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Hire Dr. Dmitri P.

Canada

Profile Summary

• Over 15 years experience in Basic and Clinical Research, Drug Development and Project Management • Broad clinical and scientific knowledge in a variety of therapeutic areas • Proven record of executing and working successfully in a multidisciplinary team environment • Extensive knowledge and understanding of the Respiratory Medicine and Cell and Molecular Biology • Solid background in research methodology, protocol development, trial design and statistics • Experienced in critiquing, interpreting and disseminating complex scientific data • Effective in training, supervising and managing staff, including students and research assistants • Numerous interactions with ethics and regulatory bodies • Experienced in authoring clinical and scientific responses to regulatory queries • Comfortable working with alliance partners • Integrated thinker with strong problem-solving abilities • Comfortable working on multiple projects simultaneously and rapidly adjusting to shifting priorities • Excellent written, verbal and interpersonal communication skills

Subject Matter Expertise

• ★ Molecular Biology
• ★ Pulmonology/Respiratory Disease
• ☆ Cell Aging
• ☆ Drug Development

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

Research Associate

University of British Columbia

March 2008 - May 2016

Visiting Scientist

University of British Columbia

June 2005 - March 2008

Research Fellow

Albert-Ludwigs-Universitat Freiburg

May 2003 - June 2005

Scientist

Research Institute of Pulmonology and Tuberculosis

August 1988 - May 2005

Research Fellow

Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften

January 1999 - December 2001

Education

Postdoctoral (Medical Clinic)

Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften

1999 - 2001

PhD (Medicine)

Medical University of Belarus

1991 - 1994

MD (Internal Medicine)

Medical University of Belarus

September 1982 - June 1988

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Schuliga, M., Pechkovsky, D.V., Read, J., Waters, D.W., Blokland, K.E.C., Reid, A.T., Hogaboam, C.M., Khalil, N., Burgess, J.K., Prêle, C.M., et al.(2018). Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts . Journal of Cellular and Molecular Medicine.

Jasmin Schnerch, Antje Prasse, Dimitrios Vlachakis, Kathrin L. Schuchardt, Dmitri V. Pechkovsky, Torsten Goldmann, Karoline I. Gaede, Joachim Müller-Quernheim, Gernot Zissel(2016). Functional Toll-Like Receptor 9 Expression and {CXCR}3 Ligand Release in Pulmonary Sarcoidosis . American Journal of Respiratory Cell and Molecular Biology. 55. (5). p. 749--757. American Thoracic Society

Schnerch, J., Prasse, A., Vlachakis, D., Schuchardt, K.L., Pechkovsky, D.V., Goldmann, T., Gaede, K.I., Muller-Quernheim, J., Zissel, G.(2016). Functional toll-like receptor 9 expression and CXCR3 ligand release in pulmonary sarcoidosis . American Journal of Respiratory Cell and Molecular Biology. 55. (5). p. 749-757.

Christenson, S.A., Brandsma, C.-A., Campbell, J.D., Knight, D.A., Pechkovsky, D.V., Hogg, J.C., Timens, W., Postma, D.S., Lenburg, M., Spira, A.(2013). MiR-638 regulates gene expression networks associated with emphysematous lung destruction . Genome Medicine. 5. (12).

Stephanie A Christenson, Corry-Anke Brandsma, Joshua D Campbell, Darryl A Knight, Dmitri V Pechkovsky, James C Hogg, Wim Timens, Dirkje S Postma, Marc Lenburg, Avrum Spira(2013). {miR}-638 regulates gene expression networks associated with emphysematous lung destruction . Genome Med. 5. (12). p. 114. Springer Science $\mathplus$ Business Media

Dmitri V. Pechkovsky, Cecilia M. Prêle, John Wong, Cory M. Hogaboam, Robin J. McAnulty, Geoffrey J. Laurent, Samuel S.-M. Zhang, Moisés Selman, Steven E. Mutsaers, Darryl A. Knight(2012). {STAT}3-Mediated Signaling Dysregulates Lung Fibroblast-Myofibroblast Activation and Differentiation in {UIP}/{IPF} . The American Journal of Pathology. 180. (4). p. 1398--1412. Elsevier {BV}

Joshua D Campbell, John E McDonough, Julie E Zeskind, Tillie L Hackett, Dmitri V Pechkovsky, Corry-Anke Brandsma, Masaru Suzuki, John V Gosselink, Gang Liu, Yuriy O Alekseyev, et al.(2012). A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide {GHK} . Genome Med. 4. (8). p. 67. Springer Science $\mathplus$ Business Media

Campbell, J.D., McDonough, J.E., Zeskind, J.E., Hackett, T.L., Pechkovsky, D.V., Brandsma, C.-A., Suzuki, M., Gosselink, J.V., Liu, G., Alekseyev, Y.O., et al.(2012). A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK . Genome Medicine. 4. (12).

