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Hire Alexander T.
Kazakhstan
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Freelance Biostatistician | Expert in GraphPad Prism | Neuroscientist with 15+ years in research and data analysis
Profile Summary
Subject Matter Expertise
Services
Work Experience
Research Assistant
Nazarbayev University
August 2023 - Present 
Senior research fellow
Institute of Experimental Medicine
November 2008 - May 2024
ESN Scholar
Centre for Neuroscience and Cell Biology
January 2023 - July 2023
Professor (Associate)
Saint Petersburg Chemical and Pharmaceutical University
September 2020 - September 2022
Junior Research Fellow
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow
October 2017 - December 2018
Visiting Researcher, Research Fellow
University Hospital of Würzburg
September 2014 - December 2016
Visiting Researcher, Research Fellow
Institute of Physiologically Active Compounds
February 2014 - December 2016
Education
Ph.D. (Department of Neuroscience)
Maastricht University
February 2022 - February 2024
PhD (I.P. Pavlov Department of Physiology)
Institute of Experimental Medicine
October 2011 - October 2018
Master of Biology (Biology and Soil Sciences)
Saint Petersburg State University
September 2009 - June 2011
Bachelor of Biology (Biology and Soil Sciences)
Saint Petersburg State University
September 2005 - June 2009
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
et al., Alexander Trofimov, Beatriz Rodrigues, Ricardo A. Leitão, Mónica Santos, Mariline Silva, Ângela S. Inácio, Mónica Abreu, Rui J. Nobre, Jéssica Costa, Ana Luísa Cardoso (2025). MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress . Molecular Psychiatry.
Trofimov, Alexander, Rodrigues, Beatriz, Leitao, Ricardo A., Santos, Monica, Silva, Mariline, Inacio, angela S., Abreu, Monica, Nobre, Rui J., Costa, Jessica, Cardoso, Ana Luisa, et al. (2025). MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress . Molecular Psychiatry.
Alexander Trofimov, Alexey Sarapultsev, Maria Komelkova, Oleg Lookin, Sergey Khatsko, Evgenii Gusev, Tursonjan Tokay, Desheng Hu (2024). Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies . Pathophysiology.
Alexander Trofimov, Alexey Sarapultsev, Maria Komelkova, Oleg Lookin, Sergey Khatsko, Евгений Гусев, Tokay.T, Desheng Hu (2024). Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies . Pathophysiology.
Alexander Trofimov, Alexey Sarapultsev, Maria Komelkova, Oleg Lookin, Sergey Khatsko, Евгений Гусев, Tokay.T, Desheng Hu (2024). Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies . Pathophysiology.
Alexander Trofimov, Burkitkan Akbay, Zhannur Omarova, Bayan Sailike, Orynbassar Karapina, Ferdinand Molnár, Tursonjan Tokay (2024). Double-Edge Effects of Leucine on Cancer Cells . Biomolecules.
Alexander Trofimov, Burkitkan Akbay, Zhannur Omarova, Bayan Sailike, Orynbassar Karapina, Ferdinand Molnár, Tokay.T (2024). Double-Edge Effects of Leucine on Cancer Cells . Biomolecules.
Alexander Trofimov, Malika Madikyzy, Aigul Durmanova, Burkitkan Akbay, Tursonjan Tokay (2024). Evaluation of Biochemical Serum Markers for the Diagnosis of Polycystic Ovary Syndrome (PCOS) in Obese Women in Kazakhstan: Is Anti-Müllerian Hormone a Potential Marker? . Biomedicines.
Alexander Trofimov, Malika Madikyzy, Aigul Durmanova, Burkitkan Akbay, Tokay.T (2024). Evaluation of Biochemical Serum Markers for the Diagnosis of Polycystic Ovary Syndrome (PCOS) in Obese Women in Kazakhstan: Is Anti-Müllerian Hormone a Potential Marker? . Biomedicines.
Trofimov, Alexander, Madikyzy, Malika, Durmanova, Aigul, Akbay, Burkitkan, Tokay, Tursonjan (2024). Evaluation of Biochemical Serum Markers for the Diagnosis of Polycystic Ovary Syndrome (PCOS) in Obese Women in Kazakhstan: Is Anti-Müllerian Hormone a Potential Marker? . Biomedicines.
Trofimov, Alexander, Akbay, Burkitkan, Omarova, Zhannur, Sailike, Bayan, Karapina, Orynbassar, Molnar, Ferdinand, Tokay, Tursonjan (2024). Double-Edge Effects of Leucine on Cancer Cells . Preprints.org.
