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Profile Details
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Hire Dr. Daniel H.
United Kingdom

Bioinformatics Scientist

Profile Summary
Subject Matter Expertise
Writing Technical Writing
Data & AI Statistical Analysis, Data Visualization
Work Experience

Founder and CEO


February 2020 - Present

Bioinformatics Scientist


May 2019 - Present


Doctor of Philosophy

University of Southampton

September 2009 - September 2013

Master's Degree in Bionformatics

University of Oxford

September 2009 - June 2010

  • Certification details not provided.
Huber, R.G., Berglund, N.A., Kargas, V., Marzinek, J.K., Holdbrook, D.A., Khalid, S., Piggot, T.J., Schmidtchen, A., Bond, P.J.(2018). A Thermodynamic Funnel Drives Bacterial Lipopolysaccharide Transfer in the TLR4 Pathway . Structure.
Daniel Holdbrook, Jan K. Marzinek, Roland G. Huber, Chandra Verma, Peter J. Bond(2017). Simulations Help Unravel Flavivirus Envelope Structure and Function . Biophysical Journal. 112. (3). p. 309a. Elsevier {BV}
Huber, R.G., Marzinek, J.K., Holdbrook, D.A., Bond, P.J.(2017). Multiscale molecular dynamics simulation approaches to the structure and dynamics of viruses . Progress in Biophysics and Molecular Biology. 128. p. 121-132.
Holdbrook, D.A., Burmann, B.M., Huber, R.G., Petoukhov, M.V., Svergun, D.I., Hiller, S., Bond, P.J.(2017). A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone . Structure. 25. (7). p. 1079-1088.e3.
Kargas, V., Marzinek, J.K., Holdbrook, D.A., Yin, H., Ford, R.C., Bond, P.J.(2017). A polar SxxS motif drives assembly of the transmembrane domains of Toll-like receptor 4 . Biochimica et Biophysica Acta - Biomembranes. 1859. (10). p. 2086-2095.
Marzinek, J.K., Holdbrook, D.A., Huber, R.G., Verma, C., Bond, P.J.(2016). Pushing the Envelope: Dengue Viral Membrane Coaxed into Shape by Molecular Simulations . Structure. 24. (8). p. 1410-1420.
Holdbrook, D.A., Huber, R.G., Piggot, T.J., Bond, P.J., Khalid, S.(2016). Dynamics of crowded vesicles: Local and global responses to membrane composition . PLoS ONE. 11. (6).
Maurer-Stroh, S., Mak, T., Ng, Y., Phuah, S., Huber, R.G., Marzinek, J.K., Holdbrook, D.A., Lee, R.T., Cui, L., Lin, R.T., et al.(2016). South-east Asian Zika virus strain linked to cluster of cases in Singapore, August 2016 . Eurosurveillance. 21. (38).
Björn M. Burmann, Daniel A. Holdbrook, Morgane Callon, Peter J. Bond, Sebastian Hiller(2015). Revisiting the Interaction between the Chaperone Skp and Lipopolysaccharide . Biophysical Journal. 108. (6). p. 1516--1526. Elsevier {BV}
Nils A. Berglund, Daniel A. Holdbrook, Syma Khalid, Peter J. Bond(2015). The Structural Basis for Lipid a Recognition in the {CD}14 Innate Immune Co-Receptor . Biophysical Journal. 108. (2). p. 350a--351a. Elsevier {BV}
Khalid, S., Berglund, N.A., Holdbrook, D.A., Leung, Y.M., Parkin, J.(2015). The membranes of Gram-negative bacteria: Progress in molecular modelling and simulation . Biochemical Society Transactions. 43. p. 162-167.
Leung, Y.M., Holdbrook, D.A., Piggot, T.J., Khalid, S.(2014). The NorM MATE transporter from N. gonorrhoeae: Insights into drug and ion binding from atomistic molecular dynamics simulations . Biophysical Journal. 107. (2). p. 460-468.