Pechkovsky, D.V., Prêle, C.M., Wong, J., Hogaboam, C.M., McAnulty, R.J., Laurent, G.J., Zhang, S.S.-M., Selman, M., Mutsaers, S.E., Knight, D.A.(2012). STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF . American Journal of Pathology. 180. (4). p. 1398-1412.

Dawn M. Cooper, Dmitri V. Pechkovsky, Tillie L. Hackett, Darryl A. Knight, David J. Granville, Silvano Sozzani(2011). Granzyme K Activates Protease-Activated Receptor-1 . {PLoS} {ONE}. 6. (6). p. e21484. Public Library of Science ({PLoS})

Abraham, T., Wadsworth, S., Carthy, J.M., Pechkovsky, D.V., McManus, B.(2011). Minimally invasive imaging method based on second harmonic generation and multiphoton excitation fluorescence in translational respiratory research . Respirology. 16. (1). p. 22-33.

Dmitri V. Pechkovsky, Antje Prasse, Florian Kollert, Kathrin M.Y. Engel, Jan Dentler, Werner Luttmann, Karlheinz Friedrich, Joachim Müller-Quernheim, Gernot Zissel(2010). Alternatively activated alveolar macrophages in pulmonary fibrosis{\textemdash}mediator production and intracellular signal transduction . Clinical Immunology. 137. (1). p. 89--101. Elsevier {BV}

Dmitri V. Pechkovsky, Tillie L. Hackett, Steven S. An, Furquan Shaheen, Lynne A. Murray, Darryl A. Knight(2010). Human Lung Parenchyma but Not Proximal Bronchi Produces Fibroblasts with Enhanced {TGF}-$\upbeta$ Signaling and $\upalpha$-{SMA} Expression . Am J Respir Cell Mol Biol. 43. (6). p. 641--651. American Thoracic Society

Pechkovsky, D.V., Hackett, T.L., An, S.S., Shaheen, F., Murray, L.A., Knight, D.A.(2010). Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-β signaling and α-SMA expression . American Journal of Respiratory Cell and Molecular Biology. 43. (6). p. 641-651.

Thomas ABRAHAM, Samuel WADSWORTH, Jon M. CARTHY, Dmitri V. PECHKOVSKY, Bruce McMANUS(2010). Minimally invasive imaging method based on second harmonic generation and multiphoton excitation fluorescence in translational respiratory research . Respirology. 16. (1). p. 22--33. Wiley-Blackwell

Pechkovsky, D.V., Prasse, A., Kollert, F., Engel, K.M.Y., Dentler, J., Luttmann, W., Friedrich, K., Müller-Quernheim, J., Zissel, G.(2010). Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction . Clinical Immunology. 137. (1). p. 89-101.

Tillie-Louise Hackett, Stephanie Mary Warner, Dorota Stefanowicz, Furquan Shaheen, Dmitri V. Pechkovsky, Lynne A. Murray, Rochelle Argentieri, Anthony Kicic, Stephen M. Stick, Tony R. Bai, et al.(2009). Induction of Epithelial{\textendash}Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-$\upbeta$1 . Am J Respir Crit Care Med. 180. (2). p. 122--133. American Thoracic Society

Hackett, T.-L., Warner, S.M., Stefanowicz, D., Shaheen, F., Pechkovsky, D.V., Murray, L.A., Argentieri, R., Kicic, A., Stick, S.M., Bai, T.R., et al.(2009). Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1 . American Journal of Respiratory and Critical Care Medicine. 180. (2). p. 122-133.

