Profile Details

Create Project

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Hire Dr. Alvaro C.

Germany

Profile Summary

I am interested to understand the processes of life and transform our knowledge acquired into products to improve our life. My line of research interests are those of using single molecule biophysical techniques, reconstitution of macromolecular assembly and dynamics and observation of those in vitro and in living cells. I currently oversee several projects from molecular dynamics simulations, theoretical physics, biochemistry, cell biology and biophysics. Beyond my academic research activities, I have developed a live-cell ‘Lifeact’ marker for actin that is now worldwide used. Furthermore, I serve as a freelance consultant for Hypermol, to research and develop new technologies to study and manipulate the actin cytoskeleton. I am looking for my next big challenge!

Subject Matter Expertise

• ☆ Molecular Modeling
• ☆ Microbiology
• ☆ Biochemistry
• ☆ Structural Biology
• ☆ Molecular Biology
• ☆ Biophysics
• ☆ Nanobiotechnology
• ☆ Microscopy
• ☆ Software Engineering
• ☆ Data Analysis
• ☆ Statistics
• ☆ Trend Analysis
• ☆ Protein/Enzyme Engineering
• ☆ Cross Cultural Communication
• ☆ Spanish Literature
• ☆ Latin American Literature
• ☆ Tropical Medicine

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

Head of Microscopy

EMBL Rome

March 2019 - Present

Scientific Consultant / R&D / Product development

HYPERMOL GmbH

December 2012 - Present

Group Leader

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica

January 2017 - February 2019

Independent Postdoctoral Fellow

Ludwig-Maximilians-Universitat Munchen

March 2010 - December 2016

Postdoc

Max-Planck-Institut für Biochemie

December 2006 - February 2010

Education

Dr rer nat

Max Planck Institute of Molecular Cell Biology and Genetics

June 2002 - November 2006

Licenciado en Investigacion Biomedica Basica (Instituto de Investigaciones Biomedicas)

Universidad Nacional Autónoma de México

August 1997 - June 2002

Emergency Medical Technician

Mexican Red Cross

September 1995 - January 1997

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Nirakar Basnet, Hana Nedozralova, Alvaro H. Crevenna, Satish Bodakuntla, Thomas Schlichthaerle, Michael Taschner, Giovanni Cardone, Carsten Janke, Ralf Jungmann, Maria M. Magiera, et al.(2018). Direct induction of microtubule branching by microtubule nucleation factor SSNA1 . Nature Cell Biology. 20. (10). p. 1172--1180.

Nicoli, F., Barth, A., Bae, W., Neukirchinger, F., Crevenna, A.H., Lamb, D.C., Liedl, T.(2017). Directional Photonic Wire Mediated by Homo-Förster Resonance Energy Transfer on a DNA Origami Platform . ACS Nano. 11. (11). p. 11264-11272.

Nicoli, F., Barth, A., Bae, W., Neukirchinger, F., Crevenna, A.H., Lamb, D.C., Liedl, T.(2017). Directional Photonic Wire Mediated by Homo-Förster Resonance Energy Transfer on a DNA Origami Platform . ACS Nano. 11. (11). p. 11264--11272.

Luitz, M.P., Barth, A., Crevenna, A.H., Bomblies, R., Lamb, D.C., Zacharias, M.(2017). Covalent dye attachment influences the dynamics and conformational properties of flexible peptides . PLoS ONE. 12. (5).

Luitz, M.P., Barth, A., Crevenna, A.H., Bomblies, R., Lamb, D.C., Zacharias, M.(2017). Covalent dye attachment influences the dynamics and conformational properties of flexible peptides . PLoS ONE. 12. (5).

Jasnin, M., Crevenna, A.H.(2016). Quantitative Analysis of Filament Branch Orientation in Listeria Actin Comet Tails . Biophysical Journal. 110. (4). p. 817--826.

Crevenna, A.H., Blank, B., Maiser, A., Emin, D., Prescher, J., Beck, G., Kienzle, C., Bartnik, K., Habermann, B., Pakde, M., et al.(2016). Secretory cargo sorting by Ca²⁺-dependent Cab45 oligomerization at the trans-Golgi network . Journal of Cell Biology. 213. (3). p. 305--314.

Kedrov, A., Wickles, S., Kedrov, A., Wickles, S., Crevenna, A.H., van der Sluis, E.O., Buschauer, R., Berninghausen, O., Lamb, D.C., Beckmann, R.(2016). Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis . Cell Reports. 17. (11). p. 2943--2954.

Jasnin, M., Crevenna, A.H.(2016). Quantitative Analysis of Filament Branch Orientation in Listeria Actin Comet Tails . Biophysical Journal. 110. (4). p. 817-826.

