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Profile Details
Subject Matter Expertise
Services
Work Experience
Senior Medical Advisor
Takeda Pharmaceuticals UK Ltd
November 2019 - Present 
UK Medical Lead Immunology HAE
Shire Pharmaceuticals Limited
October 2016 - October 2019
UK Medical Lead Immunology
Baxalta AG
June 2016 - September 2016
Research Fellow in Immunology of Liver Transplantation
King's College London
September 2011 - September 2014
Research Fellow in Immunology of Liver Transplantation
Institute of Liver Studies, King’s College London
August 2011 - August 2014
Senior Investigator in Asthma Immunotherapy
King's College London
October 2008 - August 2011
Senior Investigator in Asthma Immunotherapy
MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, King's College London
September 2008 - July 2011
Post-doctoral Research Fellow
King's College London
May 2004 - September 2008
Senior Investigator in Asthma Immunotherapy
Department of Asthma, Allergy and Respiratory sciences, King’s College London
April 2004 - August 2008
PhD student
INSERM U563
September 2000 - March 2004
PhD student
Physiopathology Centre of Toulouse-Purpan (CPTP, INSERM), Toulouse France
August 2000 - March 2004
Specialist registrar in Clinical Bio-Pathology
Clinical Immunology and Cell Therapy, University Hospital of Toulouse,
August 1998 - August 2000
Education
PhD (School of Biological Sciences, Health and Biotechnology)
Université Paul Sabatier - Complexe Scientifique de Rangueil
September 2000 - March 2004
PhD
School of Biological sciences, Health and Biotechnology, University Paul Sabatier, Toulouse, France
August 2000 - March 2004
MD (School of medicine)
Université Paul Sabatier
September 1993 - August 2000
MD
University Paul Sabatier, School of medicine, Toulouse France
August 1995 - March 2000
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
(2019). Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration . Hepatology (Baltimore, Md.).
(2018). Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration . Hepatology (Baltimore, Md.).
(2015). Impact of Donation Mode on the Proportion and Function of T Lymphocytes in the Liver . PloS one.
J. E. Vasiliou, S. Lui, S. A. Walker, V. Chohan, E. Xystrakis, A. Bush, C. M. Hawrylowicz, S. Saglani, C. M. Lloyd(2014). Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease . Allergy. 69. (10). p. 1380--1389. Wiley-Blackwell
J.Z.H. Neo, X. Huang, E. Xystrakis, M.S. Longhi, W. Jassem, G. Mieli-Vergani, D. Vergani, Y. Ma(2014). P388 {NK} {AND} {NKT} {CELLS} {EXPRESSING} {CD}161 {\textendash} A C-{TYPE} {LECTIN} {CONFERRING} {REGULATORY} {PROPERTIES} {\textendash} {ARE} {MARKEDLY} {REDUCED} {IN} {AUTOIMMUNE} {HEPATITIS} . Journal of Hepatology. 60. (1). p. S197. Elsevier {BV}
A. Sen, M. Shkodra, M. Tena, E. Xystrakis, P. Srinivasan, H. Vilca-Melendez, N. Heaton, Y. Ma, W. Jassem, C. Legido-Quigley(2014). P6 {LIPIDOME} {INVESTIGATION} {OF} {DBD}, {DCD} {AND} {LRD} {LIVERS} {SHOWS} {DIFFERENCES} {IN} {LIPID} {MEDIATED} {INTRACELLULAR} {SIGNALLING} {PATHWAYS} . Journal of Hepatology. 60. (1). p. S68. Elsevier {BV}
R. Sharma, Y. Jabri, E. Xystrakis, P. Srinivasan, A. Prachalias, X. Huang, G.M. Vijay, N. Heaton, Y. Ma, W. Jassem(2014). P13 {HUMAN} {INTRAHEPATIC} {CD}4CD25FOXP3 {REGULATORY} T {CELLS} {TREATED} {BY} {RAPAMYCIN} {AND} {RETINOIC} {ACID} {EFFECTIVELY} {SUPPRESS} {ALLOGENIC} T {EFFECTORS} {OF} {PERIPHERAL} {BLOOD} . Journal of Hepatology. 60. (1). p. S70--S71. Elsevier {BV}
E. Xystrakis, X. Huang, S. Fuggle, N. Heaton, Y. Ma, W. Jassem(2013). 188 {THE} {MODE} {OF} {DEATH} {OF} {THE} {LIVER} {DONOR} {IMPRINTS} {DISTINCT} {IMMUNE} {ADAPTIVE} {RESPONSES} {ON} {THE} {HEPATIC} {RESIDENT} {LYMPHOCYTES} . Journal of Hepatology. 58. p. S83. Elsevier {BV}
A. Gupta, S. Dimeloe, D. F. Richards, E. S. Chambers, C. Black, Z. Urry, K. Ryanna, E. Xystrakis, A. Bush, S. Saglani, et al.(2013). Defective {IL}-10 expression and in vitro steroid-induced {IL}-17A in paediatric severe therapy-resistant asthma . Thorax. 69. (6). p. 508--515. {BMJ}
Emmanuel Xystrakis, Zoë Urry, Emma S. Chambers, Sarah Dimeloe, David F. Richards, Leona Gabryšová, Jillian Christensen, Atul Gupta, Sejal Saglani, Andrew Bush, et al.(2012). The role of 1$\upalpha$,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3 $\mathplus$ and {IL}-10 $\mathplus$ {CD}4 $\mathplus$ T cells . European Journal of Immunology. 42. (10). p. 2697--2708. Wiley-Blackwell
