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Hire Dr. Connie V.

United States

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Profile Summary

GENERAL SKILLS Preparation of Phase I SBIR and STTR grant applications Preparation of pharmacology reports for Investigational New Drug Application Establishment and management of external collaborations Development and implementation of Standard Operating Procedures (SOPs) for pharmacology laboratories Assay design in support of SBIR/STTR grant specific aims SPECIFIC RESEARCH SKILLS Development and validation of in-house radioligand binding and functional assays for adenosine receptors in cell lines and native tissue (Endacea) Evaluation of ligand binding and functional properties of novel adenosine ligands (Endacea) Database management and statistical evaluation of in vivo data from animal studies (Endacea) Preliminary development of clinical diagnostic assays, including radioimmunoassay and fluorescent-based methodologies (Endacea) Development and validation of radioligand binding and functional assays for dopamine receptors in clonal cell lines generated in-house (DarPharma) Evaluation of ligand binding and functional properties of novel dopaminergic ligands (DarPharma) UM FINISH Development and characterization of site-directed mutants of kappa opioid receptor mutants (radioligand binding and functional assays) (University of Michigan) GTPgammaS binding assays and autoradiography (University of Michigan) Development and characterization of delta opioid-coupled cell line with inducible expression (University of Michigan) UNC FINISH Structure activity relationships and pharmacophore identification of a class of phenylaminotetralins (UNC-CH) Pharmacological characterization of GPCRs in rat and guinea pig brain tissue using radioligand binding, functional assays, and autoradiography (UNC-CH) In vitro dopamine synthesis assays in rat striatal tissue (UNC-CH) AREAS OF RESEARCH G protein coupled receptor pharmacology Adenosine A1 receptor pharmacology: novel A1 receptor ligands to treat polymicrobial sepsis, ischemia, reperfusion injury, renal impairment, and inflammation (Endacea) Endotoxin-induced sepsis related to Yersinia pestis (Endacea) Dopamine receptor pharmacology - Parkinson's disease, catechol isosteres, dopamine D1 agonists, cerebral vasospasm (DarPharma) Structural basis of ligand binding and signal transduction properties of opioid receptors and the ORL1/nociceptin receptor (University of Michigan) LABORATORY SAFETY SKILLS Served as Radiation Safety Officer (in charge of of all radioactive materials, staff training, record maintenance, annual reports, state license renewals and amendments) (Endacea) Prepared Slug & Spill Control Plan for Compliance with Industrial Use Pretreatment Waste Water Permit in Durham, N. (FFVC) Advise laboratories on issues related to safety plans, safety protocols, and waste disposal plans (FFVC) TEACHING EXPERIENCE Course Coordinator & Lecturer, Medicinal Chemistry II, pharmacology and medicinal chemistry of drugs used to treat cardiovascular and central nervous system disorders (UNC-CH) Lecturer, Medicinal Chemistry I, lecture topics: pharmacology and medicinal chemistry of drugs that affect the adrenergic nervous system (UNC-CH)

Subject Matter Expertise

• ☆ Biochemical Assays
• ☆ Cell Signaling Pathways
• ☆ Medicinal Chemistry
• ☆ Yersinia Pestis
• ☆ Cardiovascular Disease
• ☆ Inflammation
• ☆ Product Compliance

Services

• Writing

Work Experience

Laboratory Safety Officer

First Flight Venture Center

January 2011 - Present

Consultant

Endacea (United States)

May 2014 - December 2016

Senior Research Scientist

Endacea (United States)

May 2004 - May 2014

Lecturer & Course Coordinator (Medicinal Chemistry I & II)

UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill

January 2008 - May 2009

Lecturer (Medicinal Chemistry I & II)

UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill

January 2006 - May 2007

Research Scientist

DarPharma Inc

May 2002 - May 2004

Post-doctoral Research Fellow

University of Michigan

April 1997 - May 2002

Education

BS (Biology)

King College

August 1986 - May 1990

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Wilson, C.N. and Vance, C.O. and Lechner, M.G. and Matuschak, G.M. and Lechner, A.J.(2014). Adenosine A1 receptor antagonist, L-97-1, improves survival and protects the kidney in a rat model of cecal ligation and puncture induced sepsis . European Journal of Pharmacology. 740. p. 346-352.

