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★★★★★

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USD 75 /hr

★★★★★

☆☆☆☆☆

Hire Dr. Don N.

United States

USD 75 /hr

Accomplished scientific writer/editor, professor with 30+ years experience

Profile Summary

As a Professor in biomedical science, I have written, edited and reviewed many papers and grant applications. My team’s manuscripts have been published in prestigious journals.

Subject Matter Expertise

• ★ Apoptosis
• ☆ Biochemistry
• ☆ Cell Signaling Pathways

Services

• Services details not provided.

Work Experience

Emeritus Professor

La Jolla Institute for Immunology

June 2019 - Present

Professor

La Jolla Institute for Immunology

March 1993 - May 2019

Education

Ph.D., Biophysics

University of Rochester

September 1976 - June 1983

M.S., Mathematics

Drexel University

September 1975 - June 1976

B.S., Physics

Drexel University

September 1971 - June 1976

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Tomomi Kuwana, Louise E. King, Katia Cosentino, Julian Suess, Ana J. Garcia-Saez, Andrew P. Gilmore, Donald D. Newmeyer(2020). Mitochondrial residence of the apoptosis inducer {BAX} is more important than {BAX} oligomerization in promoting membrane permeabilization . Journal of Biological Chemistry. p. jbc.RA119.011635. American Society for Biochemistry {\&} Molecular Biology ({ASBMB})

Tong Liu, David Ron, Tomomi Kuwana, Hongkai Zhang, Matthew G. Vander Heiden, Richard A. Lerner, Donald D. Newmeyer(2019). Phenotypic selection with an intrabody library reveals an anti-apoptotic function of {PKM}2 requiring Mitofusin-1 . {PLOS} Biology. 17. (6). p. e2004413. Public Library of Science ({PLoS})

Kushnareva Y, Seong Y, Andreyev AY, Kuwana T, Kiosses WB, Votruba M, Newmeyer DD(2016). Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency . Cell death & disease.

Kuwana T, Olson NH, Kiosses WB, Peters B, Newmeyer DD(2016). Pro-apoptotic Bax molecules densely populate the edges of membrane pores . Scientific reports.

Renault TT, Floros KV, Elkholi R, Corrigan KA, Kushnareva Y, Wieder SY, Lindtner C, Serasinghe MN, Asciolla JJ, Buettner C, et al.(2014). Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis . Molecular cell.

Gillies LA, Du H, Peters B, Knudson CM, Newmeyer DD, Kuwana T(2014). Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes . Molecular biology of the cell.

Volkmann N, Marassi FM, Newmeyer DD, Hanein D(2013). The rheostat in the membrane: BCL-2 family proteins and apoptosis . Cell death and differentiation.

Kushnareva Y, Andreyev AY, Kuwana T, Newmeyer DD(2012). Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes . PLoS biology.

Yulia Kushnareva, Donald D. Newmeyer(2010). Bioenergetics and cell death . Annals of the New York Academy of Sciences. 1201. (1). p. 50--57. Wiley

Lartigue L, Kushnareva Y, Seong Y, Lin H, Faustin B, Newmeyer DD(2009). Caspase-independent mitochondrial cell death results from loss of respiration, not cytotoxic protein release . Molecular biology of the cell.

Yamaguchi R, Lartigue L, Perkins G, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD(2008). Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization . Molecular cell.

Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, et al.(2007). GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation . Cell.

Yamaguchi R, Andreyev A, Murphy AN, Perkins GA, Ellisman MH, Newmeyer DD(2006). Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity . Cell death and differentiation.

Muñoz-Pinedo C, Guío-Carrión A, Goldstein JC, Fitzgerald P, Newmeyer DD, Green DR(2006). Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration . Proceedings of the National Academy of Sciences of the United States of America.

Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD(2006). Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death . Molecular biology of the cell.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR(2005). The multidomain proapoptotic molecules Bax and Bak are directly activated by heat . Proceedings of the National Academy of Sciences of the United States of America.

Bouchier-Hayes L, Lartigue L, Newmeyer DD(2005). Mitochondria: pharmacological manipulation of cell death . The Journal of clinical investigation.

Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR(2005). PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 . Science (New York, N.Y.).

Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD(2005). BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly . Molecular cell.

Uren RT, Dewson G, Bonzon C, Lithgow T, Newmeyer DD, Kluck RM(2004). Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes . The Journal of biological chemistry.

Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR(2004). Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis . Science (New York, N.Y.).

Kuwana T, Newmeyer DD(2003). Bcl-2-family proteins and the role of mitochondria in apoptosis . Current opinion in cell biology.

Newmeyer DD, Ferguson-Miller S(2003). Mitochondria: releasing power for life and unleashing the machineries of death . Cell.

Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R, Green DR, Newmeyer DD(2002). Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane . Cell.

Abdullaev ZKh, Bodrova ME, Chernyak BV, Dolgikh DA, Kluck RM, Pereverzev MO, Arseniev AS, Efremov RG, Kirpichnikov MP, Mokhova EN, et al.(2002). A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect . The Biochemical journal.

Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, Kelekar A, Hanson DA, Kluck RM, Hitoshi Y, Johnson DE, et al.(2001). A distinct pathway of cell-mediated apoptosis initiated by granulysin . Journal of immunology (Baltimore, Md. : 1950).

Waterhouse NJ, Goldstein JC, von Ahsen O, Schuler M, Newmeyer DD, Green DR(2001). Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process . The Journal of cell biology.

Pinkoski MJ, Waterhouse NJ, Heibein JA, Wolf BB, Kuwana T, Goldstein JC, Newmeyer DD, Bleackley RC, Green DR(2001). Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway . The Journal of biological chemistry.

Waterhouse NJ, Goldstein JC, Kluck RM, Newmeyer DD, Green DR(2001). The (Holey) study of mitochondria in apoptosis . Methods in cell biology.

Von Ahsen O, Waterhouse NJ, Kuwana T, Newmeyer DD, Green DR(2000). The 'harmless' release of cytochrome c . Cell death and differentiation.

von Ahsen O, Renken C, Perkins G, Kluck RM, Bossy-Wetzel E, Newmeyer DD(2000). Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release . The Journal of cell biology.

Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD(2000). Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation . The Journal of biological chemistry.

Newmeyer DD, Bossy-Wetzel E, Kluck RM, Wolf BB, Beere HM, Green DR(2000). Bcl-xL does not inhibit the function of Apaf-1 . Cell death and differentiation.

von Ahsen O, Newmeyer DD(2000). Cell-free apoptosis in Xenopus laevis egg extracts . Methods in enzymology.

Kluck RM, Esposti MD, Perkins G, Renken C, Kuwana T, Bossy-Wetzel E, Goldberg M, Allen T, Barber MJ, Green DR, et al.(1999). The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol . The Journal of cell biology.

Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, et al.(1999). Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner . The Journal of cell biology.

Donald D. Newmeyer, Douglas R. Green(1998). Surviving the Cytochrome Seas . Neuron. 21. (4). p. 653--655. Elsevier {BV}

Kuwana T, Smith JJ, Muzio M, Dixit V, Newmeyer DD, Kornbluth S(1998). Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c . The Journal of biological chemistry.

Bossy-Wetzel E, Newmeyer DD, Green DR(1998). Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization . The EMBO journal.

Evans EK, Kuwana T, Strum SL, Smith JJ, Newmeyer DD, Kornbluth S(1997). Reaper-induced apoptosis in a vertebrate system . The EMBO journal.

Kluck RM, Martin SJ, Hoffman BM, Zhou JS, Green DR, Newmeyer DD(1997). Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system . The EMBO journal.

Farschon DM, Couture C, Mustelin T, Newmeyer DD(1997). Temporal phases in apoptosis defined by the actions of Src homology 2 domains, ceramide, Bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction . The Journal of cell biology.

Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD(1997). The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis . Science (New York, N.Y.).

Martin SJ, Newmeyer DD, Mathias S, Farschon DM, Wang HG, Reed JC, Kolesnick RN, Green DR(1995). Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis . The EMBO journal.

Newmeyer DD, Farschon DM, Reed JC(1994). Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria . Cell.

Newmeyer DD(1993). The nuclear pore complex and nucleocytoplasmic transport . Current opinion in cell biology.

Newmeyer DD, Wilson KL(1991). Egg extracts for nuclear import and nuclear assembly reactions . Methods in cell biology.

Newmeyer DD, Forbes DJ(1990). An N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear pore . The Journal of cell biology.

Finlay DR, Newmeyer DD, Hartl PM, Horecka J, Forbes DJ(1989). Nuclear transport in vitro . Journal of cell science. Supplement.

Newmeyer DD, Forbes DJ(1988). Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation . Cell.

Bürglin TR, Mattaj IW, Newmeyer DD, Zeller R, De Robertis EM(1987). Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression . Genes & development.

Finlay DR, Newmeyer DD, Price TM, Forbes DJ(1987). Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores . The Journal of cell biology.

Newmeyer DD, Finlay DR, Forbes DJ(1986). In vitro transport of a fluorescent nuclear protein and exclusion of non-nuclear proteins . The Journal of cell biology.

Newmeyer DD, Lucocq JM, Bürglin TR, De Robertis EM(1986). Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation . The EMBO journal.

Newmeyer DD, Ohlsson-Wilhelm BM(1985). Monoclonal antibody to a protein of the nucleus and mitotic spindle of mammalian cells. Localization and synthesis throughout the cell cycle . Chromosoma.

Fritz A, Parisot R, Newmeyer D, De Robertis EM(1984). Small nuclear U-ribonucleoproteins in Xenopus laevis development. Uncoupled accumulation of the protein and RNA components . Journal of molecular biology.

Maul GG, Baglia FA, Newmeyer DD, Ohlsson-Wilhelm BM(1984). The major 67 000 molecular weight protein of the clam oocyte nuclear envelope is lamin-like . Journal of cell science.