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Hire Dr. Aitor M.

Spain

USD 50 /hr

PhD Neuroscientist | Mitochondrial & CRISPR Specialist | Future Biotech Innovator (EMBA)

Profile Summary

Scientist with a strong academic and biotech background, including leadership roles at the University of Cambridge and Talisman Therapeutics. Expert in neurodegeneration, ubiquitin proteomics, and mitochondrial quality control, with extensive experience in molecular biology, cell culture (including CRISPR), and in vivo Drosophila models. PhD in Cellular and Molecular Physiology (University of Liverpool) and postdoctoral research at the MRC-Mitochondrial Biology Unit. Currently pursuing an Executive MBA (Quantic) to transition into business-focused roles in science and innovation. Strong communication skills, team leadership, and a people-oriented mindset.

Subject Matter Expertise

• ★ Oxidative Stress & Mitochondrial Function
• ★ Molecular Neuroscience
• ★ Cell Aging
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Omics
• ☆ Proteomics
• ☆ Genomics
• ☆ PCR
• ☆ Recombinant DNA
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Immunohistochemistry
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Phenotypic Assays
• ☆ High Content Screening/Imaging
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Neurology
• ☆ Parkinson's Disease
• ☆ Alzheimer's Disease
• ☆ Grant Writing
• ☆ Entrepreneurship
• ☆ Project Management

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Market Research, User Research, Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Image Processing, Image Analysis, Data Processing, Data Insights

Work Experience

Postdoctoral Fellow

University of Cambridge

October 2018 - Present

Scientist II

Talisman Therapeutics

February 2024 - November 2024

Education

PhD | Neuroscience

Univerity of Liverpool

January 2012 - January 2017

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth (2024). Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models . Molecular Neurodegeneration.

Aitor Martinez, Alvaro Sanchez-Martinez, Yi-Hsien Su, Alexander J. Whitworth (2023). FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo . PLOS Biology.

Aitor Martinez, Sofia Mauri, Greta Bernardo, Mariavittoria Favaro, Marta Trevisan, Gael Cobraiville, Marianne Fillet, Federico Caicci, Alexander J. Whitworth, Elena Ziviani (2023). USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons . Cells.

Aitor Martinez, Sofia Mauri, Greta Bernardo, Mariavittoria Favaro, MARTA TREVISAN, Gael Cobraiville, Marianne Fillet, Federico Caicci, Alexander Whitworth, Elena Ziviani (2023). USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the <i>Drosophila</i> Brain and in Human Neurons . Cells.

(2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) . Autophagy.

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, et al.(2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ . Autophagy.

Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, et al.(2020). USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation . Life science alliance.

Aitor Martinez, Charles Williams, Raquel Pazos, F&#233;lix Royo, Esperanza Gonz&#225;lez, Meritxell Roura-Ferrer, Jorge Gamiz, Niels-Christian Reichardt, Juan M Falc&#243;n-P&#233;rez (2019). Assessing the role of surface glycans of extracellular vesicles on cellular uptake . Scientific Reports.

Marcassa E, Kallinos A, Jardine J, Rusilowicz-Jones EV, Martinez A, Kuehl S, Islinger M, Clague MJ, Urb&#233; S(2018). Dual role of USP30 in controlling basal pexophagy and mitophagy . EMBO reports.

Lee JJ, Sanchez-Martinez A, Zarate AM, Beninc&#225; C, Mayor U, Clague MJ, Whitworth AJ(2018). Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin . The Journal of cell biology.

Aitor Martinez, Juanma Ramirez, Nerea Osinalde, Jesus M. Arizmendi, Ugo Mayor(2018). Neuronal Proteomic Analysis of the Ubiquitinated Substrates of the Disease-Linked E3 Ligases Parkin and Ube3a . BioMed Research International. 2018. p. 1--14. Hindawi Limited

Martinez A, Mayor U, Clague MJ(2017). Multi-story Parkin . Oncotarget.

Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urb&#233; S, Dittmar G, Clague MJ, Mayor U(2017). Quantitative proteomic analysis of Parkin substrates in Drosophila neurons . Molecular neurodegeneration.

Liang JR, Martinez A, Lane JD, Mayor U, Clague MJ, Urb&#233; S(2015). USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death . EMBO reports.

Ramirez J, Martinez A, Lectez B, Lee SY, Franco M, Barrio R, Dittmar G, Mayor U(2015). Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells . PloS one.

PREPRINT

Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alex J. Whitworth (2023). Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models .

Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth (2023). Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes inPink1/parkinmodels .

Aitor Martinez, Alvaro Sanchez-Martinez, Alexander J. Whitworth (2022). FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provides a target for Pink1 phosphorylationin vivo .