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India

USD 20 /hr

Bioinformatics, data analyst, NGS, R, Scientific writing with 15 years of experience

Profile Summary

Experience in Bioinformatics, Genome Analysis, clustering

Subject Matter Expertise

• ☆ Molecular Modeling
• ☆ Next Generation Sequencing (NGS)
• ☆ Bioinformatics
• ☆ Structural Bioinformatics
• ☆ R

Services

• Writing
• Data & AI

Writing Non-Medical Regulatory Writing, Technical Writing

Data & AI Statistical Analysis, Data Visualization

Work Experience

Central Drug Research Institute

March 2020 - Present

Education

PhD in bioinformatics

Central Drug Research Institute

May 2004 - May 2010

Certifications

• Certification details not provided.

Publications

BOOK CHAPTER

Dube, D.(2022). Polo-like kinases: An antimitotic drug target for cancer therapy . Protein Kinase Inhibitors: From Discovery to Therapeutics. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 457-477.

JOURNAL ARTICLE

Dube D, Tiwari P, Kaur P(2016). The hunt for antimitotic agents: an overview of structure-based design strategies . Expert opinion on drug discovery.

Rani L, Mathur N, Gogia A, Vishnubhatla S, Kumar L, Sharma A, Dube D, Kaur P, Gupta R(2016). Immunoglobulin heavy chain variable region gene repertoire and B-cell receptor stereotypes in Indian patients with chronic lymphocytic leukemia . Leukemia & lymphoma.

Rani, L., Mathur, N., Gogia, A., Vishnubhatla, S., Kumar, L., Sharma, A., Dube, D., Kaur, P., Gupta, R.(2016). Immunoglobulin heavy chain variable region gene repertoire and B-cell receptor stereotypes in Indian patients with chronic lymphocytic leukemia . Leukemia and Lymphoma. 57. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2389-2400.

Dube, D., Tiwari, P., Kaur, P.(2016). The hunt for antimitotic agents: an overview of structure-based design strategies . Expert Opinion on Drug Discovery. 11. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 579-597.

Dube D, Sharma S, Singh TP, Kaur P(2014). Pharmacophore Mapping, In Silico Screening and Molecular Docking to Identify Selective Trypanosoma brucei Pteridine Reductase Inhibitors . Molecular informatics.

Dube, D., Sharma, S., Singh, T.P., Kaur, P.(2014). Pharmacophore mapping, in silico screening and molecular docking to identify selective Trypanosoma brucei pteridine reductase inhibitors . Molecular Informatics. 33. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 124-134.

Sharma, P., Dube, D., Yadav, S.P., Sinha, M., Kaur, P., Sharma, S., Singh, T.P.(2014). Structural and functional studies of mammalian peptidoglycan recognition protein, pgrp-s . Journal of the Indian Institute of Science. 94. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 109-117.

Nahar, R., Dube, D., Parakh, R., Deb, R., Saxena, R., Singh, T.P., Verma, I.C.(2013). Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity . Thrombosis Research. 131. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 535-539.

Sharma, P., Dube, D., Sinha, M., Yadav, S., Kaur, P., Sharma, S., Singh, T.P.(2013). Structural Insights into the Dual Strategy of Recognition by Peptidoglycan Recognition Protein, PGRP-S: Structure of the Ternary Complex of PGRP-S with Lipopolysaccharide and Stearic Acid . PLoS ONE. 8. (1).

Sharma, P., Yamini, S., Dube, D., Singh, A., Mal, G., Pandey, N., Sinha, M., Singh, A.K., Dey, S., Kaur, P., et al.(2013). Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site . Archives of Biochemistry and Biophysics. 529. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-10.

Sharma, P., Dube, D., Sinha, M., Dey, S., Kaur, P., Sharma, S., Singh, T.P.(2012). Structural basis of heparin binding to camel peptidoglycan recognition protein-S . International Journal of Biochemistry and Molecular Biology. 3. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 86-94.

Sharma, P., Yamini, S., Dube, D., Singh, A., Sinha, M., Dey, S., Mitra, D.K., Kaur, P., Sharma, S., Singh, T.P.(2012). Structural studies on molecular interactions between camel peptidoglycan recognition protein, CPGRP-S, and peptidoglycan moieties N-acetylglucosamine and N-acetylmuramic acid . Journal of Biological Chemistry. 287. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 22153-22164.

Kukshal, V., Mishra, M., Ajay, A., Khanam, T., Sharma, R., Dube, D., Chopra, D., Tripathi, R.P., Ramachandran, R.(2012). Synthesis and bioevaluation of aryl hydroxamates distinguishing between NAD ⁺ and ATP-dependent DNA ligases . MedChemComm. 3. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 453-461.

Dube, D., Periwal, V., Kumar, M., Sharma, S., Singh, T.P., Kaur, P.(2012). 3D-QSAR based pharmacophore modeling and virtual screening for identification of novel pteridine reductase inhibitors . Journal of Molecular Modeling. 18. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1701-1711.

Dube D, Periwal V, Kumar M, Sharma S, Singh TP, Kaur P(2011). 3D-QSAR based pharmacophore modeling and virtual screening for identification of novel pteridine reductase inhibitors . Journal of molecular modeling.

Paliwal P, Tandon R, Dube D, Kaur P, Sharma A(2011). Familial segregation of a VSX1 mutation adds a new dimension to its role in the causation of keratoconus . Molecular vision.

Paliwal, P., Tandon, R., Dube, D., Kaur, P., Sharma, A.(2011). Familial segregation of a VSX1 mutation adds a new dimension to its role in the causation of keratoconus . Molecular Vision. 17. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 481-485.

