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Ethiopia

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Drug design, molecular docking, spectroscopy, nanomaterial synthesis & application, quantum chemistry, photocatalysis

Profile Summary

Dr. Ephriem Tadesse Mengesha is an Associate Professor of Physical Chemistry at Haramaya University, Ethiopia. He holds a Ph.D. from the Polish Academy of Sciences and has conducted postdoctoral research in France (CEA-Saclay) and the USA (Arizona State University), specializing in molecular spectroscopy, proton tunneling, and nanomaterials synthesis and application. His current research focuses on computational and experimental drug design against Mycobacterium tuberculosis, development of nano sensors, and he has published over 20 peer-reviewed articles. A Lindau Nobel Laureate Meeting participant and Eurotalent Fellow.

Subject Matter Expertise

• ☆ Materials Science & Engineering
• ☆ Nanotechnology & Nanomaterials
• ☆ Physical Chemistry
• ☆ Quantum Chemistry
• ☆ Biophysics
• ☆ Drug Discovery
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Drug Substance Characterization
• ☆ Drug Stability Testing

Services

• Research
• Consulting
• Product Development

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Product Development Stability/Shelf Life Testing, Concept Development

Work Experience

Associate professor

Haramaya University

December 2020 - Present

Education

PhD (Photochemistry and Spectroscopy)

Institute of Physical Chemistry

- Present

Certifications

• PhD in chemical Sciences

  Institute of physical chemistry Polish Academy of sciences

  March 2015 - Present

Publications

JOURNAL ARTICLE

F. Grollau, E. Mengesha, J.-M. Mestdagh, V. Brenner, E. Gloaguen, M. Mons, M. Briant (2025). The 4(5)-methylimidazole System in the gas phase: Insights from helium droplet experiment vs. quantum chemistry . Low Temperature Physics.

Mechalu Abebe Adose, Endale Teju Bedada, R. Ramamoorthy, S. Ramalingam, Ephrem Taddesse, Boobalan Maria Susai(2022). Molecular design, electronic structure and optoelectronic properties of vinyl fused monomeric and oligomeric benzothiazoles—A theoretical investigation . Synthetic Metals. 289. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 117133. Elsevier {BV}

Bruktawit Mekonnen Sanka, Dereje Mamo Tadesse, Endale Teju Bedada, Ephriem T. Mengesha, Neelaiah Babu G.(2022). Design, synthesis, biological screening and molecular docking studies of novel multifunctional 1,4-di (aryl/heteroaryl) substituted piperazine derivatives as potential antitubercular and antimicrobial agents . Bioorganic Chemistry. 119. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105568. Elsevier {BV}

Mekonnen Sanka, B., Mamo Tadesse, D., Teju Bedada, E., Mengesha, E.T., Babu G., N.(2022). Design, synthesis, biological screening and molecular docking studies of novel multifunctional 1,4-di (aryl/heteroaryl) substituted piperazine derivatives as potential antitubercular and antimicrobial agents . Bioorganic Chemistry. 119.

Mengesha, E.T., Le, A.T., Steimle, T.C., Cheng, L., Zhang, C., Augenbraun, B.L., Lasner, Z., Doyle, J.(2020). Branching Ratios, Radiative Lifetimes, and Transition Dipole Moments for YbOH . Journal of Physical Chemistry A. 124. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3135-3148.

Steimle, T.C., Linton, C., Mengesha, E.T., Bai, X., Le, A.T.(2019). Field-free, Stark, and Zeeman spectroscopy of the à 2 Π1/2- X 2 ς+ transition of ytterbium monohydroxide . Physical Review A. 100. (5).

Briant, M., Viel, A., Mengesha, E., Gaveau, M.-A., Soep, B., Mestdagh, J.-M., Jamet, P., Launay, J.-M., Poisson, L.(2019). Large amplitude motion within acetylene-rare gas complexes hosted in helium droplets . Physical Chemistry Chemical Physics. 21. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1038-1045.

Gutiérrez-Quintanilla, A., Briant, M., Mengesha, E., Gaveau, M.-A., Mestdagh, J.-M., Soep, B., Poisson, L.(2019). Propyne-water complexes hosted in helium droplets . Fizika Nizkikh Temperatur. 45. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 744-749.

Gutiérrez-Quintanilla, A., Briant, M., Mengesha, E., Gaveau, M.-A., Mestdagh, J.-M., Soep, B., Poisson, L.(2019). Propyne-water complexes hosted in helium droplets . Low Temperature Physics. 45. (6).

