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Hire Dr. Eduardo M.

United States

USD 100 /hr

Doctor of Veterinary Medicine & PhD in Biology. Expert in small animal clinics and basic research on mitochondria.

Profile Summary

I have 15 years experience on small animal clinics, surgery and clinical cardiology. My private practice was followed by more than 20 years experience in basic and translational research on mitochondrial metabolism in academic settings.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Membrane Biology
• ☆ Histology
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Veterinary Medicine
• ☆ Veterinary Pathology
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Human Biology
• ☆ Zoonoses
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Literature Search
• ☆ Instructional Webinars
• ☆ Continuing Medical Education (CME) Training
• ☆ Skills Training
• ☆ Medical Writing
• ☆ Medical Content Writing
• ☆ Continuing Medical Education (CME) Materials
• ☆ Research Summaries & Abstracts
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Release Notes
• ☆ Experimental Protocols
• ☆ Textbook Content Writing
• ☆ Science Communication
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Language Translation
• ☆ Creative Writing
• ☆ Grant Writing

Services

• Writing
• Research
• Consulting
• Product Development

Writing Medical Writing

Research User Research, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Product Development Product Validation, Concept Development

Work Experience

Associate Professor

Medical University of South Carolina

- Present

Practicing Veterinarian

Self employed

October 1986 - November 2004

Education

Ph D in Biology (Biología, Bioquímica y Farmacia)

Universidad Nacional del Sur

2001 - Present

Doctor of Veterinary Medicine (Facultad de Ciencias Veterinarias)

Universidad Nacional del Centro de la Provincia de Buenos Aires

1986 - Present

Certifications

• PhD in Biology

  Universidad Nacional del Sur, Argentina

  March 2001 - Present

• Doctor of Veterinary Medicine

  Universidad Nacional del Centro, Argentina

  March 1986 - Present

Publications

JOURNAL ARTICLE

Milagros Junco, Clara Ventura, Florencia Ximena Santiago Valtierra, Eduardo Maldonado (2024). Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer . Antioxidants.

Sandra E. Pérez, Monika Gooz, Eduardo Maldonado (2024). Mitochondrial Dysfunction and Metabolic Disturbances Induced by Viral Infections . Cells.

Ventura, C., Junco, M., Santiago Valtierra, F.X., Gooz, M., Zhiwei, Y., Townsend, D.M., Woster, P.M., Maldonado, E.N.(2023). Synergism of small molecules targeting VDAC with sorafenib, regorafenib or lenvatinib on hepatocarcinoma cell proliferation and survival . European Journal of Pharmacology. 957.

Gooz, M., Maldonado, E.N.(2023). Fluorescence microscopy imaging of mitochondrial metabolism in cancer cells . Frontiers in Oncology. 13.

Chakraborty, P., Parikh, R.Y., Choi, S., Tran, D., Gooz, M., Hedley, Z.T., Kim, D.-S., Pytel, D., Kang, I., Nadig, S.N., et al.(2022). Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function . Cancer Research. 82. (10). p. 1969-1990.

Heslop, K.A., Burger, P., Kappler, C., Solanki, A.K., Gooz, M., Peterson, Y.K., Mills, C., Benton, T., Duncan, S.A., Woster, P.M., et al.(2022). Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells . Biomedicine and Pharmacotherapy. 150.

Heslop, K.A., Milesi, V., Maldonado, E.N.(2021). VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges . Frontiers in Physiology. 12.

Rovini, A., Heslop, K., Hunt, E.G., Morris, M.E., Fang, D., Gooz, M., Gerencser, A.A., Maldonado, E.N.(2021). Quantitative analysis of mitochondrial membrane potential heterogeneity in unsynchronized and synchronized cancer cells . FASEB Journal. 35. (1).

Heslop, K.A., Rovini, A., Hunt, E.G., Fang, D., Morris, M.E., Christie, C.F., Gooz, M.B., DeHart, D.N., Dang, Y., Lemasters, J.J., et al.(2020). JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells . Biochemical Pharmacology. 171.

Domondon, M., Polina, I., Nikiforova, A.B., Sultanova, R.F., Kruger, C., Vasileva, V.Y., Fomin, M.V., Beeson, G.C., Nieminen, A.-L., Smythe, N., et al.(2020). Renal Glomerular Mitochondria Function in Salt-Sensitive Hypertension . Frontiers in Physiology. 10.

