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Hire Dr. Elena S.

Switzerland

Profile Summary

My major research interest has been the understanding of the molecular mechanism of lipid and glucose homeostasis and the implications of such mechanisms in the pathogenesis of obesity, diabetes, and atherosclerosis During my doctoral studies, I analyzed the role of HDACs and other chromatin-remodeling factors in the repression of CYP7A1 by bile acids. I also had the opportunity to work on another project focusing on the research of novel dual PPARalpha/gamma ligands with improved pharmacological properties. I performed my first post-doc at University of California, Los Angeles in the group of Prof. Peter Tontonoz. My study was devoted to the impact of Idol gene on the cellular regulation of low-density lipoprotein receptor (LDLR) and I contributed to the characterization of Idol role in affecting the lipid metabolism. During my second post-doc at ETH-Zurich, my research activity is focused on the identification of novel potential molecular targets for the design of anti-diabetic compounds. From a technical point of view, I can offer extensive and optimal knowledge in cell biology (immortalized and primary cell lines included experience with stem cells), molecular biology (DNA recombinant technologies, siRNA, shRNA and miRNA), biochemistry (included production and purification of recombinant proteins and monoclonal antibodies from hybridoma cell lines), a good experience in microscopy and several animal practices (generation of transgenic and knock-out mouse models). Moreover I have 6+ years of experience writing, reviewing, and editing scientific manuscripts for prestigious journal like Science, Cell Metabolism and Journal Lipid Research, developing research grant proposals, performing literature reviews and preparing abstracts and presentations for scientific conferences. I have also a long experience communicating science to an academic as well as a lay audience. During my career I was teaching assistant in the laboratory of Biochemistry (University of Milan) and in Insulin Signaling Course (ETH-Zurich) and mentor for different Biology students.

Subject Matter Expertise

• ☆ Separation & Purification
• ☆ Molecular Imaging
• ☆ Biology/Life Sciences
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Chromatin
• ☆ Monoclonal Antibody Production
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Animal Husbandry
• ☆ Pathogenesis
• ☆ Protein/Enzyme Engineering
• ☆ Antibody Engineering
• ☆ Diabetes
• ☆ Obesity
• ☆ Metabolism & Metabolic Disease
• ☆ Technical & Scientific Writing

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

Supervisor Scientific Communications

Philip Morris International Research and Development Campus Neuchâtel

February 2018 - Present

Postdoc Research Associate

ETH Zürich

October 2012 - Present

Scientist

Clinopsis - PMI

June 2016 - January 2018

Postdoc Research Associate

University of California Los Angeles

January 2009 - August 2012

Education

PhD in Biochemistry (Department of Pharmacological Sciences, Laboratory of Biochemistry and Molecular Biology of Lipids )

University of Milan-Italy

November 2005 - December 2008

M.Sc. in Pharmaceutical Biotechnology (Pharmacology Department)

University of Milan-Italy

1999 - February 2005

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2018). The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product . Toxicology in Vitro.

(2018). Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

(2017). Exploring the microbiome in health and disease: Implications for toxicology. Toxicology Research and Application.

Zanetti F, Titz B, Sewer A, Lo Sasso G, Scotti E, Schlage WK, Mathis C, Leroy P, Majeed S, Torres LO, Keppler BR, Elamin A, Trivedi K, Guedj E, Martin F, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, vol. 101, pp. 15-35, 2017 .

(2017). In Vitro Systems Toxicology Assessment of Nonflavored e-Cigarette Liquids in Primary Lung Epithelial Cells . Applied In Vitro Toxicology.

Marangoni A, Fiorino E, Gilardi F, Aldini R, Scotti E, Nardini P, Foschi C, Donati M, Montagnani M, Cevenini M, Franco P, Roda A, Crestani M, Cevenini R, Atherosclerosis, 2015, vol. 241, no. 2, pp. 471-479 .

Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P, Cell metabolism, 2014, vol. 20, no. 5, pp. 910-918 .

Zhang L, Xu M, Scotti E, Chen ZJ, Tontonoz P, Journal of lipid research, 2013, vol. 54, no. 5, pp. 1410-1420 .

Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P, Molecular and cellular biology, 2013, vol. 33, no. 8, pp. 1503-1514 .

Mitro N, Gilardi F, Giudici M, Godio C, Scotti E, Crestani M, Methods in molecular biology (Clifton, N.J.), 2013, vol. 952, pp. 137-144 .

Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P, Molecular and cellular biology, 2011, vol. 31, no. 9, pp. 1885-1893 .

Pochetti G, Mitro N, Lavecchia A, Gilardi F, Besker N, Scotti E, Aschi M, Re N, Fracchiolla G, Laghezza A, Tortorella P, Montanari R, Novellino E, Mazza F, Crestani M, Loiodice F, Journal of medicinal chemistry, 2010, vol. 53, no. 11, pp. 4354-4366 .

Scotti E, Tontonoz P, Molecular and cellular biology, 2010, vol. 30, no. 9, pp. 2076-2077 .

Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G, Journal of medicinal chemistry, 2008, vol. 51, no. 24, pp. 7768-7776 .

Mitro N, Gilardi F, Godio C, Scotti E, De Fabiani E, Caruso D, Crestani M, Frontiers in bioscience : a journal and virtual library, 2008, vol. 13, pp. 6276-6288 .

Gilardi F, Mitro N, Godio C, Scotti E, Caruso D, Crestani M, De Fabiani E, Pharmacology & therapeutics, 2007, vol. 116, no. 3, pp. 449-472 .

Scotti E, Gilardi F, Godio C, Gers E, Krneta J, Mitro N, De Fabiani E, Caruso D, Crestani M, Cellular and molecular life sciences : CMLS, 2007, vol. 64, no. 19-20, pp. 2477-2491 .

Mitro N, Godio C, De Fabiani E, Scotti E, Galmozzi A, Gilardi F, Caruso D, Vigil Chacon AB, Crestani M, Hepatology (Baltimore, Md.), 2007, vol. 46, no. 3, pp. 885-897 .

CONFERENCE POSTER

(2011). Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists.

(2010). LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor.

(2008). Identification of novel dual Peroxisome Proliferator Activated Receptor α/γ ligands and characterization of their biochemical properties by structural studies.

(2007). Key role of the histone deacetylases and the nuclear receptor HNF-4α in the regulation of bile acids synthesis.

(2006). Role of histone deacetylases in the regulation of bile acid synthesis: possibile targets for hypocholesterolemic agents?.

(2006). The recruitment of histone deacetylases induced by bile acids inhibits transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1).