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India

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Dr. Anugula Nagaraju | Organic Chemistry Expert & Technical Writer | Ph.D. (BHU) | Post-Doc (Stanford University)

Profile Summary

Specializing in Synthetic Methodology, Asymmetric Catalysis, and Photoredox Chemistry I. Professional Summary Accomplished Organic Chemist with 10+ years of research and industrial experience at world-class institutions including Stanford University and The Hebrew University of Jerusalem. Expert in designing complex synthetic routes and authoring high-impact scientific literature. I provide high-level technical writing, manuscript editing, and curriculum development services for the pharmaceutical and education sectors. II. Core Service Offerings • Academic Manuscript Development: Expert drafting and peer-review preparation for high-impact journals (Nature, Green Chem, Org. Lett). • Synthetic Route Optimization: Detailed technical reports on cost-effective and viable routes for organic molecules. • Scientific Content Creation: Developing advanced JEE/NEET study materials and university-level Organic Chemistry curricula. • Technical Consulting: Expert analysis of NMR, HPLC, LC-MS data and moisture-sensitive reaction protocols. III. Highlighted Writing & Research Samples • Asymmetric Catalysis: Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation (Published in Org. Lett., Impact Factor: 6.09). • Sustainable Chemistry: Eco-efficient access to 1,2,3-thiadiazoles via solvent-free conditions (Published in Green Chem., Impact Factor: 9.48). • Review Articles: Author of "ortho-Quinone methide (o-QM): A highly reactive intermediate in organic synthesis" (RSC Adv.). IV. Technical Proficiency • Software: ChemDraw, SciFinder, LaTeX, PGDCA (Post Graduate Diploma in Computer Applications). • Instrumentation: Advanced NMR Interpretation, HPLC Method Development, GC-MS, and Combi-Flash. • Specializations: Organoboron Synthesis, Photoredox-Mediated reactions, and Heterocyclic Chemistry.

Subject Matter Expertise

• ☆ Catalysis
• ☆ Organic Chemistry
• ☆ Retrosynthesis
• ☆ Physical Organic Chemistry
• ☆ Drug Discovery
• ☆ Medicinal Chemistry

Services

• Writing
• Research

Writing Technical Writing

Research User Research, Meta-Research, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Work Experience

Scientific Lead

Aragen Life Sciences

October 2024 - Present

Senior Research Scientist

Jubilant Life Sciences (India)

December 2021 - Present

Postdoctoral Researcher

Hebrew University of Jerusalem Faculty of Science

February 2020 - July 2021

Scientist

LAXAI Life Sciences Pvt Ltd

May 2019 - January 2020

Post doctoral research

Stanford University

January 2018 - January 2019

Postdoctoral Research

University of Hyderabad

February 2016 - December 2017

Education

PhD, Organic Chemistry

Banaras Hindu University, Varanasi, India

March 2011 - September 2015

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Anugula Nagaraju, Tamer Saiaede, Nadim Eghbarieh, Ahmad Masarwa(2023). Photoredox‐Mediated Deoxygenative Radical Additions of Aromatic Acids to Vinyl Boronic Esters and <i>gem</i> ‐Diborylalkenes** . Chemistry – A European Journal. 29. (3). Wiley

Nagaraju, A., Saiaede, T., Eghbarieh, N., Masarwa, A.(2023). Photoredox-Mediated Deoxygenative Radical Additions of Aromatic Acids to Vinyl Boronic Esters and gem-Diborylalkenes** . Chemistry - A European Journal. 29. (3).

Nagaraju Anugula, Barry M. Trost, Zhijun Zuo, Johnathan E. Schultz, Katherine A. Carr(2020). A borane-mediated palladium-catalyzed reductive allylic alkylation of α,β-unsaturated carbonyl compounds . Chemical Science. 11. (8). p. 2136--2140. Royal Society of Chemistry ({RSC})

Trost, B.M., Zuo, Z., Schultz, J.E., Anugula, N., Carr, K.A.(2020). A borane-mediated palladium-catalyzed reductive allylic alkylation of α,β-unsaturated carbonyl compounds . Chemical Science. 11. (8). p. 2136-2140.

