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USD 25 /hr
Hire Cátia G.
Portugal
USD 25 /hr

Scientific writer with 5+ years of experience in academic research | Data analyst | R, Python, SQL

Profile Summary
Subject Matter Expertise
Services
Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting, Newswriting
Research Meta-Research, Fact Checking, Gap Analysis, Systematic Literature Review
Consulting Scientific and Technical Consulting
Data & AI Statistical Analysis, Data Visualization, Big Data Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights
Work Experience

i3S

January 2017 - August 2017

Education

The University of Manchester

- Present

Wellcome Trust PhD Programme in Molecular and Cell Biology

University of Manchester

2017 - Present

MSc Cell and Molecular Biology

Universidade do Porto

2014 - 2016

BSc Biology

Universidade do Porto

2011 - 2014

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc @article { author = {Honor Morris and Cátia F Gonçalves and Michal Dudek and Judith Hoyland and Qing-Jun Meng}, title = {Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc}, journal = {Annals of the Rheumatic Diseases}, pages = {annrheumdis--2020--219515--annrheumdis--2020--219515}, year = {2021}, month = {jul}, url = {https://doi.org/10.1136/annrheumdis-2020-219515}, doi = {10.1136/annrheumdis-2020-219515} } . Annals of the Rheumatic Diseases.
Honor Morris, Cátia F Gonçalves, Michal Dudek, Judith Hoyland, Qing-Jun Meng (2021). Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc . Annals of the Rheumatic Diseases.
Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc @article{d50b083176b64be4a4d9e750162b2748, title = "Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc", abstract = "Circadian clocks in the brain and peripheral tissues temporally coordinate local physiology to align with the 24 hours rhythmic environment through light/darkness, rest/activity and feeding/fasting cycles. Circadian disruptions (during ageing, shift work and jet-lag) have been proposed as a risk factor for degeneration and disease of tissues, including the musculoskeletal system. The intervertebral disc (IVD) in the spine separates the bony vertebrae and permits movement of the spinal column. IVD degeneration is highly prevalent among the ageing population and is a leading cause of lower back pain. The IVD is known to experience diurnal changes in loading patterns driven by the circadian rhythm in rest/activity cycles. In recent years, emerging evidence indicates the existence of molecular circadian clocks within the IVD, disruption to which accelerates tissue ageing and predispose animals to IVD degeneration. The cell-intrinsic circadian clocks in the IVD control key aspects of physiology and pathophysiology by rhythmically regulating the expression of ~3.5% of the IVD transcriptome, allowing cells to cope with the drastic biomechanical and chemical changes that occur throughout the day. Indeed, epidemiological studies on long-term shift workers have shown an increased incidence of lower back pain. In this review, we summarise recent findings of circadian rhythms in health and disease, with the IVD as an exemplar tissue system. We focus on rhythmic IVD functions and discuss implications of utilising biological timing mechanisms to improve tissue health and mitigate degeneration. These findings may have broader implications in chronic rheumatic conditions, given the recent findings of musculoskeletal circadian clocks.", author = "Honor Morris and Gon{\c c}alves, {C{\'a}tia F} and Michal Dudek and Judith Hoyland and Qing-jun Meng", year = "2021", month = jan, day = "4", doi = "10.1136/annrheumdis-2020-219515", language = "English", pages = "annrheumdis--2020--219515", journal = "Annals of the rheumatic diseases", issn = "0003-4967", publisher = "BMJ ", } . Annals of the rheumatic diseases.
Morris, H., Goncąlves, C.F., Dudek, M., Hoyland, J., Meng, Q.-J.(2021). Tissue physiology revolving around the clock: Circadian rhythms as exemplified by the intervertebral disc . Annals of the Rheumatic Diseases.
Nan Yang, Achim Kramer, Nicola J. Smyllie, Honor Morris, Cátia F. Gonçalves, Michal Dudek, Dharshika R. J. Pathiranage, Johanna E. Chesham, Antony Adamson, David G. Spiller, et al.(2020). Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator . PLOS Genetics. 16. (4). p. e1008729. Public Library of Science ({PLoS})
