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Hire Dr. Chieh H.

United Kingdom

Profile Summary

I joined University of Kent, UK as a group leader since 2015 and aim for projects merging my dual backgrounds, cell biology and molecular systems biology. I am interested in synthetic and mathematical approaches to study feedback loops in membrane domain organisation. My long term scientific goal is to bridge disciplines for quantitative understanding of intracellular membrane trafficking. I did my BSc studies in National Taiwan University in 2002. I continued postgraduate studies in the Molecular Biology Program, University of Goettingen, Germany, and received an MSc in Biochemistry mentored by Dr Jobst Landgrebe (2004-2006). I developed a strong interest in cell biology and contributed to the early findings in exosome biogenesis during his PhD curriculum in Prof Mikael Simons' lab at the Max-Planck Institute for Experimental Medicine (2006-2010). Later he broadened his research interest into molecular systems biology. He joined Prof Attila Becskei's group in University of Zurich (2010-2011) and University of Basel (Biozentrum, 2011-2015), Switzerland and was awarded the long-term fellowship from Human Frontier Science Program (2011-2014) to study system stability, cellular memory, and stochastic/deterministic factors in transcriptional auto-regulatory circuits. Currently I work on the following research projects: 1. Synthetic cell biology: disentangling feedbacks in membrane organisation 2. Engineering a molecule operated switch for bio-manufacturing with yeast cells 3. Developing robust biosensors with improved bistable positive feedback loop 4. An evolutionary synthetic model on adaptation of switching rate between activities in gene regulatory network I'm very interested in different levels of collaboration projects, especially with industries in the bio-processing areas. Please feel free to contact me if you would like to know more. Expertise: Synthetic biology, molecular systems biology; dynamical systems; transcriptional regulatory networks; stochastic simulation; membrane trafficking; exosomes.

Subject Matter Expertise

• ☆ Biology/Life Sciences
• ☆ Microbiology
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Biotechnology & Bioengineering
• ☆ Computer Simulation/Computational Modeling
• ☆ Systems Biology
• ☆ Microbial Fermentation
• ☆ Audio Transcription

Services

• Research
• Consulting
• Product Development

Work Experience

Eastern ARC Research Fellow

University of Kent

March 2015 - May 2020

Postdoctoral Researcher

University of Basel

November 2011 - February 2015

Postdoctoral Researcher

University of Zurich

September 2010 - October 2011

Doctoral Candidate

Max Planck Institute for Experimental Medicine

July 2006 - June 2010

Research Assistant

National Taiwan University

May 2004 - July 2004

Education

PhD (Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB))

Georg-August-Universitat Gottingen

2006 - 2010

BSc (Department of Botany)

National Taiwan University

1998 - 2002

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Hsu C, Jaquet V, Gencoglu M, Becskei A, Cell reports, 2016, vol. 16, no. 5, pp. 1204-1210, 2016 .

Hsu C, Jaquet V, Maleki F, Becskei A, Journal of molecular biology, 2016, 2016 .

(2012). Stochastic signalling rewires the interaction map of a multiple feedback network during yeast evolution . Nature Communications. 3.

Hsu C, Scherrer S, Buetti-Dinh A, Ratna P, Pizzolato J, Jaquet V, Becskei A, Nature communications, 2012, vol. 3, pp. 682 .

Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M, Hsu C, Gorsler T, Hintermair C, Eick D, Kremmer E, Simons M, Beissbarth T, Johnsen SA, Cancer research, 2011, vol. 71, no. 17, pp. 5739-5753 .

(2011). Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B . Cancer Research. 71. (17). p. 5739-5753.

Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Grønborg M, Möbius W, Rhee J, Barr FA, Simons M, The Journal of cell biology, 2010, vol. 189, no. 2, pp. 223-232 .

(2010). Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C . Journal of Cell Biology. 189. (2). p. 223-232.

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M, Science (New York, N.Y.), 2008, vol. 319, no. 5867, pp. 1244-1247 .

(2008). Ceramide triggers budding of exosome vesicles into multivesicular endosomes . Science. 319. (5867). p. 1244-1247.