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Hire Dr. Antony M.

Canada

Profile Summary

A researcher trained in Neurobiology and genetics. My expertise mostly fall under functional genomics aspects of Central Nervous System (CNS) oncology and disorders. Being trained in Neurobiology for 6 years, I extended my research interest into translating the genomics component of childhood brain tumours (Medulloblastoma and Ependymoma). Functional genomics is fundamental key aspect of therapeutic development for any disease. Currently, I am modelling the cancer genome molecular events of Medulloblastoma and Ependymoma in mouse.

Subject Matter Expertise

• ☆ Developmental Biology
• ☆ Genetics
• ☆ Genomics
• ☆ Neuroscience
• ☆ Neurochemistry
• ☆ Neurobiology

Services

• Consulting
• Product Development

Work Experience

Post Doctoral Fellow

Hospital for Sick Children

October 2014 - Present

Research Associate

University of Delhi

May 2013 - September 2014

Education

Ph.D (Genetics)

University of Delhi

November 2007 - April 2013

MSc Biotechnology (Biotechnology )

University of Madras

July 2005 - June 2007

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2020). Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma . Cell.

Donovan, L.K., Delaidelli, A., Joseph, S.K., Bielamowicz, K., Fousek, K., Holgado, B.L., Manno, A., Srikanthan, D., Gad, A.Z., Van Ommeren, R., et al.(2020). Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma . Nature Medicine.

(2019). Childhood cerebellar tumours mirror conserved fetal transcriptional programs . Nature.

Vladoiu, M.C., El-Hamamy, I., Donovan, L.K., Farooq, H., Holgado, B.L., Sundaravadanam, Y., Ramaswamy, V., Hendrikse, L.D., Kumar, S., Mack, S.C., et al.(2019). Childhood cerebellar tumours mirror conserved fetal transcriptional programs . Nature. 572. (7767). p. 67-73.

Mack, S.C., Pajtler, K.W., Chavez, L., Okonechnikov, K., Bertrand, K.C., Wang, X., Erkek, S., Federation, A., Song, A., Lee, C., et al.(2018). Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling . Nature. 553. (7686). p. 101-105.

Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Nature, 2016, vol. 529, no. 7586, pp. 351-357 .

Morrissy, A.S., Garzia, L., Shih, D.J.H., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F.M.G., Ramaswamy, V., Lindsay, P.E., et al.(2016). Divergent clonal selection dominates medulloblastoma at recurrence . Nature. 529. (7586). p. 351-357.

Michealraj, K.A., Jatana, N., Jafurulla, M., Narayanan, L., Chattopadhyay, A., Thelma, B.K.(2014). Functional characterization of rare variants in human dopamine receptor D4 gene by genotype-phenotype correlations . Neuroscience. 262. p. 176-189.

Geetha, T.S., Michealraj, K.A., Kabra, M., Kaur, G., Juyal, R.C., Thelma, B.K.(2014). Targeted Deep Resequencing Identifies MID2 Mutation for X-Linked Intellectual Disability with Varied Disease Severity in a Large Kindred from India . Human Mutation. 35. (1). p. 41-44.

Ahmad, T., Ahmad, T., Aggarwal, K., Pattnaik, B., Mukherjee, S., Sethi, T., Tiwari, B.K., Kumar, M., Micheal, A., Mabalirajan, U., et al.(2013). Computational classification of mitochondrial shapes reflects stress and redox state . Cell Death and Disease. 4. (1).