

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Copywriting, Creative Writing

Research Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Data Visualization, Data Cleaning

Product Development Formulation, Product Evaluation, Product Validation

Work Experience

Reseacher

Fundação Oswaldo Cruz

March 2013 - Present

Education

PhD (Biochemistry and Immunology)

Universidade Federal de Minas Gerais

March 2009 - October 2013

MSc (Biochemistry and Immunology)

Universidade Federal de Minas Gerais

March 2007 - February 2009

Bachelor (Biochemistry and Immunology)

Universidade Federal de Minas Gerais

September 2003 - December 2006

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Eric Henrique Roma, Juliana Lauar Gonçalves (2026). Editorial: Immunometabolism: exploring the nexus of metabolism and immune function in health and disease . Frontiers in Immunology.

Eric Henrique Roma, Fabielle Marques-Santos, Alinne Rangel dos Santos Renzetti, Luciana Fernandes Portela, Filipe Pereira da Costa, Alejandro Marcel Hasslocher-Moreno, Marcelo Teixeira de Holanda, Luiz Henrique Conde Sangenis, Andréa Rodrigues da Costa, Joseli Lannes-Vieira, et al. (2026). Transcriptome Analysis of Circulating microRNAs Associated With Chagas Disease Susceptibility and Chronic Chagas Cardiomyopathy Severity . The Journal of Infectious Diseases.

Gilcele de Campos Martin Berber, Kevin Matheus Lima de Sarges, Thais Campos Dias da Cruz, Eric Henrique Roma, Fábio Miyajima, Jorge Reis Almeida, Cíntia Fernandes de Souza, Andrea Alice da Silva, Izaura Maria Vieira Cayres Vallinoto, Antônio Carlos Rosário Vallinoto, et al. (2025). Polymorphisms in HLA genes among Brazilian patients hospitalized with COVID-19: Insights from a multicentric study . Microbial Pathogenesis.

Costa, M.F.D.S., Pereira-Dutra, F., Deboosere, N., Jouny, S., Song, O.-R., Iack, G., Souza, A.L., Roma, E.H., Delorme, V., Bozza, P.T., et al.(2023). Mycobacterium tuberculosis induces delayed lipid droplet accumulation in dendritic cells depending on bacterial viability and virulence . Molecular Microbiology. 119. (2). p. 224-236.

Schor, D., Porto, L.C., Roma, E.H., Castro-Alves, J., Villela, A.P., Araújo, A.Q.C., Glória Bonecini-Almeida, M.(2023). Putative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population . Scientific Reports. 13. (1).

de Lima, M.R., Leandro, A.C.C.S., de Souza, A.L., Barradas, M.M., Roma, E.H., Fernandes, A.T.G., Galdino-Silva, G., Carvalho, J.K.M.R., Marchevsky, R.S., Coelho, J.M.C.O., et al.(2023). Safety and Immunogenicity of an In Vivo Muscle Electroporation Delivery System for DNA-hsp65 Tuberculosis Vaccine in Cynomolgus Monkeys . Vaccines. 11. (12).

Fernandes, A.T.G., Carvalho, M.O.O., Avvad-Portari, E., Rocha, N.P., Russomano, F., Roma, E.H., Bonecini-Almeida, M.G.(2021). A prognostic value of CD45RA⁺, CD45RO⁺, CCL20⁺ and CCR6⁺ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV . Scientific Reports. 11. (1).

Gonçalves, J.L., Silva, M.C.A., Roma, E.H., Grinsztejn, B., de Lemos, A.S., Moreira, N.G., Cruz, A.M., de Almeida, C.F., Quintana, M.S.B., Bonecini-Almeida, M.D.G., et al.(2019). Iron intake is positively associated with viral load in antiretroviral naïve brazilian men living with hiv . Memorias do Instituto Oswaldo Cruz. 114. (12).

