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Hire Dr. Arlet A.

United States

USD 25 /hr

Molecular Biology Scientist specialized in Oncology

Profile Summary

My primary scientific interest lies in the study of the molecular mechanisms governing Glioblastoma (GBM) biology, the most common malignant primary brain tumors in adults. I am responsible for leading the research project focused on the study of the role of c-Jun N-terminal kinase (JNK) pathway in the molecular and metabolic features of human patient-derived Glioblastoma stem-like cells in vitro and in vivo using GBM xenograft models. My project is focused on the application of novel drug therapies that impairs the growth and proliferation of GSCs in vitro and in vivo.

Subject Matter Expertise

• ★ Molecular Biology
• ★ Stem Cell Research
• ★ Oncology
• ☆ Kinases
• ☆ Metabolism & Metabolic Disease

Services

• Writing
• Research
• Data & AI

Writing Clinical Trial Documentation, Medical Writing, Technical Writing, Newswriting

Research Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Data & AI Statistical Analysis

Work Experience

Postdoctoral Associate

Florida International University

October 2019 - Present

Postdoctoral Associate

Florida International University

May 2017 - October 2019

PhD student

Clinica Universitaria de Navarra

October 2012 - September 2016

Education

PhD in Biomedical Research

Universidad de Navarra

September 2012 - October 2016

Master in Molecular Biology and Biomedicine (Molecular Pharmacology of G-Protein Coupled Receptors Group )

Universidad de Cantabria

October 2011 - September 2012

Degree in Biochemistry (Molecular Biology)

University of Havana

September 2002 - July 2007

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Wang W, Rodriguez-Silva M, Acanda de la Rocha AM, Wolf AL, Lai Y, Liu Y, Reinhold WC, Pommier Y, Chambers JW, Tse-Dinh YC. 2019. Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for Glioblastoma susceptibility to genotoxic agents. Cancers (Basel). 2019 Sep 23;11(10) .

Guillermo Aldave, Marisol González-Huarriz, Angel Rubio, Juan Pablo Romero, Datta Ravi, Belén Miñana, Mar Cuadrado-Tejedor, Ana García-Osta, Roeland Verhaak, Enric Xipell, Naiara Martínez-Vélez, Arlet Maria Acanda de la Rocha, Beatriz Vera, Miguel Marigil, Jaime Gállego, Oskar Marín-Bejar, Maria Stella Carro, Roberto Ferrarese, Cristóbal Belda-Iniesta, Angel Ayuso, Fernando Pastor, Ricardo Díez Valle, Sonia Tejada-Solís, Marta Alonso. (2018). The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma. Neuro Oncol. 20(7):930-941. PMID: 29373718 .

Varela MJ, Acanda de la Rocha AM, Díaz A, Lopez-Gimenez JF. (2017). Potentiation of morphine-induced antinociception and locomotion by citalopram is accompanied by anxiolytic-like effects. Pharmacol Biochem Behav. 163:83-89. PMID: 29024681 .

Acanda de la Rocha AM, Lopez-Bertoni H, Guruceaga E, González-Huarriz M, Martínez-Vélez N, Xipell E, Fueyo J, Gomez-Manzano C, Alonso MM. (2016). Analysis of SOX2-regulated transcriptome in glioma stem cells. PlosOne.11(9):e0163155. PMID: 27669421 .

Xipell E, Aragón T, Martínez-Velez N, Vera B, Idoate MA, Martínez-Irujo JJ, Garzón AG, Gonzalez-Huarriz M, Acanda AM, Jones C, Lang FF, Fueyo J, Gomez-Manzano C, Alonso MM. (2016). Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51. Neuro Oncol. 18(8):1109-19. PMID: 26951384 .

Vera B, Martínez-Vélez N, Xipell E, de la Rocha A, Patiño A, Castresana JS, Gonzalez-Huarriz M, Cascallo M, Alemany R, Alonso MM. (2016). Characterization of the antiglioma effect of the oncolytic adenovirus VCN-01. PLoS One. 11(1): e0147211.PMID: 26808201 .

Martínez-Vélez N, Xipell E, Vera B, Acanda de la Rocha A, Zalacain M, Marrodan L, Gonzalez-Huarriz M, Toledo G, Cascallo M, Alemany R, Patiño-García A, Alonso MM. (2016). The oncolytic adenovirus VCN-01 as therapeutic approach against pediatric osteosarcoma. Clin Cancer Res. 22(9):2217-25. PMID: 26603261 .

Campa VM, Capilla A, Varela MJ, Acanda de la Rocha AM, Fernandez-Troyano JC, Barreiro RB, Lopez-Gimenez JF. (2015). Endocytosis as a Biological Response in Receptor Pharmacology: Evaluation by Fluorescence Microscopy. Plos-One. Apr 7;10(4):e0122604. PMID: 25849355 .

de la Rocha AM, Sampron N, Alonso MM, Matheu A. (2014). Role of SOX family of transcription factors in central nervous system tumors. Am J Cancer Res 16;4(4):31224.PMID: 25057435 .

Lavaut K, Rubio T, Collazo T, Esperón AA, Reyes L, Collazo T, Acanda AM. (2011). Identification of a Novel Mutation, I403T, in Cuban Type 1 Gaucher Disease. Blood Cells Mol Dis. 46, 327. PMID: 21411350 .