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Hire Dr. Dr. Himanshu Narayan S.

United States

USD 20 /hr

Functional Genomics, Bioinformatics and drug designing

Profile Summary

I am a Sr. Research Scientist with a particular research interest in exploring the genetic and epigenetic mechanisms of high-grade tumors arising in the overall course of the disease and in relation to treatment. My present work is focused on understanding the aggressiveness of pancreatic neuroendocrine tumors that are resistant to multiple treatments. I have a broad background in cancer genomics, with specific training and expertise in state-of-the-art bioinformatics. During my postdoctoral training, I worked on different genomics and epigenomics aspects of cancer biology, including: 1) investigating the differential regulatory networks in cancer and normal tissues, 2) demonstrating regulatory regions (Epromoters, i.e., promoter with enhancer activity) in cancer cell lines, and 3) advancing the understanding role of polypurine repeats in the human genome and its association with human diseases mainly cancer and neurological diseases. In addition, I contributed to the understanding of how SARS-CoV2 variants may have better host-pathogen interactions. I have been awarded an Independent Research Grant from the Indian Council of Medical Research (ICMR), India, from 2014-2016. I have also been awarded several National and International Travel Grants from National and International Funding Agencies to present my research work in my home country and overseas.

Subject Matter Expertise

• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Hypothesis
• ☆ Research Methodology
• ☆ Gap Analysis

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing, Copywriting

Research Market Research, User Research, Fact Checking, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Big Data Analytics, Data Processing

Work Experience

Sr. Research Scientist

Memorial Sloan Kettering Cancer Center

January 2024 - Present

Senior Research Scientist

Sloan Kettering Institute

March 2022 - Present

Postdoctoral Research Scientist

Columbia University Irving Medical Center

March 2021 - Present

Postdoctoral Research Scientist

Columbia University

March 2021 - March 2022

Postdoctrate

Aix Marseille University

August 2018 - February 2021

Post Doctoral Fellow

Aix-Marseille Université

July 2016 - February 2021

Post Doctoral Fellow

CSIR-Institute of Genomcis & Integrative Biology

August 2018 - July 2020

Research Associate

CSIR-Institute of Genomics and Integrative Biology

November 2016 - July 2018

Research Scholar

All India Management Association

September 2011 - November 2016

Education

Ph.D

Noida International University

September 2013 - December 2016

PhD (School of Sciences)

Noida International University

July 2013 - December 2016

M.Tech. (Bioinformatics) (Department of Computer, Science Faculty of Management & Information Technology)

Jamia Hamdard

July 2009 - June 2011

B.Tech. (Biotechnology) (Life Science)

Institute of Advanced Studies in Education

July 2004 - June 2008

10+2

Udai Pratap College

July 2003 - June 2004

10

Udai Pratap College

July 2001 - June 2002

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Anjaneyulu Musini, Himanshu Narayan Singh, Jhansi Vulise, S.S. Sravanthi Pammi, Archana Giri (2024). Quercetin's antibiofilm effectiveness against drug resistant Staphylococcus aureus and its validation by in silico modeling . Research in Microbiology.

Pritee Chunarkar-Patil, Mohammed Kaleem, Richa Mishra, Subhasree Ray, Aftab Ahmad, Devvret Verma, Sagar Bhayye, Rajni Dubey, Himanshu Singh, Sanjay Kumar (2024). Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies . Biomedicines.

Pritee Patil (Chunarkar), Mohammed Kaleem, Richa Mishra, Subhasree Ray, Aftab Ahmad, Devvret Verma, Sagar Bhayye, Rajni Dubey, Himanshu Narayan Singh, Sanjay Kumar (2024). Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies . Biomedicines.