Juliana Lauar Gonçalves, Maria Clara Amorim Silva, Eric Henrique Roma, Beatriz Grinsztejn, Alberto dos Santos de Lemos, Nathalia Gorni, Adele Moura Cruz, Cristiane Fonseca de Almeida, Marcel de Souza Borges Quintana, Maria da Gloria Bonecini-Almeida, et al.(2019). Iron intake is positively associated with viral load in antiretroviral naïve Brazilian men living with HIV . Memórias do Instituto Oswaldo Cruz. 114. {FapUNIFESP} ({SciELO})

Da Rocha, N.P., Avvad-Portari, E., Russomano, F., Roma, E.H., Pinto, A.C., Klumb, E., Macedo, J., Fernandes, A.T.G., Bonecini-Almeida, M.D.G.(2019). TNFR1 single nucleotide polymorphisms are not associated with cervical HPV-induced pre-malignant lesion but regulate in situ cervical TNFR1 expression . Oncotarget. 10. (9). p. 953-965.

Doris Schor, Luís Cristóvão Porto, Eric Henrique Roma, Marcel de Souza Borges Quintana, Gustavo Milson Fabricio-Silva, Maria Gloria Bonecini-Almeida, Abelardo Queiroz-Campos Araújo, Maria Jose Andrada-Serpa(2018). Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil . BMC Infectious Diseases. 18. (1). Springer Nature

Matheus B H Carneiro, Eric H Roma, Adam J Ranson, Nicole A Doria, Alain Debrabant, David L Sacks, Leda Q Vieira, Nathan C Peters (2018). NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis . The Journal of Immunology.

Carneiro, M.B.H., Roma, E.H., Ranson, A.J., Doria, N.A., Debrabant, A., Sacks, D.L., Vieira, L.Q., Peters, N.C.(2018). NOX2-derived reactive oxygen species control inflammation during leishmania amazonensis infection by mediating infection-induced neutrophil apoptosis . Journal of Immunology. 200. (1). p. 196-208.

Holanda, M.T., Mediano, M.F.F., Hasslocher-Moreno, A.M., Xavier, S.S., Saraiva, R.M., Sousa, A.S., MacIel, E.R., Carneiro, F.M., Da Silva, P.S., Sangenis, L.H.C., et al.(2018). A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial . Trials. 19. (1).

Schor, D., Porto, L.C., Roma, E.H., Quintana, M.D.S.B., Fabricio-Silva, G.M., Bonecini-Almeida, M.G., Araújo, A.Q.-C., Andrada-Serpa, M.J.(2018). Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil . BMC Infectious Diseases. 18. (1).

Ingebourg Georg, Alain Debrabant, Alejandro Marcel Hasslocher-Moreno, Sergio Salles Xavier, Marcelo Teixeira de Holanda, Eric Henrique Roma, Maria da Gloria Bonecini-Almeida(2017). Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: Correlation between antibody titers and development of cardiac disease severity . PLOS Neglected Tropical Diseases. 11. (7). p. e0005796. Public Library of Science ({PLoS})

Georg, I., Hasslocher-Moreno, A.M., Xavier, S.S., Holanda, M.T.D., Roma, E.H., Bonecini-Almeida, M.D.G.(2017). Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: Correlation between antibody titers and development of cardiac disease severity . PLoS Neglected Tropical Diseases. 11. (7).

Romano, A., Carneiro, M. B. H., Doria, N. A., Roma, E. H., Ribeiro-Gomes, F. L., Inbar, E., Lee, S. H., Mendez, J., Paun, A., Sacks, D. L., et al.(2017). Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major . PLoS Pathog. 13. (6). p. e1006479.

Romano, A., Carneiro, M.B.H., Doria, N.A., Roma, E.H., Ribeiro-Gomes, F.L., Inbar, E., Lee, S.H., Mendez, J., Paun, A., Sacks, D.L., et al.(2017). Divergent roles for Ly6C⁺CCR2⁺CX3CR1⁺inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major . PLoS Pathogens. 13. (6).

