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Hire Dr. Anwar H.

United States

USD 100 /hr

Medicinal Chemist | Expert in small molecule drug design and discovery | Expert in drug metabolism and disposition

Profile Summary

Small molecule drug discovery. Experienced in retrosynthesis for organic compounds and drug design and synthesis. Proficient in drug discovery project management and large scale research.

Subject Matter Expertise

• ★ Drug Discovery
• ★ Medicinal Chemistry
• ★ Technical & Scientific Writing
• ☆ Microbiology
• ☆ Virology
• ☆ Coronaviruses
• ☆ Molecular Biology
• ☆ Kinases
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Data Collection
• ☆ Drug Development
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Case Studies
• ☆ Science Communication
• ☆ Grant Writing

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Non-Medical Regulatory Writing, Technical Writing, Creative Writing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Processing

Work Experience

Research Assistant Professor

University of North Carolina at Chapel Hill

March 2025 - Present

Postdoctoral Research Associate

The University of North Carolina at Chapel Hill

March 2020 - March 2025

Research Assistant

Texas Tech University Health Sciences Center

January 2015 - March 2020

Education

Ph.D. (Pharmaceutical Sciences)

Texas Tech University Health Sciences Center

January 2015 - December 2019

M. Pharm

University of Dhaka

January 2009 - December 2010

Certifications

• NA

  NA

  January 2024 - Present

Publications

PREPRINT

Muthu Ramalingam Bose, John D. Sears, Kacey M. Talbot, Yuan-Wei Norman Su, Scott Houliston, Mohammed Anwar Hossain, Zachary W. Davis-Gilbert, Chunqing Zhao, Hans J. Oh, Peter J. Brown, et al. (2025). Identification of Direct-acting nsP2 Helicase Inhibitors with Antialphaviral Activity .

Mohammad Anwar Hossain, Abigail K. Mayo, Anirban Ghoshal, Sharon A. Taft-Benz, Elizabeth J. Anderson, Noah L. Morales, Katia D. Pressey, Ava M. Vargason, Kim L. R. Brouwer, Nathaniel J. Moorman, et al. (2025). Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor within VivoAnti-alphaviral Activity .

Hernan Navarro, John E. Scott, Ginger R. Smith, Pegah Ghiabi, Elisa Gibson, Peter Loppnau, Rachel J. Harding, Mohammad Anwar Hossain, Muthu Ramalingam Bose, Kenneth H. Pearce, et al. (2024). Identification of Inhibitors ofChikungunyavirus nsP2 ATPase .

Holli-Joi Martin, Mohammad A. Hossain, James Wellnitz, Enes Kelestemur, Joshua E. Hochuli, Sumera Parveen, Cheryl Arrowsmith, Timothy M. Willson, Eugene Muratov, Alexander Tropsha (2024). Heli-SMACC: Helicase-targeting SMAll Molecule Compound Collection .

Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J. Brown, Eric M. Merten, John D. Sears, Sumera Perveen, Kenneth H. Pearce, Konstantin I. Popov, Nathaniel J. Moorman, et al. (2024). Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors ofChikungunyansP2 Cysteine Protease with Anti-alphavirus Activity .

Joseph A Newman, Angeline E Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme, Hans J. Oh, Carrow I. Wells, et al. (2024). Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy .

Anirban Ghoshal, Álvaro Magalhães, Kesatebrhan Asressu, Mohammad Hossain, Matthew Todd, Timothy Willson (2024). Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of Beta-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors .

Eric M. Merten, John D. Sears, Tina M. Leisner, Paul B. Hardy, Anirban Ghoshal, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Peter J. Brown, Michael A. Stashko, Laura Herring, et al. (2024). Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach .

Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, et al. (2022). SGC-CAMKK2-1: A chemical probe for CAMKK2 .

Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Catta-Preta, Priscila Zonzini Ramos, et al.(2022). SGC-CAMKK2-1: A chemical probe for CAMKK2 . biorxiv. Cold Spring Harbor Laboratory

JOURNAL ARTICLE

Anirban Ghoshal, Edwin G. Tse, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Eric M. Merten, John D. Sears, Stefanie Howell, Sumera Perveen, Jane Burdick, Noah L. Morales, et al. (2025). A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity . Scientific Reports.

Joseph A. Newman, Angeline E. Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Robert te Poele, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme, Hans J. Oh, et al. (2025). Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy . Nature Communications.

Eric M. Merten, John D. Sears, Tina M. Leisner, P. Brian Hardy, Anirban Ghoshal, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Peter J. Brown, Edwin G. Tse, Michael A. Stashko, et al. (2024). Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach . Proceedings of the National Academy of Sciences.

Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J. Brown, Meganathan Nandakumar, Anand Vala, Eric M. Merten, John D. Sears, Isabella Law, Jane E. Burdick, et al. (2024). Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity . Journal of Medicinal Chemistry.

Anirban Ghoshal, Álvaro F. Magalhães, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew H. Todd, Timothy M. Willson (2024). Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors . Pharmaceuticals.

Anirban Ghoshal, &#193;lvaro F. Magalh&#227;es, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew Todd, Timothy M Willson (2024). Identification of Dihydropyrazolo[1,5-<i>a</i>]pyrazin-4(5<i>H</i>)-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors . Pharmaceuticals.

Siavash Shahbazi Nia, Yuma T. Ortiz, Julio D. Zuarth Gonzalez, Leila Shamir, Kofi Frimpong-Manson, Mohammad Anwar Hossain, Sadisna Shahi, Rayna Bandy, Anoushka Bhat, Dhavalkumar Patel, et al. (2024). Characterization of a Nonselective Opioid Receptor Functional Antagonist: Implications for Development as a Novel Opioid Dependence Medication . ACS Pharmacology & Translational Science.

Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David Harold Drewry (2023). How many kinases are druggable? A review of our current understanding . Biochemical Journal.

Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T.A. Lewis, Danial Ahwazi, Naomi X.Y. Ling, et al. (2023). CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle . Molecular Metabolism.

Zachary W. Davis-Gilbert, Andreas Kr&#228;mer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Frances M. Bashore, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, et al. (2023). Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2 . ACS Medicinal Chemistry Letters.

Thaila Fernanda dos Reis, Patr&#237;cia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro F. N. Souza, Suzanne Ackloo, Mohammad Anwar Hossain, David Harold Drewry, Sondus Alkhazraji, Ashraf S. Ibrahim, et al. (2023). A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi . Nature Communications.

Siavash Shahbazi Nia, Mohammad Anwar Hossain, Guangchen Ji, Sravan K. Jonnalagadda, Samuel Obeng, Md Ashrafur Rahman, Ali Ehsan Sifat, Saeideh Nozohouri, Collin Blackwell, Dhavalkumar Patel, Jon Thompson, Scott Runyon, Takato Hiranita, Christopher R. McCurdy, Lance McMahon, Thomas J. Abbruscato, Paul C. Trippier, Volker Neugebauer, Nadezhda A. German, Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands, European Journal of Medicinal Chemistry, Volume 254, 2023, 115309, ISSN 0223-5234, https://doi.org/10.1016/j.ejmech.2023.115309 .

Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, et al. (2023). SGC-CAMKK2-1: A Chemical Probe for CAMKK2 . Cells.

Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean N. O&#39;Byrne, Mohammad Anwar Hossain, Carolina Catta-Preta, Priscila Zonzini Ramos, et al. (2023). SGC-CAMKK2-1: A Chemical Probe for CAMKK2 . Cells.

David H. Drewry, Frances M. Potjewyd, Armin Bayati, Jeffery L. Smith, Rebekah J. Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M. Min, Mohammad Anwar Hossain, Mark Heise, et al. (2022). Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses . Journal of Medicinal Chemistry.

Mohammad Anwar Hossain(2022). Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses . Journal of Medicinal Chemistry. American Chemical Society ({ACS})

Update on modulators of quorum sensing pathways in Pseudomonas Aeruginosa. Hossain Anwar Mohammad and German A. Nadezhda *, Update on Modulators of Quorum Sensing Pathways in Pseudomonas aeruginosa, Current Topics in Medicinal Chemistry 2021; 21(23) . https://dx.doi.org/10.2174/1568026621666210924160004 . Current topics in medicinal chemistry.

Benjamin J. Eduful, Sean N. O’Byrne, Louisa Temme, Christopher R. M. Asquith, Yi Liang, Alfredo Picado, Joseph R. Pilotte, Mohammad Anwar Hossain, Carrow I. Wells, William J. Zuercher, et al. (2021). Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes . Journal of Medicinal Chemistry.

Benjamin J. Eduful and Sean N. O'Byrne and Louisa Temme and Christopher R. M. Asquith and Yi Liang and Alfredo Picado and Joseph R. Pilotte and Mohammad Anwar Hossain and Carrow I. Wells and William J. Zuercher and Carolina M. C. Catta-Preta and Priscila Zonzini Ramos and Andr{\'{e}} de S. Santiago and Rafael M. Cou{\~{n}}ago and Christopher G. Langendorf and K{\'{e}}vin Nay and Jonathan S. Oakhill and Thomas L. Pulliam and Chenchu Lin and Dominik Awad and Timothy M. Willson and Daniel E. Frigo and John W. Scott and David H. Drewry(2021). Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes . Journal of Medicinal Chemistry. American Chemical Society ({ACS})

(2021). Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects . Journal of controlled release : official journal of the Controlled Release Society.

(2019). Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence . European Journal of Medicinal Chemistry.

Patel, R., Hossain, M.A., German, N., Al-Ahmad, A.J.(2018). Gliotoxin penetrates and impairs the integrity of the human blood-brain barrier in vitro . Mycotoxin Research. 34. (4). p. 257-268.

Binte Amir, S., Hossain, M. A., & Mazid, M. A. (2013). Development and Validation of UV Spectrophotometric Method for the Determination of Cefuroxime Axetil in Bulk and Pharmaceutical Formulation. Journal of Scientific Research, 6(1), 133-141. https://doi.org/10.3329/jsr.v6i1.14879 .

PATENT

German Nadezhda, Neugebauer Volker, Hossain Mohammad Anwar, Abbruscatto Thomas(2024). SELECTIVE AND NON-SELECTIVE OPIOID RECEPTOR FUNCTIONAL ANTAGONISTS AND METHODS RELATED THERETO FOR TREATMENT OF ADDICTION, OPIOD DEPENDENCE, AND NEUROPATHIC PAIN . US 2024/0165110 A1

German Nadezhda, Neugebauer Volker, Hossain Mohammad, Abbruscatto Thomas(2020). NOVEL SELECTIVE KAPPA OPIOID RECEPTOR ANTAGONISTS AND METHODS RELATED THERETO FOR TREATMENT OF ADDICTION AND NEUROPATHIC PAIN . WO 2020/092996 A1

German Nadezhda, Hossain Mohammad(2020). NOVEL OPIOID ANTAGONISTS AND METHODS RELATED THERETO . WO 2020/092603 A1

DATA SET

Davis-Gilbert, Zachary and Drewry, David H. and Hossain, Mohammad Anwar(2022). LMW Binding Affinity Screen for TBXT . Zenodo

BOOK CHAPTER

Hossain, M. A., & German, N. A. (2018). The role of hormones in bone health and diseases. Bone regeneration: Concepts, clinical aspects and future directions (pp. 151-196) .