S. A. Apryatin, D. S. Traktirov, M. N. Karpenko, I. S. Ivleva, N. S. Pestereva, M. V. Bolshakova, A. N. Trofimov, Z. S. Fesenko, V. M. Klimenko (2023). Antioxidant system alterations and physiological characteristics of neonatal and juvenile DAT‐KO rats . Journal of Neuroscience Research.
Alexander P. Schwarz, Dragan Hrncic, Veronika A. Nikitina, Darya U. Krytskaya, Ksenia P. Shcherbakova, Alexander N. Trofimov (2023). Reference gene expression stability within the rat brain under mild intermittent ketosis induced by supplementation with medium-chain triglycerides . PLOS ONE.
Alexander Trofimov, Ksenia Shcherbakova, Alexander Schwarz, Irina Ivleva, Veronika Nikitina, Darya Krytskaya, Sergey Apryatin, Marina Karpenko (2023). Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats . Heliyon.
Trofimov, Alexander, Shcherbakova, Ksenia, Schwarz, Alexander, Ivleva, Irina, Nikitina, Veronika, Krytskaya, Darya, Apryatin, Sergey, Karpenko, Marina (2023). Short- and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats . Heliyon.
Trofimov, Alexander, Pavlov, Dmitrii, Goswami, Anand, Gorlova, Anna, Chaprov, Kirill, Umriukhin, Aleksei, Kalueff, Allan, Deykin, Alexey, Lesch, Klaus-Peter, Anthony, Daniel Clive, et al. (2023). Lipopolysaccharide triggers exacerbated microglial activation, excessive cytokine release and behavioural disturbances in mice with truncated Fused-in-Sarcoma Protein (FUS) . Brain, Behavior, & Immunity Health.
Schwarz, Alexander P., Nikitina, Veronika A., Krytskaya, Darya U., Shcherbakova, Ksenia P., Trofimov, Alexander N. (2023). Reference gene expression stability within the rat brain under mild intermittent ketosis induced by supplementation with medium-chain triglycerides . Plos One.
Apryatin, S. A., Traktirov, D. S., Karpenko, M. N., Ivleva, I. S., Pestereva, N. S., Bolshakova, M. V., Trofimov, A. N., Fesenko, Z. S., Klimenko, V. M. (2023). Antioxidant system alterations and physiological characteristics of neonatal and juvenile DAT-KO rats . Journal of Neuroscience Research.
Alexander Trofimov(2022). Molecular mechanisms of molecular transfer across the blood-brain barrier as a target for pharmacological action Part 1. Structure, function and pathology of the BBB . Pharmacy Formulas. {ECO}-Vector {LLC}
Ksenia Shcherbakova and Alexander Schwarz and Sergey Apryatin and Marina Karpenko and Alexander Trofimov(2022). Supplementation of Regular Diet With Medium-Chain Triglycerides for Procognitive Effects: A Narrative Review . Frontiers in Nutrition. 9. Frontiers Media {SA}
Alexander Trofimov, Tatyana Strekalova, Dmitrii Pavlov, Daniel C. Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, Raymond Cespuglio(2022). Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice . International Journal of Molecular Sciences. 23. (4). p. 2061. {MDPI} {AG}
Alexander Trofimov, Tatyana Strekalova, Dmitrii Pavlov, Anthony DC, Andrei Svistunov, Proshin A.T., Aleksei Umriukhin, Alexey Lyundup, Klaus-Peter Lesch, Raymond Cespuglio (2022). Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice . International Journal of Molecular Sciences.
Trofimov, Alexander, Strekalova, Tatyana, Pavlov, Dmitrii, Anthony, Daniel C., Svistunov, Andrei, Proshin, Andrey, Umriukhin, Aleksei, Lyundup, Alexei, Lesch, Klaus-Peter, Cespuglio, Raymond (2022). Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice . International Journal of Molecular Sciences.
Trofimov, Alexander, Schwarz, Alexander, Ivleva, Irina, Nikitina, Veronika, Krytskaya, Darya, Apryatin, Sergey, Karpenko, Marina, Shcherbakova, Ksenia (2022). Intermittent ketosis induced by MCT supplement: Dose-dependent differential effects on cognitive and metabolic parameters in rats . Journal of Neurochemistry.