Gutiérrez-Quintanilla, A., Briant, M., Mengesha, E., Gaveau, M.-A., Mestdagh, J.-M., Soep, B., Crépin, C., Poisson, L.(2018). A HElium NanoDroplet Isolation (HENDI) investigation of the weak hydrogen bonding in the propyne dimer (CH₃CCH)₂ . Physical Chemistry Chemical Physics. 20. (45). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 28658-28666.

Mengesha, E.T., Demissie, T.B., Redi-Abshiro, M., Mohammed, A.M.(2018). Dual fluorescence of (E)-N-(4-(dimethylamino)benzylidene)-2H-1,2,4-triazol-3-amine (DMABA-Amtr): A ground state perspective . Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 189. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 601-607.

Briant, M., Mengesha, E., Gaveau, M.-A., Soep, B., Mestdagh, J.-M., Poisson, L.(2018). Dynamics of acetylene dimers hosted in helium droplets . Physical Chemistry Chemical Physics. 20. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2597-2605.

Demissie, E.G., Mengesha, E.T., Woyessa, G.W.(2017). Modified solvatochromic equations for better estimation of ground and excited state dipole moments of p-aminobenzoicacid (PABA): Accounting for real shape over hypothetical spherical solvent shell . Journal of Photochemistry and Photobiology A: Chemistry. 337. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 184-191.

Fita, P., Grill, L., Listkowski, A., Piwoński, H., Gawinkowski, S., Pszona, M., Sepioł, J., Mengesha, E., Kumagai, T., Waluk, J.(2017). Spectroscopic and microscopic investigations of tautomerization in porphycenes: Condensed phases, supersonic jets, and single molecule studies . Physical Chemistry Chemical Physics. 19. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4921-4937.

P. Fita, L. Grill, A. Listkowski, H. Piwoński, S. Gawinkowski, M. Pszona, J. Sepioł, E. Mengesha, T. Kumagai, J. Waluk (2017). Spectroscopic and microscopic investigations of tautomerization in porphycenes: condensed phases, supersonic jets, and single molecule studies . Physical Chemistry Chemical Physics.

Briant, M., Mengesha, E., De Pujo, P., Gaveau, M.-A., Soep, B., Mestdagh, J.-M., Poisson, L.(2016). Large amplitude motion of the acetylene molecule within acetylene-neon complexes hosted in helium droplets . Physical Chemistry Chemical Physics. 18. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 16414-16422.

Kijak, M., Peukert, S., Mengesha, E., Sepioł, J., Gil, M.(2016). Supersonic Jet Spectroscopy and Density Functional Theory Study of Isomeric Diazines: 1,4- and 1,8-Diazatriphenylene. Why Do They Differ so Deeply? . Journal of Physical Chemistry A. 120. (40). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7817-7827.

Mengesha, E.T., Zehnacker-Rentien, A., Sepioł, J., Kijak, M., Waluk, J.(2015). Spectroscopic study of jet-cooled deuterated porphycenes: Unusual isotopic effects on proton tunneling . Journal of Physical Chemistry B. 119. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2193-2203.

Mengesha, E.T., Sepio, J., Borowicz, P., Waluk, J.(2013). Vibrations of porphycene in the S₀ and S₁ electronic states: Single vibronic level dispersed fluorescence study in a supersonic jet . Journal of Chemical Physics. 138. (17).

Sepioł, J., Grabowska, A., Kijak, M., Borowicz, P., Mengesha, E., Nowacki, J.(2012). Partial deuterium substitution as a tool for identification of the most stable conformer of a polyatomic molecule. A case of the 2,5-bis(2-benzoxazolyl) -1,4-dimethoxybenzene in supersonic jet . Chemical Physics Letters. 554. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 43-46.

OTHER

Mengesha, E.T., Nibret, Y.T., Tadesse Mengesha, A., Bedada, E.T., Mekonnen, T.B., Bezu Gemechu, Z.(2023). Size Dependent Solvatochromism of CDS Nanoparticles: Experimental Absorption and Fluorescence Analyses . SSRN.

Ephriem Tadesse Mengesha, Yordanos T. Nibret, Abi Tadesse, Endale T. Bedada, Tigabu B. Mekonnen, Zewdu Bezu(2023). Size Dependent Solvatochromism of CDS Nanoparticles: Experimental Absorption and Fluorescence Analyses . Elsevier {BV}

Mengesha, E.T., Le, A.T., Steimle, T.C., Cheng, L., Zhang, C., Augenbraun, B.L., Lasner, Z., Doyle, J.(2020). Branching ratios, radiative lifetimes and transition dipole moments for YbOH . arXiv.