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Hire Dr. Christopher R.

United States

USD 50 /hr

Experienced biochemist/chemical biologist with expertise in intellectual property generation and lead discovery

Profile Summary

My interests lie at the interface of chemistry and microbiology. During my sophomore year i discovered my interest in chemistry through my introductory organic chemistry and physical chemistry courses. This interest was later fused with biology and in particular microbiology by the time I finished my undergraduate degree. I moved to the University of Waterloo to complete a MSc in chemistry studying non-natural amino acid and peptide synthesis. It is during this time that I was introduced to biological mass spectrometry, a discipline that has followed be ever since. I then moved to the University of Guelph where I completed a PhD in the lab of Dr. Anthony Clarke. It is here that I developed my interest in carbohydrate chemistry, glycobiology, and carbohydrate recognition. I thoroughly enjoyed my time as a graduate student and looked to expand on my interests in biological mass spectrometry and glycobiology at the National Research Council (NRC) in Ottawa Canada. While working in the group of Dr. Christine Szymanski I developed mass spectrometry tools for glycobiology, specifically in the analysis of lipid-linked oligosaccharides of N-linked protein glycosylation biosynthetic pathways. The resulting methodology was an enabling technology for glycoengineering efforts in bacteria. As an assistant research officer in Dr. Susan Logan's group at the NRC I worked on microbial glycomics projects in the pathogen Clostridium difficile and small molecule discovery program for anti-virulence compounds in Helicobacter pylori. Here at Bryant, I have returned to investigating bacterial carbohydrate acting enzymes involved in Gram positive peptidoglycan metabolism and the identification of small molecule inhibitors of these enzymes as chemical biology tools and antimicrobials.

Subject Matter Expertise

• ☆ Analytical Chemistry
• ☆ Mass Spectrometry
• ☆ Peptide Synthesis
• ☆ Microbiology
• ☆ Biochemistry
• ☆ Lipidomics
• ☆ Chemical Biology
• ☆ Protein/Enzyme Engineering
• ☆ Leadership
• ☆ Higher Education
• ☆ Science Education

Services

• Writing
• Research
• Consulting
• Product Development

Work Experience

associate professor

Bryant University

August 2010 - Present

assistant research officer

National Research Council Canada

December 2005 - July 2010

Education

PhD (Chemistry and Biochemistry)

University of Guelph

January 2002 - November 2005

MSc (Chemistry)

University of Waterloo

September 1999 - November 2001

BSc (Chemistry and Biochemistry)

Laurentian University

September 1995 - May 1999

Certifications

• Certification details not provided.

Publications

OTHER

Brad A Haubrich, Saman Nayyab, Caroline Williams, Andrew Whitman, Tahl Zimmerman, Qiong Li, Yuxing Chen, Cong-Zhao Zhou, Amit Basu, Christopher W Reid (2020). Inhibition of Streptococcus pneumoniae autolysins highlight distinct differences between chemical and genetic inactivation .

Evelyn C. Soo, Christopher W. Reid, David J. McNally, Jean-Robert Brisson(2008). Campylobacter Metabolomics . 523--542American Society for Microbiology

JOURNAL ARTICLE

Keyana Roohani, Brad A. Haubrich, Kai-Lou Yue, Nigel D’Souza, Amanda Montalbano, Tatiana Rynearson, Susanne Menden-Deuer, Christopher W. Reid(2019). Trophic upgrading and mobilization of wax esters in microzooplankton . {PeerJ}. 7. p. e7549. {PeerJ}

Andrew M. Smith, Cassandra Papaleo, Christopher W. Reid, Joseph M. Bliss(2017). {RNA}-Seq reveals a central role for lectin, C1q and von Willebrand factor A domains in the defensive glue of a terrestrial slug . Biofouling. 33. (9). p. 741--754. Informa {UK} Limited

Saman Nayyab, Mary O’Connor, Jennifer Brewster, James Gravier, Mitchell Jamieson, Ethan Magno, Ryan D. Miller, Drew Phelan, Keyana Roohani, Paul Williard, et al.(2017). Diamide Inhibitors of the Bacillus subtilis N-Acetylglucosaminidase {LytG} That Exhibit Antibacterial Activity . {ACS} Infectious Diseases. 3. (6). p. 421--427. American Chemical Society ({ACS})

R. Menard, I. C. Schoenhofen, L. Tao, A. Aubry, P. Bouchard, C. W. Reid, P. Lachance, S. M. Twine, K. M. Fulton, Q. Cui, et al.(2014). Small-Molecule Inhibitors of the Pseudaminic Acid Biosynthetic Pathway: Targeting Motility as a Key Bacterial Virulence Factor . Antimicrobial Agents and Chemotherapy. 58. (12). p. 7430--7440. American Society for Microbiology