Anugula Nagaraju, Barry M. Trost, Feijun Wang, Zhijun Zuo, Jiayi Xu, Kami L. Hull(2019). Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones . Organic Letters. 21. (6). p. 1784--1788. American Chemical Society ({ACS})

Trost, B.M., Nagaraju, A., Wang, F., Zuo, Z., Xu, J., Hull, K.L.(2019). Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones . Organic Letters. 21. (6). p. 1784-1788.

Anugula Nagaraju, K. Sandeep, K.C. Kumara Swamy (2018). Copper catalyzed access to functionalized oxazoles from oximes via carbenoids . Tetrahedron Letters.

Nagaraju, A., Sandeep, K., Kumara Swamy, K.C.(2018). Copper catalyzed access to functionalized oxazoles from oximes via carbenoids . Tetrahedron Letters. 59. (23). p. 2238-2242.

Solvent-free one-pot efficient and highly regioselective access to functionalized thiazolopyridones from α-enolic dithioesters @article{2015,doi = {10.3998/ark.5550190.p009.179},url = {https://doi.org/10.3998%2Fark.5550190.p009.179},year = 2015,month = {aug},publisher = {{ARKAT} {USA}, Inc.},volume = {2016},number = {2},pages = {42},title = {Solvent-free one-pot efficient and highly regioselective access to functionalized thiazolopyridones from $\upalpha$-enolic dithioesters},journal = {Arkivoc}} . Arkivoc.

Anugula Nagaraju, B. Janaki Ramulu, Sushobhan Chowdhury, Suvajit Koley, Maya Shankar Singh(2015). Copper-catalyzed site-selective S–S and C–C homocoupling of α-enolic dithioesters: straightforward and efficient access to 1,2-dithiols . Tetrahedron Letters. 56. (20). p. 2593--2596. Elsevier {BV}

Anugula Nagaraju, B. Janaki Ramulu, Gaurav Shukla, Abhijeet Srivastava, Girijesh Kumar Verma, Keshav Raghuvanshi, Maya Shankar Singh(2015). A facile and highly convergent approach to thiazolo[3,2-a]pyridines via one-pot multicomponent domino reaction under metal-free and solvent-free conditions . Tetrahedron. 71. (21). p. 3422--3427. Elsevier {BV}

Anugula Nagaraju, Maya Singh, B. Ramulu, Sushobhan Chowdhury, Suvajit Koley, Namrata Anand(2015). Iodine-Mediated Annulation of S-Allylated α-Enolic Dithioesters: Rapid Access to 2-Alkylidene-1,3-dithiolanes at Room Temperature . Synthesis. 47. (10). p. 1510--1518. Georg Thieme Verlag {KG}

Anugula Nagaraju, B. Janaki Ramulu, Sushobhan Chowdhury, Suvajit Koley, Maya Shankar Singh(2015). Metal-Free Reagent Dependent SS and CC Homocoupling of α-Enolic Dithioesters at Room Temperature: Direct Access to Fully Substituted Symmetrical ThiophenesviaChemoselective Paal-Knorr Approach . Advanced Synthesis & Catalysis. 357. (2-3). p. 530--538. Wiley-Blackwell

Ramulu, B.J., Nagaraju, A.A., Chowdhury, S., Koley, S., Singh, M.S.(2015). Metal-free reagent dependent S-S and C-C homocoupling of a-enolic dithioesters at room temperature: Direct access to fully substituted symmetrical thiophenes via chemoselective paal-knorr approach . Advanced Synthesis and Catalysis. 357. (2-3). p. 530-538.

Anugula Nagaraju, B. Janaki Ramulu, Gaurav Shukla, Abhijeet Srivastava, Girijesh Kumar Verma, Keshav Raghuvanshi, Maya Shankar Singh(2015). Catalyst-free one-pot four-component domino reactions in water–PEG-400: highly efficient and convergent approach to thiazoloquinoline scaffolds . Green Chemistry. 17. (2). p. 950--958. Royal Society of Chemistry ({RSC})

Nagaraju, A., Ramulu, B.J., Shukla, G., Srivastava, A., Verma, G.K., Raghuvanshi, K., Singh, M.S.(2015). Catalyst-free one-pot four-component domino reactions in water-PEG-400: Highly efficient and convergent approach to thiazoloquinoline scaffolds . Green Chemistry. 17. (2). p. 950-958.