(2020). Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator . PLOS Genetics.
Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator @article { author = {Gonçalves, Cátia F.}, title = {Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator}, journal = {PLOS Genetics}, year = {2020}, month = {apr}, url = {http://dx.doi.org/10.1371/journal.pgen.1008729}, doi = {10.1371/journal.pgen.1008729} } . PLOS Genetics.
Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator @article{9e50ee1fcddf4cc08ed45be54bcfa166, title = "Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator", abstract = "Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordinator of the cell-autonomous clocks distributed across all major tissues. The importance of robust daily rhythms is highlighted by experimental and epidemiological associations between circadian disruption and human diseases. BMAL1 (a bHLH-PAS domain-containing transcription factor) is the master positive regulator within the transcriptional-translational feedback loops (TTFLs) that cell-autonomously define circadian time. It drives transcription of the negative regulators Period and Cryptochrome alongside numerous clock output genes, and thereby powers circadian time-keeping. Because deletion of Bmal1 alone is sufficient to eliminate circadian rhythms in cells and the whole animal it has been widely used as a model for molecular disruption of circadian rhythms, revealing essential, tissue-specific roles of BMAL1 in, for example, the brain, liver and the musculoskeletal system. Moreover, BMAL1 has clock-independent functions that influence ageing and protein translation. Despite the essential role of BMAL1 in circadian time-keeping, direct measures of its intra-cellular behaviour are still lacking. To fill this knowledge-gap, we used CRISPR Cas9 to generate a mouse expressing a knock-in fluorescent fusion of endogenous BMAL1 protein (Venus::BMAL1) for quantitative live imaging in physiological settings. The Bmal1Venus mouse model enabled us to visualise and quantify the daily behaviour of this core clock factor in central (SCN) and peripheral clocks, with single-cell resolution that revealed its circadian expression, anti-phasic to negative regulators, nuclear-cytoplasmic mobility and molecular abundance.", author = "Nan Yang and Smyllie, {Nicola J.} and Honor Morris and Gon{\c c}alves, {C{\'a}tia F.} and Michal Dudek and Pathiranage, {Dharshika R. J.} and Chesham, {Johanna E.} and Antony Adamson and Spiller, {David G.} and Egor Zindy and James Bagnall and Neil Humphreys and Judith Hoyland and Loudon, {Andrew S. I.} and Hastings, {Michael H.} and Qing-jun Meng and Achim Kramer", year = "2020", month = apr, day = "30", doi = "10.1371/journal.pgen.1008729", language = "English", volume = "16", pages = "e1008729", journal = "PL o S Genetics", issn = "1553-7390", publisher = "Public Library of Science", number = "4", } . PLoS Genetics.
Yang, N., Smyllie, N.J., Morris, H., Gonçalves, C.F., Dudek, M., Pathiranage, D., Chesham, J.E., Adamson, A., Spiller, D., Zindy, E., et al.(2020). Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator . PLoS Genetics. 16. (4).
Cátia F. Gonçalves, Qing Jun Meng(2019). Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis . Journal of Endocrinology. BioScientifica
Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis @article { author = {Cátia F. Gonçalves and Qing Jun Meng}, title = {Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis}, journal = {Journal of Endocrinology}, year = {2019}, month = {aug}, url = {https://pureprojects.ppad.man.ac.uk/portal/en/publications/timing-metabolism-in-cartilage-and-bone-links-between-circadian-clocks-and-tissue-homeostasis(d0a58887-78d7-412e-b736-778d71266223).html}, doi = {10.1530/JOE-19-0256} } . Journal of Endocrinology.
(2019). Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis . Journal of Endocrinology.