Zhang, L., Townsend, D.M., Morris, M., Maldonado, E.N., Jiang, Y.-L., Broome, A.-M., Bethard, J.R., Ball, L.E., Tew, K.D.(2020). Voltage-dependent anion channels influence cytotoxicity of ME-344, a therapeutic isoflavone . Journal of Pharmacology and Experimental Therapeutics. 374. (2). p. 308-318.

Christie, C.F., Fang, D., Hunt, E.G., Morris, M.E., Rovini, A., Heslop, K.A., Beeson, G.C., Beeson, C.C., Maldonado, E.N.(2019). Statin-dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content . FASEB Journal. 33. (7). p. 8186-8201.

DeHart, D.N., Lemasters, J.J., Maldonado, E.N.(2018). Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells . SLAS Discovery. 23. (1). p. 23-33.

DeHart, D.N., Fang, D., Heslop, K., Li, L., Lemasters, J.J., Maldonado, E.N.(2018). Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells . Biochemical Pharmacology. 148. p. 155-162.

Maldonado, E.N., DeHart, D.N., Patnaik, J., Klatt, S.C., Gooz, M.B., Lemasters, J.J.(2017). Erratum: ATP/ADP turnover and import of glycolytic ATP into mitochondria in cancer cells is independent of the adenine nucleotide translocator (Journal of Biological Chemistry DOI: 10.1074/jbc.M116.734814) . Journal of Biological Chemistry. 292. (41). p. 16969.

Maldonado, E.N.(2017). VDAC-tubulin, an anti-Warburg pro-oxidant switch . Frontiers in Oncology. 7. (JAN).

Shoshan-Barmatz, V., Maldonado, E.N., Krelin, Y.(2017). VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress . Cell Stress. 1. (1). p. 11-36.

Maldonado, E.N., DeHart, D.N., Patnaik, J., Klatt, S.C., Gooz, M.B., Lemasters, J.J.(2016). ATP/ADP turnover and import of glycolytic ATP into mitochondria in cancer cells is independent of the adenine nucleotide translocator . Journal of Biological Chemistry. 291. (37). p. 19642-19650.

Gooz Beck, M., Maldonado, E.N., Dang, Y., Amria, M.Y., Higashiyama, S., Abboud, H.E., Lemasters, J.J., Bell, P.D.(2014). ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease . American Journal of Physiology - Renal Physiology. 307. (5).

Maldonado, E.N., Lemasters, J.J.(2014). ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect . Mitochondrion. 19. (Part A). p. 78-84.

Maldonado, E.N., Delgado, I., Furland, N.E., Buqué, X., Iglesias, A., Aveldaño, M.I., Zubiaga, A., Fresnedo, O., Ochoa, B.(2014). The E2F2 transcription factor sustains hepatic glycerophospholipid homeostasis in mice . PLoS ONE. 9. (11).

Hung, H.-I., Schwartz, J.M., Maldonado, E.N., Lemasters, J.J., Nieminens, A.-L.(2013). Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy . Journal of Biological Chemistry. 288. (1). p. 677-686.

Maldonado, E.N., Sheldon, K.L., Dehart, D.N., Patnaik, J., Manevich, Y., Townsend, D.M., Bezrukov, S.M., Rostovtseva, T.K., Lemasters, J.J.(2013). Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: Regulation by free tubulin and erastin . Journal of Biological Chemistry. 288. (17). p. 11920-11929.

Czerny, C., Kholmukhamedov, A., Theruvath, T.P., Maldonado, E.N., Ramshesh, V.K., Lehnert, M., Marzi, I., Zhong, Z., Lemasters, J.J.(2012). Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice . HPB Surgery. 2012.

Maldonado, E.N., Lemasters, J.J.(2012). Warburg revisited: Regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells . Journal of Pharmacology and Experimental Therapeutics. 342. (3). p. 637-641.

Czerny, C., Theruvath, T.P., Maldonado, E.N., Lehnert, M., Marzi, I., Zhong, Z., Lemasters, J.J.(2012). C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation . HPB Surgery. 2012.

Lemasters, J.J., Holmuhamedov, E.L., Czerny, C., Zhong, Z., Maldonado, E.N.(2012). Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect . Biochimica et Biophysica Acta - Biomembranes. 1818. (6). p. 1536-1544.

Sheldon, K.L., Maldonado, E.N., Lemasters, J.J., Rostovtseva, T.K., Bezrukov, S.M.(2011). Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin . PLoS ONE. 6. (10).

Maldonado, E.N., Patnaik, J., Mullins, M.R., Lemasters, J.J.(2010). Free tubulin modulates mitochondrial membrane potential in cancer cells . Cancer Research. 70. (24). p. 10192-10201.