Tillie-Louise Hackett, Furquan Shaheen, Andrew Johnson, Samuel Wadsworth, Dmitri V. Pechkovsky, David B. Jacoby, Anthony Kicic, Stephen M. Stick, Darryl A. Knight(2008). Characterization of Side Population Cells from Human Airway Epithelium . {STEM} {CELLS}. 26. (10). p. 2576--2585. Wiley-Blackwell

D. V. Pechkovsky, A. K. Scaffidi, T. L. Hackett, J. Ballard, F. Shaheen, P. J. Thompson, V. J. Thannickal, D. A. Knight(2008). Transforming Growth Factor ~1 Induces ~v~3 Integrin Expression in Human Lung Fibroblasts via a ~3 Integrin-, c-Src-, and p38 {MAPK}-dependent Pathway . Journal of Biological Chemistry. 283. (19). p. 12898--12908. American Society for Biochemistry {\&} Molecular Biology ({ASBMB})

Hackett, T.-L., Shaheen, F., Johnson, A., Wadsworth, S., Pechkovsky, D.V., Jacoby, D.B., Kicic, A., Stick, S.M., Knight, D.A.(2008). Characterization of side population cells from human airway epithelium . Stem Cells. 26. (10). p. 2576-2585.

Pechkovsky, D.V., Scaffidi, A.K., Hackett, T.L., Ballard, J., Shaheen, F., Thompson, P.J., Thannickal, V.J., Knight, D.A.(2008). Transforming growth factor β1 induces αvβ3 integrin expression in human lung fibroblasts via a β3 integrin-, c-Src-, and p38 MAPK-dependent pathway . Journal of Biological Chemistry. 283. (19). p. 12898-12908.

Antje Prasse, Martin Germann, Dmitri V. Pechkovsky, Anna Markert, Tibor Verres, Mirjam Stahl, Inga Melchers, Werner Luttmann, Joachim Müller-Quernheim, Gernot Zissel(2007). {IL}-10{\textendash}producing monocytes differentiate to alternatively activated macrophages and are~increased in atopic patients . Journal of Allergy and Clinical Immunology. 119. (2). p. 464--471. Elsevier {BV}

Antje Prasse, Dmitri V. Pechkovsky, Galen B. Toews, Markus Schäfer, Stephan Eggeling, Corinna Ludwig, Martin Germann, Florian Kollert, Gernot Zissel, Joachim Müller-Quernheim(2007). {CCL}18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis . Arthritis {\&} Rheumatism. 56. (5). p. 1685--1693. Wiley-Blackwell

Prasse, A., Pechkovsky, D.V., Toews, G.B., Schäfer, M., Eggeling, S., Ludwig, C., Germann, M., Kollert, F., Zissel, G., Müller-Quernheim, J.(2007). CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis . Arthritis and Rheumatism. 56. (5). p. 1685-1693.

McWhinnie, R., Pechkovsky, D.V., Zhou, D., Lane, D., Halayko, A.J., Knight, D.A., Bai, T.R.(2007). Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells . American Journal of Physiology - Lung Cellular and Molecular Physiology. 292. (1).

Prasse, A., Germann, M., Pechkovsky, D.V., Markert, A., Verres, T., Stahl, M., Melchers, I., Luttmann, W., Müller-Quernheim, J., Zissel, G.(2007). IL-10-producing monocytes differentiate to alternatively activated macrophages and are increased in atopic patients . Journal of Allergy and Clinical Immunology. 119. (2). p. 464-471.

R. McWhinnie, D. V. Pechkovsky, D. Zhou, D. Lane, A. J. Halayko, D. A. Knight, T. R. Bai(2006). Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells . {AJP}: Lung Cellular and Molecular Physiology. 292. (1). p. L278--L286. American Physiological Society

Antje Prasse, Dmitri V. Pechkovsky, Galen B. Toews, Wolfgang Jungraithmayr, Florian Kollert, Torsten Goldmann, Ekkehard Vollmer, Joachim Müller-Quernheim, Gernot Zissel(2006). A Vicious Circle of Alveolar Macrophages and Fibroblasts Perpetuates Pulmonary Fibrosis via {CCL}18 . Am J Respir Crit Care Med. 173. (7). p. 781--792. American Thoracic Society

Dmitri V. Pechkovsky, Torsten Goldmann, Ekkehard Vollmer, Joachim Müller-Quernheim, Gernot Zissel(2006). Interleukin-18 expression by alveolar epithelial cells type {II} in tuberculosis and sarcoidosis . {FEMS} Immunology {\&} Medical Microbiology. 46. (1). p. 30--38. Oxford University Press ({OUP})

Prasse, A., Pechkovsky, D.V., Toews, G.B., Jungraithmayr, W., Kollert, F., Goldmann, T., Vollmer, E., Müller-Quernheim, J., Zissel, G.(2006). A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18 . American Journal of Respiratory and Critical Care Medicine. 173. (7). p. 781-792.