Anugula Nagaraju, Gaurav Shukla, Abhijeet Srivastava, Keshav Raghuvanshi, Maya Shankar Singh(2015). Iodine-Mediated Copper-Catalyzed Efficientα-C(sp2)-Thiomethylation ofα-Oxoketene Dithioacetals with Dimethyl Sulfoxide in One Pot . Advanced Synthesis & Catalysis. 357. (18). p. 3969--3976. Wiley-Blackwell

Shukla, G., Srivastava, A., Nagaraju, A., Raghuvanshi, K., Singh, M.S.(2015). Iodine-Mediated Copper-Catalyzed Efficient α-C(sp²)-Thiomethylation of α-Oxoketene Dithioacetals with Dimethyl Sulfoxide in One Pot . Advanced Synthesis and Catalysis. 357. (18). p. 3969-3976.

Nagaraju, A., Ramulu, B.J., Shukla, G., Srivastava, A., Verma, G.K., Singh, M.S.(2015). Solvent-free one-pot efficient and highly regioselective access to functionalized thiazolopyridones from α-enolic dithioesters . Arkivoc. 2016. (2). p. 42-52.

Ramulu, B.J., Chowdhury, S., Nagaraju, A., Koley, S., Anand, N., Singh, M.S.(2015). Iodine-mediated annulation of s-allylated α-enolic dithioesters: Rapid access to 2-alkylidene-1,3-dithiolanes at room temperature . Synthesis (Germany). 47. (10). p. 1510-1518.

Nagaraju, A., Janaki Ramulu, B., Shukla, G., Srivastava, A., Verma, G.K., Raghuvanshi, K., Singh, M.S.(2015). A facile and highly convergent approach to thiazolo[3,2-a]pyridines via one-pot multicomponent domino reaction under metal-free and solvent-free conditions . Tetrahedron. 71. (21). p. 3422-3427.

Ramulu, B.J., Nagaraju, A., Chowdhury, S., Koley, S., Singh, M.S.(2015). Copper-catalyzed site-selective S-S and C-C homocoupling of α-enolic dithioesters: Straightforward and efficient access to 1,2-dithiols . Tetrahedron Letters. 56. (20). p. 2593-2596.

Anugula Nagaraju, Girijesh Kumar Verma, Gaurav Shukla, Abhijeet Srivastava, Maya Shankar Singh(2014). In(OTf)3-mediated dehydrative annulation of β-ketothioamides with phenylglyoxal: one-pot access to diversely functionalized pyrrol-2-thiones . Tetrahedron Letters. 55. (37). p. 5182--5185. Elsevier {BV}

Anugula Nagaraju, Girijesh Kumar Verma, Gaurav Shukla, Abhijeet Srivastava, Maya Shankar Singh(2014). DMAP-promoted cascade C–S/C–N bonds formation approach to 1,3-thiazolidin-4-ones via annulation of β-ketothioamides with α-halocarboxylic acids at room temperature . Tetrahedron. 70. (39). p. 6980--6984. Elsevier {BV}

Anugula Nagaraju, Gaurav Shukla, Abhijeet Srivastava, B. Janaki Ramulu, Girijesh Kumar Verma, Keshav Raghuvanshi, Maya Shankar Singh(2014). Easy access to α-hydroxyimino-β-oxodithioesters and application towards the synthesis of diverse 1,4-thiazine-3-ones via reduction/annulation cascade . Tetrahedron. 70. (23). p. 3740--3746. Elsevier {BV}

Anugula Nagaraju, B. Janaki Ramulu, Gaurav Shukla, Abhijeet Srivastava, Girijesh Kumar Verma, Keshav Raghuvanshi, Maya Shankar Singh(2014). A facile and straightforward synthesis of 1,2,3-thiadiazoles from α-enolicdithioesters via nitrosation/reduction/diazotization/cyclization cascade in one-pot . Tetrahedron Letters. 55. (15). p. 2430--2433. Elsevier {BV}