Mendes, T.M., Roma, E.H., Costal-Oliveira, F., Dhom-Lemos, L.D., Toledo-Machado, C.M., Bruna-Romero, O., Bartholomeu, D.C., Fujiwara, R.T., Chávez-Olórtegui, C.(2017). Epitope mapping of recombinant Leishmania donovani virulence factor A2 (recLdVFA2) and canine leishmaniasis diagnosis using a derived synthetic bi-epitope . PLoS Neglected Tropical Diseases. 11. (5).

Roma, E. H., Macedo, J. P., Goes, G. R., Gonçalves, J. L., Castro, W., Cisalpino, D., Vieira, L. Q.(2016). Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection . Parasit Vectors. 9. (1). p. 193.

Roma, E.H., Macedo, J.P., Goes, G.R., Gonçalves, J.L., Castro, W.D., Cisalpino, D., Vieira, L.Q.(2016). Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection . Parasites and Vectors. 9. (1).

Ribeiro-Gomes, F.L., Roma, E.H., Carneiro, M.B., Doria, N.A., Sacks, D.L., Peters, N.C.(2014). Site-dependent recruitment of inflammatory cells determines the effective dose of Leishmania major . Infection and Immunity. 82. (7). p. 2713-2727.

Peters, N.C., Pagán, A.J., Lawyer, P.G., Hand, T.W., Henrique Roma, E., Stamper, L.W., Romano, A., Sacks, D.L.(2014). Chronic Parasitic Infection Maintains High Frequencies of Short-Lived Ly6C⁺CD4⁺ Effector T Cells That Are Required for Protection against Re-infection . PLoS Pathogens. 10. (12).

Gonçalves, J.L., Roma, E.H., Gomes-Santos, A.C., Aguilar, E.C., Cisalpino, D., Fernandes, L.R., Vieira, A.T., Oliveira, D.R., Cardoso, V.N., Teixeira, M.M., et al.(2012). Pro-inflammatory effects of the mushroom Agaricus blazei and its consequences on atherosclerosis development . European Journal of Nutrition. 51. (8). p. 927-937.

Horta, M.F., Mendes, B.P., Roma, E.H., Noronha, F.S.M., MacDo, J.P., Oliveira, L.S., Duarte, M.M., Vieira, L.Q.(2012). Reactive oxygen species and nitric oxide in cutaneous leishmaniasis . Journal of Parasitology Research. 2012.

PREPRINT

Gabrielle Galdino-Silva, Nicole Estanislau Martins, Valeria C. Rolla, Maria da Gloria Bonecini-Almeida, Eric Henrique Roma (2026). Reorganization of Renin-Angiotensin-Neutrophil Correlation Network Is Associated with COVID-19 Severity .

Eric Henrique Roma, Fabielle Marques-Santos, Alinne Rangel dos Santos Renzetti, Luciana Fernandes Portela, Filipe Pereira da Costa, Alejandro Marcel Hasslocher-Moreno, Marcelo Teixeira de Holanda, Luiz Henrique Conde Sangenis, Andréa Rodrigues da Costa, Joseli Lannes-Vieira, et al. (2025). Transcriptome analysis of circulating microRNAs associated with Chagas disease susceptibility and chronic Chagas cardiomyopathy severity .

OTHER

Lopes, G.S., Rocha, N.P., Russomano, F.B., Avvad-Portari, E., Andrade, C.V., Furtado, Y.L., Guerra-Neto, N.G.M., Roma, E.H., da Gloria Bonecini-Almeida, M., Fernandes, A.T.G.(2022). Exploratory cross-sectional study to evaluate the metalloproteinases role as ‘immunoscore’ for HPV-induced cervical lesions . Research Square.

Schor, D., Porto, L.C., Roma, E.H., Castro-Alves, J., Villela, A.P., Araújo, A.Q.C., Bonecini-Almeida, M.D.G.(2022). The influence of human leukocyte antigen class I loci -A, -B, -C, and class II HLA-DRB1 alleles in a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population and association with disease outcome and proviral load . Research Square.