Pechkovsky, D.V., Goldmann, T., Vollmer, E., Müller-Quernheim, J., Zissel, G.(2006). Interleukin-18 expression by alveolar epithelial cells type II in tuberculosis and sarcoidosis . FEMS Immunology and Medical Microbiology. 46. (1). p. 30-38.

K. Sendide, A.-E. Deghmane, D. Pechkovsky, Y. Av-Gay, A. Talal, Z. Hmama(2005). Mycobacterium bovis {BCG} Attenuates Surface Expression of Mature Class {II} Molecules through {IL}-10-Dependent Inhibition of Cathepsin S . The Journal of Immunology. 175. (8). p. 5324--5332. The American Association of Immunologists

Sendide, K., Deghmane, A.-E., Pechkovsky, D., Av-Gay, Y., Talal, A., Hmama, Z.(2005). Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S . Journal of Immunology. 175. (8). p. 5324-5332.

Pechkovsky, D.V., Goldmann, T., Ludwig, C., Prasse, A., Vollmer, E., Müller-Quernheim, J., Zissel, G.(2005). CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II . Respiratory Research. 6.

D.V. Pechkovsky, G. Zissel, C. Stamme, T. Goldmann, H. Ari Jaffe, M. Einhaus, C. Taube, H. Magnussen, M. Schlaak, J. Muller-Quernheim(2002). Human alveolar epithelial cells induce nitric oxide synthase-2 expression in alveolar macrophages . European Respiratory Journal. 19. (4). p. 672--683. European Respiratory Society ({ERS})

T. Goldmann, K.H. Wiedorn, H. Kühl, J. Olert, D. Branscheid, D. Pechkovsky, G. Zissel, J. Galle, J. Müller-Quernheim, E. Vollmer(2002). Assessment of Transcriptional Gene Activity in situ by Application of {HOPE}-fixed, Paraffin-embedded Tissues . Pathology - Research and Practice. 198. (2). p. 91--95. Elsevier {BV}

Pechkovsky, D.V., Zissel, G., Goldmann, T., Einhaus, M., Taube, C., Magnussen, H., Schlaak, M., Müller-Quernheim, J.(2002). Pattern of NOS2 and NOS3 mRNA expression in human A549 cells and primary cultured AEC II . American Journal of Physiology - Lung Cellular and Molecular Physiology. 282. (4 26-4).

Pechkovsky, D.V., Zissel, G., Stamme, C., Goldmann, T., Ari Jaffe, H., Einhaus, M., Taube, C., Magnussen, H., Schlaak, M., Müller-Quernheim, J.(2002). Human alveolar epithelial cells induce nitric oxide synthase-2 expression in alveolar macrophages . European Respiratory Journal. 19. (4). p. 672-683.

Goldmann, T., Wiedorn, K.H., Kühl, H., Olert, J., Branscheid, D., Pechkovsky, D., Zissel, G., Galle, J., Müller-Quernheim, J., Vollmer, E.(2002). Assessment of transcriptional gene activity in situ by application of HOPE-fixed, paraffinembedded tissues . Pathology Research and Practice. 198. (2). p. 91-95.

D Pechkovsky(2000). Calprotectin ({MRP}8/14 protein complex) release during mycobacterial infection in vitro and in vivo . {FEMS} Immunology and Medical Microbiology. 29. (1). p. 27--33. Wiley-Blackwell

Pechkovsky, D.V., Zalutskaya, O.M., Ivanov, G.I., Misuno, N.I.(2000). Calprotectin (MRP8/14 protein complex) release during mycobacterial infection in vitro and in vivo . FEMS Immunology and Medical Microbiology. 29. (1). p. 27-33.

Pechkovsky, D.V., Zissel, G., Ziegenhagen, M.W., Einhaus, M., Taube, C., Rabe, K.F., Magnussen, H., Papadopoulos, T., Schlaak, M., Müller-Quernheim, J.(2000). Effect of proinflammatory cytokines on interleukin-8 mRNA expression and protein production by isolated human alveolar epithelial cells type II in primary culture . European Cytokine Network. 11. (4). p. 618-625.