Syma Khalid, Thomas J. Piggot, Daniel A. Holdbrook, Jamie Parkin(2013). The Complexities of the E.Coli Cell Envelope: Details Revealed by {MD} Simulations . Biophysical Journal. 104. (2). p. 548a. Elsevier {BV}
Holdbrook, D.A., Piggot, T.J., Sansom, M.S.P., Khalid, S.(2013). Stability and membrane interactions of an autotransport protein: MD simulations of the Hia translocator domain in a complex membrane environment . Biochimica et Biophysica Acta - Biomembranes. 1828. (2). p. 715-723.
Piggot, T.J., Holdbrook, D.A., Khalid, S.(2013). Conformational dynamics and membrane interactions of the E. coli outer membrane protein FecA: A molecular dynamics simulation study . Biochimica et Biophysica Acta - Biomembranes. 1828. (2). p. 284-293.
Joseph Goose, Daniel A. Holdbrook, Syma Khalid, Mark Sansom(2012). The Role of Instantaneous Lipid {\textquotedblleft}Flows{\textquotedblright} Within the E. coli Outer Membrane . Biophysical Journal. 102. (3). p. 299a. Elsevier {BV}
Daniel A. Holdbrook, Thomas J. Piggot, Syma Khalid(2012). The Autotransporter $\upbeta$ Domain: Insights into Structure and Function through Molecular Dynamics Simulations . Biophysical Journal. 102. (3). p. 624a. Elsevier {BV}
Thomas J. Piggot, Daniel A. Holdbrook, Syma Khalid(2011). Environmental Influences on the Conformational Dynamics of Tonb-Dependent Transporters: Molecular Dynamics Simulations of Complex Membrane Models . Biophysical Journal. 100. (3). p. 359a. Elsevier {BV}
Phedra Marius, Daniel A. Holdbrook, Syma Khalid, Philip T.F. Williamson(2011). A Putative Role for Lipid-Protein Interactions in the Localisation of Glycosyltransferases within the Cell? . Biophysical Journal. 100. (3). p. 636a--637a. Elsevier {BV}
Piggot, T.J., Holdbrook, D.A., Khalid, S.(2011). Electroporation of the E. coli and S. aureus membranes: Molecular dynamics simulations of complex bacterial membranes . Journal of Physical Chemistry B. 115. (45). p. 13381-13388.
Holdbrook, D.A., Leung, Y.M., Piggot, T.J., Marius, P., Williamson, P.T.F., Khalid, S.(2010). Stability and membrane orientation of the fukutin transmembrane domain: A combined multiscale molecular dynamics and circular dichroism study . Biochemistry. 49. (51). p. 10796-10802.
Vohra, S., Hall, B.A., Holdbrook, D.A., Khalid, S., Biggin, P.C.(2010). Bookshelf: a simple curation system for the storage of biomolecular simulation data . Database : the journal of biological databases and curation. 2010.
Jiang Yeow, Kang Wei Tan, Daniel A Holdbrook, Zhi-Soon Chong, Jan K Marzinek, Peter J Bond, Shu Sin Chng(2017). Molecular basis for the maintenance of lipid asymmetry in the outer membrane of Escherichia coli . Cold Spring Harbor Laboratory
Rathi Saravanan, Daniel A Holdbrook, Jitka Petrlova, Shalini Singh, Nils A Berglund, Yeu Khai Choong, Peter J Bond, Martin Malmsten, Artur Schmidtchen(2017). Structural basis for endotoxin neutralization and anti-inflammatory activity of thrombin-derived C-terminal peptides . Cold Spring Harbor Laboratory
Teresa Paramo, Diana Garzón, Daniel A. Holdbrook, Syma Khalid, Peter J. Bond(2012). The Simulation Approach to Lipid{\textendash}Protein Interactions . 435--455Humana Press
Khalid, S., Goose, J., Holdbrook, D.A., Piggot, T.J., Sansom, M.S.P.(2013). Diffusion, aggregation and penetration: Modelling the complex cell envelope of E.coli . IFMBE Proceedings. 40 IFMBE. p. 376-379.