Trofimov, Alexander, Shcherbakova, Ksenia, Schwarz, Alexander, Apryatin, Sergey, Karpenko, Marina (2022). Supplementation of Regular Diet With Medium-Chain Triglycerides for Procognitive Effects: A Narrative Review . Frontiers in Nutrition.
Trofimov, Alexander, Schwarz, Alexander, Zakharova, Maria, Kovalenko, Anna, Dyomina, Alexandra, Malygina, Daria, Zubareva, Olga, Zaitsev, Aleksey (2022). Reference gene stability within the rat brain in the lithium pilocarpine epilepsy model: Timing and region specificity . Journal of Neurochemistry.
Trofimov, Alexander, Nikitina, Veronika, Krytskaya, Darya, Schwarz, Alexander, Veniaminova, Ekaterina, Shavva, Vladimir, Ivleva, Irina, Apryatin, Sergey, Karpenko, Marina, Shcherbakova, Ksenia (2022). Supplementation with medium-chain triglycerides (MCT) improves memory and alters glutamatergic gene expression in the rat brain . Journal of Neurochemistry.
Veronika A. Nikitina and Maria V. Zakharova and Alexander N. Trofimov and Alexander P. Schwarz and Gleb V. Beznin and Sergei G. Tsikunov and Olga E. Zubareva(2021). Neonatal Exposure to Bacterial Lipopolysaccharide Affects Behavior and Expression of Ionotropic Glutamate Receptors in the Hippocampus of Adult Rats after Psychogenic Trauma . Biochemistry (Moscow). 86. (6). p. 761--772. Pleiades Publishing Ltd
Nikitina, Veronika A., Zakharova, Maria, V, Trofimov, Alexander N., Schwarz, Alexander P., Beznin, Gleb, V, Tsikunov, Sergei G., Zubareva, Olga E. (2021). Neonatal Exposure to Bacterial Lipopolysaccharide Affects Behavior and Expression of Ionotropic Glutamate Receptors in the Hippocampus of Adult Rats after Psychogenic Trauma . Biochemistry. Biokhimiia.
A. N. Trofimov and A. Yu. Rotov and E. A. Veniaminova and K. Fomalont and A. P. Schwarz and O. E. Zubareva(2020). Changes in Behavior and the Expression of Ionotropic Glutamate Receptor Genes in the Brains of Adult Rats after Neonatal Administration of Bacterial Lipopolysaccharide . Neuroscience and Behavioral Physiology. 50. (9). p. 1239--1248. Springer Science and Business Media {LLC}
(2020). Multiplex qPCR assay for assessment of reference gene expression stability in rat tissues/samples . Molecular and cellular probes.
Schwarz, Alexander P., Malygina, Daria A., Kovalenko, Anna A., Trofimov, Alexander N., Zaitsev, Aleksey, V (2020). Multiplex qPCR assay for assessment of reference gene expression stability in rat tissues/samples . Molecular and Cellular Probes.
Trofimov, A., Schwarz, A., Krytskaya, D., Shavva, V., Veniaminova, E., Sizoff, V., Shcherbakova, A. (2019). Mild ketogenic diet as promising approach for cognition enhancement: medium-chain triglyceride supplement improves memory in rats . Journal of Neurochemistry.
Alexander P. Schwarz, Alexander Yu. Rotov, Olga I. Chuprina, Darya U. Krytskaya, Alexander N. Trofimov, Vera V. Kosheverova, Alexander M. Ischenko, Olga E. Zubareva(2018). Developmental prefrontal mRNA expression of D2 dopamine receptor splice variants and working memory impairments in rats after early life Interleukin-1β elevation . Neurobiology of Learning and Memory. 155. p. 231--238. Elsevier {BV}
Strekalova, T., Bahzenova, N., Trofimov, A., Schmitt-Böhrer, A.G., Markova, N., Grigoriev, V., Zamoyski, V., Serkova, T., Redkozubova, O., Vinogradova, D., et al.(2018). Pro-neurogenic, memory-enhancing and anti-stress effects of DF302, a novel fluorine gamma-carboline derivative with multi-target mechanism of action . Molecular Neurobiology. 55. (1). p. 335-349.
Trofimov, Alexander, Strekalova, Tatyana, Bahzenova, Nataliia, Schmitt-Boehrer, Angelika G., Markova, Nataliia, Grigoriev, Vladimir, Zamoyski, Vladimir, Serkova, Tatiana, Redkozubova, Olga, Vinogradova, Daria, et al. (2018). Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action . Molecular Neurobiology.
