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Hire Dr. Dr. Matthew S.

United States

USD 75 /hr

Freelance Neuroscientist with expertise in pre-clinical small molecule drug development to combat neurological disease.

Profile Summary

I am a perseverant pre-clinical drug development neuroscientist with over 12 years of research experience covering NEUROSCIENCE, Biochemistry, Molecular and Cellular Biology, Synaptic Physiology and Stem Cell Biology. My "never give up" attitude and vast experience in many disciplines adopts me the ability to address scientific questions in creative and unique ways. I have experience in pre-clinical small molecule drug development to support chemistry SAR to identify lead therapeutic candidates for neurology related targets. Experience in design, optimization and execution of both cell based and biochemical assays. I can provide expertise in synaptic physiology, and neuropsychiatric disease modeling. I have comprehensively studied the biological basis of addiction utilizing human stem cell biology and cellular reprogramming techniques. I am well versed in cutting edge induced neuronal (iN) cell technology. My main roles at PTC as a preclinical drug development Neuroscientist: -Provide subject matter expertise and leadership in the expansion of neuroscience and neurological disease understanding -Design and execute high-throughput in-vitro cell-based assays to screen 100s of small molecules to assist in driving chemistry SAR -Validation of new drug targets accomplished through elegant experimental design (both cell-based and biochemical) -My main focus was elucidating the mechanism(s) of action of one of PTCs lead small molecule drug candidates for a rare neurological disorder -Comprehensively screened primary mouse neuronal cultures (as well as human cell lines) to identify disease specific biomarkers for pharmacodynamic studies -Mentored and trained associate level scientists on both the technical and conceptual framework of our teams small molecule pipeline -Translating in-vitro cell based findings into in-vivo rodent models to better understand the PK/PD relationship of our lead small molecule -Team lead for a gene-therapy focused project to combat a devastating rare pediatric indication ➢ Scientific communication is a great strength of mine. My experience has provided me with excellent presentation skills and the ability to convey my work to diverse audiences. https://www.ncbi.nlm.nih.gov/myncbi/matthew.scarnati.1/bibliography/public/ EMAIL: xxxxxxxxxxxxxxxxxxxxxxxxx SKILLS: Pre-Clinical Drug Discovery I Electrophysiology | Human Stem Cell Biology | Mammalian Tissue Culture | Cell Signaling Pathways | Confocal Microscopy | Protein Purification and Expression | qPCR | Cellular Assays | Science Writing | Problem Solving | ELISA

Subject Matter Expertise

• ★ Neuroscience
• ☆ Microbiology
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Stem Cell Research
• ☆ Electrophysiology
• ☆ Microscopy
• ☆ Biomarker Discovery
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Phenotypic Assays
• ☆ High Content Screening/Imaging
• ☆ Science Communication

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Non-Medical Regulatory Writing, Technical Writing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization

Product Development Product Evaluation

Work Experience

Scientist II - Neuroscience

PTC Therapeutics, Inc.

January 2022 - Present

Postdoctoral Fellow

Rutgers Robert Wood Johnson Medical School New Brunswick

January 2018 - Present

Senior Research Investigator

Eternity Biosciences

May 2021 - November 2021

Graduate Assistant

Rutgers University

January 2014 - December 2017

Research Technician

Rutgers University

October 2014 - December 2014

Graduate Assistant

University of Medicine and Dentistry of New Jersey

October 2010 - May 2013

Research Technician

University of Medicine and Dentistry of New Jersey

October 2009 - May 2010

Undergraduate Research

The Richard Stockton College of New Jersey

September 2007 - May 2009

Education

PhD | Neuroscience

Rutgers University

May 2014 - December 2017

PhD Candidate (Cell Biology and Neuroscience)

Rutgers University - Busch Campus

January 2014 - December 2017

PhD Student (Molecular Biology)

UMDNJ-School of Osteopathic Medicine Department of Molecular Biology

September 2010 - May 2013

BS Biochemistry and Molecular Biology (Biochemsitry and Molecular Biology)

Stockton University

September 2005 - May 2009

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Matthew S. Scarnati, Andrew J. Boreland, Marisa Joel, Ronald P. Hart, Zhiping P. Pang(2020). Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol . Alcohol. 87. p. 97--109. Elsevier {BV}

Apoorva Halikere, Dina Popova, Matthew S. Scarnati, Aula Hamod, Mavis R. Swerdel, Jennifer C. Moore, Jay A. Tischfield, Ronald P. Hart, Zhiping P. Pang(2020). Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons . Molecular Psychiatry. 25. (7). p. 1406--1419. Springer Science and Business Media {LLC}

Matthew S. Scarnati, Apoorva Halikere, Zhiping P. Pang(2019). Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook . Alcohol. 74. p. 83--93. Elsevier {BV}

Matthew S Scarnati, Rahul Kataria, Mohana Biswas, Kenneth G Paradiso(2018). Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition . eLife. 7. {eLife} Sciences Publications, Ltd

Stephen G. Clarke, Matthew S. Scarnati, Kenneth G. Paradiso(2016). Neurotransmitter Release Can Be Stabilized by a Mechanism That Prevents Voltage Changes Near the End of Action Potentials from Affecting Calcium Currents . The Journal of Neuroscience. 36. (45). p. 11559--11572. Society for Neuroscience

Cooper KF, Scarnati MS, Krasley E, Mallory MJ, Jin C, Law MJ, Strich R, Journal of cell science, 2012, vol. 125, no. Pt 4, pp. 1015-1026, 2012 .

OTHER

Matthew S. Scarnati, Rahul Kataria, Mohana Biswas, Kenneth G. Paradiso(2018). Active presynaptic ribosomes in mammalian brain nerve terminals, and increased transmitter release after protein synthesis inhibition . Cold Spring Harbor Laboratory