Identification of inner membrane translocase components of TolC‐mediated secretion in the cyanobacterium Synechocystis sp. PCC 6803 @article{57d4052133014a7b96526989baa70b6b, title = "Identification of inner membrane translocase components of TolC‐mediated secretion in the cyanobacterium Synechocystis sp. PCC 6803", abstract = "Cyanobacteria were the first organisms ever to perform oxygenic photosynthesis and still significantly contribute to primary production on a global scale. To assure the proper functioning of their primary metabolism and cell homeostasis, cyanobacteria must rely on efficient transport systems to cross their multilayered cell envelope. However, cyanobacterial secretion mechanisms remain largely unknown. Here, we report on the identification of 11 putative inner membrane translocase components of TolC‐mediated secretion in the unicellular cyanobacterium Synechocystis sp. PCC 6803. Gene‐inactivation of each of the candidate genes followed by a comprehensive phenotypic characterization allowed to link specific protein components to the processes of protein export (as part of the type I secretion system) and drug efflux (part of the resistance‐division‐nodulation efflux pumps). In addition, mutants in genes sll0141, sll0180 and slr0369 exhibited alterations in pilin glycosylation, but pili structures could still be observed by transmission electron microscopy. By studying the release of outer membrane vesicles (OMVs), an alternative secretion route, on mutants with impaired secretory functions we suggest that the hyper‐vesiculating phenotype of the TolC‐deficient mutant is related to cell envelope stress management. Altogether, these findings highlight how both classical (TolC‐mediated) and nonclassical (OMVs‐mediated) secretion systems are crucial for cyanobacterial cell homeostasis.", author = "Gon{\c c}alves, {C{\'a}tia F.} and Pacheco, {Catarina C.} and Paula Tamagnini and Paulo Oliveira", year = "2018", month = jul, doi = "10.1111/1462-2920.14095", language = "English", volume = "20", pages = "2354--2369", journal = "Environmental microbiology", issn = "1462-2912", publisher = "John Wiley & Sons Ltd", number = "7", } . Environmental microbiology.
(2018). Identification of inner membrane translocase components of TolC‐mediated secretion in the cyanobacterium Synechocystis sp. PCC 6803 . Environmental Microbiology.
Identification of inner membrane translocase components of TolC-mediated secretion in the cyanobacterium Synechocystis sp. PCC 6803 @article { author = {Gonçalves, Cátia}, title = {Identification of inner membrane translocase components of TolC-mediated secretion in the cyanobacterium Synechocystis sp. PCC 6803}, journal = {Environmental Microbiology}, year = {2018}, month = {mar}, url = {http://doi.wiley.com/10.1111/1462-2920.14095}, doi = {10.1111/1462-2920.14095} } . Environmental Microbiology.
Gonçalves, C.F., Pacheco, C.C., Tamagnini, P., Oliveira, P.(2018). Identification of inner membrane translocase components of TolC-mediated secretion in the cyanobacterium Synechocystis sp. PCC 6803 . Environmental Microbiology. 20. (7). p. 2354-2369.
BOOK CHAPTER
C{\'{a}}tia F. Gon{\c{c}}alves and Steeve Lima and Paulo Oliveira(2021). Product Export in Cyanobacteria . Cyanobacteria Biotechnology. p. 369--406. Wiley
Product Export in Cyanobacteria @inbook { author = {Gonçalves, Cátia F.}, title = {Product Export in Cyanobacteria}, pages = {369--406}, publisher = {Wiley}, year = {2021}, url = {http://dx.doi.org/10.1002/9783527824908.ch12}, doi = {10.1002/9783527824908.ch12} } .
Cyanobacterial Secretion Systems: Understanding Fundamental Mechanisms Toward Technological Applications @inbook { author = {Gonçalves, Cátia F.}, title = {Cyanobacterial Secretion Systems: Understanding Fundamental Mechanisms Toward Technological Applications}, year = {2019}, url = {http://dx.doi.org/10.1016/b978-0-12-814667-5.00018-0}, doi = {10.1016/b978-0-12-814667-5.00018-0} } .
(2019). Cyanobacterial Secretion Systems: Understanding Fundamental Mechanisms Toward Technological Applications . Cyanobacteria.
Cátia F. Gonçalves, Steeve Lima, Paula Tamagnini, Paulo Oliveira(2019). Cyanobacterial secretion systems . Cyanobacteria: from basic science to applications. p. 359--381. Elsevier BV
Cyanobacterial secretion systems: understanding fundamental mechanisms towards technological applications @inbook { author = {Gonçalves, Cátia}, title = {Cyanobacterial secretion systems: understanding fundamental mechanisms towards technological applications}, year = {2018}, url = {https://www.sciencedirect.com/science/article/pii/B9780128146675000180}, doi = {10.1016/B978-0-12-814667-5.00018-0} } .
Gonçalves, C.F., Lima, S., Tamagnini, P., Oliveira, P.(2018). Cyanobacterial Secretion Systems: Understanding Fundamental Mechanisms Toward Technological Applications . Cyanobacteria: From Basic Science to Applications. p. 359-381.