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Hire Dr. Brian C.

United Kingdom

USD 50 /hr

PhD in Biochemistry and Molecular Biology. Expert in electron microscopy/spectroscopy. Industry/Academic experience.

Profile Summary

Brian completed a B.Sc. (1st) in Chemistry at University College Dublin in 2015. Before entering his final year in UCD, he spent a year as a chemistry intern in industry, where he worked on several chemical engineering projects for a pharmaceutical consulting company. Brian was awarded a PhD studentship from the Wellcome Trust-NIH program and during his PhD at the NIH in the US, he researched areas across nanotechnology, physiology and pharmacology. He then moved to the University of British Columbia, Canada to focus on the structure and function of mutant proteins implicated in neurodegenerative disease using cryo-electron microscopy. There he graduated with a PhD in Biochemistry and Molecular Biology and moved to Gandeeva Therapeutics to continue work on small-molecule therapeutic development. He is currently using Scanning Transmission Electron Microscopy (STEM) and electron spectroscopy techniques to analyze the elemental composition and distribution in tissues and cells at the Rosalind Franklin Institute in Oxford, UK. He has also written multiple successful grant applications.

Subject Matter Expertise

• ☆ Spectroscopy
• ☆ Biochemistry
• ☆ Structural Biology
• ☆ Molecular Biology
• ☆ Cell Biology
• ☆ Cytochemistry
• ☆ Microscopy
• ☆ Electron Microscopy
• ☆ Process Chemistry
• ☆ Data Analysis
• ☆ Statistics
• ☆ Health Data Analysis
• ☆ Drug Development
• ☆ Oncology
• ☆ Market Research

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Copywriting, Newswriting

Research Market Research, User Research, Meta-Research, Feasibility Study, Fact Checking, Gap Analysis, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Digital Strategy Consulting, Scientific and Technical Consulting, Regulatory Consulting

Data & AI Statistical Analysis, Data Visualization, Big Data Analytics, Data Processing, Data Insights

Product Development Formulation, Stability/Shelf Life Testing, Product Evaluation, Material Sourcing, Manufacturing

Work Experience

PostDoctoral Research Associate

Rosalind Franklin Institute

April 2022 - Present

Research Associate III

Gandeeva Therapeutics

- March 2022

Adjunct Professor

Georgetown University

January 2018 - May 2018

Graduate Research Assistant

University College Dublin

September 2015 - August 2016

Process Chemist

APC Ltd.

September 2013 - August 2014

Education

PhD (Biochemistry and Molecular Biology)

University of British Columbia

September 2018 - September 2020

PhD Student (Department of Cell Biology)

National Cancer Institute

September 2016 - September 2018

BSc. (Hons) in Chemistry (1st class) (Science)

University College Dublin

September 2010 - May 2015

Certifications

• Certification details not provided.

Publications

BOOK CHAPTER

Brian J. Caffrey(2022). Imaging Cellular Architecture in Three Dimensions Through Electron Microscopy . Reference Module in Life Sciences. Elsevier

JOURNAL ARTICLE

Xing Zhu, Alison Berezuk, Katharine Tuttle, Sagar Chittori, Sriram Subramaniam, Brian Caffrey(2021). AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation . Journal of Biological Chemistry. 297. (4). p. 101187. Elsevier {BV}

(2021). Examining Nanoparticle Interactions on a Cellular Scale Using Correlative Light Electron Microscopy . Molecular Biology and Nanomedicine.

Brian Caffrey, Alexander V. Maltsev, Marta Gonzalez-Freire, Lisa M. Hartnell, Luigi Ferrucci, Sriram Subramaniam (2019). Semi-Automated 3D Segmentation of Human Skeletal Muscle Using Focused Ion Beam-Scanning Electron Microscopic Images . Journal of Structural Biology.

Caffrey, B.J., Maltsev, A.V., Gonzalez-Freire, M., Hartnell, L.M., Ferrucci, L., Subramaniam, S.(2019). Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images . Journal of Structural Biology. 207. (1). p. 1-11.

DISSERTATION THESIS

(2020). Three-dimensional transmission and scanning electron microscopy of molecular and cellular structures .

DATA SET

Caffrey, Brian J. and Maltsev, Alexander V. and Gonzalez-Freire, Marta and Hartnell, Lisa M. and Ferrucci, Luigi and Subramaniam, Sriram(2019). Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images (6 of 6) . Zenodo. Zenodo

Caffrey, Brian J and Maltsev, Alexander and Gonzalez-Freire, Marta and Hartnell, Lisa M. and Ferrucci, Luigi and Subramaniam, Sriram(2019). Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images (1 of 6) . Zenodo. Zenodo

Caffrey, Brian J. and Maltsev, Alexander and Gonzalez-Freire, Marta and Hartnell, Lisa M. and Ferrucci, Luigi and Subramaniam, Sriram(2019). Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images (2 of 6) . Zenodo. Zenodo

Caffrey, Brian J. and Maltsev, Alexander and Gonzalez-Freire, Marta and Hartnell, Lisa M. and Ferrucci, Luigi and Subramaniam, Sriram(2019). Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images (3 of 6) . Zenodo. Zenodo

Caffrey, Brian J. and Maltsev, Alexander V and Gonzalez-Freire, Marta and Hartnell, Lisa M. and Ferrucci, Luigi and Subramaniam, Sriram(2019). Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images (4 of 6) . Zenodo. Zenodo

Caffrey, Brian J. and Maltsev, Alexander V. and Gonzalez-Freire, Marta and Hartnell, Lisa M. and Ferrucci, Luigi and Subramaniam, Sriram(2019). Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images (5 of 6) . Zenodo. Zenodo