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★★★★★

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Hire Dr. Amanda C.

Saint Martin (French Part)

Profile Summary

I am originally from Australia but moved to the University of Pittsburgh for postdoctoral training. My primary project is focused on investigating breast cancer metastasis using a 3D micro physiological model. I am very curious and always looking to learn something new. My skill set: a) condensing large amounts of information into a concise summary which can be understood by both scientists and lay individuals, and b) identifying problems, elucidating solutions and making recommendations on how best to proceed.

Subject Matter Expertise

• ☆ Biology/Life Sciences
• ☆ Medicine
• ☆ Oncology
• ☆ Technical & Scientific Writing

Services

• Writing
• Consulting
• Product Development

Work Experience

University of Pittsburgh

- Present

Research Assistant Professor

University of Pittsburgh

August 2019 - Present

Research Associate

University of Pittsburgh

October 2016 - July 2019

Postdoctoral Associate

University of Pittsburgh School of Medicine

January 2013 - September 2016

Education

Doctor of Philosophy

Griffith University

February 2009 - November 2012

Doctor of Philosophy (PhD) (Griffith Health Institute)

Griffith University - Gold Coast Campus

February 2009 - November 2012

BBiomedSc (Hons; First Class) (Griffith Health Institute)

Griffith University - Gold Coast Campus

February 2004 - July 2008

BBiomedSc (Hons; First Class)

Griffith University

February 2004 - July 2008

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Amanda M Clark, Nancy L Allbritton, Alan Wells(2020). Integrative microphysiological tissue systems of cancer metastasis to the liver . Seminars in Cancer Biology. Elsevier {BV}

(2019). The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment . Seminars in cancer biology.

(2019). Adult Stem Cell Functioning in the Tumor Micro-Environment . International journal of molecular sciences.

(2018). The great escape: How metastases of melanoma, and other carcinomas, avoid elimination . Experimental biology and medicine (Maywood, N.J.).

(2018). Statins attenuate outgrowth of breast cancer metastases . British journal of cancer.

(2018). A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures . Molecular & cellular proteomics : MCP.

(2017). Liver 'organ on a chip' . Experimental cell research.

(2017). Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy . British journal of cancer.

(2017). Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells . Molecular cancer.

(2017). A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms . Stem cell reviews and reports.

(2016). A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties . Lab on a chip.

(2016). Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling . Hepatology (Baltimore, Md.).

(2016). Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells . BMC cancer.

(2016). Liver metastases: Microenvironments and ex-vivo models . Experimental biology and medicine (Maywood, N.J.).

Low P, Clark AM, Chou TC, Chang TC, Reynolds M, Ralph SJ, International immunopharmacology, 2015, vol. 26, no. 1, pp. 257-264 .

(2015). Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines . International immunopharmacology.

(2015). Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells . PloS one.

Masashi Furukawa, Sarah Wheeler, Amanda M. Clark, Alan Wells, Rajeev Samant(2015). Lung Epithelial Cells Induce Both Phenotype Alteration and Senescence in Breast Cancer Cells . {PLoS} {ONE}. 10. (1). p. e0118060. Public Library of Science ({PLoS})

S E Wheeler, A M Clark, D P Taylor, C L Young, V C Pillai, D B Stolz, R Venkataramanan, D Lauffenburger, L Griffith, A Wells(2014). Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system . British Journal of Cancer. 111. (12). p. 2342--2350. Nature Publishing Group

A. M. Clark, S. E. Wheeler, D. P. Taylor, V. C. Pillai, C. L. Young, R. Prantil-Baun, T. Nguyen, D. B. Stolz, J. T. Borenstein, D. A. Lauffenburger, et al.(2014). A microphysiological system model of therapy for liver micrometastases . Experimental Biology and Medicine. 239. (9). p. 1170--1179. {SAGE} Publications

Amanda Clark, Donald P. Taylor, Sarah Wheeler, Alan Wells(2014). Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition . Breast Cancer Res Treat. 144. (3). p. 551--560. Springer Science $\mathplus$ Business Media

Rachel E. Horton, Gary D. Grant, Ben Matthews, Michael Batzloff, Suzzanne J. Owen, Stephanie Kyan, Cameron P. Flegg, Amanda M. Clark, Glen C. Ulett, Nigel Morrison, et al.(2013). Quorum Sensing Negatively Regulates Multinucleate Cell Formation during Intracellular Growth of Burkholderia pseudomallei in Macrophage-Like Cells . {PLoS} {ONE}. 8. (5). p. e63394. Public Library of Science ({PLoS})

Sarah E Wheeler, Jeffrey T Borenstein, Amanda M Clark, Mohammed Ebrahimkhani, Ira J Fox, Linda Griffith, Walker Inman, Douglas Lauffenburger, Transon Nguyen, Venkateswaran C Pillai, et al.(2013). All-human microphysical model of metastasis therapy . Stem Cell Res Ther. 4. (Suppl 1). p. S11. Springer Science $\mathplus$ Business Media

Koichi Ito, Kimberley Stannard, Elwyn Gabutero, Amanda M. Clark, Shi-Yong Neo, Selda Onturk, Helen Blanchard, Stephen J. Ralph(2012). Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment . Cancer Metastasis Rev. 31. (3-4). p. 763--778. Springer Science $\mathplus$ Business Media