Wilson, C.N., Vance, C.O., Doyle, T.M., Brink, D.S., Matuschak, G.M., Lechner, A.J.(2012). A novel post-exposure medical countermeasure L-97-1 improves survival and acute lung injury following intratracheal infection with Yersinia pestis . Innate Immunity. 18. (3). p. 373-389.

Grubbs, R.A., Lewis, M.M., Owens-Vance, C., Gay, E.A., Jassen, A.K., Mailman, R.B., Nichols, D.E.(2004). 8,9-Dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms . Bioorganic and Medicinal Chemistry. 12. (6). p. 1403-1412.

Neal Jr., C.R., Owens, C.E., Taylor, L.P., Hoversten, M.T., Akil, H., Watson Jr., S.J.(2003). Binding and GTPγS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors . Journal of Chemical Neuroanatomy. 25. (4). p. 233-247.

Owens, C.E., Owens, C.E., Akil, H., Owens, C.E., Akil, H.(2002). Determinants of ligand selectivity at the κ-receptor based on the structure of the orphanin FQ receptor . Journal of Pharmacology and Experimental Therapeutics. 300. (3). p. 992-999.

Booth, R.G. and Owens, C.E. and Brown, R.L. and Bucholtz, E.C. and Lawler, C.P. and Wyrick, S.D.(1999). Putative σ3 sites in mammalian brain have histamine H1 receptor properties: Evidence from ligand binding and distribution studies with the novel H1 radioligand [3H]-(-)-trans-1-phenyl-3-aminotetralin . Brain Research. 837. (1-2). p. 95-105.

(1998). Endogenous opioids: Overview and current issues . Drug and Alcohol Dependence. 51. (1-2). p. 127-140.

(1998). 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene (H2-PAT): Effect of stereochemistry on binding and function at brain histamine receptors . Medicinal Chemistry Research. 8. (6). p. 322-332.

Wyrick, S.D. and Booth, R.G. and Myers, A.M. and Owens, C.E. and Bucholtz, E.C. and Hooper, P.C. and Kula, N.S. and Baldessarini, R.J. and Mailman, R.B.(1995). 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and Related Derivatives as Ligands for the Neuromodulatory σ3 Receptor: Further Structure-Activity Relationships . Journal of Medicinal Chemistry. 38. (19). p. 3857-3864.

Booth, R.G., Baldessarini, R.J., Marsh, E., Booth, R.G., Booth, R.G., Baldessarini, R.J., Marsh, E., Owens, C.E.(1994). Actions of (±)-7-hydroxy-N,N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain . Brain Research. 662. (1-2). p. 283-288.

Myers, A.M. and Charifson, P.S. and Owens, C.E. and Kula, N.S. and McPhail, A.T. and Baldessarini, R.J. and Booth, R.G. and Wyrick, S.D.(1994). Conformational Analysis, Pharmacophore Identification, and Comparative Molecular Field Analysis of Ligands for the Neuromodulatory σ3 Receptor . Journal of Medicinal Chemistry. 37. (24). p. 4109-4117.

Wyrick, S.D., Booth, R.G., Myers, A.M., Owens, C.E., Kula, N.S., Baldessarini, R.J., McPhail, A.T., Mailman, R.B.(1993). Synthesis and Pharmacological Evaluation of 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as Ligands for a Novel Receptor with σ-like Neuromodulatory Activity . Journal of Medicinal Chemistry. 36. (17). p. 2542-2551.

BOOK

Blackburn, M.R., Vance, C.O., Morschl, E., Wilson, C.N.(2009). Adenosine receptors and inflammation . Handbook of Experimental Pharmacology. 193. p. 215-269.