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☆☆☆☆☆

Hire Dr. Alessandro D.

Germany

USD 160 /hr

Biotechnology Consultant | Techno-Economic Analysis, Patent Strategy & Scale-Up

Profile Summary

I am a biotechnology consultant with a PhD and over 10 years of experience in industrial biotechnology, synthetic biology, bioprocess development, intellectual property strategy, and technology commercialization. My expertise includes techno-economic analysis (TEA), product opportunity assessment, patent landscaping, invention evaluation, commercialization strategy, microbial fermentation, plant cell culture, and biomass valorization. I currently serve as CTO and co-founder of a biotechnology startup developing sustainable plant-derived ingredients through plant cell culture technology. I have worked with startups, research organizations, and innovation programs across Europe to evaluate technologies, identify high-value opportunities, develop IP strategies, and define R&D and commercialization roadmaps. I support projects involving TEA, scientific and technical due diligence, patent scouting and landscape analysis, product and market assessment, R&D strategy, bioprocess optimization, scale-up planning, grant applications, and biotechnology innovation management.

Subject Matter Expertise

• ☆ Materials Science & Engineering
• ☆ Biomaterials
• ☆ Bioplastics
• ☆ Biochemistry
• ☆ Biotechnology & Bioengineering
• ☆ Plant Biotechnology
• ☆ Industrial Biotechnology
• ☆ Microbial Fermentation
• ☆ Agricultural Biotechnology
• ☆ Biomolecular Engineering
• ☆ Gene Synthesis
• ☆ Pharmaceutical Manufacturing
• ☆ Bioprocess Development
• ☆ Project Management

Services

• Writing

Writing Technical Writing, Copywriting

Work Experience

CEO & Founder

Fondaco SynBio

June 2024 - Present

IP and project manager

Omne Possibile

March 2021 - May 2023

Postdoc

INSA Toulouse

December 2016 - May 2019

Education

PhD (Synthetic Biology)

Technische Universität Berlin

January 2011 - June 2016

Certifications

• Training Course on European and German Patent Law

  Vossius

  September 2022 - Present

• Advanced course on Basics of patent drafting

  World Intellectual Property Organization WIPO

  August 2022 - Present

• Business Strategy and Operations in a Biobased Economy

  Wageningen University & Research

  August 2020 - Present

Publications

JOURNAL ARTICLE

Jade Dussart‐Gautheret, Julie Rivollier, Cédric Simon, Alessandro De Simone, Jérôme Berthet, Stéphanie Delbaere, Régina Maruchenko, Claire Troufflard, Denis Lesage, Yves Gimbert, et al. (2023). Front Cover: Synthesis and Enzymatic Conversion of Amino Acids Equipped with the Silanetriol Functionality: A Prelude to Silicon Biodiversification (ChemistryEurope 3/2023) . ChemistryEurope.

Jade Dussart‐Gautheret, Julie Rivollier, Cédric Simon, Alessandro De Simone, Jérôme Berthet, Stéphanie Delbaere, Régina Maruchenko, Claire Troufflard, Denis Lesage, Yves Gimbert, et al. (2023). Synthesis and Enzymatic Conversion of Amino Acids Equipped with the Silanetriol Functionality: A Prelude to Silicon Biodiversification . ChemistryEurope.

Jade Dussart‐Gautheret, Julie Rivollier, Cédric Simon, Alessandro De Simone, Jérôme Berthet, Stéphanie Delbaere, Régina Maruchenko, Claire Troufflard, Denis Lesage, Yves Gimbert, et al. (2023). Synthesis and Enzymatic Conversion of Amino Acids Equipped with the Silanetriol Functionality: A Prelude to Silicon Biodiversification . ChemistryEurope.

De Simone, A., Vicente, C.M., Peiro, C., Gales, L., Bellvert, F., Enjalbert, B., Heux, S.(2020). Mixing and matching methylotrophic enzymes to design a novel methanol utilization pathway in E. coli . Metabolic Engineering. 61. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 315-325.

Peiro, C., Millard, P., de Simone, A., Cahoreau, E., Peyriga, L., Enjalbert, B., Heux, S.(2019). Chemical and metabolic controls on dihydroxyacetone metabolism lead to suboptimal growth of Escherichia coli . Applied and Environmental Microbiology. 85. (15).

Worst, E.G., Exner, M.P., de Simone, A., Schenkelberger, M., Noireaux, V., Budisa, N., Ott, A.(2016). Residue-specific incorporation of noncanonical amino acids into model proteins using an Escherichia coli cell-free transcription-translation system . Journal of Visualized Experiments. 2016. (114).

De Simone, A., Acevedo-Rocha, C.G., Hoesl, M.G., Budisa, N.(2016). Towards reassignment of the methionine codon aug to two different noncanonical amino acids in bacterial translation . Croatica Chemica Acta. 89. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 243-253.

Worst, E.G., Exner, M.P., De Simone, A., Schenkelberger, M., Noireaux, V., Budisa, N., Ott, A.(2015). Cell-free expression with the toxic amino acid canavanine . Bioorganic and Medicinal Chemistry Letters. 25. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3658-3660.

PREPRINT

A. De Simone, C.M. Vicente, C. Peiro, L. Gales, F. Bellvert, B. Enjalbert, S. Heux (2020). Mixing and matching methylotrophic enzymes to design a novel methanol utilization pathway inE. coli .

OTHER

de Simone, A., Vicente, C.M., Peiro, C., Gales, L., Bellvert, F., Enjalbert, B., Heux, S.(2020). Mixing and matching methylotrophic enzymes to design a novel methanol utilization pathway in E. coli . bioRxiv.

BOOK CHAPTER

de Simone, A., Hoesl, M.G., Budisa, N.(2016). Engineering lipases with an expanded genetic code . Applied Biocatalysis: From Fundamental Science to Industrial Applications. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3-12.