Dmitry Lapotko, Georgy Kuchinsky, Michael Potapnev, Dmitry Pechkovsky(1996). Photothermal image cytometry of human neutrophils. Cytometry. 24. (3). p. 198--203. Wiley

Dmitry V. Pechkovsky, Michael P. Potapnev, Oksana M. Zalutskaya(1996). Different patterns of cytokine regulation of phagocytosis and bacterial killing by human neutrophils . International Journal of Antimicrobial Agents. 7. (1). p. 33--40. Elsevier {BV}

Pechkovsky, D.V., Potapnev, M.P., Zalutskaya, O.M.(1996). Different patterns of cytokine regulation of phagocytosis and bacterial killing by human neutrophils . International Journal of Antimicrobial Agents. 7. (1). p. 33-40.

Lapotko, D., Kuchinsky, G., Potapnev, M., Pechkovsky, D.(1996). Photothermal image cytometry of human neutrophils. Cytometry. 24. (3). p. 198-203.

Potapnev, M.P., Pechkovsky, D.V., Garbuzenko, T.S., Zobnin, V.D., Mitskevich, P.B.(1994). Lymphokine-activated killer (LAK) cell function depends on the presence of monocytes/macrophages . Immunologiya. (6). p. 30-32.

Pechkovsky, D.V., Vilkitskaya, N.O., Potapnev, M.P.(1993). Neutrophil antibacterial activity in patients with chronic bronchitis. The use of proinflammatory cytokines and allogeneic lymphocytes for immunocorrection in vitro . Terapevticheskii Arkhiv. 65. (7). p. 67-70.

Pechkovsky, D.V., Potapnev, M.P., Voznyuk, A.V.(1993). The enhancement of bactericidity but not of phagocyting activity of human neutrophils under interleukin 6 action . Immunologiya. (6). p. 29-30.

(1992). The stimulation of the bactericidal activity of human neutrophils by lymphoid cells activated by interleukin-2; the effect of inflammatory cytokines. Biull Eksp Biol Med.

Potapnev, M.P., Pechkovsky, D.V.(1992). Modulation of human neutrophil phagocytosis and bacterial killing by inflammatory cytokines . Immunologiya. (3). p. 34-36.

CONFERENCE PAPER

Dmitri V. Pechkovsky, Cory M. Hogaboam, Eric Yao, Nasreen Khalil, Moises Selman, Darryl A. Knight(2012). Fibroblast Senescence In {UIP}/{IPF}: A Contributing Factor Or Consequence Of The Disease? . American Thoracic Society

Dmitri V. Pechkovsky, John Wong, Tillie-Louise Hackett, Furquan Shaheen, Martin R. Kolb, Darryl Knight(2011). Expression And Responsiveness To {CCN}2/{CTGF} Plays A Critical Role In The Phenotypic Heterogeneity Of Human Pulmonary Fibroblasts . American Thoracic Society

Dmitri V. Pechkovsky, Tillie L. Hackett, John Wong, Furquan Shaheen, Sarah Neumann, Michael S. Kobor, Darryl A. Knight(2010). Tissue-specific Collagen Deposition And Phenotype Of Human Pulmonary Fibroblasts: Significance For Airway Remodeling . American Thoracic Society

F Shaheen, TL Hackett, DA Knight, DV Pechkovsky(2009). Blockade of {ALK}5 in Normal Lung Parenchymal Fibroblasts Inhibits Exaggerated Smad3 and {JNK} Signaling and Reverses Their Myofibroblast-Like Phenotype Compared with Paired Bronchial Wall-Derived Fibroblasts . American Thoracic Society

T Hackett, D Stefanowicz, F Shaheen, D Pechkovsky, SM Warner, L Murray, A Kicic, S Stick, TR Bai, DA Knight(2009). Epithelial-Mesenchymal Transition Occurs in Undifferentiated Basal Airway Epithelial Cells Derived from Normal and Asthmatic Subjects . American Thoracic Society

T Hackett, F Shaheen, D Pechkovsky, G Singhera, TR Bai, DA Knight(2009). The Role of Apical Junction Proteins E-Cadherin and Zonular Occluding-1 in Epithelial Repair in Asthmatic Airways . American Thoracic Society

DV Pechkovsky, TL Hackett, F Shaheen, CM Hogaboam, M Selman, RJ McAnulty, GJ Laurent, SE Mutsaers, DA Knight(2009). Altered Level of {STAT}3 Basal Activity Influences Lung Fibroblast Thy-1 and $\upalpha$v$\upbeta$3 Integrin Expression . American Thoracic Society