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Hire Dr. Catherine S.

Germany

USD 80 /hr

Freelance Bioinformatician | Expert in Python, R and all thing 'Omics

Profile Summary

Highly motivated bioinformatician with more than 13 years’ experience working in UK and German academic research institutes honing programming, analytical and statistical skills. Since July 2020, I have worked as a freelance bioinformatics consultant working with both academic and biotech companies worldwide.

Subject Matter Expertise

• ☆ Computational Biology
• ☆ Biochemistry
• ☆ Structural Biology
• ☆ Molecular Biology
• ☆ Omics
• ☆ Transcriptomics
• ☆ Genomics
• ☆ Data Analysis
• ☆ Data Processing
• ☆ Data Exploration
• ☆ Cluster Analysis
• ☆ Data Visualization
• ☆ Data Manipulation
• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Systems Biology
• ☆ Structural Bioinformatics

Services

• Research
• Consulting
• Data & AI

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Image Analysis, Data Visualization, Big Data Analytics, Text Mining & Analytics, Data Mining, Data Cleaning, Data Insights

Work Experience

Postdoctoral Researcher

Max Delbruck Center for Molecular Medicine

January 2018 - June 2020

Education

PhD

UNIVERSITY OF CAMBRIDGE

September 2004 - March 2008

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Daniel Reichart, Eric L. Lindberg, Henrike Maatz, Antonio M. A. Miranda, Anissa Viveiros, Nikolay Shvetsov, Anna Gärtner, Emily R. Nadelmann, Michael Lee, Kazumasa Kanemaru, et al.(2022). Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies . Science. 377. (6606). American Association for the Advancement of Science ({AAAS})

Monika Litviňuková, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Catherine L. Worth, Eric L. Lindberg, Masatoshi Kanda, Krzysztof Polanski, Matthias Heinig, Michael Lee, et al.(2020). Cells of the adult human heart . Nature. 588. (7838). p. 466--472. Springer Science and Business Media {LLC}

(2019). The Translational Landscape of the Human Heart . Cell.

(2018). Structural changes of TasA in biofilm formation of Bacillus subtilis . Proceedings of the National Academy of Sciences of the United States of America.

(2017). Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level . Cellular and molecular life sciences : CMLS.

(2017). GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors . Nucleic acids research.

(2017). Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work . Frontiers in endocrinology.

(2017). Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors . Nature communications.

(2015). Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options . Nature genetics.

(2013). Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma . Nature genetics.

(2013). Residues of a proposed gate region in type I ATP-binding cassette import systems are crucial for function as revealed by mutational analysis . Biochimica et biophysica acta.

(2011). Binding sites in membrane proteins--diversity, druggability and prospects . European journal of cell biology.

(2011). Development of immune-specific interaction potentials and their application in the multi-agent-system VaccImm . PloS one.

(2011). GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models . BMC bioinformatics.

(2011). SDM--a server for predicting effects of mutations on protein stability and malfunction . Nucleic acids research.

(2011). From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs) . The Journal of biological chemistry.

(2011). Meet me halfway: when genomics meets structural bioinformatics . Journal of cardiovascular translational research.

(2011). Research resource: Update and extension of a glycoprotein hormone receptors web application . Molecular endocrinology (Baltimore, Md.).

(2010). FragmentStore--a comprehensive database of fragments linking metabolites, toxic molecules and drugs . Nucleic acids research.

(2010). SuperSweet--a resource on natural and artificial sweetening agents . Nucleic acids research.

(2010). An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors . Human mutation.

(2010). On the evolutionary conservation of hydrogen bonds made by buried polar amino acids: the hidden joists, braces and trusses of protein architecture . BMC evolutionary biology.

(2010). Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor . PloS one.

(2010). Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor . FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

(2009). Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis . Proteins.

(2009). Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models . PloS one.

(2009). Structural and functional constraints in the evolution of protein families . Nature reviews. Molecular cell biology.

(2009). Structural and functional restraints in the evolution of protein families and superfamilies . Biochemical Society transactions.

(2009). Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains . Proteins.

(2008). Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR . Cellular and molecular life sciences : CMLS.

(2007). A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease . Journal of bioinformatics and computational biology.

(2007). AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity . The Journal of biological chemistry.

(2007). Genome bioinformatic analysis of nonsynonymous SNPs . BMC bioinformatics.

(2006). Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery . Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

(2004). PDBLIG: classification of small molecular protein binding in the Protein Data Bank . Journal of medicinal chemistry.