Anugula Nagaraju, Maya Singh, Gaurav Shukla, Abhijeet Srivastava, Girijesh Verma, Keshav Raghuvanshi(2014). Regioselectivity in the Ring Opening of Epoxides: A Metal-Free Cascade C–S/C–O Bond Formation Approach to 1,3-Oxathiolan-2-ylidenes through Heteroannulation of α-Enolic Dithioesters at Room Temperature . Synthesis. 46. (13). p. 1815--1822. Georg Thieme Verlag {KG}

Shukla, G., Nagaraju, A., Srivastava, A., Verma, G.K., Raghuvanshi, K., Singh, M.S.(2014). Regioselectivity in the ring opening of epoxides: A metal-free cascade C-S/C-O bond formation approach to 1,3-oxathiolan-2-ylidenes through heteroannulation of α-enolic dithioesters at room temperature . Synthesis (Germany). 46. (13). p. 1815-1822.

Anugula Nagaraju, Girijesh Kumar Verma, Gaurav Shukla, Abhijeet Srivastava, Keshav Raghuvanshi, Maya Shankar Singh(2014). DMAP-promoted domino annulation of β-ketothioamides with internal alkynes: a highly regioselective access to functionalized 1,3-thiazolidin-4-ones at room temperature . RSC Adv. 4. (23). p. 11640--11647. Royal Society of Chemistry ({RSC})

Verma, G.K., Shukla, G., Nagaraju, A., Srivastava, A., Raghuvanshi, K., Singh, M.S.(2014). DMAP-promoted domino annulation of β-ketothioamides with internal alkynes: A highly regioselective access to functionalized 1,3-thiazolidin-4-ones at room temperature . RSC Advances. 4. (23). p. 11640-11647.

Anugula Nagaraju, Abhijeet Srivastava, Gaurav Shukla, Girijesh Kumar Verma, Keshav Raghuvanshi, Raymond C. F. Jones, Maya Shankar Singh(2014). In(OTf)3-catalysed one-pot versatile pyrrole synthesis through domino annulation of α-oxoketene-N,S-acetals with nitroolefins . Org. Biomol. Chem. 12. (29). p. 5484--5491. Royal Society of Chemistry ({RSC})

Srivastava, A., Shukla, G., Nagaraju, A., Verma, G.K., Raghuvanshi, K., Jones, R.C.F., Singh, M.S.(2014). In(OTf)₃-catalysed one-pot versatile pyrrole synthesis through domino annulation of α-oxoketene-N,S-acetals with nitroolefins . Organic and Biomolecular Chemistry. 12. (29). p. 5484-5491.

Anugula Nagaraju, Maya Shankar Singh, Namrata Anand, Sushobhan Chowdhury(2014). ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis . RSC Adv. 4. (99). p. 55924--55959. Royal Society of Chemistry ({RSC})

Singh, M.S., Nagaraju, A., Anand, N., Chowdhury, S.(2014). ortho-Quinone methide (o-QM): A highly reactive, ephemeral and versatile intermediate in organic synthesis . RSC Advances. 4. (99). p. 55924-55959.

Verma, G.K., Shukla, G., Nagaraju, A., Srivastava, A., Singh, M.S.(2014). DMAP-promoted cascade CeS/CeN bonds formation approach to 1,3-thiazolidin-4-ones via annulation of β-ketothioamides with α-halocarboxylic acids at room temperature . Tetrahedron. 70. (39). p. 6980-6984.

Nagaraju, A., Ramulu, B.J., Shukla, G., Srivastava, A., Verma, G.K., Raghuvanshi, K., Singh, M.S.(2014). A facile and straightforward synthesis of 1,2,3-thiadiazoles from α-enolicdithioesters via nitrosation/reduction/diazotization/cyclization cascade in one-pot . Tetrahedron Letters. 55. (15). p. 2430-2433.