Crevenna, A.H., Crevenna, A.H., Blank, B., Maiser, A., Emin, D., Prescher, J., Beck, G., Kienzle, C., Bartnik, K., Habermann, B., et al.(2016). Secretory cargo sorting by Ca²⁺-dependent Cab45 oligomerization at the trans-Golgi network . Journal of Cell Biology. 213. (3). p. 305-314.

Kedrov, A., Wickles, S., Crevenna, A.H., van der Sluis, E.O., Buschauer, R., Berninghausen, O., Lamb, D.C., Beckmann, R.(2016). Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis . Cell Reports. 17. (11). p. 2943-2954.

Alvaro H Crevenna, Marcelino Arciniega, Aurélie Dupont, Naoko Mizuno, Kaja Kowalska, Oliver F Lange, Roland Wedlich-Söldner, Don C Lamb(2015). Side-binding proteins modulate actin filament dynamics . eLife. 4.

Geng, Y., Kedrov, A., Caumanns, J.J., Crevenna, A.H., Lamb, D.C., Beckmann, R., Driessen, A.J.M.(2015). Role of the cytosolic loop C2 and the C terminus of YidC in ribosome binding and insertion activity . Journal of Biological Chemistry. 290. (28). p. 17250--17261.

Geng, Y., Geng, Y., Kedrov, A., Caumanns, J.J., Crevenna, A.H., Lamb, D.C., Beckmann, R., Driessen, A.J.M.(2015). Role of the cytosolic loop C2 and the C terminus of YidC in ribosome binding and insertion activity . Journal of Biological Chemistry. 290. (28). p. 17250-17261.

Crevenna, A.H., Arciniega, M., Dupont, A., Crevenna, A.H., Arciniega, M., Dupont, A., Mizuno, N., Kowalska, K., Lange, O.F., Wedlich-Söldner, R., et al.(2015). Side-binding proteins modulate actin filament dynamics . eLife. 2015. (4).

Kienzle, C., Basnet, N., Crevenna, A.H., Beck, G., Habermann, B., Mizuno, N., von Blume, J.(2014). Cofilin recruits F-actin to SPCA1 and promotes Ca²⁺-mediated secretory cargo sorting . Journal of Cell Biology. 206. (5). p. 635--654.

Wang, Q., Crevenna, A.H., Kunze, I., Mizuno, N.(2014). Structural basis for the extended CAP-Gly domains of p150glued binding to microtubules and the implication for tubulin dynamics . Proceedings of the National Academy of Sciences of the United States of America. 111. (31). p. 11347--11352.

Wang, Q., Crevenna, A.H., Kunze, I., Mizuno, N.(2014). Structural basis for the extended CAP-Gly domains of p150glued binding to microtubules and the implication for tubulin dynamics . Proceedings of the National Academy of Sciences of the United States of America. 111. (31). p. 11347-11352.

Kienzle, C., Basnet, N., Crevenna, A.H., Beck, G., Habermann, B., Mizuno, N., von Blume, J.(2014). Cofilin recruits F-actin to SPCA1 and promotes Ca²⁺-mediated secretory cargo sorting . Journal of Cell Biology. 206. (5). p. 635-654.

Crevenna, A.H., Naredi-Rainer, N., Schonichen, A., Dzubiella, J., Barber, D.L., Lamb, D.C., Wedlich-Söldner, R.(2013). Electrostatics control actin filament nucleation and elongation kinetics . Journal of Biological Chemistry. 288. (17). p. 12102--12113.

Crevenna, A.H., Naredi-Rainer, N., Schonichen, A., Dzubiella, J., Barber, D.L., Lamb, D.C., Wedlich-Söldner, R.(2013). Electrostatics control actin filament nucleation and elongation kinetics . Journal of Biological Chemistry. 288. (17). p. 12102-12113.

Schmoller, K.M., Köhler, S., Crevenna, A.H., Wedlich-Söldner, R., Schmoller, K.M., Köhler, S., Crevenna, A.H., Wedlich-Söldner, R., Bausch, A.R.(2012). Modulation of cross-linked actin networks by pH . Soft Matter. 8. (37). p. 9685-9690.

Schmoller, K.M., Köhler, S., Crevenna, A.H., Wedlich-Söldner, R., Bausch, A.R.(2012). Modulation of cross-linked actin networks by pH . Soft Matter. 8. (37). p. 9685--9690.

Köhler, S., Schmoller, K., Crevenna, A., Bausch, A.(2012). Regulating Contractility of the Actomyosin Cytoskeleton by pH . Cell Reports. 2. (3). p. 433-439.