Schwarz, A.P., Rotov, A.Y., Chuprina, O.I., Krytskaya, D.U., Trofimov, A.N., Kosheverova, V.V., Ischenko, A.M., Zubareva, O.E.(2018). Developmental prefrontal mRNA expression of D2 dopamine receptor splice variants and working memory impairments in rats after early life Interleukin-1β elevation . Neurobiology of Learning and Memory. 155. p. 231-238.
Schwarz, Alexander P., Rotov, Alexander Yu., Chuprina, Olga I., Krytskaya, Darya U., Trofimov, Alexander N., Kosheverova, Vera V., Ischenko, Alexander M., Zubareva, Olga E. (2018). Developmental prefrontal mRNA expression of D2 dopamine receptor splice variants and working memory impairments in rats after early life Interleukin-1β elevation . Neurobiology of Learning and Memory.
Shavva, V.S., Bogomolova, A.M., Efremov, A.M., Trofimov, A.N., Nikitin, A.A., Babina, A.V., Nekrasova, E.V., Dizhe, E.B., Oleinikova, G.N., Missyul, B.V., et al.(2018). Insulin downregulates C3 gene expression in human HepG2 cells through activation of PPARγ . European Journal of Cell Biology. 97. (3). p. 204-215.
Shavva, Vladimir S., Bogomolova, Alexandra M., Efremov, Alexander M., Trofimov, Alexander N., Nikitin, Artemy A., Babina, Anna, V, Nekrasov, Ekaterina, V, Dizhe, Ella B., Oleinikova, Galina N., Missyul, Boris, V, et al. (2018). Insulin downregulates C3 gene expression in human HepG2 cells through activation of PPARγ . European Journal of Cell Biology.
Schwarz, Alexander P., Trofimov, Alexander N., Zubareva, Olga E., Lioudyno, Victoria I., Kosheverova, Vera V., Ischenko, Alexander M., Klimenko, Victor M. (2017). Prefrontal mRNA expression of long and short isoforms of D2 dopamine receptor: Possible role in delayed learning deficit caused by early life interleukin-1β treatment . Behavioural Brain Research.
Trofimov, Alexander, Strekalova, Tatyana, Mortimer, Niall, Zubareva, Olga, Schwarz, Alexander, Svirin, Evgeniy, Umriukhin, Aleksei, Svistunov, Andrei, Lesch, Klaus-Peter, Klimenko, Victor (2017). Postnatal LPS Challenge Impacts Escape Learning and Expression of Plasticity Factors <i>Mmp9</i> and <i>Timp1</i> in Rats: Effects of Repeated Training . Neurotoxicity Research.
Trofimov, A., Strekalova, T., Mortimer, N., Zubareva, O., Schwarz, A., Svirin, E., Umriukhin, A., Svistunov, A., Lesch, K.-P., Klimenko, V.(2017). Postnatal LPS Challenge Impacts Escape Learning and Expression of Plasticity Factors Mmp9 and Timp1 in Rats: Effects of Repeated Training . Neurotoxicity Research. 32. (2). p. 175-186.
Schwarz, A., Trofimov, A., Veniaminova, E., Zubareva, O. (2017). Neonatal proinflammatory treatment affects the cognitive functions development and brain neuroplasticity-related gene expression . Journal of Neurochemistry.
Schwarz, A.P., Trofimov, A.N., Zubareva, O.E., Lioudyno, V.I., Kosheverova, V.V., Ischenko, A.M., Klimenko, V.M.(2017). Prefrontal mRNA expression of long and short isoforms of D2 dopamine receptor: Possible role in delayed learning deficit caused by early life interleukin-1β treatment . Behavioural Brain Research. 333. p. 118-122.
(2016). Expression of the FGF2 and TIMP1 Genes in the Adult Rat Brain after Administration of Interleukin-1β during Early Postnatal Ontogeny . Neuroscience and Behavioral Physiology.
Couch, Y., Trofimov, A., Markova, N., Nikolenko, V., Steinbusch, H.W., Chekhonin, V., Schroeter, C., Lesch, K.-P., Anthony, D.C., Strekalova, T.(2016). Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice . Journal of Neuroinflammation. 13. (1).
Trofimov, Alexander, Couch, Yvonne, Markova, Natalyia, Nikolenko, Vladimir, Steinbusch, Harry W., Chekhonin, Vladimir, Schroeter, Careen, Lesch, Klaus-Peter, Anthony, Daniel C., Strekalova, Tatyana (2016). Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice . Journal of Neuroinflammation.