Ashutosh Kumar, Adil Asghar, Himanshu N Singh, Muneeb A Faiq, Sujeet Kumar, Ravi K Narayan, Gopichand Kumar, Prakhar Dwivedi, Chetan Sahni, Rakesh K Jha, et al. (2023). SARS-CoV-2 Omicron Variant Genomic Sequences and Their Epidemiological Correlates Regarding the End of the Pandemic: In Silico Analysis . JMIR Bioinformatics and Biotechnology.

Sanjay Kumar, Chun-Ming Shih, Lung-Wen Tsai, Rajni Dubey, Deepika Gupta, Tanmoy Chakraborty, Naveen Sharma, Abhishek Singh, Vishnu Swarup, Himanshu Singh (2022). Transcriptomic Profiling Unravels Novel Deregulated Gene Signatures Associated with Acute Myocardial Infarction: A Bioinformatics Approach . Genes.

Sanjay Kumar, Chun-Ming Shih, Lung-Wen Tsai, Rajni Dubey, Deepika Gupta, Tanmoy Chakraborty, Naveen Sharma, Abhishek Vikram Singh, Vishnu Swarup, Himanshu Narayan Singh (2022). Transcriptomic Profiling Unravels Novel Deregulated Gene Signatures Associated with Acute Myocardial Infarction: A Bioinformatics Approach . Genes.

Genome-wide expression reveals potential biomarkers in breast cancer bone metastasis <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Journal of Integrative Bioinformatics.

Ashutosh Kumar, Rakesh Parashar, Sujeet Kumar, Muneeb A Faiq, Chiman Kumari, Maheswari Kulandhasamy, Ravi K. Narayan, Rakesh K. Jha, Himanshu N. Singh, Pranav Prasoon, et al.(2022). Emerging SARS‐CoV‐2 variants can potentially break set epidemiological barriers in COVID‐19 . Journal of Medical Virology. 94. (4). p. 1300--1314. Wiley

Epromoters function as a hub to recruit key transcription factors required for the inflammatory response <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Nature Communications.

Appunni, S., Gupta, D., Rubens, M., Singh, A.K., Swarup, V., Singh, H.N.(2021). Targeting rock2 isoform with its widely used inhibitors for faster post-stroke recovery . Indian Journal of Biochemistry and Biophysics. 58. (1). p. 27-34.

Swarup, V., Kumar, V., Faruq, M., Singh, H., Singh, I., Srivastava, A.K.(2020). CRISPR/Cas9 technology in neurological disorders: An update for clinicians . Annals of Movement Disorders. 3. (1). p. 23-32.

Kumar, A., Faiq, M.A., Pareek, V., Raza, K., Narayan, R.K., Prasoon, P., Kumar, P., Kulandhasamy, M., Kumari, C., Kant, K., et al.(2020). Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients . Medical Hypotheses. 144.

Kumar, A., Pareek, V., Faiq, M.A., Kumar, P., Kumari, C., Singh, H.N., Ghosh, S.K.(2020). Transcriptomic analysis of the signature of neurogenesis in human hippocampus suggests restricted progenitor cell progression post-childhood . IBRO Reports. 9. p. 224-232.

(2019). Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia . Frontiers in Psychiatry.

(2019). A Novel Mathematical Model of Glaucoma Pathogenesis . Journal of current glaucoma practice.

Faiq, M.A., Sidhu, T., Sofi, R.A., Singh, H.N., Qadri, R., Dada, R., Bhartiya, S., Gagrani, M., Dada, T.(2019). A novel mathematical model of glaucoma pathogenesis . Journal of Current Glaucoma Practice. 13. (1). p. 3-8.

Kumar, A., Pareek, V., Singh, H.N., Faiq, M.A., Narayan, R.K., Raza, K., Kumar, P.(2019). Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia . Frontiers in Psychiatry. 10.

(2018). Commentary: A Possible Mechanism of Zika Virus Associated Microcephaly: Imperative Role of Retinoic Acid Response Element (RARE) Consensus Sequence Repeats in the Viral Genome . Frontiers in microbiology.