Kirsten Hokeness, Jacqueline Kratch, Christina Nadolny, Kristie Aicardi, Christopher W. Reid(2014). The effects of fungal volatile organic compounds on bone marrow stromal cells . Can. J. Microbiol. 60. (1). p. 1--4. Canadian Science Publishing

Christopher Reid, Helene Kuhn, Danielle Gutelius, Eimear Black, Christina Nadolny, Amit Basu(2014). Anti-bacterial glycosyl triazoles {\textendash} identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus . Med. Chem. Commun. 5. (8). p. 1213--1217. Royal Society of Chemistry ({RSC})

Joseph M. Bliss, Christopher W. Reid(2013). Medical Mycology and the Chemistry Classroom: Germinating Student Interest in Organic Chemistry . Journal of Chemical Education. 90. (10). p. 1320--1324. American Chemical Society ({ACS})

D. Gutelius, K. Hokeness, S. M. Logan, C. W. Reid(2013). Functional analysis of {SleC} from Clostridium difficile: an essential lytic transglycosylase involved in spore germination . Microbiology. 160. (Pt{\_}1). p. 209--216. Society for General Microbiology

Christopher W. Reid, Evgeny Vinogradov, Jianjun Li, Harold C. Jarrell, Susan M. Logan, Jean-Robert Brisson(2012). Structural characterization of surface glycans from Clostridium difficile . Carbohydrate Research. 354. p. 65--73. Elsevier {BV}

Christopher W. Reid, Jacek Stupak, Christine M. Szymanski, Jianjun Li(2009). Analysis of Bacterial Lipid-Linked Oligosaccharide Intermediates Using Porous Graphitic Carbon Liquid Chromatography-Electrospray Ionization Mass Spectrometry: Heterogeneity in the Polyisoprenyl Carrier Revealed . Anal. Chem. 81. (20). p. 8472--8478. American Chemical Society ({ACS})

S. M. Twine, C. W. Reid, A. Aubry, D. R. McMullin, K. M. Fulton, J. Austin, S. M. Logan(2009). Motility and Flagellar Glycosylation in Clostridium difficile . Journal of Bacteriology. 191. (22). p. 7050--7062. American Society for Microbiology

Christopher W. Reid, Jacek Stupak, Mark M. Chen, Barbara Imperiali, Jianjun Li, Christine M. Szymanski(2008). Affinity-Capture Tandem Mass Spectrometric Characterization of Polyprenyl-Linked Oligosaccharides: Tool to Study Protein N-Glycosylation Pathways . Anal. Chem. 80. (14). p. 5468--5475. American Chemical Society ({ACS})

Christopher W. Reid, Blaine A. Legaree, Anthony J. Clarke(2007). Role of Ser216 in the mechanism of action of membrane-bound lytic transglycosylase B: Further evidence for substrate-assisted catalysis . {FEBS} Letters. 581. (25). p. 4988--4992. Elsevier {BV}

Mark M. Chen, Eranthie Weerapana, Ewa Ciepichal, Jacek Stupak, Christopher W. Reid, Ewa Swiezewska, Barbara Imperiali(2007). Polyisoprenol Specificity in the Campylobacter jejuni N-Linked Glycosylation Pathway {\textdagger} . Biochemistry. 46. (50). p. 14342--14348. American Chemical Society ({ACS})

Christopher W. Reid, Neil T. Blackburn, Anthony J. Clarke(2006). Role of Arginine Residues in the Active Site of the Membrane-Bound Lytic Transglycosylase B from Pseudomonas aeruginosa {\textdagger} . Biochemistry. 45. (7). p. 2129--2138. American Chemical Society ({ACS})

Christopher W. Reid, Dyanne Brewer, Anthony J. Clarke(2004). Substrate Binding Affinity of Pseudomonas aeruginosa Membrane-Bound Lytic Transglycosylase B by Hydrogen-Deuterium Exchange {MALDI} {MS} {\textdagger} . Biochemistry. 43. (35). p. 11275--11282. American Chemical Society ({ACS})

C.W. Reid, N.T. Blackburn, B.A. Legaree, F.-I. Auzanneau, A.J. Clarke(2004). Inhibition of membrane-bound lytic transglycosylase B by {NAG}-thiazoline . {FEBS} Letters. 574. (1-3). p. 73--79. Elsevier {BV}