Trofimov, A.N., Zubareva, O.E., Shvarts, A.P., Ishchenko, A.M., Klimenko, V.M.(2016). Expression of the FGF2 and TIMP1 genes in the adult rat brain after administration of interleukin-1β during early postnatal ontogeny . Neuroscience and Behavioral Physiology. 46. (4). p. 413-420.
A. N. Trofimov, O. E. Zubareva, A. P. Shvarts, A. M. Ishchenko, V. M. Klimenko (2016). Expression of the FGF2 and TIMP1 Genes in the Adult Rat Brain after Administration of Interleukin-1β during Early Postnatal Ontogeny . Neuroscience and Behavioral Physiology.
(2014). Effects of Neonatal Increases in Interleukin-1beta Levels on the Formation of Spatial Memory in Adult Rats . Neuroscience and Behavioral Physiology.
K.J. Fomalont, E.A. Veniaminova, S.V. Kalemenev, A.N. Trofimov, A.P. Schwarz, O.E. Zubareva (2014). 91. Early-life LPS administrations induce cognitive decline and changes in NMDA receptor subunit gene expression in the rodent brain . Brain, Behavior, and Immunity.
Trofimov, A.N., Zubareva, O.E., Simbirtsev, A.S., Klimenko, V.M.(2014). Effects of neonatal increases in interleukin-1β levels on the formation of spatial memory in adult rats . Neuroscience and Behavioral Physiology. 44. (3). p. 359-364.
A. N. Trofimov, O. E. Zubareva, A. S. Simbirtsev, V. M. Klimenko (2014). Effects of Neonatal Increases in Interleukin-1β Levels on the Formation of Spatial Memory in Adult Rats . Neuroscience and Behavioral Physiology.
Trofimov, A.N., Zubareva, O.E., Shvarts, A.P., Ishchenko, A.M., Klimenko, V.M.(2014). [The administration of interleukin-1beta during early postnatal develop ment impairs FGF2, but not TIMP1, mRNA expression in brain structures of adult rats] . Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. 100. (9). p. 1025-1037.
[The administration of interleukin-1beta during early postnatal develop ment impairs FGF2, but not TIMP1, mRNA expression in brain structures of adult rats] @article {
author = {Trofimov, A.N. and Zubareva, O.E. and Shvarts, A.P. and Ishchenko, A.M. and Klimenko, V.M.},
title = {[The administration of interleukin-1beta during early postnatal develop ment impairs FGF2, but not TIMP1, mRNA expression in brain structures of adult rats]},
journal = {Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk},
volume = {100},
number = {9},
pages = {1025--1037},
year = {2014},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84925283859&partnerID=MN8TOARS}
} . Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk.
Trofimov, A.N., Zubareva, O.E., Simbirtsev, A.S., Klimenko, V.M.(2012). [The influence of neonatal interleukin-1beta increase on the formation of adult rats' spatial memory] . Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk. 98. (6). p. 782-792.
[The influence of neonatal interleukin-1beta increase on the formation of adult rats' spatial memory]. @article {
author = {Trofimov, A.N. and Zubareva, O.E. and Simbirtsev, A.S. and Klimenko, V.M.},
title = {[The influence of neonatal interleukin-1beta increase on the formation of adult rats' spatial memory].},
journal = {Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk},
volume = {98},
number = {6},
pages = {782--792},
year = {2012},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84867165130&partnerID=MN8TOARS}
} . Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk.
Alexander Trofimov Behavioral and molecular consequences of a ‘double-hit’ challenge on the pathogenesis of mouse models of depression and amyotrophic lateral sclerosis (ALS) . Maastricht University.
PREPRINT
Alexander Trofimov, Malika Madikyzy, Aigul Durmanova, Burkitkan Akbay, Tursonjan Tokay (2024). Evaluation of Biochemical Serum Indicators for Polycystic Ovarian Syndrome Diagnosis among Women with Obesity .
CONFERENCE PAPER
Alexander Trofimov, Ksenia Shcherbakova, Alexander Schwarz, Irina Ivleva, Veronika Nikitina, Darya Krytskaya, Sergey Apryatin, Marina Karpenko(2021). Acute and Chronic Effects of Medium-Chain Triglyceride Supplementation on Metabolic Parameters and Working Memory in Rats . {MDPI}
(2014). Early-life LPS administrations induce cognitive decline and changes in NMDA receptor subunit gene expression in the rodent brain . Brain, Behavior, and Immunity.
Ratings and Comments
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