Faiq, M.A., Kumar, A., Singh, H.N., Pareek, V., Kumar, P.(2018). Commentary: A possible mechanism of Zika virus associated microcephaly: Imperative role of Retinoic Acid Response Element (RARE) consensus sequence repeats in the viral genome . Frontiers in Microbiology. 9. (FEB).

Singh, H.N., Scheiber-Mojdehkar, B., Rajeswari, M.R.(2018). DNA trinucleotide (GAA) repeats in human genome: hint for disease pathogenesis? . Journal of Biomolecular Structure and Dynamics. 36. (8). p. 1958-1965.

Lohani, N., Singh, H.N., Rajeswari, M.R.(2018). Assessment of binding properties of Actinomycin-D to 21nt DNA segment of hmgb1 gene promoter using spectroscopic and calorimetric techniques . Journal of Biomolecular Structure and Dynamics. 36. (2). p. 504-511.

(2017). DNA trinucleotide (GAA) repeats in human genome: hint for disease pathogenesis? . Journal of biomolecular structure & dynamics.

(2017). DNA-triplex Forming Purine Repeat Containing Genes in Acinetobacter baumannii and Their Association with Infection and Adaptation . Frontiers in Cellular and Infection Microbiology.

(2017). nTrackAnnotator : Software for detection and annotation of sequence tracks of chosen nucleic acid bases with defined length in genome . Gene Reports.

(2017). No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells . Gene.

(2017). Assessment of binding properties of Actinomycin-D to 21nt DNA segment of hmgb1 gene promoter using spectroscopic and calorimetric techniques . Journal of biomolecular structure & dynamics.

(2017). Targeting PknB, an eukaryotic-like serine/threonine protein kinase of Mycobacterium tuberculosis with phytomolecules . Computational biology and chemistry.

Appunni, S., Rajisha, P.M., Rubens, M., Chandana, S., Singh, H.N., Swarup, V.(2017). Targeting PknB, an eukaryotic-like serine/threonine protein kinase of Mycobacterium tuberculosis with phytomolecules . Computational Biology and Chemistry. 67. p. 200-204.

Kumar, V., Singh, H.N., Tomar, A.K., Dantham, S., Yadav, S.(2017). Searching new targets to counter drug resistance–GTPase-Obg mRNA expression analysis in Mycobacterium under stress and in silico docking with GTPase inhibitors . Journal of Biomolecular Structure and Dynamics. 35. (8). p. 1804-1812.

Steinkellner, H., Singh, H.N., Muckenthaler, M.U., Goldenberg, H., Moganty, R.R., Scheiber-Mojdehkar, B., Sturm, B.(2017). No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells . Gene. 621. p. 5-11.

Singh, H.N., Rajeswari, M.R.(2017). DNA-triplex forming purine repeat containing genes in Acinetobacter baumannii and their association with infection and adaptation . Frontiers in Cellular and Infection Microbiology. 7. (JUN).

Singh, H.N., Rajeswari, M.R.(2017). nTrackAnnotator: Software for detection and annotation of sequence tracks of chosen nucleic acid bases with defined length in genome . Gene Reports. 7. p. 32-34.

(2016). Searching new targets to counter drug resistance - GTPase-Obg mRNA expression analysis in Mycobacterium under stress and in silico docking with GTPase inhibitors . Journal of biomolecular structure & dynamics.

(2016). A Possible Mechanism of Zika Virus Associated Microcephaly: Imperative Role of Retinoic Acid Response Element (RARE) Consensus Sequence Repeats in the Viral Genome . Frontiers in human neuroscience.

(2016). Structural aspects of the interaction of anticancer drug Actinomycin-D to the GC rich region of hmgb1 gene . International journal of biological macromolecules.

Kumar, A., Singh, H.N., Pareek, V., Raza, K., Dantham, S., Kumar, P., Mochan, S., Faiq, M.A.(2016). A possible mechanism of zika virus associated microcephaly: Imperative role of retinoic acid response element (RARE) consensus sequence repeats in the viral genome . Frontiers in Human Neuroscience. 10. p. 11.