Sharma, P., Dube, D., Sinha, M., Mishra, B., Dey, S., Mal, G., Pathak, K.M.L., Kaur, P., Sharma, S., Singh, T.P.(2011). Multiligand specificity of pathogen-associated molecular pattern-binding site in peptidoglycan recognition protein . Journal of Biological Chemistry. 286. (36). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 31723-31730.

Sharma, P., Dube, D., Singh, A., Mishra, B., Singh, N., Sinha, M., Dey, S., Kaur, P., Mitra, D.K., Sharma, S., et al.(2011). Structural basis of recognition of pathogen-associated molecular patterns and inhibition of proinflammatory cytokines by camel peptidoglycan recognition protein . Journal of Biological Chemistry. 286. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 16208-16217.

Tripathi, R.P., Pandey, J., Kukshal, V., Ajay, A., Mishra, M., Dube, D., Chopra, D., Dwivedi, R., Chaturvedi, V., Ramachandran, R.(2011). Synthesis, in silico screening and bioevaluation of dispiro-cycloalkanones as antitubercular and mycobacterial NAD⁺-dependent DNA ligase inhibitors . MedChemComm. 2. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 378-384.

Paliwal P, Sharma A, Tandon R, Sharma N, Titiyal JS, Sen S, Kaur P, Dube D, Vajpayee RB(2010). TGFBI mutation screening and genotype-phenotype correlation in north Indian patients with corneal dystrophies . Molecular vision.

Paliwal P, Gupta J, Tandon R, Sharma N, Titiyal JS, Kashyap S, Sen S, Kaur P, Dube D, Sharma A, et al.(2010). Identification and characterization of a novel TACSTD2 mutation in gelatinous drop-like corneal dystrophy . Molecular vision.

Kumar, S., Singh, N., Sinha, M., Dube, D., Singh, S.B., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S., Singh, T.P.(2010). Crystal structure determination and inhibition studies of a novel xylanase and α-amylase inhibitor protein (XAIP) from Scadoxus multiflorus . FEBS Journal. 277. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2868-2882.

Kumar, S., Singh, N., Mishra, B., Dube, D., Sinha, M., Singh, S.B., Dey, S., Kaur, P., Sharma, S., Singh, T.P.(2010). Modulation of inhibitory activity of xylanase - α-amylase inhibitor protein (XAIP): Binding studies and crystal structure determination of XAIP- II from Scadoxus multiflorus at 1.2 Å resolution . BMC Structural Biology. 10.

Paliwal, P., Sharma, A., Tandon, R., Sharma, N., Titiyal, J.S., Sen, S., Kaur, P., Dube, D., Vajpayee, R.B.(2010). TGFBI mutation screening and genotype-phenotype correlation in north Indian patients with corneal dystrophies . Molecular Vision. 16. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1429-1438.

Paliwal, P., Gupta, J., Tandon, R., Sharma, N., Titiyal, J.S., Kashyap, S., Sen, S., Kaur, P., Dube, D., Sharma, A., et al.(2010). Identification and characterization of a novel TACSTD2 mutation in gelatinous drop-like corneal dystrophy . Molecular Vision. 16. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 729-739.

Misra, G., Aggarwal, A., Dube, D., Zaman, M.S., Singh, Y., Ramachandran, R.(2009). Crystal structure of the Bacillus anthracis nucleoside diphosphate kinase and its characterization reveals an enzyme adapted to perform under stress conditions . Proteins: Structure, Function and Bioinformatics. 76. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 496-506.

Pandey, J., Sharma, A., Tiwari, V.K., Dube, D., Ramachandran, R., Chaturvedi, V., Sinha, S.K., Mishra, N.N., Shukla, P.K., Tripathi, R.P.(2009). Solution-phase synthesis of a library of carbapeptide analogues based on glycosylamino acid scaffolds and their in silico screening and antimicrobial evaluation . Journal of Combinatorial Chemistry. 11. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 422-427.

Dwivedi, N., Dube, D., Pandey, J., Singh, B., Kukshal, V., Ramachandran, R., Tripathi, R.P.(2008). NAD⁺-dependent DNA ligase: A novel target waiting for the right inhibitor . Medicinal Research Reviews. 28. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 545-568.

Srivastava, S.K., Dube, D., Kukshal, V., Jha, A.K., Hajela, K., Ramachandran, R.(2007). NAD⁺-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: Novel structure-function relationship and identification of a specific inhibitor . Proteins: Structure, Function and Genetics. 69. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 97-111.

Srivastava SK, Dube D, Tewari N, Dwivedi N, Tripathi RP, Ramachandran R(2005). Mycobacterium tuberculosis NAD+-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I . Nucleic acids research.

Srivastava, S.K., Dube, D., Tewari, N., Dwivedi, N., Tripathi, R.P., Ramachandran, R.(2005). Mycobacterium tuberculosis NAD⁺-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I . Nucleic Acids Research. 33. (22). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7090-7101.

CONFERENCE PAPER

Dube, D., Tripathi, S.M., Ramachandran, R.(2008). Identification of in vitro inhibitors of Mycobacterium tuberculosis Lysine ε-aminotransferase by pharmacophore mapping and three-dimensional flexible searches . Medicinal Chemistry Research. 17. (2-7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 182-188.

Dube, D., Kukshal, V., Srivastava, S.K., Tripathi, R.P., Ramachandran, R.(2008). NAD⁺-dependent DNA ligase (Rv3014c) from M. tuberculosis: Strategies for inhibitor design . Medicinal Chemistry Research. 17. (2-7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 189-198.

Dube, D., Srivastava, S.K., Kukshal, V., Tripathi, R.P., Ramachandran, R.(2006). Novel specific inhibitors of NAD⁺-dependent DNA ligase (RV3014C) from M. tuberculosis identified from virtual screening . Medicinal Chemistry Research. 15. (1-6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93-94.