Nagaraju, A., Shukla, G., Srivastava, A., Ramulu, B.J., Verma, G.K., Raghuvanshi, K., Singh, M.S.(2014). Easy access to α-hydroxyimino-β-oxodithioesters and application towards the synthesis of diverse 1,4-thiazine-3-ones via reduction/annulation cascade . Tetrahedron. 70. (23). p. 3740-3746.

Verma, G.K., Shukla, G., Nagaraju, A., Srivastava, A., Singh, M.S.(2014). In(OTf)₃-mediated dehydrative annulation of β-ketothioamides with phenylglyoxal: One-pot access to diversely functionalized pyrrol-2-thiones . Tetrahedron Letters. 55. (37). p. 5182-5185.

Nagaraju Anugula, Girijesh Kumar Verma, Rajiv Kumar Verma, Gaurav Shukla, Abhijeet Srivastava, Maya Shankar Singh(2013). One-pot straightforward approach to 2,3-disubstituted benzo/naphtho[b]furans via domino annulation of α-oxoketene dithioacetals and 1,4-benzo/naphthoquinone mediated by AlCl3 at room temperature . Tetrahedron. 69. (32). p. 6612--6619. Elsevier {BV}

Verma, G.K., Verma, R.K., Shukla, G., Anugula, N., Srivastava, A., Singh, M.S.(2013). One-pot straightforward approach to 2,3-disubstituted benzo/naphtho[b] furans via domino annulation of α-oxoketene dithioacetals and 1,4-benzo/naphthoquinone mediated by AlCl<inf>3</inf> at room temperature . Tetrahedron. 69. (32). p. 6612-6619.

Anugula Nagaraju, Gaurav Shukla, Girijesh Kumar Verma, Rajiv Kumar Verma, Keshav Raghuvanshi, Maya Shankar Singh(2013). DMAP mediated one-pot domino thienannulation: a versatile, regioselective and green mechanochemical route to naphtho[2,3-b]thiophenes . RSC Advances. 3. (33). p. 13811. Royal Society of Chemistry ({RSC})

Shukla, G., Verma, G.K., Nagaraju, A., Verma, R.K., Raghuvanshi, K., Singh, M.S.(2013). DMAP mediated one-pot domino thienannulation: A versatile, regioselective and green mechanochemical route to naphtho[2,3-b]thiophenes . RSC Advances. 3. (33). p. 13811-13817.

Anugula Nagaraju, Maya Shankar Singh, Girijesh Kumar Verma, Gaurav Shukla, Rajiv Kumar Verma, Abhijeet Srivastava, Keshav Raghuvanshi(2013). Eco-efficient, regioselective and rapid access to 4,5-disubstituted 1,2,3-thiadiazoles via [3 + 2] cycloaddition of α-enolicdithioesters with tosyl azide under solvent-free conditions . Green Chemistry. 15. (4). p. 954. Royal Society of Chemistry ({RSC})

Singh, M.S., Nagaraju, A., Verma, G.K., Shukla, G., Verma, R.K., Srivastava, A., Raghuvanshi, K.(2013). Eco-efficient, regioselective and rapid access to 4,5-disubstituted 1,2,3-thiadiazoles via [3 + 2] cycloaddition of α-enolicdithioesters with tosyl azide under solvent-free conditions . Green Chemistry. 15. (4). p. 954-962.

Anugula Nagaraju, Rajiv Kumar Verma, Girijesh Kumar Verma, Gaurav Shukla, Maya Shankar Singh(2012). 4-Dimethylamino Pyridine-Promoted One-Pot Three-Component Regioselective Synthesis of Highly Functionalized 4H-Thiopyrans via Heteroannulation of β-Oxodithioesters . ACS Combinatorial Science. 14. (3). p. 224--230. American Chemical Society ({ACS})

Verma, R.K., Verma, G.K., Shukla, G., Nagaraju, A., Singh, M.S.(2012). 4-Dimethylamino pyridine-promoted one-pot three-component regioselective synthesis of highly functionalized 4 H -thiopyrans via heteroannulation of β-oxodithioesters . ACS Combinatorial Science. 14. (3). p. 224-230.