Lohani, N., Singh, H.N., Moganty, R.R.(2016). Structural aspects of the interaction of anticancer drug Actinomycin-D to the GC rich region of hmgb1 gene . International Journal of Biological Macromolecules. 87. p. 433-442.

Singh, H.N., Rajeswari, M.R.(2016). Identification of genes containing expanded purine repeats in the human genome and their apparent protective role against cancer . Journal of Biomolecular Structure and Dynamics. 34. (4). p. 689-704.

(2015). Gene regulation by long purine tracks in brain related diseases . Data in Brief.

(2015). Role of long purine stretches in controlling the expression of genes associated with neurological disorders . Gene.

(2015). Identification of genes containing expanded purine repeats in the human genome and their apparent protective role against cancer . Journal of biomolecular structure & dynamics.

Singh, H.N., Rajeswari, M.R.(2015). Gene regulation by long purine tracks in brain related diseases . Data in Brief. 5. p. 218-225.

Lohani, N., Singh, H.N., Agarwal, S., Mehrotra, R., Rajeswari, M.R.(2015). Interaction of adriamycin with a regulatory element of hmgb1: Spectroscopic and calorimetric approach . Journal of Biomolecular Structure and Dynamics. 33. (8). p. 1612-1623.

Singh, H.N., Rajeswari, M.R.(2015). Role of long purine stretches in controlling the expression of genes associated with neurological disorders . Gene. 572. (2). p. 175-183.

(2014). Interaction of adriamycin with a regulatory element of hmgb1: spectroscopic and calorimetric approach . Journal of biomolecular structure & dynamics.

(2013). In-Silico Identification of LTR type Retrotransposons and Their Transcriptional Activities in Solanum Tuberosum. International Journal of Soft Computing and Engineering.

PREPRINT

Ashutosh Kumar, Adil Asghar, Himanshu N. Singh, Muneeb A. Faiq, Sujeet Kumar, Ravi K. Narayan, Gopichand Kumar, Prakhar Dwivedi, Chetan Sahni, Rakesh K. Jha, et al. (2021). An in silico analysis of early SARS-CoV-2 variant B.1.1.529 (Omicron) genomic sequences and their epidemiological correlates .

Subrata Saha, Himanshu Narayan Singh, Ahmed Soliman, Sanguthevar Rajasekaran(2021). A novel computational methodology for GWAS multi-locus analysis based on graph theory and machine learning . Cold Spring Harbor Laboratory

OTHER

Kumar, A., Faiq, M.A., Pareek, V., Raza, K., Narayan, R.K., Prasoon, P., Kumar, P., Kulandhasamy, M., Kumari, C., Kant, K., et al.(2020). Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients . bioRxiv.

Kumar, A., Pareek, V., Faiq, M.A., Kumar, P., Kumari, C., Singh, H.N., Ghosh, S.K.(2019). Transcriptomic analysis of the neurogenesis signature suggests continued but minimal neurogenesis in the Adult Human Hippocampus . bioRxiv.

(2019). Encephalitis (Brain Fever): A medical mystry due to brain viral infection leading cause of premature deaths in India. EC Paediatrics.

Kumar, A., Singh, H.N., Pareek, V., Raza, K., Kumar, P., Faiq, M.A., Mochan, S., Dantham, S., Upadhyaya, A.D.(2017). Altered expression of a unique set of genes reveals complex etiology of Schizophrenia . bioRxiv.

BOOK CHAPTER

(2018). Recent Advances in Stroke Genetics . Advances in Stroke Research.

(2017). Recent Advances in Stroke Genetics . Advances in Stroke Research.

WORKING PAPER

COVID-19: A Review on Molecular Basis, Pathogenic Mechanisms, Therapeutic Aspects and Future Projections<strong> </strong> .