Rodriguez-Enriquez, S., Kai, Y., Maldonado, E., Currin, R.T., Lemasters, J.J.(2009). Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes . Autophagy. 5. (8). p. 1099-1106.

Maldonado, E.N., Alderson, N.L., Monje, P.V., Wood, P.M., Hama, H.(2008). FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin . Journal of Lipid Research. 49. (1). p. 153-161.

Furland, N.E., Zanetti, S.R., Oresti, G.M., Maldonado, E.N., Aveldanõ, M.I.(2007). Ceramides and sphingomyelins with high proportions of very long-chain polyunsaturated fatty acids in mammalian germ cells . Journal of Biological Chemistry. 282. (25). p. 18141-18150.

Furland, N.E., Maldonado, E.N., Aresti, P.A., Aveldaño, M.I.(2007). Changes in lipids containing long- and very long-chain polyunsaturated fatty acids in cryptorchid rat testes . Biology of Reproduction. 77. (1). p. 181-188.

Zanetti, S.R., Maldonado, E.N., Aveldaño, M.I.(2007). Doxorubicin affects testicular lipids with long-chain (C ₁₈-C₂₂) and verylong-chain (C₂₄-C₃₂) polyunsaturated fatty acids . Cancer Research. 67. (14). p. 6973-6980.

Furland, N.E., Oresti, G.M., Antollini, S.S., Venturino, A., Maldonado, E.N., Aveldaño, M.I.(2007). Very long-chain polyunsaturated fatty acids are the major acyl groups of sphingomyelins and ceramides in the head of mammalian spermatozoa . Journal of Biological Chemistry. 282. (25). p. 18151-18161.

Alderson, N.L., Maldonado, E.N., Kern, M.J., Bhat, N.R., Hama, H.(2006). FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain . Journal of Lipid Research. 47. (12). p. 2772-2780.

Pérez, S., Maldonado, E.N., Aspichueta, P., Ochoa, B., Chico, Y.(2004). Differential modulation of prostaglandin receptor mRNA abundance by prostaglandins in primary cultured rat hepatocytes . Molecular and Cellular Biochemistry. 266. (1-2). p. 183-189.

Maldonado, E.N., Chico, Y., Botham, K.M., Aveldaño, M.I., Ochoa, B.(2003). Influence of the fatty acid composition of lipids in chylomicron remnants derived from fish or corn oil on the lipid profile of cultured rat hepatocytes . Journal of Physiology and Biochemistry. 59. (2). p. 85-100.

Furland, N.E., Maldonado, E.N., Aveldaño, M.I.(2003). Very long chain PUFA in murine testicular triglycerides and cholesterol esters . Lipids. 38. (1). p. 73-80.

Maldonado, E.N., Casanave, E.B., Aveldao, M.I.(2002). Major plasma lipids and fatty acids in four HDL mammals . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 132. (2). p. 297-303.

Maldonado, E.N., Furland, N.E., Pennacchiotti, G.L., Aveldao, M.I.(2002). Reversibility of the changes induced by n-3 fatty acids in mouse plasma, liver and blood cell lipids . Journal of Nutritional Biochemistry. 13. (1). p. 36-46.

Maldonado, E.N., Romero, J.R., Ochoa, B., Aveldao, M.I.(2001). Lipid and fatty acid composition of canine lipoproteins . Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 128. (4). p. 719-729.

Pennacchiotti, G.L., Maldonado, E.N., Aveldaño, M.I.(2001). Major clofibrate effects on liver and plasma lipids are independent of changes in polyunsaturated fatty acid composition induced by dietary fat . Lipids. 36. (2). p. 121-127.

Botham, K.M., Maldonado, E.N., Chico, Y., Zheng, X., Avella, M., Ochoa, B.(2001). The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: Comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1534. (2-3). p. 96-109.

BOOK CHAPTER

Heslop, K.A., Rovini, A., Gooz, M., Maldonado, E.N.(2022). Fast Determination of Mitochondrial Metabolism and Respiratory Complex Activity in Permeabilized and Intact Cells . Methods in Molecular Biology. 2497. p. 1-10.

Rovini, A., Heslop, K.A., Maldonado, E.N.(2022). Mitochondria and Tumor Metabolic Flexibility: Mechanisms and Therapeutic Perspectives . Comprehensive Pharmacology. 6. p. 493-510.

Fang, D., Maldonado, E.N.(2018). VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation . Advances in Cancer Research. 138. p. 41-69.