Crevenna, A.H., Naredi-Rainer, N., Lamb, D.C., Wedlich-Söldner, R., Dzubiella, J.(2012). Effects of hofmeister ions on the α-helical structure of proteins . Biophysical Journal. 102. (4). p. 907-915.

Crevenna, A.H., Naredi-Rainer, N., Lamb, D.C., Wedlich-Söldner, R., Dzubiella, J.(2012). Effects of hofmeister ions on the a-helical structure of proteins . Biophysical Journal. 102. (4). p. 907--915.

Köhler, S., Schmoller, K., Crevenna, A., Bausch, A.(2012). Regulating Contractility of the Actomyosin Cytoskeleton by pH . Cell Reports. 2. (3). p. 433--439.

Yu, J.H., Crevenna, A.H., Bettenbühl, M., Freisinger, T., Wedlich-Söldner, R.(2011). Cortical actin dynamics driven by formins and myosin V . Journal of Cell Science. 124. (9). p. 1533--1541.

Domínguez-Escobar, J., Chastanet, A., Crevenna, A.H., Fromion, V., Wedlich-Söldner, R., Carballido-López, R.(2011). Processive movement of MreB-associated cell wall biosynthetic complexes in bacteria . Science. 333. (6039). p. 225--228.

Yu, J.H., Crevenna, A.H., Bettenbühl, M., Freisinger, T., Wedlich-Söldner, R.(2011). Cortical actin dynamics driven by formins and myosin V . Journal of Cell Science. 124. (9). p. 1533-1541.

Domínguez-Escobar, J., Chastanet, A., Crevenna, A.H., Fromion, V., Wedlich-Söldner, R., Carballido-López, R.(2011). Processive movement of MreB-associated cell wall biosynthetic complexes in bacteria . Science. 333. (6039). p. 225-228.

Riedl, J., Crevenna, A.H., Kessenbrock, K., Yu, J.H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T.A., Werb, Z., et al.(2008). Lifeact: A versatile marker to visualize F-actin . Nature Methods. 5. (7). p. 605-607.

Crevenna, A.H., Madathil, S., Cohen, D.N., Wagenbach, M., Fahmy, K., Howard, J.(2008). Secondary structure and compliance of a predicted flexible domain in kinesin-1 necessary for cooperation of motors . Biophysical Journal. 95. (11). p. 5216-5227.

Riedl, J., Crevenna, A.H., Kessenbrock, K., Yu, J.H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T.A., Werb, Z., et al.(2008). Lifeact: A versatile marker to visualize F-actin . Nature Methods. 5. (7). p. 605--607.

Crevenna, A.H., Madathil, S., Cohen, D.N., Wagenbach, M., Fahmy, K., Howard, J.(2008). Secondary structure and compliance of a predicted flexible domain in kinesin-1 necessary for cooperation of motors . Biophysical Journal. 95. (11). p. 5216--5227.

Schief, W.R., Clark, R.H., Crevenna, A.H., Howard, J.(2004). Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism . Proceedings of the National Academy of Sciences of the United States of America. 101. (5). p. 1183-1188.

Schief, W.R., Clark, R.H., Crevenna, A.H., Howard, J.(2004). Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism . Proceedings of the National Academy of Sciences of the United States of America. 101. (5). p. 1183--1188.

Morales-Mulia, S., Cardin, V., Torres-Márquez, M.E., Crevenna, A., Pasantes-Morales, H.(2001). Influence of protein kinases on the osmosensitive release of taurine from cerebellar granule neurons . Neurochemistry International. 38. (2). p. 153-161.

Morales-Mulia, S., Cardin, V., Torres-Márquez, M.E., Crevenna, A., Pasantes-Morales, H., Morales-Mulia, S., Cardin, V., Torres-Márquez, M.E., Crevenna, A., Pasantes-Morales, H.(2001). Influence of protein kinases on the osmosensitive release of taurine from cerebellar granule neurons . Neurochemistry International. 38. (2). p. 153--161.

OTHER

Maria Hoyer, Jose Rafael Cabral Correia, Don C. Lamb, Alvaro H. Crevenna Dimer arrangement and monomer flattening determine actin filament formation .

PATENT

WEDLICH-SOELDNER ROLAND, SIXT MICHAEL, RIEDL JULIA, CREVENNA ALVARO .

WEDLICH-SOELDNER ROLAND, SIXT MICHAEL, RIEDL JULIA, CREVENNA ALVARO .

WEDLICH-SOELDNER ROLAND, SIXT MICHAEL, RIEDL JULIA, CREVENNA ALVARO .