Emmanuel Xystrakis, Robin Daniel Abeles, Mark J. McPhail, David Sowter, Charalambos G. Antoniades, Nikhil Vergis, Godhev K. Manakkat Vijay, Wafa Khamri, Debbie L. Shawcross, Yun Ma, et al.(2012). {CD}14, {CD}16 and {HLA}-{DR} reliably identifies human monocytes and their subsets in the context of pathologically reduced {HLA}-{DR} expression by {CD}14hi/{CD}16neg monocytes: Expansion of {CD}14hi/{CD}16pos and contraction of {CD}14lo/{CD}16pos monocytes in acute liver fail . Cytometry Part A. 81A. (10). p. 823--834. Wiley-Blackwell
Emmanuel Xystrakis, Zoë Urry, David F. Richards, Joanne McDonald, Zahid Sattar, David J. Cousins, Christopher J. Corrigan, Emma Hickman, Zarin Brown, Catherine M. Hawrylowicz(2009). Ligation of {TLR}9 induced on human {IL}-10{\textendash}secreting Tregs by 1$\upalpha$,25-dihydroxyvitamin D3 abrogates regulatory function . Journal of Clinical Investigation. American Society for Clinical Investigation
Emmanuel Xystrakis, Zoë Urry, Catherine M Hawrylowicz(2007). Regulatory T cell therapy as individualized medicine for asthma and allergy . Current Opinion in Allergy and Clinical Immunology. 7. (6). p. 535--541. Ovid Technologies (Wolters Kluwer Health)
Emmanuel Xystrakis, Catherine Hawrylowicz, Zoe Urry, Patricia Ozegbe, Chris Corrigan, Dave Richards(2007). Drug-induced T regulatory cells in asthma . World Allergy Organization Journal. {\&}{NA}$\mathsemicolon$. p. S37--S38. Ovid Technologies (Wolters Kluwer Health)
Emmanuel Xystrakis, Zoë Urry, Catherine M. Hawrylowicz(2006). Interleukin-10-Secreting regulatory T cells in allergy and asthma . Curr Allergy Asthma Rep. 6. (5). p. 363--371. Springer Science $\mathplus$ Business Media
Emmanuel Xystrakis, Zoë Urry, Nabila Mahfiche, Patricia Ozegbe, Sandra Boswell, Catherine M Hawrylowicz(2006). Vitamin D3 in inflammatory airway disease and immunosuppression . Drug Discovery Today: Disease Mechanisms. 3. (1). p. 91--97. Elsevier {BV}
E Xystrakis, S E Boswell, C M Hawrylowicz(2006). T regulatory cells and the control of allergic disease . Expert Opin. Biol. Ther. 6. (2). p. 121--133. Informa Healthcare
(2005). Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients . Journal of Clinical Investigation.
E. Xystrakis(2004). Identification of a novel natural regulatory {CD}8 T-cell subset and analysis of its mechanism of regulation . Blood. 104. (10). p. 3294--3301. American Society of Hematology
E. Xystrakis, P. Cavailles, A. S. Dejean, B. Cautain, C. Colacios, D. Lagrange, M.-J. van de Gaar, I. Bernard, D. Gonzalez-Dunia, J. Damoiseaux, et al.(2004). Functional and Genetic Analysis of Two {CD}8 T Cell Subsets Defined by the Level of {CD}45RC Expression in the Rat . The Journal of Immunology. 173. (5). p. 3140--3147. The American Association of Immunologists
Emmanuel Xystrakis, Isabelle Bernard, Anne S. Dejean, Talal Alsaati, Philippe Druet, Abdelhadi Saoudi(2004). Alloreactive {CD}4 T lymphocytes responsible for acute and chronic graft-versus-host disease are contained within the {CD}45RChigh but not the {CD}45RClow subset . European Journal of Immunology. 34. (2). p. 408--417. Wiley-Blackwell
B. Cautain, J. Damoiseaux, I. Bernard, E. Xystrakis, E. Fournie, P. van Breda Vriesman, P. Druet, A. Saoudi(2002). The {CD}8 T Cell Compartment Plays a Dominant Role in the Deficiency of Brown-Norway Rats to Mount a Proper Type 1 Immune Response . The Journal of Immunology. 168. (1). p. 162--170. The American Association of Immunologists
Emmanuel Xystrakis, Lucette Pelletier, Magali Savignac, Valérie Duplan, Philippe Druet, Saoudi Abdelhadi(2001). Self major histocompatibility complex class-{II}-specific regulatory {CD}4~T cells prevent both Th1- and Th2-mediated autoimmune diseases in the rat . Microbes and Infection. 3. (11). p. 955--960. Elsevier {BV}
J.-F. Subra, B. Cautain, E. Xystrakis, M. Mas, D. Lagrange, H. van der Heijden, M.-J. van de Gaar, P. Druet, G. J. Fournie, A. Saoudi, et al.(2001). The Balance Between {CD}45RChigh and {CD}45RClow {CD}4 T Cells in Rats Is Intrinsic to Bone Marrow-Derived Cells and Is Genetically Controlled . The Journal of Immunology. 166. (5). p. 2944--2952. The American Association of Immunologists
Emmanuel Xystrakis, Gilbert J. Fournie, Bastien Cautain, Jan Damoiseaux, Magali Mas Dominique Lagrange, Isabelle Bernard, Jean-Francois Subra, Lucette Pelletier, Philippe Druet, Abdelhadi Saoudi(2001). Cellular and genetic factors involved in the difference between Brown Norway and Lewis rats to develop respectively type-2 and type-1 immune-mediated diseases . Immunol Rev. 184. (1). p. 145--160. Wiley-Blackwell
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