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Hire Dr. Claire H.

United Kingdom

Profile Summary

I am a Research Scientist with an interest in how new technologies can be applied to biological research problems, particularly in the areas of biosensing, drug discovery and molecular interaction studies. My previous work was largely focused on characterising the 18 kDa translocator protein (TSPO); its function, structure and drug interactions. The TSPO is an integral membrane protein likely to have a key role in modulating mitochondrial energy production, and is a potential therapeutic target in conditions as diverse as diabetes, anxiety, and Alzheimer’s disease. As part of my doctoral research I worked on developing a system to study the structure of TSPO and its drug interactions in a lipid membrane environment. I constructed supported protein-lipid bilayers and studied their drug interactions using quartz crystal microbalance with dissipation monitoring (QCM-D), and their structure and composition with neutron reflectometry. Additionally, I used these techniques to investigate interactions between drugs and the lipid membrane, as a potential source of off-target effects of these drugs. Furthermore, I was involved in the characterisation of a novel TSPO gene knockout mouse. I hold a PhD in the area of Life Sciences, and a Bachelor of Science (Hons I) with first class Honours in Physiology and additional majors in Neuroscience and Computer Science. My laboratory and experimental skills include recombinant protein production and purification, small angle neutron and X-ray scattering, quartz crystal microbalance experiments, Langmuir-Blodgettry, impedance spectroscopy, primary and cell line culture, tissue cryo-sectioning, receptor autoradiography and radioligand binding. Additionally, I have programming skills in C, C++ and Java. I am open to a variety of collaborations and consulting opportunities, and particularly interested in lending my expertise towards the design and feasibility assessment of experimental work, in carrying out literature research, and providing English language writing and editing services.

Subject Matter Expertise

• ☆ Separation & Purification
• ☆ Crystallography
• ☆ Biology/Life Sciences
• ☆ Structural Biology
• ☆ Biomarkers
• ☆ Lipidomics
• ☆ Biophysics
• ☆ Recombinant Protein Expression
• ☆ Nanobiotechnology
• ☆ Particle Physics
• ☆ Biosensors
• ☆ Protein/Enzyme Engineering
• ☆ Java

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

Research Affiliate

University of Sydney

May 2014 - Present

Research Scientist

University of Sydney

October 2012 - April 2014

Visiting Scientist

Australian Nuclear Science and Technology Organisation

April 2008 - April 2014

Research Assitant

University of Sydney

April 2008 - September 2012

Education

Doctor of Philosophy (Medical imaging and Radiation Scienes, Faculty of Health Sciences)

University of Sydney

April 2008 - September 2012

Bachelor of Science (Honours I) (Faculty of Science)

University of Sydney

March 2003 - November 2007

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Claire R. Hatty, Richard B. Banati(2015). Protein-ligand and membrane-ligand interactions in pharmacology: the case of the translocator protein ({TSPO}) . Pharmacological Research. 100. p. 58--63. Elsevier {BV}

Richard B. Banati, Ryan J. Middleton, Ronald Chan, Claire R. Hatty, Winnie Wai-Ying Kam, Candice Quin, Manuel B. Graeber, Arvind Parmar, David Zahra, Paul Callaghan, et al.(2014). Positron emission tomography and functional characterization of a complete {PBR}/{TSPO} knockout . Nat Comms. 5. p. 5452. Nature Publishing Group

Guo-Jun Liu, Ryan J. Middleton, Claire R. Hatty, Winnie Wai-Ying Kam, Ronald Chan, Tien Pham, Meredith Harrison-Brown, Eoin Dodson, Kelly Veale, Richard B. Banati(2014). The 18 {kDa} Translocator Protein, Microglia and Neuroinflammation . Brain Pathology. 24. (6). p. 631--653. Wiley-Blackwell

Claire R. Hatty, Anton P. Le Brun, Vanessa Lake, Luke A. Clifton, Guo Jun Liu, Michael James, Richard B. Banati(2014). Investigating the interactions of the 18kDa translocator protein and its ligand {PK}11195 in planar lipid bilayers . Biochimica et Biophysica Acta ({BBA}) - Biomembranes. 1838. (3). p. 1019--1030. Elsevier {BV}

M. P. Boland, C. R. Hatty, F. Separovic, A. F. Hill, D. J. Tew, K. J. Barnham, C. L. Haigh, M. James, C. L. Masters, S. J. Collins(2010). Anionic Phospholipid Interactions of the Prion Protein N Terminus Are Minimally Perturbing and Not Driven Solely by the Octapeptide Repeat Domain . Journal of Biological Chemistry. 285. (42). p. 32282--32292. American Society for Biochemistry {\&} Molecular Biology ({ASBMB})