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Hire Dr. Adriana D.

Brazil

Expert in molecular biology and medical genetics.

Profile Summary

Extensive knowledge of molecular biology laboratory techniques applied to human and medical genetics. Solid experience in genomic sequencing and data analysis. 6+ years of academic and research background, developing project management experience, and troubleshooting skills. In my first research project, I developed genetic research, using biochemistry, microbiology, and molecular biology strategies in the study of Aspergillus fumigatus. With this project, we were able to partially characterization of rlmA gene, which has an important role in the formation and recomposition of the fungus cell wall. During my second project, we performed an investigation on chromosomal rearrangements involving the X chromosome and the impact of skewed X inactivation at patients’ phenotype. The development of this project recruited techniques as FISH, CGH-array, SNP-array, and RT-qPCR. The detailed identification of the involved regions and gene disruptions provided better genotype-phenotype and specific details for genetic counseling. In my Ph.D. project, we investigated the three-dimensional structure of chromatin and its effect on gene expression in patients with balanced X-autosomes translocations and premature ovarian insufficiency. The results provided a better understanding of the complex mechanism of gene regulation related to the chromatin organization in the interphase nucleus, as well as ovarian insufficiency. To address these questions, we use several NGS techniques, Sanger sequencing, and RT-qPCR.

Subject Matter Expertise

• ★ Genetics
• ★ Medicine
• ★ Research

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Newswriting

Research Market Research, Feasibility Study, Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis

Product Development Formulation

Work Experience

Research and Development Bioinformatician

Genera Group

November 2020 - Present

PhD in molecular biology

Federal University of São Paulo

July 2016 - October 2020

MSc in Human and Medical Genetics

Universidade de São Paulo

October 2014 - June 2016

Lab technician III

Associação Fundo de Incentivo à Pesquisa

September 2014 - November 2014

Lab Technician III

Associação Fundo de Incentivo à Pesquisa

February 2013 - August 2014

Education

PhD in Molecular Biology

Federal University of Sao Paulo

July 2016 - October 2020

MSc in Human and Medical Genetics

Federal University of Sao Paulo

October 2014 - June 2016

Bachelor in Biological Sciences

Federal University of Sao Carlos

February 2008 - June 2012

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2020). Genetics of premature ovarian insufficiency and the association with X-autosome translocations . Reproduction. 160. (4). p. R55--R64. Bioscientifica

(2020). Disruption of PCDH10 and TNRC18 Genes due to a Balanced Translocation . Cytogenetic and Genome Research.

(2019). Search for appropriate reference genes for quantitative reverse transcription PCR studies in somite, prosencephalon and heart of early mouse embryo . Gene.

(2019). Breakpoint mapping at nucleotide resolution in X-autosome balanced translocations associated with clinical phenotypes . European Journal of Human Genetics.

(2018). Inactivation of AMMECR1 is associated with growth, bone, and heart alterations . Human Mutation.

(2016). Unusual X-chromosome inactivation pattern in patients with Xp11.23-p11.22 duplication: Report and review . American Journal of Medical Genetics Part A.

(2016). Incorporation of 5-ethynyl-2′-deoxyuridine (EdU) as a novel strategy for identification of the skewed X inactivation pattern in balanced and unbalanced X-rearrangements . Human Genetics.

(2015). X-linked intellectual disability related genes disrupted by balanced X-autosome translocations . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.